Acute Myeloid Leukemia Diagnosis Prognosis Treatment And Outcomes

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Acute Myeloid Leukemia Diagnosis Prognosis Treatment And Outcomes

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Author : Rina Kansal
language : en
Publisher:
Release Date : 2023

Acute Myeloid Leukemia Diagnosis Prognosis Treatment And Outcomes written by Rina Kansal and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023 with Acute myeloid leukemia categories.

"This book is written by multidisciplinary specialists who diagnose and treat acute myeloid leukemia (AML) patients and is meant for anyone interested in the clinical care of patients with hematologic malignancies, including students and trainees. The 21 contributors for this book include expert clinicians in leukemia and hematologic malignancies, infectious diseases, pharmacological drug administration, pathology, cytogenetics, molecular genetics, and artificial intelligence, and one medical student and advanced trainees. The book comprises nine chapters, starting with a comprehensive overview of the global epidemiology, etiology, prognosis, treatment, and outcomes in patients with AML. Chapter 2 describes the classification of myeloid neoplasms, including AML, with a historical perspective and current diagnostic criteria. This chapter describes the fifth edition of the World Health Organization (WHO) classification and the updates from the revised fourth edition of the WHO classification. It compares the similarities and differences from the International Consensus Classification. Chapter 3 is focused on genetic evaluation in AML, emphasizing cytogenetic techniques, with numerous illustrations depicting genetic abnormalities in AML. Chapter 4 discusses measurable residual disease (MRD) in AML and explains the approaches and current guidelines for MRD detection by multiparametric flow cytometry and molecular techniques, emphasizing the pre-analytical, analytical, and post-analytical factors in evaluating MRD, with illustrations for essential concepts. Chapter 5 describes clonal hematopoiesis and its role in the development of myeloid neoplasms. Chapter 6 discusses inherited germline predisposition to myeloid malignancies, including inherited bone marrow failure syndromes and syndromic and non-syndromic predisposition syndromes for hematologic malignancies. Chapter 7 describes and illustrates novel therapeutic agents in AML, including genetically-targeted therapies, non-genetically targeted therapies, and immunotherapies. Chapter 8 covers the management of infectious complications in patients with AML, and Chapter 9 introduces the reader, with many illustrations, to the emerging applications of artificial intelligence in diagnostic hematopathology"--

Allogeneic Stem Cell Transplantation

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Author : Hillard M. Lazarus
language : en
Publisher: Springer Science & Business Media
Release Date : 2010-03-02

Allogeneic Stem Cell Transplantation written by Hillard M. Lazarus and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010-03-02 with Medical categories.

Since the original publication of Allogeneic Stem Cell Transplantation: Clinical Research and Practice, Allogeneic hematopoietic stem cell transplantation (HSC) has undergone several fast-paced changes. In this second edition, the editors have focused on topics relevant to evolving knowledge in the field in order to better guide clinicians in decision-making and management of their patients, as well as help lead laboratory investigators in new directions emanating from clinical observations. Some of the most respected clinicians and scientists in this discipline have responded to the recent advances in the field by providing state-of-the-art discussions addressing these topics in the second edition. The text covers the scope of human genomic variation, the methods of HLA typing and interpretation of high-resolution HLA results. Comprehensive and up-to-date, Allogeneic Stem Cell Transplantation: Clinical Research and Practice, Second Edition offers concise advice on today's best clinical practice and will be of significant benefit to all clinicians and researchers in allogeneic HSC transplantation.

Fast Facts Acute Myeloid Leukemia

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Author : William Blum
language : en
Publisher: Karger Medical and Scientific Publishers
Release Date : 2018-05-14

Fast Facts Acute Myeloid Leukemia written by William Blum and has been published by Karger Medical and Scientific Publishers this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-05-14 with Medical categories.

This last year has seen the approval of the first targeted treatments for acute myeloid leukemia (AML) - following decades with no new developments and a poor prognosis for most patients with the disease. The new drugs reflect the remarkable progress that has been made in our understanding of the pathophysiology of AML and its underlying cytogenetic and molecular abnormalities - which differ not only between patients but also within a patient over time and with treatment. 'Fast Facts: Acute Myeloid Leukemia' provides a comprehensive yet concise foundation for understanding AML: from basic epidemiology, diagnosis, classification and the current 'standard' treatment, through to recent advances in our understanding of the cytogenetic and molecular underpinnings of the disease, such as the IDH2 mutation, and the future for tailored therapy. It will be useful to primary care providers, medical students, specialist nurses, junior doctors and allied healthcare professionals who want to develop a thorough grounding in our evolving understanding of AML and its treatment. Contents: • Epidemiology, pathophysiology and etiology • Diagnosis • Treatment • Supportive care • Prognosis and monitoring • Emerging treatments • Useful resources

Diagnosis And Management Of Myelodysplastic Syndromes

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Author : Aziz Nazha
language : en
Publisher: Springer Nature
Release Date : 2020-08-13

Diagnosis And Management Of Myelodysplastic Syndromes written by Aziz Nazha and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-08-13 with Medical categories.

