A Review Of Imaging Of Adverse Events Related To Cancer Immunotherapy Treatments
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A Review Of Imaging Of Adverse Events Related To Cancer Immunotherapy Treatments
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Author : Ren Yuan
language : en
Publisher:
Release Date : 2017
A Review Of Imaging Of Adverse Events Related To Cancer Immunotherapy Treatments written by Ren Yuan and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017 with categories.
Learning Objectives:1. To review the mechanisms and potential side effects of immunotherapy agents.2. To review the role of imaging in assessing the potential side effects.3. To review the imaging findings of associated adverse events. Background:Immunotherapy is emerging as an effective tool in the fight against cancer. Using either a passive or active mechanism, immunotherapy aims to boost the immune system and aid a more effective response against tumour cells.In doing this, potential complications can occur secondary to associated autoimmune or inflammatory responses and can affect multiple systems of the patient inclusive of respiratory, endocrine, gastrointestinal and musculoskeletal. Radiologist awareness of the potential complications is important to prevent misdiagnosis of disease progression, allow appropriate imaging to be performed where required in the acute setting and to aid early detection in the elective follow up setting. By detecting the potential adverse events early, treatment can be modified to reduce the severity and related morbidity.Using a variety of imaging modalities inclusive of X-ray, Computed Tomography, MRI and PET imaging, we aim to highlight the potential adverse events associated with immunotherapy treatments at our centre. Conclusion:Immunotherapy treatments can lead to potential multi-systemic adverse events. Radiologist awareness of these may lead to early diagnosis and reduced associated morbidities.
Evidence Based Advance And Management Of Adverse Events Of Immunotherapy For Cancer
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Author : Yonggang Zhang
language : en
Publisher: Frontiers Media SA
Release Date : 2020-12-22
Evidence Based Advance And Management Of Adverse Events Of Immunotherapy For Cancer written by Yonggang Zhang and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-12-22 with Science categories.
This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact.
Adverse Effects Of Cancer Chemotherapy Anything New To Improve Tolerance And Reduce Sequelae
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Author : Kulmira Nurgali
language : en
Publisher: Frontiers Media SA
Release Date : 2018-06-12
Adverse Effects Of Cancer Chemotherapy Anything New To Improve Tolerance And Reduce Sequelae written by Kulmira Nurgali and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-06-12 with categories.
Advances in anti-cancer chemotherapy over recent years have led to improved efficacy in curing or controlling many cancers. Some chemotherapy-related side-effects are well recognized and include: nausea, vomiting, bone marrow suppression, peripheral neuropathy, cardiac and skeletal muscle dysfunction and renal impairment. However, it is becoming clearer that some chemotherapy-related adverse effects may persist even in long term cancer survivors. Problems such as cognitive, cardiovascular and gastrointestinal dysfunction, and neuropathy may lead to substantial long term morbidity. Despite improvements in treatments to counteract acute chemotherapy-induced adverse effects, they are often incompletely effective. Furthermore, counter-measures for some acute side-effects and many potential longer term sequelae of anti-cancer chemotherapy have not been developed. Thus, new insights into prevalence and mechanisms of cancer chemotherapy-related side effects are needed and new approaches to improving tolerance and reduce sequelae of cancer chemotherapy are urgently needed. The present Research Topic focuses on adverse effects and sequelae of chemotherapy and strategies to counteract them.
Disputes And Challenges Of Immune Checkpoint Inhibitors In Gastrointestinal Cancers
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Author : Hongwei Yao
language : en
Publisher: Frontiers Media SA
Release Date : 2024-05-15
Disputes And Challenges Of Immune Checkpoint Inhibitors In Gastrointestinal Cancers written by Hongwei Yao and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-05-15 with Science categories.
Recently, immune checkpoint inhibitors (ICIs) have received a lot of attention to treat gastrointestinal cancers. Compared with traditional treatments, immunotherapy can kill cancer cells by activating the antitumor immunity, the specific recognition of cancer antigens preventing normal cells from being attacked. However, the application of ICIs is accompanied by a series of specific toxic reactions caused by the functional stimulation of the immune system, which are called immune-related adverse events (irAEs). Early identification and timely intervention to handle irAEs are usually required to maximize the therapeutic effect of ICIs. In addition, related surgical complications after neoadjuvant immunotherapy is increasingly reported. Thus, although immunotherapy has shown obvious advantages in the clinical treatment of gastrointestinal cancers, the safety and potential risks of such treatment have to be considered. Many clinical studies have shown that cancer patients receiving neoadjuvant immunotherapy experience different degrees of immune-inflammatory reaction, immune disorders, immune-related pneumonia, and other adverse events. In addition, some patients suffering from irAEs during the treatment have to face a delayed operation or even lose the opportunity to be operated. Finally, because the clinical imaging manifestations of immunotherapy are complex and diverse, the imaging evaluation criteria have so far not been standardized. The aim of this Research Topic is to report disputes and challenges of immune checkpoint inhibitors in gastrointestinal cancers. We welcome original research articles, Review articles, Mini Reviews, and Case reports. Preferred topics include but are not limited to the following: • Timely discovery of immune-related adverse events during immunotherapy • Identification and differentiation between immune-related adverse events and adverse drug events • Treatment and drug withdrawal timing upon immune-related adverse events • Management of related surgical complications after neoadjuvant immunotherapy • Imaging evaluation criteria or methods of immunotherapy efficacy
Immune Checkpoint Inhibitors In Cancer
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Author : Fumito Ito
language : en
Publisher: Elsevier Health Sciences
Release Date : 2018-09-03
Immune Checkpoint Inhibitors In Cancer written by Fumito Ito and has been published by Elsevier Health Sciences this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-09-03 with Medical categories.
