A Marca Chamada Voc
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Translational Medicine
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Author : Joy A. Cavagnaro
language : en
Publisher: CRC Press
Release Date : 2021-11-26
Translational Medicine written by Joy A. Cavagnaro and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-11-26 with Medical categories.
Translational Medicine: Optimizing Preclinical Safety Evaluation of Biopharmaceuticals provides scientists responsible for the translation of novel biopharmaceuticals into clinical trials with a better understanding of how to navigate the obstacles that keep innovative medical research discoveries from becoming new therapies or even making it to clinical trials. The book includes sections on protein-based therapeutics, modified proteins, oligonucleotide-based therapies, monoclonal antibodies, antibody–drug conjugates, gene and cell-based therapies, gene-modified cell-based therapies, combination products, and therapeutic vaccines. Best practices are defined for efficient discovery research to facilitate a science-based, efficient, and predictive preclinical development program to ensure clinical efficacy and safety. Key Features: Defines best practices for leveraging of discovery research to facilitate a development program Includes general principles, animal models, biomarkers, preclinical toxicology testing paradigms, and practical applications Discusses rare diseases Discusses "What-Why-When-How" highlighting different considerations based upon product attributes. Includes special considerations for rare diseases About the Editors Joy A. Cavagnaro is an internationally recognized expert in preclinical development and regulatory strategy with an emphasis on genetic medicines.. Her 40-year career spans academia, government (FDA), and the CRO and biotech industries. She was awarded the 2019 Arnold J Lehman Award from the Society of Toxicology for introducing the concept of science-based, case-by-case approach to preclinical safety evaluation, which became the foundation of ICH S6. She currently serves on scientific advisory boards for advocacy groups and companies and consults and lectures in the area of preclinical development of novel therapies. Mary Ellen Cosenza is a regulatory toxicology consultant with over 30 years of senior leadership experience in the biopharmaceutical industry in the U.S., Europe, and emerging markets. She has held leadership position in both the American College of Toxicology (ACT) and the International Union of Toxicology (IUTOX) and is also an adjunct assistant professor at the University of Southern California where she teaches graduate-level courses in toxicology and regulation of biologics.
Sapiens
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Author : Yuval Noah Harari
language : en
Publisher: Random House
Release Date : 2014-09-04
Sapiens written by Yuval Noah Harari and has been published by Random House this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-09-04 with History categories.
'Interesting and provocative... It gives you a sense of how briefly we've been on this Earth' Barack Obama What makes us brilliant? What makes us deadly? What makes us Sapiens? One of the world's preeminent historians and thinkers, Yuval Noah Harari challenges everything we know about being human. Earth is 4.5 billion years old. In just a fraction of that time, one species among countless others has conquered it: us. In this bold and provocative book, Yuval Noah Harari explores who we are, how we got here and where we're going. **ONE OF THE GUARDIAN'S 100 BEST BOOKS OF THE 21st CENTURY** PRAISE FOR SAPIENS: 'Jaw-dropping from the first word to the last... It may be the best book I've ever read' Chris Evans 'Startling... It changes the way you look at the world' Simon Mayo 'I would recommend Sapiens to anyone who's interested in the history and future of our species' Bill Gates
The One And Only Sparkella
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Author : Channing Tatum
language : en
Publisher: Feiwel & Friends
Release Date : 2021-05-04
The One And Only Sparkella written by Channing Tatum and has been published by Feiwel & Friends this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-05-04 with Juvenile Fiction categories.
An Instant #1 New York Times Bestseller! A Publishers Weekly Bestseller! Leading actor, producer and director Channing Tatum's picture book debut, The One and Only Sparkella is a charming ode to self-esteem and the love between a father and daughter—illustrated by Kim Barnes. Ella is excited for her first day at a new school. Glimmering pencil case? Check! Shimmering backpack? Check! Glittery ribbons in her hair? Check! She can't wait to meet the other kids and share her sparkly personality. But her first day doesn't go quite as planned: Her new classmates don't like her disco-ball shoes, her PB&J-with-sprinkles sandwich, or her rainbow-y unicorn painting. Ella decides to try to be less sparkly at school the next day so the other kids won't make fun of her. But with a little help from her dad, she soon learns the importance of just being herself, no matter what other people say.
The House Without Windows
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Author : Barbara Newhall Follett
language : en
Publisher: Penguin UK
Release Date : 2019-10-03
The House Without Windows written by Barbara Newhall Follett and has been published by Penguin UK this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-10-03 with Juvenile Fiction categories.
Escape into the wild from the comfort of your own home this winter, with a dazzling lost classic of nature writing... Eepersip is a girl with the wild in her heart. She does not want to live locked up behind the walls of a house. So she runs away - first to the Meadow, then to the Sea, and finally to the Mountain. Her heartbroken parents follow their daughter, trying to bring her home safe, but Eepersip has other ideas... Republished by Penguin with a new introduction and hand-inked illustrations by beloved artist Jackie Morris, The House Without Windows is a timeless fable about wildness, freedom and the redemptive power of the natural world. 'I can safely promise joy to any reader of The House Without Windows. Perfection' Eleanor Farjeon, winner of the Carnegie Medal and The Hans Christian Andersen Award 'Gloriously illuminated by Jackie Morris's moving art, this is a work of strange power for our own bewildered times' Nick Drake 'A classic, as miraculous and awe-inspiring as the author' Xinran, author of The Good Women of China
A Tropical Belle Epoque
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Author : Jeffrey D. Needell
language : en
Publisher: Cambridge University Press
Release Date : 1987
A Tropical Belle Epoque written by Jeffrey D. Needell and has been published by Cambridge University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1987 with History categories.
