Advances In Combinatorial Chemistry And High Throughput Screening
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Advances In Combinatorial Chemistry High Throughput Screening
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Author : Rathnam Chaguturu
language : en
Publisher: Bentham Science Publishers
Release Date : 2013-08-06
Advances In Combinatorial Chemistry High Throughput Screening written by Rathnam Chaguturu and has been published by Bentham Science Publishers this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-08-06 with Science categories.
Advances in Combinatorial Chemistry & High Throughput Screening, is an e-book series comprising updated research articles previously published in the impact factor journal, Combinatorial Chemistry & High Throughput Screening (CCHTS). A wide range of topics are covered by these articles including chemical biology, high throughput screening, combinatorial chemistry, chemoinformatics, laboratory automation and compound management. This series is, therefore, a testament to CCHTS contributions in advancing drug discovery on full throttle. This eBook series opens up a new avenue for rapid access for readers – including academic researchers and industry professionals - to a focused collection of highly regarded contributions in the field.
Advances In Combinatorial Chemistry And High Throughput Screening
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Author : Rathnam Chaguturu
language : en
Publisher:
Release Date :
Advances In Combinatorial Chemistry And High Throughput Screening written by Rathnam Chaguturu and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on with Electronic book categories.
Annotation Advances in Combinatorial Chemistry & High Throughput Screening, is an e-book series comprising updated research articles previously published in the impact factor journal, Combinatorial Chemistry & High Throughput Screening (CCHTS). a wide range of topics are covered by these articles including chemical biology, high throughput screening, combinatorial chemistry, chemoinformatics, laboratory automation and compound management. This series is, therefore, a testament to CCHTS contributions in advancing drug discovery on full throttle. This eBook series opens up a new avenue for rapid access for readers - including academic researchers and industry professionals - to a focused collection of highly regarded contributions in the field.
Advances In Drug Discovery Techniques
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Author : Alan L. Harvey
language : en
Publisher: CRC Press
Release Date : 1998-08-15
Advances In Drug Discovery Techniques written by Alan L. Harvey and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1998-08-15 with Medical categories.
A guide to techniques for the discovery and evaluation of pharamcologically active compounds for therapeutic development, this book covers rational drug design, high-throughput screening, and genetic approaches to drug discovery. The authors focus on advances in the use of combinatorial chemistry and natural products, both of which support the chemical diversity for many drug screening programmes. They examine typical screening studies and their link to robotics and informatics in detail and present an overview of current progress within anitsense therapeutics. The book explores the rapid changes in drug discovery resulting from developments in molecular biology, robotics, and informatics.
Microfluidics Enabled Combinatorial Chemistry For High Throughput Screening
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Author : Siwei Zhao
language : en
Publisher:
Release Date : 2013
Microfluidics Enabled Combinatorial Chemistry For High Throughput Screening written by Siwei Zhao and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013 with categories.
Combinatorial chemistry is one of the most important technological advances in the last century in the field of biomedicine and material sciences. Allowing rapid synthesis and screening of a large number of compounds for certain functions or properties, combinatorial chemistry has greatly speeded up the discovery of new materials in the areas of cancer treatment and diagnosis, cell surface profiling, biomolecule epitope mapping, electronic/magnetic system, catalyst development, etc. Although current combinatorial chemistry methods have been capable of creating and screening very large-scale combinatorial libraries, the structural identification of positive hits is not straight forward and can be extremely time consuming. In this dissertation, we aim to develop a novel Microfluidics-enabled Combinatorial Chemistry method, which delivers large-scale peptide library, enables high-throughput screening and permits easy chemical identification as a package. Inspired by the contemporary matrix theories, a systemic approach has been developed to design and optimize a microfluidic network for parallel synthesis of exclusive large-scale combinatorial libraries. A facile multi-layer microfluidics fabrication strategy is implemented by the theoretical operations utilizing laser micromachining and reversible bonding techniques, which makes it widely applicable to regular biomedical and material discoveries. Moreover, a novel digitally encoded microdisc array platform is used as the substrate for combinatorial library synthesis, in which each carrier is assigned with a binary barcode and exhibits a unique chemical activity. This platform allows direct chemical identification of library compounds and thus leads to high-efficient and high-throughput combinatorial screening. We demonstrate the applicability of our Microfluidics-enabled Combinatorial Chemistry method by synthesizing and screening a combinatorial tetrapeptide library for discovery of cancer-targeting ligands. Peptide ligands against [alpha]4[beta]1 cancer cell surface integrin with high binding affinity have been identified. Therefore, we believe that our Microfluidics-enabled Combinatorial Chemistry approach can serve as a generic platform for broader applications of high-throughput biomolecule screening, including but not limited to peptidomimetics, small molecules, DNA/RNA and polysaccharides.
Analysis And Purification Methods In Combinatorial Chemistry
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Author : Bing Yan
language : en
Publisher: John Wiley & Sons
Release Date : 2004-02-03
Analysis And Purification Methods In Combinatorial Chemistry written by Bing Yan and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2004-02-03 with Science categories.