Get a quick, expert overview of the latest clinical information and guidelines for cancer checkpoint inhibitors and their implications for specific types of cancers. This practical title by Drs. Fumito Ito and Marc Ernstoff synthesizes the most up-to-date research and clinical guidance available on immune checkpoint inhibitors and presents this information in a compact, easy-to-digest resource. It’s an ideal concise reference for trainee and practicing medical oncologists, as well as those in research. Discusses the current understanding of how to best harness the immune system against different types of cancer at various stages. Helps you translate current research and literature into practical information for daily practice. Presents information logically organized by disease site. Covers tumor immunology and biology; toxicities associated with immune checkpoint inhibitors; and future outlooks. Consolidates today’s available information on this timely topic into one convenient resource.
Atlas Of Response To Immunotherapy
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Author : Egesta Lopci
language : en
Publisher: Springer
Release Date : 2019-12-06
Atlas Of Response To Immunotherapy written by Egesta Lopci and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-12-06 with Medical categories.
This atlas is a concise but comprehensive guide to the diverse patterns of response to immunotherapy as observed on Positron Emission Tomography/Computed Tomography (PET/CT) and other conventional imaging modalities, including CT and Magnetic Resonance Imaging (MRI). The purpose for this publication is to fill the gap between the growing clinical relevance and utilization of immunotherapy in medical oncology, mainly based on checkpoint inhibitors, and the need for experienced imagers with reliable tools assessing response to treatment. A series of disease-oriented chapters will present the imaging findings during immunotherapy in the major oncological settings, with helpful comparison of functional (PET/CT) and morphological (CT/MRI) patterns of response in individual cases. To complete the atlas, a dedicated chapter will focus on major pitfalls and immune-related adverse events (irAEs) affecting image interpretation during the course of immunotherapy. The concluding chapter will lastly examine the available data and potential developments of immuno-PET, which is considered as the novel frontier of research in this oncological scenario. The atlas will be of high value for radiologists and nuclear medicine specialists at all levels of experience.
Immunotherapy A Primer For The Abdominal Radiologist
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Author : Simon Clifford
language : en
Publisher:
Release Date : 2017
Immunotherapy A Primer For The Abdominal Radiologist written by Simon Clifford and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017 with categories.
Title Immunotherapy: A primer for the abdominal radiologist.AuthorsS Clifford, Z Hutchinson & AC Ou2019NeillDepartment of Radiology, St. Vincentu2019s Healthcare Group, Elm Park, Dublin 4, IrelandLearning objectivesAn understanding of immunotherapies is important for radiologists. Immunotherapies have different imaging response patterns, as well as specific immune related adverse events, which are important to recognise and not mistake for progression of disease 1,2. BackgroundImmunotherapies including Ipilimumab, Nivolumab and Pembrolizumab are part of an evolution in cancer treatment and involve augmenting the bodyu2019s response to fight cancer cells. These expensive treatments are licensed for multiple malignancies and are being researched as treatments in countless others. Immunotherapies demonstrate different response patterns when compared with conventional chemotherapies, monitored with specific immune-related response criteria. They have the potential to cause unique immune related adverse events.Imaging Findings or Procedure DetailsResponse patterns (Type A to D) and immune-related response criteria are explained with imaging examples. Abdominal specific immune related adverse events include hepatitis, pancreatitis, diffuse colitis and segmental colitis associated with diverticulosis: These are described, with imaging examples.ConclusionIt is important for the abdominal radiologist to be aware of the newer immunotherapies, with regard to their response patterns and especially their potential for immune related adverse events. This pictorial review will explain and demonstrate these entities.References:1. Kwak JJ,Tirumani SH,Van den Abbeele AD,Koo PJ &Jacene HA. (2015). Cancer immunotherapy: imaging assessment of novel treatment response patterns and immune-related adverse events. Radiographics, 35(2):424-37. 2. Braschi-Amirfarzan, M., Tirumani, S. H., Hodi, F. S., & Nishino, M. (2017). Immune-Checkpoint Inhibitors in the Era of Precision Medicine: What Radiologists Should Know.Korean Journal of Radiology,18(1), 42u201353.
