A New Approach To Bone Regeneration

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A New Approach To Bone Regeneration

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Author : Eduardo Anitua Aldecoa
language : en
Publisher:
Release Date : 2001

A New Approach To Bone Regeneration written by Eduardo Anitua Aldecoa and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2001 with categories.

Principles Of Bone Regeneration

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Author : Jona J. Sela
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-03-13

Principles Of Bone Regeneration written by Jona J. Sela and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-03-13 with Technology & Engineering categories.

Principles of Bone Regeneration is a timely publication that addresses the modern aspects of bone healing and repair. This exciting new volume details the convergence of the different experimental and clinical approaches designed for the study and treatment of bone healing in its diverse forms and under varying conditions. Bone healing is affected by a multitude of genetic, environmental, mechanical, cellular and endocrine variables which eventually lead to changes in gene expression that enhance the guided action of osteoblasts (and chondroblasts) to lay down bone that restores, or even improves, the skeletal load bearing capacity. Recent breakthroughs in understanding the regulatory aspects of bone formation and resorption, in both research and clinical arenas offer new modalities to induce, enhances and guide repair processes in bone for the benefit of millions of patients with conditions such as nonunion fractures, critical size defects, orthodontic tooth movement, periodontal bone loss, intraosseous implants and deformed bones.

A Tissue Regeneration Approach To Bone And Cartilage Repair

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Author : Hala Zreiqat
language : en
Publisher: Springer
Release Date : 2014-12-05

A Tissue Regeneration Approach To Bone And Cartilage Repair written by Hala Zreiqat and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-12-05 with Technology & Engineering categories.

Reviewing exhaustively the current state of the art of tissue engineering strategies for regenerating bones and joints through the use of biomaterials, growth factors and stem cells, along with an investigation of the interactions between biomaterials, bone cells, growth factors and added stem cells and how together skeletal tissues can be optimised, this book serves to highlight the importance of biomaterials composition, surface topography, architectural and mechanical properties in providing support for tissue regeneration. Maximizing reader insights into the importance of the interplay of these attributes with bone cells (osteoblasts, osteocytes and osteoclasts) and cartilage cells (chondrocytes), this book also provides a detailed reference as to how key signalling pathways are activated. The contribution of growth factors to drive tissue regeneration and stem cell recruitment is discussed along with a review the potential and challenges of adult or embryonic mesenchymal stem cells to further enhance the formation of new bone and cartilage tissues. This book serves to demonstrate the interconnectedness of biomaterials, bone/cartilage cells, growth factors and stem cells in determining the regenerative process and thus the clinical outcome.

Advanced Techniques In Bone Regeneration

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Author : Alessandro Rozim Zorzi
language : en
Publisher: BoD – Books on Demand
Release Date : 2016-08-31

Advanced Techniques In Bone Regeneration written by Alessandro Rozim Zorzi and has been published by BoD – Books on Demand this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-08-31 with Medical categories.

Advanced Techniques in Bone Regeneration is a book that brings together over 15 chapters, written by leading practitioners and researchers, of the latest advances in the area, including surgical techniques, new discoveries, and promising methods involving biomaterials and tissue engineering. This book is intended for all who work in the treatment of disorders involving problems with the regeneration of bone tissue, are doctors or dentists, as well as are researchers and teachers involved in this exciting field of scientific knowledge.

New Approaches In Calcium Phosphate Cements And Ceramics For Bone Regeneration

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Author : Sara Gallinetti
language : en
Publisher:
Release Date : 2014

New Approaches In Calcium Phosphate Cements And Ceramics For Bone Regeneration written by Sara Gallinetti and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014 with categories.

Bone is among the most frequently transplanted tissues in the body. In Europe, about one million patients encounter a surgical bone reconstruction annually. The worldwide market of bone replacement materials is currently estimated at 5 billion Euros, with a 10% growth due to the ageing of the population. Natural grafts present several drawbacks which pushed scientists to investigate synthetic biomaterials. Although most synthetic bone substitutes available possess some of the positive properties of autografts, none yet have all the benefits of one's own bone. Among the available biomaterials, Calcium Phosphates (CaPs) are of great interest. Nonetheless, these materials can still be improved in several respects. The main aim of this PhD Thesis is to contribute to the improvement of the properties of CaPs for bone regeneration with primary regard to Calcium Phosphate Cements (CPCs). The Thesis is divided in three main parts: i) Biphasic Calcium Phosphate Cements (BCPCs) with modified solubility and ion release; ii) Fibre Reinforced Calcium Phosphate cements (FRCPCs) with improved mechanical properties; iii) Macroporous CaP scaffolds for simvastatin acid release. In the first part novel biphasic CDHA/ß-TCP cements were obtained by mixing two Tricalcium Phosphate (TCP) polymorphs with different solubility (a-TCP and ß-TCP) at different a-TCP/ß-TCP ratios, and characterised in terms of setting properties, mechanical properties, and degradation. In the second part of this manuscript, new FRCPCs were fabricated with a focus on improving the adhesion fibres/matrix, in order to enhance the load transfer and, thus, the toughness of the material and their physico-chemical properties were investigated. Different approaches were studied. The first approach was to increase the chemical affinity of the fibres towards the matrix, adding an element in the matrix with high affinity to the fibres. In the first approach, TryMethyl Chitosan (TMC) was introduced in the liquid phase of a matrix reinforced with chitosan fibres. In the same line, lactic acid (LA) was added in the liquid phase of cements reinforced with Poly-L-lactic acid (PLLA) yarns. The biological characterisation of FRCPCs was explored using human osteoblastic-like cells MG63 . Another approach was to investigate the potential of low temperature plasma surface modification of PLLA yarns for reinforcement of CPCs. Oxygen low pressure plasma was employed at different treatment times and the surface properties of the untreated and plasma-treated PLLA were evaluated. The third part of this Thesis consisted in producing low temperature (CDHA) or high temperature (ß-TCP) macroporous scaffolds as carriers for Simvastatin acid (SVA), an osteogenic and angiogenic promoter. In order to modulate the drug release beyond the intrinsic capacity of the material, plasma polymerisation with PCL:PEG copolymers was used to dry-coat the CaP scaffolds. The material properties, the plasma polymer layer and the drug release from the scaffold were characterised.

