A Novel Low Energy Electron Microscope For Dna Sequencing And Surface Analysis
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A Novel Low Energy Electron Microscope For Dna Sequencing And Surface Analysis
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Author :
language : en
Publisher:
Release Date : 2014
A Novel Low Energy Electron Microscope For Dna Sequencing And Surface Analysis written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014 with categories.
Monochromatic, aberration-corrected, dual-beam low energy electron microscopy (MAD-LEEM) is a novel technique that is directed towards imaging nanostructures and surfaces with sub-nanometer resolution. The technique combines a monochromator, a mirror aberration corrector, an energy filter, and dual beam illumination in a single instrument. The monochromator reduces the energy spread of the illuminating electron beam, which significantly improves spectroscopic and spatial resolution. Simulation results predict that the novel aberration corrector design will eliminate the second rank chromatic and third and fifth order spherical aberrations, thereby improving the resolution into the sub-nanometer regime at landing energies as low as one hundred electron-Volts. The energy filter produces a beam that can extract detailed information about the chemical composition and local electronic states of non-periodic objects such as nanoparticles, interfaces, defects, and macromolecules. The dual flood illumination eliminates charging effects that are generated when a conventional LEEM is used to image insulating specimens. A potential application for MAD-LEEM is in DNA sequencing, which requires high resolution to distinguish the individual bases and high speed to reduce the cost. The MAD-LEEM approach images the DNA with low electron impact energies, which provides nucleobase contrast mechanisms without organometallic labels. Furthermore, the micron-size field of view when combined with imaging on the fly provides long read lengths, thereby reducing the demand on assembling the sequence. Finally, experimental results from bulk specimens with immobilized single-base oligonucleotides demonstrate that base specific contrast is available with reflected, photo-emitted, and Auger electrons. Image contrast simulations of model rectangular features mimicking the individual nucleotides in a DNA strand have been developed to translate measurements of contrast on bulk DNA to the detectability of individual DNA bases in a sequence.
Principles Of Electron Optics Volume 1
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Author : Peter W. Hawkes
language : en
Publisher: Elsevier
Release Date : 2017-10-29
Principles Of Electron Optics Volume 1 written by Peter W. Hawkes and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-10-29 with Science categories.
Volume one of Principles of Electron Optics: Basic Geometrical Optics, Second Edition, explores the geometrical optics needed to analyze an extremely wide range of instruments: cathode-ray tubes; the family of electron microscopes, including the fixed-beam and scanning transmission instruments, the scanning electron microscope and the emission microscope; electron spectrometers and mass spectrograph; image converters; electron interferometers and diffraction devices; electron welding machines; and electron-beam lithography devices. The book provides a self-contained, detailed, modern account of electron optics for anyone involved with particle beams of modest current density in the energy range up to a few mega-electronvolts. You will find all the basic equations with their derivations, recent ideas concerning aberration studies, extensive discussion of the numerical methods needed to calculate the properties of specific systems and guidance to the literature of all the topics covered. A continuation of these topics can be found in volume two, Principles of Electron Optics: Applied Geometrical Optics. The book is intended for postgraduate students and teachers in physics and electron optics, as well as researchers and scientists in academia and industry working in the field of electron optics, electron and ion microscopy and nanolithography. Offers a fully revised and expanded new edition based on the latest research developments in electron optics Written by the top experts in the field Covers every significant advance in electron optics since the subject originated Contains exceptionally complete and carefully selected references and notes Serves both as a reference and text
Electron Microscopy And Analysis
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Author : Peter J. Goodhew
language : en
Publisher:
Release Date : 1975
Electron Microscopy And Analysis written by Peter J. Goodhew and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1975 with Science categories.
Principles Of Electron Optics Volume 2
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Author : Peter W. Hawkes
language : en
Publisher: Academic Press
Release Date : 2017-12-13
Principles Of Electron Optics Volume 2 written by Peter W. Hawkes and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-12-13 with Science categories.
