A Menina Centop Ia
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Translational Medicine
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Author : Joy A. Cavagnaro
language : en
Publisher: CRC Press
Release Date : 2021-11-26
Translational Medicine written by Joy A. Cavagnaro and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-11-26 with Medical categories.
Translational Medicine: Optimizing Preclinical Safety Evaluation of Biopharmaceuticals provides scientists responsible for the translation of novel biopharmaceuticals into clinical trials with a better understanding of how to navigate the obstacles that keep innovative medical research discoveries from becoming new therapies or even making it to clinical trials. The book includes sections on protein-based therapeutics, modified proteins, oligonucleotide-based therapies, monoclonal antibodies, antibody–drug conjugates, gene and cell-based therapies, gene-modified cell-based therapies, combination products, and therapeutic vaccines. Best practices are defined for efficient discovery research to facilitate a science-based, efficient, and predictive preclinical development program to ensure clinical efficacy and safety. Key Features: Defines best practices for leveraging of discovery research to facilitate a development program Includes general principles, animal models, biomarkers, preclinical toxicology testing paradigms, and practical applications Discusses rare diseases Discusses "What-Why-When-How" highlighting different considerations based upon product attributes. Includes special considerations for rare diseases About the Editors Joy A. Cavagnaro is an internationally recognized expert in preclinical development and regulatory strategy with an emphasis on genetic medicines.. Her 40-year career spans academia, government (FDA), and the CRO and biotech industries. She was awarded the 2019 Arnold J Lehman Award from the Society of Toxicology for introducing the concept of science-based, case-by-case approach to preclinical safety evaluation, which became the foundation of ICH S6. She currently serves on scientific advisory boards for advocacy groups and companies and consults and lectures in the area of preclinical development of novel therapies. Mary Ellen Cosenza is a regulatory toxicology consultant with over 30 years of senior leadership experience in the biopharmaceutical industry in the U.S., Europe, and emerging markets. She has held leadership position in both the American College of Toxicology (ACT) and the International Union of Toxicology (IUTOX) and is also an adjunct assistant professor at the University of Southern California where she teaches graduate-level courses in toxicology and regulation of biologics.
Cracking The Code
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Author : UNESCO
language : en
Publisher: UNESCO Publishing
Release Date : 2017-09-04
Cracking The Code written by UNESCO and has been published by UNESCO Publishing this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-09-04 with categories.
This report aims to 'crack the code' by deciphering the factors that hinder and facilitate girls' and women's participation, achievement and continuation in science, technology, engineering and mathematics (STEM) education and, in particular, what the education sector can do to promote girls' and women's interest in and engagement with STEM education and ultimately STEM careers.
The Book Thief
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Author : Markus Zusak
language : en
Publisher: Knopf Books for Young Readers
Release Date : 2007-12-18
The Book Thief written by Markus Zusak and has been published by Knopf Books for Young Readers this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007-12-18 with Young Adult Fiction categories.
#1 NEW YORK TIMES BESTSELLER • ONE OF TIME MAGAZINE’S 100 BEST YA BOOKS OF ALL TIME The extraordinary, beloved novel about the ability of books to feed the soul even in the darkest of times. When Death has a story to tell, you listen. It is 1939. Nazi Germany. The country is holding its breath. Death has never been busier, and will become busier still. Liesel Meminger is a foster girl living outside of Munich, who scratches out a meager existence for herself by stealing when she encounters something she can’t resist–books. With the help of her accordion-playing foster father, she learns to read and shares her stolen books with her neighbors during bombing raids as well as with the Jewish man hidden in her basement. In superbly crafted writing that burns with intensity, award-winning author Markus Zusak, author of I Am the Messenger, has given us one of the most enduring stories of our time. “The kind of book that can be life-changing.” —The New York Times “Deserves a place on the same shelf with The Diary of a Young Girl by Anne Frank.” —USA Today DON’T MISS BRIDGE OF CLAY, MARKUS ZUSAK’S FIRST NOVEL SINCE THE BOOK THIEF.
Penguin Readers Level 3 Wonder Elt Graded Reader
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Author : R J Palacio
language : en
Publisher: Penguin UK
Release Date : 2020-07-30
Penguin Readers Level 3 Wonder Elt Graded Reader written by R J Palacio and has been published by Penguin UK this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-07-30 with Juvenile Fiction categories.
Penguin Readers is an ELT graded reader series. Please note that the eBook edition does NOT include access to the audio edition and digital book. Written for learners of English as a foreign language, each title includes carefully adapted text, new illustrations and language learning exercises. Titles include popular classics, exciting contemporary fiction, and thought-provoking non-fiction, introducing language learners to bestselling authors and compelling content. The eight levels of Penguin Readers follow the Common European Framework of Reference for language learning (CEFR). Exercises at the back of each Reader help language learners to practise grammar, vocabulary, and key exam skills. Before, during and after-reading questions test readers' story comprehension and develop vocabulary. Wonder, a Level 3 Reader, is A2 in the CEFR framework. The text is made up of sentences with up to three clauses, introducing first conditional, past continuous and present perfect simple for general experience. It is well supported by illustrations, which appear on most pages. August "Auggie" Pullman has been home-schooled all his life. Now he is starting fifth grade at a school in New York City. He doesn't want other students to look at him, but that isn't easy when he looks like he does. Visit the Penguin Readers website Register to access online resources including tests, worksheets and answer keys. Exclusively with the print edition, readers can unlock a digital book and audio edition (not available with the eBook).
