Activating Neuron Intrinsic Growth Pathways To Promote Spinal Cord Regeneration After Dorsal Root Injury
DOWNLOAD
Download Activating Neuron Intrinsic Growth Pathways To Promote Spinal Cord Regeneration After Dorsal Root Injury PDF/ePub or read online books in Mobi eBooks. Click Download or Read Online button to get Activating Neuron Intrinsic Growth Pathways To Promote Spinal Cord Regeneration After Dorsal Root Injury book now. This website allows unlimited access to, at the time of writing, more than 1.5 million titles, including hundreds of thousands of titles in various foreign languages. If the content not found or just blank you must refresh this page
Activating Neuron Intrinsic Growth Pathways To Promote Spinal Cord Regeneration After Dorsal Root Injury
DOWNLOAD
Author : Meredith Ann Manire
language : en
Publisher:
Release Date : 2019
Activating Neuron Intrinsic Growth Pathways To Promote Spinal Cord Regeneration After Dorsal Root Injury written by Meredith Ann Manire and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019 with categories.
Primary sensory axons fail to regenerate into the spinal cord following dorsal root injury leading to permanent sensory deficits. Re-entry is prevented at the dorsal root entry zone (DREZ), the CNS-PNS interface. Current approaches for promoting DR regeneration across the DREZ have had some success, but sustained, long-distance regeneration, particularly of large-diameter myelinated axons, still remains a formidable challenge. Our lab has previously shown that induced expression of constitutively active B-RAF (kaBRAF) enhanced the regenerative competence of injured DRG neurons in adult mice. In this study, I investigated whether robust intraspinal regeneration can be achieved by selective expression of kaBRAF alone or in combination with deletion of the myelin-associated inhibitors or neuron-intrinsic growth suppressors (PTEN or SOCS3). To this end, I used LSL-kaBRAF: brn3a-CreERT2 transgenic mice in which kaBRAF can be induced selectively in sensory neurons. I have also bred LSL-kaBRAF: brn3a-CreERT2 mice with triple knock-out mice lacking Nogo, Mag and OMgp or mouse lines carrying floxed alleles of PTEN or SOCS3. Single, double, and triple conditional mice were subjected to cervical DR crush and AAV2-eGFP vectors were used to selectively label regenerating axons of large-diameter neurons. I compared the extent of regeneration at 3 weeks or 2 months after DR injury using conventional anatomical and behavioral analyses. I found that kaBRAF alone promoted axon regeneration across the DREZ but did not produce significant functional recovery by two months. Supplementary deletion of Nogo, MAG, and OMgp did not improve kaBRAF-induced regeneration. Deletion of PTEN or SOCS3 individually or in combination failed to promote axon regeneration across the DREZ. In marked contrast, simultaneous deletion of PTEN, but not SOCS3, dramatically enhanced kaBRAF-mediated regeneration enabling many more axons to penetrate the DREZ and grow deep into the spinal cord. This study shows that dual activation of BRAF-MEK-ERK and PI3K-Akt signaling is an effective strategy to stimulate robust intraspinal DR regeneration and may lead to recovery of sensory function after DR injury.
Cns Regeneration
DOWNLOAD
Author : Jeffrey Kordower
language : en
Publisher: Elsevier
Release Date : 2011-04-28
Cns Regeneration written by Jeffrey Kordower and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-04-28 with Medical categories.
This second edition of CNS Regeneration updates the burgeoning field of regeneration in the Central Nervous System (CNS) from molecular, systems, and disease-based perspective. While the book covers numerous areas in detail, special emphasis is given to discussions of movement disorders such as Parkinson’s disease, Alzheimer’s disease, and spinal cord injury. Incorporates information gained from cutting-edge photomicroscopy techniques Includes current information on clinical trials Presents chapters on stem cells and other novel treatments for diseases of the CNS
Mechanisms Of Regeneration
DOWNLOAD
Author :
language : en
Publisher: Academic Press
Release Date : 2014-02-07
Mechanisms Of Regeneration written by and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-02-07 with Science categories.