Quality measurement, control, and improvement in combinatorial chemistry Combinatorial chemistry has developed rapidly in the past decade, with great advances made by scientists working on analysis and purification of a large number of compounds and the analysis of polymer-bound compounds. However, formidable challenges lie ahead of today's researcher. For example, high-throughput analysis and purification technologies must be further developed to ensure combinatorial libraries are "purifiable," and "drugable." To this end, Analysis and Purification Methods in Combinatorial Chemistry describes various analytical techniques and systems for the development, validation, quality control, purification, and physicochemical testing of combinatorial libraries. A new volume in Wiley's Chemical Analysis series, this text has four parts covering: * Various approaches to monitoring reactions on solid support and optimizing reactions for library synthesis * High-throughput analytical methods used to analyze the quality of libraries * High-throughput purification techniques * Analytical methods applied in post-synthesis and post-purification stages Drawing from the contributions of respected experts in combinatorial chemistry, this comprehensive book provides coverage of applications of Nuclear Magnetic Resonance (NMR), liquid chromatography/mass spectrometry (LC/MS), Fourier Transform Infrared (FTIR), micellar electrokinetic chromatography (MEKC) technologies, as well as other analytical techniques. This eminently useful volume is an essential addition to the library of students and researchers studying or working in analytical chemistry, combinatorial chemistry, medicinal chemistry, organic chemistry, biotechnology, biochemistry, or biophysics.
High Throughput Screening
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Author : John P. Devlin
language : en
Publisher: CRC Press
Release Date : 1997-05-06
High Throughput Screening written by John P. Devlin and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1997-05-06 with Medical categories.
Furnishing the latest interdisciplinary information on the most important and frequently the only investigational system available for discovery programs that address the effects of small molecules on newly discovered enzyme and receptor targets emanating from molecular biology, this timely resource facilitates the transition from classical to high
Combinatorial Chemistry
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Author : Willi Bannwarth
language : en
Publisher: John Wiley & Sons
Release Date : 2006-05-12
Combinatorial Chemistry written by Willi Bannwarth and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2006-05-12 with Science categories.
The new edition of this practice-oriented handbook features thoroughly updated contents, including recent developments in parallel synthesis. A new chapter on screening complements the overview of combinatorial strategy and synthetic methods. "Experimental details and complete reaction data [...] are a constant theme running through this work" (Angewandte Chemie) "Recommended to newcomers in the field of combinatorial chemical synthesis because of its broad scope" (Journal of the American Chemical Society)
A Practical Guide To Assay Development And High Throughput Screening In Drug Discovery
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Author : Taosheng Chen
language : en
Publisher: CRC Press
Release Date : 2009-12-21
A Practical Guide To Assay Development And High Throughput Screening In Drug Discovery written by Taosheng Chen and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009-12-21 with Medical categories.
The development of suitable assays, the integration of appropriate technology, and the effective management of the essential infrastructure are all critical to the success of any high-throughput screening (HTS) endeavor. However, few scientists have the multidisciplinary experience needed to control all aspects of an HTS drug discovery project. A Practical Guide to Assay Development and High-Throughput Screening in Drug Discovery integrates the experience of diverse experts who offer fundamental and practical guidance across numerous situations. The book first discusses assay developments for important target classes such as protein kinases and phosphatases, proteases, nuclear receptors, G protein-coupled receptors, ion channels, and heat shock proteins. It next examines assay developments for cell viability, apoptosis, and infectious diseases. The contributors explore the application of emerging technologies and systems, including image-based high content screening, RNA interference, and primary cells. Finally, they discuss the essential components of the integrated HTS process, such as screening automation, compound library management, the screening of natural products from botanical sources, and screening informatics. Designed to motivate researchers to bring further advances to the field, this volume provides practical guidance on how to initiate, validate, optimize, and manage a bioassay intended to screen large collections of compounds. Drawing on the knowledge from experts actively involved in assay development and HTS, this is a resource that is both comprehensive and focused.
High Throughput Screening For Novel Anti Inflammatories
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Author : Michael Kahn
language : en
Publisher: Birkhäuser
Release Date : 2012-12-06
High Throughput Screening For Novel Anti Inflammatories written by Michael Kahn and has been published by Birkhäuser this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Science categories.
Combinatorial chemistry in conjunction with High Throughput Screening (HTS) is revolutionizing the drug discovery process. Yet, we have much to learn about the integration of these powerful techniques with information from genomics, proteomics, computation and pharmacokinetics before dramatic increases in the drug discovery/development processes can be achieved. The chapters in this book represent the state of the art regarding the integration of combinatorial chemistry and HTS in connection with anti-inflammatory targets. Obviously, there is much work to be done beyond what is described in this text, nevertheless, it should set the stage for creative thinking among scientists of many disciplines for the accomplishment of our ultimate goals in treating inflammatory diseases.
Combinatorial And High Throughput Discovery And Optimization Of Catalysts And Materials
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Author : Radislav A. Potyrailo
language : en
Publisher: CRC Press
Release Date : 2006-07-19
Combinatorial And High Throughput Discovery And Optimization Of Catalysts And Materials written by Radislav A. Potyrailo and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2006-07-19 with Science categories.
The development of parallel synthesis and high-throughput characterization tools offer scientists a time-efficient and cost-effective solution for accelerating traditional synthesis processes and developing the structure-property relationships of multiple materials under variable conditions. Written by renowned contributors to the field, Combina