A M Sica E O Risco
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Translational Medicine
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Author : Joy A. Cavagnaro
language : en
Publisher: CRC Press
Release Date : 2021-11-26
Translational Medicine written by Joy A. Cavagnaro and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-11-26 with Medical categories.
Translational Medicine: Optimizing Preclinical Safety Evaluation of Biopharmaceuticals provides scientists responsible for the translation of novel biopharmaceuticals into clinical trials with a better understanding of how to navigate the obstacles that keep innovative medical research discoveries from becoming new therapies or even making it to clinical trials. The book includes sections on protein-based therapeutics, modified proteins, oligonucleotide-based therapies, monoclonal antibodies, antibody–drug conjugates, gene and cell-based therapies, gene-modified cell-based therapies, combination products, and therapeutic vaccines. Best practices are defined for efficient discovery research to facilitate a science-based, efficient, and predictive preclinical development program to ensure clinical efficacy and safety. Key Features: Defines best practices for leveraging of discovery research to facilitate a development program Includes general principles, animal models, biomarkers, preclinical toxicology testing paradigms, and practical applications Discusses rare diseases Discusses "What-Why-When-How" highlighting different considerations based upon product attributes. Includes special considerations for rare diseases About the Editors Joy A. Cavagnaro is an internationally recognized expert in preclinical development and regulatory strategy with an emphasis on genetic medicines.. Her 40-year career spans academia, government (FDA), and the CRO and biotech industries. She was awarded the 2019 Arnold J Lehman Award from the Society of Toxicology for introducing the concept of science-based, case-by-case approach to preclinical safety evaluation, which became the foundation of ICH S6. She currently serves on scientific advisory boards for advocacy groups and companies and consults and lectures in the area of preclinical development of novel therapies. Mary Ellen Cosenza is a regulatory toxicology consultant with over 30 years of senior leadership experience in the biopharmaceutical industry in the U.S., Europe, and emerging markets. She has held leadership position in both the American College of Toxicology (ACT) and the International Union of Toxicology (IUTOX) and is also an adjunct assistant professor at the University of Southern California where she teaches graduate-level courses in toxicology and regulation of biologics.
Behavioral Analysis Of Societies And Cultural Practices
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Author : Peter A. Lamal
language : en
Publisher: Taylor & Francis
Release Date : 1991
Behavioral Analysis Of Societies And Cultural Practices written by Peter A. Lamal and has been published by Taylor & Francis this book supported file pdf, txt, epub, kindle and other format this book has been release on 1991 with Behavioral assessment categories.
Aims to establish a new subdiscipline, namely, behaviour analysis of societies and cultural practices. Included is a discussion of the Soviet Union and Eastern Europe. It looks at entire cultures as the units of analysis and is for anyone with a basic knowledge of the principles of behaviour.
Brazilian Estuaries
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Author : Paulo da Cunha Lana
language : en
Publisher: Springer
Release Date : 2018-07-09
Brazilian Estuaries written by Paulo da Cunha Lana and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-07-09 with Science categories.
This book presents the main drivers of benthic structure and processes in estuaries from the 8,000 km-Brazilian coast, assesses the influence of natural and human disturbance, and discusses their ecological importance and management needs. Estuaries are unique coastal ecosystems often with low biodiversity that sustain and provide essential ecological services to mankind. These ecosystems include a variety of habitats with their own sediment and fauna dynamics, all of them globally altered or threatened by human activities. Mangroves, saltmarshes, tidal flats and other confined estuarine systems are under increasing stress by overfishing and other human activities leading to habitat and species loss. Combined changes in estuarine hydromorphology and in climate pose severe threats to estuarine ecosystems at a global scale.
Directing
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Author : Michael Rabiger
language : en
Publisher: Taylor & Francis
Release Date : 2013-04-02
Directing written by Michael Rabiger and has been published by Taylor & Francis this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-04-02 with Performing Arts categories.
Directing: Film Techniques and Aesthetics is a comprehensive manual that teaches the essentials of filmmaking from the perspective of the director. Ideal for film production and directing classes, as well as for aspiring and current directors, Directing covers all phases of preproduction and production, from idea development to final cut. Thoroughly covering the basics, Directing guides the reader to professional standards of expression and control, and goes to the heart of what makes a director. The book outlines a great deal of practical work to meet this goal, with projects, exercises. The third edition emphasizes the connection between knowing and doing, with every principle realizable through projects and exercises. Much has been enhanced and expanded, notably: aspects of dramaturgy; beats and dramatic units; pitching stories and selling one's work; the role of the entrepreneurial producer; and the dangers of embedded moral values. Checklists are loaded with practical recommendations for action, and outcomes assessment tables help the reader honestly gauge his or her progress. Entirely new chapters present: preproduction procedures; production design; script breakdown; procedures and etiquette on the set; shooting location sound; continuity; and working with a composer. The entire book is revised to capitalize on the advantages offered by the revolutionary shift to digital filmmaking.
Mediapolis
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Author : Alex de Jong
language : en
Publisher: 010 Publishers
Release Date : 2006
Mediapolis written by Alex de Jong and has been published by 010 Publishers this book supported file pdf, txt, epub, kindle and other format this book has been release on 2006 with Popular culture categories.