Mem Rias A Menina Sem Estrela
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Author : Nelson Rodrigues
language : pt-BR
Publisher: BOD GmbH DE
Release Date : 2015-01-01
Mem Rias A Menina Sem Estrela written by Nelson Rodrigues and has been published by BOD GmbH DE this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-01-01 with Fiction categories.
Em Memórias — A menina sem estrela, mais que nunca Nelson foi o escritor que encontrou o universal na mais íntima e pessoal das experiências. Para ele “nada é intranscendente”, nem mesmo o menor fato cotidiano. Os temas se cruzam, as histórias de sua família — como o nascimento de Daniela, a “menina sem estrela” — são entrelaçadas com acontecimentos da história do Brasil e do mundo que marcaram o autor. O resultado é uma obra que, fragmentada em crônicas diárias publicadas no jornal Correio da Manhã, faz uma autobiografia da figura complexa de Nelson Rodrigues.
Vaccines A Biography
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Author : Andrew W. Artenstein
language : en
Publisher: Springer Science & Business Media
Release Date : 2009-12-11
Vaccines A Biography written by Andrew W. Artenstein and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009-12-11 with Science categories.
Why another book about vaccines? There are already a few extremely well-written medical textbooks that provide comprehensive, state-of-the-art technical reviews regarding vaccine science. Additionally, in the past decade alone, a number of engrossing, provocative books have been published on various related issues ra- ing from vaccines against specific diseases to vaccine safety and policy. Yet there remains a significant gap in the literature – the history of vaccines. Vaccines: A Biography seeks to fill a void in the extant literature by focusing on the history of vaccines and in so doing, recounts the social, cultural, and scientific history of vaccines; it places them within their natural, historical context. The book traces the lineage – the “biography” – of individual vaccines, originating with deeply rooted medical problems and evolving to an eventual conclusion. Nonetheless, these are not “biographies” in the traditional sense; they do not trace an individual’s growth and development. Instead, they follow an idea as it is conceived and dev- oped, through the contributions of many. These are epic stories of discovery, of risk-takers, of individuals advancing medical science, in the words of the famous physical scientist Isaac Newton, “by standing on the shoulders of giants. ” One grant reviewer described the book’s concept as “triumphalist”; although meant as an indictment, this is only partially inaccurate.
All This Time
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Author : Mikki Daughtry
language : en
Publisher: Simon and Schuster
Release Date : 2020-09-29
All This Time written by Mikki Daughtry and has been published by Simon and Schuster this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-09-29 with Young Adult Fiction categories.
From the team behind #1 New York Times bestseller Five Feet Apart comes a gripping new romance that asks: Can you find true love after losing everything? Kyle and Kimberly have been the perfect couple all through high school, but when Kimberly breaks up with him on the night of their graduation party, Kyle’s entire world upends—literally. Their car crashes and when he awakes, he has a brain injury. Kimberly is dead. And no one in his life could possibly understand. Until Marley. Marley is suffering from her own loss, a loss she thinks was her fault. And when their paths cross, Kyle sees in her all the unspoken things he’s feeling. As Kyle and Marley work to heal each other’s wounds, their feelings for each other grow stronger. But Kyle can’t shake the sense that he’s headed for another crashing moment that will blow up his life as soon as he’s started to put it back together. And he’s right. This book includes bonus content.
Poncia Vicencio
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Author : Conceição Evaristo
language : en
Publisher: Host Publications, Inc.
Release Date : 2007
Poncia Vicencio written by Conceição Evaristo and has been published by Host Publications, Inc. this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007 with Fiction categories.
Fiction. Latino/Latina Studies. Translated from the Portuguese by Paloma Martinez-Cruz. The story of a young Afro-Brazilian woman's journey from the land of her enslaved ancestors to the emptiness of urban life. However, the generations of creativity, violence and family cannot be so easily left behind as Ponci is heir to a mysterious psychic gift from her grandfather. Does this gift have the power to bring Poncia back from the emotional vacuum and absolute solitude that has overtaken her in the city? Do the elemental forces of earth, air, fire and water mean anything in the barren urban landscape? A mystical story of family, dreams and hope by the most talented chronicler of Afro-Brazilian life writing today.
The Book Of Disquiet
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Author : Fernando Pessoa
language : en
Publisher: Serpent's Tail
Release Date : 2017-08-17
The Book Of Disquiet written by Fernando Pessoa and has been published by Serpent's Tail this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-08-17 with Fiction categories.
The Book of Disquiet is one of the great literary works of the twentieth century. Written over the course of Fernando Pessoa's life, it was first published in 1982, pieced together from the thousands of individual manuscript pages left behind by Pessoa after his death in 1935. Now this fragmentary modernist masterpiece appears in a major new edition that unites Margaret Jull Costa's celebrated translation with the most complete version of the text ever produced. It is presented here, for the first time in English, by order of original composition, and accompanied by facsimiles of the original manuscript. Narrated principally by an assistant bookkeeper named Bernardo Soares - an alias of sorts for Pessoa himself - The Book of Disquiet is 'the autobiobraphy of someone who never existed', a mosaic of dreams, of hope and despair; a hymn to the streets and cafs of 1930s Lisbon, and an extraordinary record of the inner life of one of the century's most important writers. This new edition represents the most complete vision of Pessoa's genius.
A Menina Do Narizinho Arrebitado
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Author : Marly Piece
language : pt-BR
Publisher: Editora Bibliomundi
Release Date : 2022-06-25
A Menina Do Narizinho Arrebitado written by Marly Piece and has been published by Editora Bibliomundi this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-06-25 with Juvenile Fiction categories.
Aventure-se com Narizinho no Reino das Águas numa história criada por Monteiro Lobato.
