Adhesion G Protein Coupled Receptors
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G Protein Coupled Receptors Part B
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Author :
language : en
Publisher: Elsevier
Release Date : 2023-02
G Protein Coupled Receptors Part B written by and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-02 with Science categories.
G protein-coupled receptors (GPCRs) represent the largest class of cell surface proteins with an intricate involvement of nearly every physiological process in our body. Approximately, one third of the clinically prescribed medicines target GPCRs and the quest to improve the exiting GPCR-targeting therapeutics continues. These two volumes are focused on activation, signaling and regulation of GPCRs with specific examples of receptor systems and cellular processes. Covers a broad range of topics related to GPCR activation and signaling Covers several receptor systems with an emphasis on emerging paradigms Covers different processes and model systems with a focus on GPCRs
Adhesion G Protein Coupled Receptors
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Author : Tobias Langenhan
language : en
Publisher: Springer
Release Date : 2016-11-09
Adhesion G Protein Coupled Receptors written by Tobias Langenhan and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-11-09 with Medical categories.
Latest research on Adhesion GPCRs has unearthed surprising revelations about the events that govern the signal transduction of these receptor molecules and the cellular and organ requirements for these signals. Unexpected and unprecedented findings suggest that Adhesion GPCRs constitute a group of receptors that sense mechanical stimuli and transcode them into metabotropic signals through the action of a novel activation paradigm. Interdisciplinary efforts transcending many areas of biomedical research including pharmacology, physiology, genetics, cell biology, structural biology, biochemistry and bioinformatics were necessary to unveil these fundamental properties. The scientific leaders in the field that carried this research effort have teamed up here to provide a comprehensive overview of our current understanding, how Adhesion GPCRs signal and how these receptors shape organ structure and function.
Ligand Design For G Protein Coupled Receptors Volume 30
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Author : Didier Rognan
language : en
Publisher: John Wiley & Sons
Release Date : 2006-03-10
Ligand Design For G Protein Coupled Receptors Volume 30 written by Didier Rognan and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2006-03-10 with Medical categories.
1. G protein-coupled receptors in the human genome -- 2. Why G protein-coupled receptors databases are needed -- 3. A novel drug screening assay for G protein-coupled receptors -- 4. Importance of GPCR dimerization for function : the case of the class C GPCRs -- 5. Molecular mechanisms of GPCR activation -- 6. Allosteric properties and regulation of G protein-coupled receptors -- 7. Chemogenomics approaches to ligand design -- 8. Strategies for the design of pGPCR-targeted libraries -- 9. Ligand-based rational design : virtual screening -- 10. 3-D structure of G protein-coupled receptors --11. 7TM models in structure-based drug design -- 12. Receptor-based rational design : virtual screening.
G Protein Coupled Receptors
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Author : Gabriel Berstein
language : en
Publisher: CRC Press
Release Date : 2019-04-24
G Protein Coupled Receptors written by Gabriel Berstein and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-04-24 with Medical categories.
Covering recently developed methods in membrane-bound receptors, this book emphasizes receptor structure and function, knowledge of which is essential to the study of signal transduction. G Protein-Coupled Receptors has culled contributors from domestic and international sources, providing a broad base of knowledge. Some topics covered are the r
Adhesion G Protein Coupled Receptors
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Author :
language : en
Publisher:
Release Date : 2019
Adhesion G Protein Coupled Receptors written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019 with Cell adhesion molecules categories.
"This special Annals issue presents eleven papers focusing on adhesion G protein-coupled receptor research in the areas of development, biological functions, signaling and activation, structure, and health and disease."--New York Academy of Sciences website, viewed November 21, 2019.
The G Protein Coupled Receptors Handbook
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Author : Lakshmi A. Devi
language : en
Publisher: Springer Science & Business Media
Release Date : 2008-03-01
The G Protein Coupled Receptors Handbook written by Lakshmi A. Devi and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-03-01 with Medical categories.