Myelodysplastic syndromes (MDS) are a group of clonal disorders characterized by pancytopenias and the risk of progression to acute myeloid leukemia. The diagnosis of MDS can be challenging, while the outcomes of MDS patients vary widely. This book provides a concise yet comprehensive overview of MDS. The book begins by reviewing the diagnostic workup of MDS, with a specific focus on the 2016 WHO criteria for MDS diagnosis, and the biology and pathophysiology of the disease. The text then presents the molecular landscape of MDS and its impact on disease diagnosis, prognosis, and treatment decisions. The book continues by profiling different prognostic models of MDS and concludes with a thorough review of treatment algorithms for lower and higher-risk MDS, as well as the use of hematopoietic stem cell transplant to combat the disease. Written by experts in the field, Diagnosis and Management of Myelodysplastic Syndromes: A Clinical Guide is a valuable resource for clinicians, practitioners, and researchers who are interested in MDS. The text also features over 100 illustrations, photographs, and tables.

Acute Myeloid Leukemia

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Author : Christoph Röllig
language : en
Publisher: Springer Nature
Release Date : 2021-05-18

Acute Myeloid Leukemia written by Christoph Röllig and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-05-18 with Medical categories.

This book, written by a team of leading experts, provides a comprehensive overview of acute myeloid leukemia (AML), the most frequent acute leukemia in adults. The opening chapters present current knowledge of epidemiology, etiologic factors, and the pathogenesis and molecular development of AML. Detailed guidance is offered on laboratory and clinical diagnostic workup and disease classification, and the patient- and disease-related factors that determine prognosis and treatment allocation are identified. On the basis of these general considerations, initial treatments in patients considered fit for intensive treatment and in older and co-morbid patients are reviewed, and the available relapse treatment strategies, explained. For all clinical scenarios, the most recent data on the optimal use of newly approved agents in different AML subgroups are presented. Separate chapters address the treatment of acute promyelocytic leukemia, current practice of allogeneic stem cell transplantation, and special clinical situations. Finally, promising approaches in drug development, current standards and challenges in assessment of measurable residual disease, immune approaches, and ideas for innovative trial designs are considered.

Pathogenesis And Treatment Of Leukemia

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Author : Harinder Gill
language : en
Publisher: Springer Nature
Release Date : 2023-09-27

Pathogenesis And Treatment Of Leukemia written by Harinder Gill and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-09-27 with Medical categories.

This book covers a comprehensive update on acute and chronic leukemia. In 54 chapters, authors introduce research progress and clinical trials of acute myeloid leukaemia (AML), acute promyelocytic leukaemia (APL), acute lymphoblastic leukaemia (ALL), myelodysplastic syndrome (MDS), myeloproliferative neoplasm (MPN) and chronic myeloid leukemia (CML). The last decade has seen the integration of genetic and clinical information to determine the prognosis and treatment strategies. This book provides practitioners, researchers and graduate students of Hematology and Hematopathology a comprehensive update on the pathobiology, genomics, classification, diagnosis, monitoring, prognostication and therapy of both acute and chronic leukemias.

Acute Myeloid Leukaemia Aml

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Author : Irvin Mendez
language : en
Publisher:
Release Date : 2018

Acute Myeloid Leukaemia Aml written by Irvin Mendez and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018 with Acute myeloid leukemia categories.

Acute myeloid leukemia is the most common adult acute leukemia, but its etiology in individual patients is poorly understood. An increased risk of acute myeloid leukemia may be inherited (through congenital hematologic diseases and syndromes or germline disorders) or be acquired due to a lifetime of exposure to environmental or chemical agents, or genotoxic stress. In this collection, the authors explore risk factors for acute myeloid leukemia, newer epidemiologic studies on the connections between these risks and clinical phenotypes and outcomes of the disease. The subsequent chapter evaluates different prognostic factors and stratifications of risk that have been published in the attempt to assess the influence of acute myeloid leukemia progression on the overall survival of myelodysplastic syndromes patients, evaluating them in a population-based registry. Many acute myeloid leukemia patients cannot tolerate standard chemotherapy due to its high toxicity. A milder therapy for acute myeloid leukemia has long been sought after, and until now the only successful clinical application has been all-trans-retinoic acid-based therapy for just one subtype of acute myeloid leukemia, acute promyelocytic leukaemia. The concluding chapter aims to address other therapeutic candidates.