Principles of Electron Optics: Applied Geometrical Optics, Second Edition gives detailed information about the many optical elements that use the theory presented in Volume 1: electrostatic and magnetic lenses, quadrupoles, cathode-lens-based instruments including the new ultrafast microscopes, low-energy-electron microscopes and photoemission electron microscopes and the mirrors found in their systems, Wien filters and deflectors. The chapter on aberration correction is largely new. The long section on electron guns describes recent theories and covers multi-column systems and carbon nanotube emitters. Monochromators are included in the section on curved-axis systems. The lists of references include many articles that will enable the reader to go deeper into the subjects discussed in the text. The book is intended for postgraduate students and teachers in physics and electron optics, as well as researchers and scientists in academia and industry working in the field of electron optics, electron and ion microscopy and nanolithography. Offers a fully revised and expanded new edition based on the latest research developments in electron optics Written by the top experts in the field Covers every significant advance in electron optics since the subject originated Contains exceptionally complete and carefully selected references and notes Serves both as a reference and text
Multidisciplinary Microfluidic And Nanofluidic Lab On A Chip
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Author : Xiujun (James) Li
language : en
Publisher: Newnes
Release Date : 2021-09-19
Multidisciplinary Microfluidic And Nanofluidic Lab On A Chip written by Xiujun (James) Li and has been published by Newnes this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-09-19 with Science categories.
Multidisciplinary Microfluidic and Nanofluidic Lab-on-a-Chip: Principles and Applications provides chemists, biophysicists, engineers, life scientists, biotechnologists, and pharmaceutical scientists with the principles behind the design, manufacture, and testing of life sciences microfluidic systems. This book serves as a reference for technologies and applications in multidisciplinary areas, with an emphasis on quickly developing or new emerging areas, including digital microfluidics, nanofluidics, papers-based microfluidics, and cell biology. The book offers practical guidance on how to design, analyze, fabricate, and test microfluidic devices and systems for a wide variety of applications including separations, disease detection, cellular analysis, DNA analysis, proteomics, and drug delivery. Calculations, solved problems, data tables, and design rules are provided to help researchers understand microfluidic basic theory and principles and apply this knowledge to their own unique designs. Recent advances in microfluidics and microsystems for life sciences are impacting chemistry, biophysics, molecular, cell biology, and medicine for applications that include DNA analysis, drug discovery, disease research, and biofluid and environmental monitoring. Provides calculations, solved problems, data tables and design rules to help understand microfluidic basic theory and principles Gives an applied understanding of the principles behind the design, manufacture, and testing of microfluidic systems Emphasizes on quickly developing and emerging areas, including digital microfluidics, nanofluidics, papers-based microfluidics, and cell biology
Forest Genomics And Biotechnology
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Author : Richard Meilan
language : en
Publisher: CABI
Release Date : 2019-12-19
Forest Genomics And Biotechnology written by Richard Meilan and has been published by CABI this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-12-19 with Technology & Engineering categories.
Developments in genomics and biotechnology are opening up new avenues for accelerating the domestication of forest trees in a climate change-driven world. This book presents an authoritative update of forest tree biotechnology and genomics methodologies, procedures and accomplishments, from basic biological science to applications in forestry and related sciences. It gives expert evaluation of achievements and discussion about the impact that novel forest biotechnological and genomics approaches are having on traditional breeding for improvement of forest tree species and production of forest-based products. It also describes the legal and regulatory aspects of forest biotechnology, with an emphasis on biosafety. It is a reference for forest biologists, including basic and applied scientists involved in forest tree breeding and biotechnology, bioenergy research, biomaterial product development. It is a comprehensive text for graduate-level students in the areas of Plant Biology and Forest Genetics, Silviculture and Agroforestry, and Bioenergy Science and Technology.
Salvia Biotechnology
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Author : Vasil Georgiev
language : en
Publisher: Springer
Release Date : 2018-03-19
Salvia Biotechnology written by Vasil Georgiev and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-03-19 with Medical categories.