This book, originally published in 1987, is a socio-cultural analysis of a tropical belle epoque: Rio de Janeiro between 1898 and 1914. It relates how the city's elite evolved from the semi-rural, slave-owning patriarchy of the coffee-port seat of a monarchy into an urbane, professional, rentier upper crust dominating the centre of a 'modernising' oligarchical republic. It explores such varied topics as architecture, literature, prostitution, urban reform, the family, secondary schools, and the salon. It evokes a milieu increasingly marked by Europe, demonstrating how French and English culture permeated the lives of elite members who adapted it to their needs and perspectives as a dominant stratum of relatively recent and varied origin. This exploration of cultural 'dependency' in a unique, cosmopolitan, fin-de-siecle urban culture will also interest those concerned with the broader questions of culture and colonialism during the high tide of European imperialism.
Addenda Voc Bulario
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Author : António de Morais Silva
language : pt-BR
Publisher:
Release Date : 1949
Addenda Voc Bulario written by António de Morais Silva and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1949 with Portuguese language categories.
The Jesuit Makasar Documents
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Author : Hubert Jacobs
language : en
Publisher: Institutum Historicum S. I.
Release Date : 1988
The Jesuit Makasar Documents written by Hubert Jacobs and has been published by Institutum Historicum S. I. this book supported file pdf, txt, epub, kindle and other format this book has been release on 1988 with History categories.
Asylums
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Author : Erving Goffman
language : en
Publisher: Routledge
Release Date : 2017-09-08
Asylums written by Erving Goffman and has been published by Routledge this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-09-08 with Social Science categories.
A total institution is defined by Goffman as a place of residence and work where a large number of like-situated, individuals, cut off from the wider society for an appreciable period of time, together lead an enclosed, formally administered round of life. Prisons serve as a clear example, providing we appreciate that what is prison-like about prisons is found in institutions whose members have broken no laws. This volume deals with total institutions in general and, mental hospitals, in particular. The main focus is, on the world of the inmate, not the world of the staff. A chief concern is to develop a sociological version of the structure of the self. Each of the essays in this book were intended to focus on the same issue--the inmate's situation in an institutional context. Each chapter approaches the central issue from a different vantage point, each introduction drawing upon a different source in sociology and having little direct relation to the other chapters. This method of presenting material may be irksome, but it allows the reader to pursue the main theme of each paper analytically and comparatively past the point that would be allowable in chapters of an integrated book. If sociological concepts are to be treated with affection, each must be traced back to where it best applies, followed from there wherever it seems to lead, and pressed to disclose the rest of its family.
Just One Year
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Author : Penelope Ward
language : en
Publisher: Penelope Ward Books, Inc.
Release Date : 2020-02-24
Just One Year written by Penelope Ward and has been published by Penelope Ward Books, Inc. this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-02-24 with Fiction categories.
From New York Times bestselling author Penelope Ward, comes a new standalone novel. The beginning of my sophomore year in college was off to a rough start. On the first day of orientation, I had an altercation with an infuriating British dude in a campus bathroom. (The ladies’ room was out of order. So, I used the men’s room. Don’t judge.) I got home later that night and realized that the foreign student we were expecting to rent a room in my parents’ house was allergic to our cat. So, the spare room went to someone else: Caleb—the British guy from the men’s room. And so it began…my love-hate story with Caleb Yates. Or was it hate-love in that order? The guy knew how to push every one of my buttons. Sometimes I’d email him to express my aggravation and disdain. He’d actually rewrite my own words and send them back to me. That was the type of infuriating person Caleb was. So frustrating. And… Sometimes incredibly funny and endearingly sweet. And hot. He eventually grew on me, and Caleb soon became one of my best friends that year. Too bad he was headed back to England soon, so nothing could happen between us—for so many reasons. I definitely couldn't fall in love with him, especially since all we had was just one year.
H Lderlin S Hymns
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Author : Martin Heidegger
language : en
Publisher: Indiana University Press
Release Date : 2014-09-16
H Lderlin S Hymns written by Martin Heidegger and has been published by Indiana University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-09-16 with Philosophy categories.
“Translated with skill and precision, these lectures . . . present the most penetrating analysis of two of Hölderlin’s most significant hymns” (Choice). Martin Heidegger’s 1934–1935 lectures on Friedrich Hölderlin’s hymns “Germania” and “The Rhine” are considered the most significant among Heidegger’s lectures on Hölderlin. Coming at a crucial time in his career, the text illustrates Heidegger’s turn toward language, art, and poetry while reflecting his despair at his failure to revolutionize the German university and his hope for a more profound revolution through the German language, guided by Hölderlin’s poetry. These lectures are important for understanding Heidegger’s changing relation to politics, his turn toward Nietzsche, his thinking about the German language, and his breakthrough to a new kind of poetic thinking. “[This translation], including a clear and concise introduction and useful glossaries, attains both accuracy and clarity, rarely faltering in its choice of words.” —Notre Dame Philosophical Reviews