A comprehensive survey of the many recent advances in the field of G protein-coupled receptors (GPCR). The authors describe the current knowledge of GPCR receptor structure and function, the different mechanisms involved in the regulation of GPCR function, and the role of pharmacological chaperones in GPCR folding and maturation. They also present new findings about how GPCR dimerization/oligomerization modifies the properties of individual receptors and show how recent developments are leading to significant advances in drug discovery, such as the detection of ligands for orphan GPCRs. Also discussed are the most recent developments that could lead to new drug discoveries: the role of GPCRs in mediating pain, the development of receptor-type selective drugs based on the structural plasticity of receptor activation, and the identification of natural ligands of orphan GPCRs (deorphanization) as possible drug targets.
G Protein Coupled Receptors
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Author : Tiina P. Iismaa
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-06-29
G Protein Coupled Receptors written by Tiina P. Iismaa and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-06-29 with Science categories.
This book is about the recent advances in the structural and functional characterization of receptors that influence intracellular signalling events through interaction with intracellular GTP-binding proteins (G proteins). Molecular cloning of members of the G protein-coupled receptor superfamily has complemented pharmacological investigations in providing a realization of the structural and functional diversity of these receptors. An increased understanding of the involvement of particular receptor subtypes in normal and pathophysiological processes represents exciting possibilities for the development of highly specific and effective therapeutic agents.
Molecular Aspects Of G Protein Coupled Receptors
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Author : Francisco Ciruela
language : en
Publisher: Nova Publishers
Release Date : 2008
Molecular Aspects Of G Protein Coupled Receptors written by Francisco Ciruela and has been published by Nova Publishers this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008 with Science categories.
In the recent years, studies based on two-hybrid screens, proteomic, biochemical and cell biology approaches, have shown that intracellular domains of G protein-coupled receptors (GPCR) or heptaspanning membrane receptors (HSMRs) interact with intracellular proteins. These interactions are the basis of a protein network associated to these receptors which includes scaffolding proteins containing one or several PDZ (post-synaptic density-95, discs large, zona occludens-1) domains, signalling proteins and proteins of the cytoskeleton. The present book is focused on the emerging evidence for interactions of G protein-coupled receptors with scaffolding, cytoskeletal and signalling proteins that will play a role in the targeting, anchoring and functioning of these receptors in the plasma membrane, thus contributing to cell development and plasticity.
G Protein Coupled Receptors
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Author : Jesús Giraldo
language : en
Publisher: Royal Society of Chemistry
Release Date : 2011
G Protein Coupled Receptors written by Jesús Giraldo and has been published by Royal Society of Chemistry this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011 with Medical categories.
G protein-coupled receptors (GPCRs) are the largest family of cell-surface receptors, with more than 800 members identified thus far in the human genome. The book lies between the fields of chemical biology, molecular pharmacology, and medicinal chemistry.
G Protein Coupled Receptors
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Author : Xinfeng Zhao
language : en
Publisher: Springer Nature
Release Date : 2023-02-20
G Protein Coupled Receptors written by Xinfeng Zhao and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-02-20 with Science categories.
This book summarizes the progress made to functional immobilize G protein-coupled receptors (GPCRs) through site-specific or orientated recognition in both non-covalent and covalent manners. The last decade is the dawn of the “post-structural biology” era for G protein-coupled receptor research. As an emerging approach for state-of-the-art immobilization, this book discusses efforts to explore the elegance of naturally-occurring biochemical reactions by using their high specificity and robust reactivity in the complex system, such as site-specific conjugation by covalent recognition between enzymes and their substrates. With the perspective of protein-drug interactions, this book also reviews the applications of protein immobilization, with an emphasis on G protein-coupled receptors, in drug discovery and protein-ligand interaction analysis. In addition, the merits, opportunities and disadvantages are analyzed for different immobilization methods, and a perspective for future directions is presented. Given its scope, this book appeals to a broad readership, particularly researchers engaged in the field of analytical chemistry, bioconjugate chemistry, and chemical biology, and other related field, as well as teachers of relevant majors in colleges and universities.