The genus Salvia represents nearly 1,000 species that are widely distributed around the world. It is the largest in the Lamiaceae family. Traditionally, infusions of Salvia species have been widely used to treat oral inflammation, throat and headaches, and digestive disturbances in various folklore- and ethno-medicine practices worldwide. The antispasmodic, antiseptic and hypoglycemic effects of their extracts have been recognized by the ancient healers a long time ago before the development of modern medicine. With the advances in phytochemistry and pharmacology, terpenes, polyphenols and volatile compounds have been recognized as the source of bioactivity in Salvia extracts. Nowadays, because of their valuable pharmaceutical and nutraceutical properties, many Salvia species have been widely used as ingredients in food, pharmacy and cosmetic industries. The economic importance of Salvia plants continues to increase, following closely the growing interest to the concept for modern healthy lifestyle, based on prevention by consuming quality foods and nutraceutical supplements of natural origin. However, the growing demand has led to overexploitation of natural habitats and in the last few years many wild growing Salvia species have shrunk or fallen under threat. Obviously, to deal with that problem and to prevent ecological crisis, there is an urgent need for alternative, renewable sources of Salvia biomass. Plant biotechnology can provide a wide range of tools for development of economically feasible continuous production of standardized valuable phytochemicals. Plant in vitro culture technology is a powerful method for continuous production of plant secondary metabolites under controlled conditions, recently adapted to various Salvia species. Salvia in vitro systems are harmless to natural plant populations and can be grown independently of environmental factors, geographical latitude, climatic change, and seasonal variations. Several bioactive metabolites from rare and endangered Salvia plants can be produced by employing different plant in vitro systems. However, the researches on development of large scale biotechnology, based on Salvia in vitro systems, are still in early stages and many points still have to be addressed before the commercialization to take place. In this book we intend to summarize the recent achievements in research with Salvia in vitro systems as biological matrixes for the production of pharmaceutically important secondary metabolites. Further we invited leading experts to present their recent studies on phytochemistry, ethnobotanical and ethnophamacological aspects of genus Salvia. Safety and legal issues related to implementation of Salvia plants and in vitro cultures extracts in foods, cosmetics and pharmaceutical products will be discussed as well.
Minimal Residual Disease Testing
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Author : Todd E. Druley
language : en
Publisher: Springer
Release Date : 2018-11-15
Minimal Residual Disease Testing written by Todd E. Druley and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-11-15 with Medical categories.
This volume provides a concise yet comprehensive overview of minimal residual disease (MRD) testing. The text reviews the history of MRD testing, MRD testing for acute lymphoblastic leukemia/lymphoma, molecular diagnostics for MRD analysis in hematopoietic malignancies, the use of "difference from normal" flow cytometry in monitoring AML response, ML-DS for measurable residual disease detection, and advancements in next generation sequencing for detecting MRD. Written by experts in the field, Minimal Residual Disease Testing: Current Innovations and Future Directions is a valuable resource for hematologists, oncologists, pathologists, and radiologists on the variety of technologies available to detect MRD and how best to integrate these platforms into clinical practice.
Molecular Diagnostics
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Author : George P. Patrinos
language : en
Publisher: Academic Press
Release Date : 2016-10-27
Molecular Diagnostics written by George P. Patrinos and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-10-27 with Medical categories.
Molecular Diagnostics, Third Edition, focuses on the technologies and applications that professionals need to work in, develop, and manage a clinical diagnostic laboratory. Each chapter contains an expert introduction to each subject that is next to technical details and many applications for molecular genetic testing that can be found in comprehensive reference lists at the end of each chapter. Contents are divided into three parts, technologies, application of those technologies, and related issues. The first part is dedicated to the battery of the most widely used molecular pathology techniques. New chapters have been added, including the various new technologies involved in next-generation sequencing (mutation detection, gene expression, etc.), mass spectrometry, and protein-specific methodologies. All revised chapters have been completely updated, to include not only technology innovations, but also novel diagnostic applications. As with previous editions, each of the chapters in this section includes a brief description of the technique followed by examples from the area of expertise from the selected contributor. The second part of the book attempts to integrate previously analyzed technologies into the different aspects of molecular diagnostics, such as identification of genetically modified organisms, stem cells, pharmacogenomics, modern forensic science, molecular microbiology, and genetic diagnosis. Part three focuses on various everyday issues in a diagnostic laboratory, from genetic counseling and related ethical and psychological issues, to safety and quality management. Presents a comprehensive account of all new technologies and applications used in clinical diagnostic laboratories Explores a wide range of molecular-based tests that are available to assess DNA variation and changes in gene expression Offers clear translational presentations by the top molecular pathologists, clinical chemists, and molecular geneticists in the field
Electron Microscopy And Analysis
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Author : Peter John Goodhew
language : en
Publisher:
Release Date : 1988
Electron Microscopy And Analysis written by Peter John Goodhew and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1988 with Electron microscopy categories.