Real World Treatment Patterns And Outcomes Among Elderly Acute Myeloid Leukemia Patients In The United States

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Author : Sacha Satram- Hoang
language : en
Publisher:
Release Date : 2016

Real World Treatment Patterns And Outcomes Among Elderly Acute Myeloid Leukemia Patients In The United States written by Sacha Satram- Hoang and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016 with Computers categories.

Over half of patients diagnosed with acute myeloid leukemia (AML) are 65 years or older. Using the linked SEER-Medicare database, we conducted a retrospective cohort analysis to examine patient characteristics, treatment patterns, and survival among the elderly AML patients in routine clinical practice. Out of 29,857 patients with AML in the database, 8336 were eligible for inclusion in the study. The inclusion criteria included a diagnosis with first primary AML between January 1, 2000 and December 31, 2009, >66 years of age, and continuous enrollment in Medicare Parts A and B in the year before diagnosis. Forty percent (N = 3327) of the cohort received chemotherapy within 3 months after diagnosis. The multivariable overall survival analyses showed a lower risk of death among those receiving intensive and hypomethylating agent therapies compared with no therapy. Among the younger cohort, a significant lower mortality was also noted with receipt of allogeneic hematopoietic stem cell transplantation. Over the past decade, about 60% of the elderly AML patients remain untreated in routine clinical practice. Use of antileukemic therapy was associated with a significant survival benefit and provides further support that age alone should not deter the use of guideline-recommended therapies particularly because of the high disparities in outcomes between treatment receipt and palliative care in this elderly cohort.

Leukemia A Comprehensive Guide To Understanding Diagnosis And Treatment

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Author : Ethan D. Anderson
language : en
Publisher: BornIncredible.com
Release Date : 2023-01-01

Leukemia A Comprehensive Guide To Understanding Diagnosis And Treatment written by Ethan D. Anderson and has been published by BornIncredible.com this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-01-01 with Health & Fitness categories.