This new volume of Current Topics in Developmental Biology covers the area of mechanisms in regeneration. With an international board of authors, it provides a comprehensive set of reviews covering such topics as control of growth during regeneration, skeletal muscle degeneration and regeneration in mammals and flies, and suppression of regeneration in mammals. Covers the area of mechanisms in regeneration International board of authors Provides a comprehensive set of reviews
Cajal S Degeneration And Regeneration Of The Nervous System
DOWNLOAD
Author : Santiago Ramón y Cajal
language : en
Publisher: History of Neuroscience
Release Date : 1991
Cajal S Degeneration And Regeneration Of The Nervous System written by Santiago Ramón y Cajal and has been published by History of Neuroscience this book supported file pdf, txt, epub, kindle and other format this book has been release on 1991 with Nervous system categories.
This book is a reprint of an English translation of Cajal's original work, with abundant notes and commentaries by the editor. This text describes Cajal's fundamental contributions to neuroscience, which continue to be important today. It accurately details Cajal's ideas and data, and providesreaders with the opportunity to learn what Cajal thought about his research career and the significance of his observations. Excerpts from Tello's memorial lectures also provide a contemporary view of Cajal's work.
Spinal Cord Injury Sci Repair Strategies
DOWNLOAD
Author : Giuseppe Perale
language : en
Publisher: Woodhead Publishing
Release Date : 2019-10-30
Spinal Cord Injury Sci Repair Strategies written by Giuseppe Perale and has been published by Woodhead Publishing this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-10-30 with Medical categories.
Spinal Cord Injury (SCI) Repair Strategies provides researchers the latest information on potential regenerative approaches to spinal cord injury, specifically focusing on therapeutic approaches that target regeneration, including cell therapies, controlled drug delivery systems, and biomaterials. Dr. Giuseppe Perale and Dr. Filippo Rossi lead a team of authoritative authors in academia and industry in this innovative reference on the field of regenerative medicine and tissue engineering. This book presents all the information readers need to understand the current and potential array of techniques, materials, applications and their benefits for spinal cord repair. Covers current and future repair strategies for spinal cord injury repair Focuses on key research trends, clinics, biology and engineering Provides fundamentals on regenerative engineering and tissue engineering
Recovery Of Motor Function Following Spinal Cord Injury
DOWNLOAD
Author : Heidi Fuller
language : en
Publisher: BoD – Books on Demand
Release Date : 2016-08-17
Recovery Of Motor Function Following Spinal Cord Injury written by Heidi Fuller and has been published by BoD – Books on Demand this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-08-17 with Medical categories.
Restoration of motor function following spinal cord injury is a complex and challenging task. By reviewing emerging cellular, pharmacological, rehabilitative, as well as surgical approaches, this book seeks to highlight promising therapeutic strategies for the repair and regeneration of motor circuitry. The multidisciplinary nature of these approaches illustrates various routes to bridging the gap between the bench and the bedside and to identify the challenges that must be overcome in order to bring about a viable therapeutic strategy for spinal cord injury patients.
Peripheral Nerve Regeneration
DOWNLOAD
Author : Giovanna Gambarotta
language : en
Publisher: Frontiers Media SA
Release Date : 2019-12-24
Peripheral Nerve Regeneration written by Giovanna Gambarotta and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-12-24 with categories.
Translational Neuroscience
DOWNLOAD
Author : Mark H. Tuszynski
language : en
Publisher: Springer
Release Date : 2016-03-08
Translational Neuroscience written by Mark H. Tuszynski and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-03-08 with Medical categories.
Translational Neuroscience offers a far-reaching and insightful series of perspectives on the effort to bring potentially revolutionary new classes of therapies to the clinic, thereby transforming the treatment of human nervous system disorders. Great advances in the fields of basic neuroscience, molecular biology, genomics, gene therapy, cell therapy, stem cell biology, information technology, neuro devices, rehabilitation and others over the last 20 years have generated unprecedented opportunities to treat heretofore untreatable disorders of the nervous system. This book provides a wide-ranging yet detailed sample of many of these efforts, together with the methods for pursuing clinical translation and assessing clinical outcomes. Among the topics covered are Alzheimer’s disease, Parkinson’s disease, stroke, multiple sclerosis, epilepsy, motor neuron disease, pain, inborn errors of metabolism, brain tumors, spinal cord injury, neuroprosthetics, rehabilitation and clinical trial design/consideration. Translational Neuroscience is aimed at basic neuroscientists, translational neuroscientists and clinicians who seek to gain a perspective on the nature and promise of translational therapies in the current era. Both students and established professionals will benefit from the content.