Sitc S Guide To Managing Immunotherapy Toxicity
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Author : Marc S. Ernstoff, MD
language : en
Publisher: Springer Publishing Company
Release Date : 2019-03-15
Sitc S Guide To Managing Immunotherapy Toxicity written by Marc S. Ernstoff, MD and has been published by Springer Publishing Company this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-03-15 with Medical categories.
The Society for Immunotherapy of Cancer's handbook,SITC’s Guide to Managing Immunotherapy Toxicity, is a practical reference to managing side effects associated with FDA-approved cancer immunotherapy drugs. Separated into two parts, Part I contains chapter-based overviews of immune checkpoint inhibitors in the clinic, starting with anti-CTLA4 agents, anti-PD1/PD-L1 agents, and approved immunotherapeutic combinations. These chapters cover relevant mechanisms of action, indications, and toxicities seen while combating early, advanced, and metastatic stages in cancer patients. Part II is structured by common and uncommon toxicities that affect major organ sites throughout the body. It begins with a general summary of principles and management options followed by chapters focusing on specific toxicities such as rash and mucosal irritation, muscle and joint toxicity, diarrhea and colitis, pneumonitis, endocrine toxicities, neurological toxicities, cardiac toxicity, renal toxicity, hematologic toxicity, and ocular toxicities. Each chapter provides guidance on how to assess and treat the toxicity and how to support the patient through acute and chronic effects with detailed summary tables for quick reference. Part II concludes with chapters covering management of special patient populations, including patients with autoimmune disease and geriatric patients, treatment and management of fatigue, and a final chapter dedicated to cost effectiveness and the toll of financial toxicity on patients and caregivers. With chapters written by world-recognized leaders in the immuno-oncology field, this text provides thorough coverage of the toxicity and management of adverse effects for immune checkpoint inhibitors. It is an indispensable resource for clinical oncologists, emergency physicians, hospitalists and other medical practitioners in both the hospital and community clinic settings, especially as the use of immune checkpoint inhibitors becomes a fixture in oncology care. Key Features: Outlines strategies for treating high-risk patients facing an acute or chronic side effect to immunotherapy Provides numerous tables that condense and highlight pertinent information for quick reference Describes the various clinical presentations and toxic reactions caused by immunotherapy Purchase includes access to the eBook for use on most mobile devices or computer
Policy Issues In The Clinical Development And Use Of Immunotherapy For Cancer Treatment
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Author : National Academies of Sciences, Engineering, and Medicine
language : en
Publisher: National Academies Press
Release Date : 2016-12-10
Policy Issues In The Clinical Development And Use Of Immunotherapy For Cancer Treatment written by National Academies of Sciences, Engineering, and Medicine and has been published by National Academies Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-12-10 with Medical categories.
Immunotherapy is a form of cancer therapy that harnesses the body's immune system to destroy cancer cells. In recent years, immunotherapies have been developed for several cancers, including advanced melanoma, lung cancer, and kidney cancer. In some patients with metastatic cancers who have not responded well to other treatments, immunotherapy treatment has resulted in complete and durable responses. Given these promising findings, it is hoped that continued immunotherapy research and development will produce better cancer treatments that improve patient outcomes. With this promise, however, there is also recognition that the clinical and biological landscape for immunotherapies is novel and not yet well understood. For example, adverse events with immunotherapy treatment are quite different from those experienced with other types of cancer therapy. Similarly, immunotherapy dosing, therapeutic responses, and response time lines are also markedly different from other cancer therapies. To examine these challenges and explore strategies to overcome them, the National Academies of Sciences, Engineering, and Medicine held a workshop in February and March of 2016. This report summarizes the presentations and discussions from the workshop.
Drug Induced Liver Injury
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Author :
language : en
Publisher: Academic Press
Release Date : 2019-07-13
Drug Induced Liver Injury written by and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-07-13 with Medical categories.
Drug-Induced Liver Injury, Volume 85, the newest volume in the Advances in Pharmacology series, presents a variety of chapters from the best authors in the field. Chapters in this new release include Cell death mechanisms in DILI, Mitochondria in DILI, Primary hepatocytes and their cultures for the testing of drug-induced liver injury, MetaHeps an alternate approach to identify IDILI, Autophagy and DILI, Biomarkers and DILI, Regeneration and DILI, Drug-induced liver injury in obesity and nonalcoholic fatty liver disease, Mechanisms of Idiosyncratic Drug-Induced Liver Injury, the Evaluation and Treatment of Acetaminophen Toxicity, and much more. Includes the authority and expertise of leading contributors in pharmacology Presents the latest release in the Advances in Pharmacology series