"A comprehensive guide for patients, families, and caregivers facing leukemia." Are you or a loved one facing a leukemia diagnosis? Arm yourself with knowledge, hope, and support with "Leukemia: A Comprehensive Guide to Understanding, Diagnosis, and Treatment." This essential guidebook provides a clear and thorough overview of leukemia, demystifying the complexities of this blood cancer for patients, families, and caregivers. Carefully written, this book helps to empower readers to make informed decisions about their healthcare journey. Inside this invaluable resource, you'll discover: A detailed introduction to leukemia, its types, causes, and risk factors. In-depth explanations of blood and bone marrow anatomy, and how leukemia affects these crucial components. An extensive look at the signs and symptoms, diagnostic procedures, and staging systems for leukemia. A comprehensive overview of treatment options, including chemotherapy, radiation therapy, stem cell transplantation, immunotherapy, and clinical trials. Specific chapters on pediatric leukemia, living with leukemia, and survivorship, addressing unique challenges and opportunities for patients and their families. Guidance on supportive care, palliative care, and caregiving, with practical advice and resources for managing side effects, emotional well-being, and financial considerations. "Leukemia: A Comprehensive Guide to Understanding, Diagnosis, and Treatment" is more than just a reference book. It is a powerful tool that empowers those affected by leukemia to take control of their lives, providing them with the knowledge and resources they need to face blood cancer with confidence and hope. Don't let leukemia define your journey. Order your copy today and take the first step towards understanding, healing, and hope. Table of Contents What is Leukemia? Definition and Types Causes and Risk Factors Epidemiology and Statistics Anatomy of Blood and Bone Marrow Components of Blood Bone Marrow Structure and Function Hematopoiesis Pathophysiology of Leukemia Genetic and Molecular Abnormalities Leukemic Cell Development Effects on Normal Blood Cells Signs and Symptoms General Symptoms Organ-Specific Manifestations Complications The different types of Leukemia Acute Lymphocytic Leukemia Acute Myelogenous Leukemia (AML) Chronic Lymphocytic Leukemia (CLL) Chronic Myelogenous Leukemia (CML) Hairy Cell Leukemia Myelodysplastic Syndromes Myeloproliferative Disorders. Who’s at risk for Leukemia? How do you get Leukemia? What are the symptoms of Leukemia? What causes Leukemia? How can Leukemia be prevented? How is Leukemia diagnosed? Medical History and Physical Examination Laboratory Tests Imaging Studies Biopsy and Cytogenetics Classification and Staging World Health Organization Classification Prognostic Factors Staging Systems How do you treat Leukemia? Goals of Treatment Multidisciplinary Approach Factors Influencing Treatment Decisions Chemotherapy for Leukemia patients Radiation therapy for Leukemia patients Bone marrow and stem cell transplants for Leukemia patients Immunotherapy and targeted therapy for Leukemia patients Induction Therapy Consolidation and Maintenance Therapy Targeted Therapy External Beam Radiation Radioimmunotherapy Total Body Irradiation Stem Cell Transplantation Autologous Transplant Allogeneic Transplant Preparative Regimens and Graft-Versus-Host Disease Immunotherapy Monoclonal Antibodies Adoptive Cell Therapy Immune Checkpoint Inhibitors Supportive Care Blood Transfusions Infection Prevention and Management Clinical trials for Leukemia patients Types of Clinical Trials Benefits and Risks Participating in Clinical Trials Pediatric Leukemia Unique Characteristics Treatment Approaches Alternative treatments for Leukemia What is the prognosis for Leukemia Long-Term Effects and Follow-Up Care Research and Future Directions Advances in Leukemia Research Emerging Treatments Personalized Medicine and Precision Oncology Coping with Leukemia Emotional impact of Leukemia Coping strategies for patients and caregivers Emotional and Psychological Support Pain Management The role of diet in Leukemia The role of stress in Leukemia What are the risks and complications associated with Leukemia? Living with Leukemia Palliative Care and Hospice Goals of Palliative Care Managing Symptoms Hospice Care Survivorship Follow-Up Care Late Effects and Secondary Cancers Caregiving and Family Support Roles and Responsibilities Communication and Decision-Making Resources for Caregivers Financial and Legal Considerations Health Insurance and Medical Expenses Employment and Disability Rights Advance Directives and Estate Planning Frequently Asked Questions. What are the first signs of having Leukemia? What is the survival rate of leukaemia? What causes leukaemia? What happens when a person has Leukemia? How long can you have leukaemia without knowing? What are the red flags for Leukemia? How long can a leukaemia patient live? Is Leukemia able to be cured? Can you suddenly get Leukemia? Where does Leukemia usually begin? Is Leukemia curable if caught early? What age is Leukemia most common? Would Leukemia show up in blood test? Who is most likely to get Leukemia? What can be confused for Leukemia? How fatal is Leukemia? Can you live a full life after Leukemia? Is Leukemia always terminal? How successful is chemotherapy for Leukemia? What is lemons for Leukemia? Can Leukemia be inherited? How serious is lymphocytic Leukemia? Is lymphocytic Leukemia curable? What is the survival rate of lymphocytic Leukemia? What causes lymphocytic Leukemia? Is lymphocytic Leukemia terminal? Can you have Leukemia for years without knowing? What is the best treatment for lymphocytic Leukemia? What kills people with CLL? What is the average age of CLL patients? Is lymphocytic Leukemia an autoimmune disease? What is the meaning of lymphocytic? Where does Leukemia start in the body? What are the stages of