Principles Of Regenerative Medicine
DOWNLOAD
Author : Anthony Atala
language : en
Publisher: Academic Press
Release Date : 2010-12-16
Principles Of Regenerative Medicine written by Anthony Atala and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010-12-16 with Science categories.
Virtually any disease that results from malfunctioning, damaged, or failing tissues may be potentially cured through regenerative medicine therapies, by either regenerating the damaged tissues in vivo, or by growing the tissues and organs in vitro and implanting them into the patient. Principles of Regenerative Medicine discusses the latest advances in technology and medicine for replacing tissues and organs damaged by disease and of developing therapies for previously untreatable conditions, such as diabetes, heart disease, liver disease, and renal failure. Key for all researchers and instituions in Stem Cell Biology, Bioengineering, and Developmental Biology The first of its kind to offer an advanced understanding of the latest technologies in regenerative medicine New discoveries from leading researchers on restoration of diseased tissues and organs
The Spinal Cord
DOWNLOAD
Author : Charles Watson
language : en
Publisher: Academic Press
Release Date : 2009-11-27
The Spinal Cord written by Charles Watson and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009-11-27 with Medical categories.
Many hundreds of thousands suffer spinal cord injuries leading to loss of sensation and motor function in the body below the point of injury. Spinal cord research has made some significant strides towards new treatment methods, and is a focus of many laboratories worldwide. In addition, research on the involvement of the spinal cord in pain and the abilities of nervous tissue in the spine to regenerate has increasingly been on the forefront of biomedical research in the past years. The Spinal Cord, a collaboration with the Christopher and Dana Reeve Foundation, is the first comprehensive book on the anatomy of the mammalian spinal cord. Tens of thousands of articles and dozens of books are published on this subject each year, and a great deal of experimental work has been carried out on the rat spinal cord. Despite this, there is no comprehensive and authoritative atlas of the mammalian spinal cord. Almost all of the fine details of spinal cord anatomy must be searched for in journal articles on particular subjects. This book addresses this need by providing both a comprehensive reference on the mammalian spinal cord and a comparative atlas of both rat and mouse spinal cords in one convenient source. The book provides a descriptive survey of the details of mammalian spinal cord anatomy, focusing on the rat with many illustrations from the leading experts in the field and atlases of the rat and the mouse spinal cord. The rat and mouse spinal cord atlas chapters include photographs of Nissl stained transverse sections from each of the spinal cord segments (obtained from a single unfixed spinal cord), detailed diagrams of each of the spinal cord segments pictured, delineating the laminae of Rexed and all other significant neuronal groupings at each level and photographs of additional sections displaying markers such as acetylcholinesterase (AChE), calbindin, calretinin, choline acetlytransferase, neurofilament protein (SMI 32), enkephalin, calcitonin gene-related peptide (CGRP), and neuronal nuclear protein (NeuN). The text provides a detailed account of the anatomy of the mammalian spinal cord and surrounding musculoskeletal elements The major topics addressed are: development of the spinal cord; the gross anatomy of the spinal cord and its meninges; spinal nerves, nerve roots, and dorsal root ganglia; the vertebral column, vertebral joints, and vertebral muscles; blood supply of the spinal cord; cytoarchitecture and chemoarchitecture of the spinal gray matter; musculotopic anatomy of motoneuron groups; tracts connecting the brain and spinal cord; spinospinal pathways; sympathetic and parasympathetic elements in the spinal cord; neuronal groups and pathways that control micturition; the anatomy of spinal cord injury in experimental animals The atlas of the rat and mouse spinal cord has the following features: Photographs of Nissl stained transverse sections from each of 34 spinal segments for the rat and mouse; Detailed diagrams of each of the 34 spinal segments for rat and mouse, delineating the laminae of Rexed and all other significant neuronal groupings at each level. ; Alongside each of the 34 Nissl stained segments, there are additional sections displaying markers such as acetylcholinesterase, calbindin, calretinin, choline acetlytransferase, neurofilament protein (SMI 32), and neuronal nuclear protein (NeuN) All the major motoneuron clusters are identified in relation to the individual muscles or muscle groups they supply