The Effect Of Biological Factors On Bone Healing In Implant Dentistry

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Author : Dimitris Nikolidakis
language : en
Publisher: LAP Lambert Academic Publishing
Release Date : 2013

The Effect Of Biological Factors On Bone Healing In Implant Dentistry written by Dimitris Nikolidakis and has been published by LAP Lambert Academic Publishing this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013 with Bone regeneration categories.

Current research focuses on parameters that may improve the bone response to oral implants. One of the investigated parameters is the effect of growth factors on bone healing around medical and oral implants. Platelet rich plasma (PRP) is a new approach in tissue regeneration and a developing area for clinicians and researchers. It is used in various surgical fields, including oral and maxillofacial surgery. PRP is prepared out of the patient's own blood and contains growth factors that influence wound healing. Among them, platelet-derived growth factor (PDGF), transforming growth factor (TGF), insulin-like growth factor (IGF) and epidermal growth factor (EGF) play a pivotal role in tissue repair mechanisms. Although the growth factors and mechanisms involved are still poorly understood, the easy application of PRP in the clinic and its possible beneficial outcome, including reduction of bleeding, rapid soft tissue healing and bone regeneration, holds promise for new treatment approaches. However, animal studies and human trials demonstrate conflicting results regarding the application of PRP. Well-designed studies are needed to provide solid evidence of the PRP capacity.

Bone Tissue Engineering

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Author : Jeffrey O. Hollinger
language : en
Publisher: CRC Press
Release Date : 2004-10-14

Bone Tissue Engineering written by Jeffrey O. Hollinger and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2004-10-14 with Medical categories.

Focusing on bone biology, Bone Tissue Engineering integrates basic sciences with tissue engineering. It includes contributions from world-renowned researchers and clinicians who discuss key topics such as different models and approaches to bone tissue engineering, as well as exciting clinical applications for patients. Divided into four sections, t

Novel Combination Scaffold For Bone Tissue Engineering

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Author : Shivaji Bhikaji Kashte
language : en
Publisher: Independent Author
Release Date : 2023-04-06

Novel Combination Scaffold For Bone Tissue Engineering written by Shivaji Bhikaji Kashte and has been published by Independent Author this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-04-06 with categories.

"Novel Combination Scaffold for Bone Tissue Engineering" by Shivaji Bhikaji Kashte presents a new approach to bone tissue engineering by combining two different materials to create a scaffold for bone regeneration. The author discusses the synthesis and characterization of the scaffold and evaluates its biocompatibility and osteogenic potential. The study demonstrates that the combination scaffold enhances cell adhesion, proliferation, and differentiation compared to traditional scaffolds. The research also highlights the potential of the combination scaffold in promoting bone regeneration in vivo. Overall, "Novel Combination Scaffold for Bone Tissue Engineering" is a valuable resource for researchers and scientists working in the field of tissue engineering and regenerative medicine. The study's findings provide insights into the development of advanced materials for bone regeneration and repair.

New Developments In Tissue Engineering And Regeneration

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Author : Paulo Rui Fernandes
language : en
Publisher: Springer
Release Date : 2019-03-27

New Developments In Tissue Engineering And Regeneration written by Paulo Rui Fernandes and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-03-27 with Technology & Engineering categories.

This volume presents a new contribution for the field of Tissue Engineering with a focus on the development of mathematical and computational methods that are relevant to understand human tissues, as well to model, design, and fabricate optimized and smart scaffolds. The multidisciplinary character of this field has motivated contributions from different areas with a common objective to replace damaged tissues and organs by healthy ones. This work treats tissue healing approaches, mathematic modelling for scaffold design and bio fabrication methods, giving the reader a broad view of the state of the art in Tissue Engineering. The present book contains contributions from recognized researchers in the field, who were keynote speakers in the Fourth International Conference on Tissue Engineering, held in Lisbon in 2015, and covering different aspects of Tissue Engineering. The book is strongly connected with the conference series of ECCOMAS Thematic Conferences on Tissue Engineering, an event that brings together a considerable number of researchers from all over the world, representing several fields of study related to Tissue Engineering.

Osteogenesis And Bone Regeneration

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Author : Haisheng Yang
language : en
Publisher: BoD – Books on Demand
Release Date : 2019-04-24

Osteogenesis And Bone Regeneration written by Haisheng Yang and has been published by BoD – Books on Demand this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-04-24 with Medical categories.

Osteogenesis is a core component of the skeletal system and depends on the well-coordinated proliferation and differentiation of osteogenic cells. Multiple signaling pathways and transcriptional factors tightly regulate the process of osteogenesis. Any abnormities in bone formation could cause severe disorders such as osteogenesis imperfecta and osteoporosis. Bone regeneration, a complex and well-orchestrated physiological process of osteogenesis, remains a medical challenge in the field of orthopedics and maxillofacial surgery. This book provides an overview of the current developments in osteogenesis and bone regeneration, including molecular and cellular mechanisms, physical therapies (low-level laser, distraction osteogenesis), biological therapies (mesenchymal stem cells, stem cell derived exosomes, inflammatory factor, Chinese medicine), as well as tissue engineering approaches promoting bone regeneration by targeting osteogenesis.