lymphocytic Leukemia? What are signs that CLL is progressing? Can blood test detect Leukemia? Is lymphocytic Leukemia painful? Can I live a normal life with CLL? What happens if chronic lymphocytic Leukemia is left untreated? Can I drink alcohol with CLL? What is the most common cause of death in CLL? What is the best vitamin for CLL? What is survival rate for AML? What are the 3 stages of AML Leukemia? Is AML Leukemia curable? How aggressive is AML Leukemia? How long do AML patients live? Does AML spread quickly? What triggers AML Leukemia? How quickly does AML progress? What were your first AML symptoms? What are the 5 stages of Leukemia AML? Is AML considered terminal? Does AML come on suddenly? How long does chemo last for AML? Is AML Leukemia genetic? Who is most likely to get AML? Can AML run in families? What are the end stages of AML Leukemia? What organs are affected by AML? What is palliative care for AML? How many rounds of chemo is needed for AML? What is the 7 day rule in chemotherapy? Can you have AML for years and not know it? What is the survival rate for CLL Leukemia? How serious is CLL cancer? How is CLL different from Leukemia? Is CLL Leukemia fatal? Can CLL patients live 20 years? What should be avoided in CLL? What age group is CLL most common? How quickly does CLL progress? What is end stage CLL like? What is the 1st line treatment for CLL? How painful is CLL? Does CLL shorten life expectancy? How do you know what stage you are with CLL? Does exercise help CLL? What is the 15 year survival rate for CLL? What can trigger CLL? What organs are affected by CLL? What is the 10 year survival rate for CLL? What is very high risk CLL? Does CLL go to the brain? Can CLL spread to other organs? What is the survival rate of Leukemia CML? Is CML life threatening? Is CML a good cancer? How do you get CML Leukemia? How long can a CML patient live? Is CML treated with chemo? What are the signs of CML getting worse? What organs are affected by CML? What is the best treatment for CML? What were your first CML symptoms? What is the first stage of CML? Is CML considered a rare disease? How long is chemotherapy for CML? Can CML turn into other cancers? What to expect when you have CML? Are you born with CML? Does CML reduce life expectancy? Does CML have a good prognosis? Can stress cause CML? Does CML go to brain? Is CML the same as Leukemia? What is the survival rate for hairy cell Leukemia? How serious is hairy cell Leukemia? What is a common finding in patients with hairy cell Leukemia? How treatable is hairy cell Leukemia? Why do you get hairy cell Leukemia? Should hairy cell Leukemia patients get Covid vaccine? What are some fun facts about hairy cell Leukemia? What is another name for hairy cell Leukemia? How long is chemo for hairy cell Leukemia? How can you prevent hairy cell Leukemia? Is the COVID vaccine safe for Leukemia patients? Does COVID vaccine affect chemotherapy? Can Covid affect your blood count? Does hair fully grow back after chemo? Does body hair grow back after chemo? Does body hair always grow back after chemo? What happens if you get COVID during chemo? Can Leukemia be cured? Should you vaccinate a FeLV positive cat? Can I have flu jab while on chemo? Can COVID vaccine lower red blood cell count? What are examples of myelodysplastic syndromes? How serious is myelodysplastic syndrome? What causes myelodysplastic syndrome? Is myelodysplasia a form of Leukemia? What is early stage myelodysplastic syndrome? Can you live a full life with MDS? What are signs that MDS is progressing? Is myelodysplastic syndrome always fatal? What is the most common finding in myelodysplastic syndrome? Does myelodysplasia run in families? Does MDS start suddenly? What causes death in MDS patients? How is MDS treated in the elderly? What are the symptoms of myelodysplasia? Does chemotherapy work on MDS? What should I avoid if I have MDS? Can MDS be cured with chemo? What age group gets MDS? Can MDS lead to other cancers? Does MDS cause pain? What part of the body does MDS affect? What are the symptoms of myeloproliferative disorder? How serious is myeloproliferative disorder? Is myeloproliferative disorders a cancer? What is the most common myeloproliferative disorder? How long can you live with myeloproliferative disorder? What is the survival rate of myeloproliferative? What is the difference between Leukemia and myeloproliferative disorder? How do you test for myeloproliferative disorder? How common is myeloproliferative disorders? Is myeloproliferative disorder rare? What is the average age of myelofibrosis? What is the life expectancy of a person with myelofibrosis? What does myeloproliferative mean? What is the prognosis for myeloproliferative neoplasm? How long can you live with JAK2 mutation? What is the cause of myeloproliferative disorder? What are the first symptoms of myelofibrosis? What is the end stage of myelofibrosis? How long can you have myelofibrosis without knowing? Can you live 20 years with myelofibrosis? Have Questions / Comments?

Acute Myeloid Leukemia

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Author : Juan M. Garza
language : en
Publisher: Nova Science Publishers
Release Date : 2015

Acute Myeloid Leukemia written by Juan M. Garza and has been published by Nova Science Publishers this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015 with Acute myeloid leukemia categories.

Acute myeloid leukemia (AML) is an aggressive bone marrow cancer associated with high morbidity and mortality and most commonly affects older patient populations. In this book, the clinical presentation of acute myeloid leukemia are presented. Other chapters present the differences in the outcomes of two subtypes of core binding factor (CBF) acute myeloid leukemia (AML); examine the occurrence of the Philadelphia chromosome in AML with core binding factor leukemia; and therapeutic options of older patients with AML.