Popular culture is taking an ever firmer grip on our living environment and on our lives. Survey of the urban pop culture and of concepts of pop philosophy. Bespreking van K. Wenz 'Changing popular culture in relation to urban space' verschenen in: Krisis. (2008)1(.89-91).
Well Being Of Youth And Emerging Adults Across Cultures
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Author : Radosveta Dimitrova
language : en
Publisher: Springer
Release Date : 2018-01-02
Well Being Of Youth And Emerging Adults Across Cultures written by Radosveta Dimitrova and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-01-02 with Psychology categories.
The current volume presents new empirical data on well-being of youth and emerging adults from a global international perspective. Its outstanding features are the focus on vast geographical regions (e.g., Europe, Asia, Africa, North and South America), and on strengths and resources for optimal well-being. The international and multidisciplinary contributions address the complexities of young people’s life in a variety of cultural settings to explore how key developmental processes such as identity, religiosity and optimism, social networks, and social interaction in families and society at large promote optimal and successful adaptation. The volume draws on core theoretical models of human development to highlight the applicability of these frameworks to culturally diverse youth and emerging adults as well as universalities and cultural specifics in optimal outcomes. With its innovative and cutting-edge approaches to cultural, theoretical and methodological issues, the book offers up-to-date evidence and insights for researchers, practitioners and policy makers in the fields of cross-cultural psychology, developmental science, human development, sociology, and social work.
Toolkit For Counseling Spanish Speaking Clients
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Author : Lorraine T. Benuto
language : en
Publisher: Springer
Release Date : 2017-11-14
Toolkit For Counseling Spanish Speaking Clients written by Lorraine T. Benuto and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-11-14 with Psychology categories.
This timely practical reference addresses the lack of Spanish-language resources for mental health professionals to use with their Latino clients. Geared toward both English- and Spanish-speaking practitioners in a variety of settings, this volume is designed to minimize misunderstandings between the clinician and client, and with that the possibility of inaccurate diagnosis and/or ineffective treatment. Coverage for each topic features a discussion of cultural considerations, guidelines for evidence-based best practices, a review of available findings, a treatment plan, plus clinical tools and client handouts, homework sheets, worksheets, and other materials. Chapters span a wide range of disorders and problems over the life-course, and include reproducible resources for: Assessing for race-based trauma. Using behavioral activation and cognitive interventions to treat depression among Latinos. Treating aggression, substance use, abuse, and dependence among Latino Adults. Treating behavioral problems among Latino adolescents. Treating anxiety among Latino children. Working with Latino couples. Restoring legal competency with Latinos. The Toolkit for Counseling Spanish-Speaking Clients fills a glaring need in behavioral service delivery, offering health psychologists, social workers, clinical psychologists, neuropsychologists, and other helping professionals culturally-relevant support for working with this under served population. The materials included here are an important step toward dismantling barriers to mental health care.
Obesity And Cardiovascular Disease
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Author : Malcolm K Robinson
language : en
Publisher: CRC Press
Release Date : 2006-03-07
Obesity And Cardiovascular Disease written by Malcolm K Robinson and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2006-03-07 with Medical categories.
Although cardiovascular disease remains the leading proximate cause of death in the United States, it is now estimated that obesity may be equivalent to smoking as the leading cause of preventable death in America. In light of these statistics, this reference presents our current understanding of the epidemiology, pathology, and genetics of the obe
Regionalism In Latin America
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Author : JOSÉ BRICEÑO-RUIZ
language : en
Publisher: Routledge
Release Date : 2020-11-18
Regionalism In Latin America written by JOSÉ BRICEÑO-RUIZ and has been published by Routledge this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-11-18 with Business & Economics categories.
This interdisciplinary edited volume explores the political economy of regionalism in Latin America. It identifies convergent forces which have existed in the region since its very conception and analyses these dynamics in their different historical, geographic and structural contexts. Particular attention is paid to key countries such as Argentina, Brazil and Mexico, as well as subregions like the Southern Cone and Central America. To understand the resilience of regionalism in Latin America, this book proposes to highlight four main issues. Firstly, that resilience is linked to mechanisms of self-enforcement that are part of the accumulation of experiences, institution building and common cultural features described in this book as regionalist acquis. Secondly, the elements and driving forces behind the promotion and expression of the regionalist acquis are influenced and shaped by nested systems in which social processes are inserted. Thirdly, when looking at systems, there is a particular influence by national and global ones, which condition the form and endurance of regional projects. Finally, beyond systems, the book highlights the relevance of agents as crucial players in the shaping of the resilience of regionalism in Latin America. This insightful collection will appeal to advanced students and researchers in international economics, international relations, international political economy, economic history and Latin American studies.
Communication And Health Outcomes
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Author : Gary L. Kreps
language : en
Publisher: Hampton Press (NJ)
Release Date : 1995
Communication And Health Outcomes written by Gary L. Kreps and has been published by Hampton Press (NJ) this book supported file pdf, txt, epub, kindle and other format this book has been release on 1995 with Language Arts & Disciplines categories.
The studies provided in this volume provide evidence of the pervasive influences of communication on health, health care, and health promotion, helping to validate assertions about these influences made by many health communication scholars.