Advances In Late Metal Carbon Nitrogen Bond Formation For The Synthesis Of Substituted Heterocycles
DOWNLOAD
Download Advances In Late Metal Carbon Nitrogen Bond Formation For The Synthesis Of Substituted Heterocycles PDF/ePub or read online books in Mobi eBooks. Click Download or Read Online button to get Advances In Late Metal Carbon Nitrogen Bond Formation For The Synthesis Of Substituted Heterocycles book now. This website allows unlimited access to, at the time of writing, more than 1.5 million titles, including hundreds of thousands of titles in various foreign languages. If the content not found or just blank you must refresh this page
Advances In Late Metal Carbon Nitrogen Bond Formation For The Synthesis Of Substituted Heterocycles
DOWNLOAD
Author : Nicolas Rotta-Loria
language : en
Publisher:
Release Date : 2017
Advances In Late Metal Carbon Nitrogen Bond Formation For The Synthesis Of Substituted Heterocycles written by Nicolas Rotta-Loria and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017 with categories.
Late-metal catalyzed cross-couplings have emerged as efficient and selective methodologies for the formation of C-C and C-N bonds. The ability to synthesize complex heterocycles from cheap and abundant starting materials is an invaluable asset to the pharmaceutical industry, given that many pharmaceuticals contain at least one heterocyclic component. This reactivity can be achieved by tuning the steric and electronic properties of ancillary ligands to support metal catalysts in the reaction steps leading to the target substrate. The Stradiotto group has developed several state-of-the-art methodologies involving ligands for palladium catalysis, for both C-C and C-N bond-forming reactions. These methodologies can be amalgamated into a multicomponent reaction platform to synthesize more complex products from simple materials. Chapter 1 outlines this concept with the application of a Mor-DalPhos/Pd catalyst in the one-pot synthesis of indoles from acetone and simple amines involving C-C and C-N bond formation. The robust nature of this method can be extended to include benchtop reaction conditions in a one-step, one-pot synthesis of indoles, thus representing a useful synthetic protocol. While palladium provides a powerful tool for C-C and C-N bond formation, the general trend in catalysis has shifted away from the precious metals toward first row metals as economic alternatives. Nickel complexes have recently emerged as excellent catalysts for a number of amination reactions. The ability to utilize ammonia also represents a sought after reaction, due to the widespread availability and synthetic utility of amino-functionalized products. In this regard, Chapter 2 will focus on the development and application of both commercially available and strategically designed ligand classes for the monoarylation of ammonia with substituted heterocycles. Hydrazine represents an important synthon in synthetic chemistry. It is synthesized on multi-ton scale every year and represents an important building block in many industrial processes. Many synthetic challenges arise from using free hydrazine as reactant, which has led to lethargic growth of its application in the field of late-metal catalyzed C-N bond-formation. However, gold-catalyzed methodologies have been developed utilizing NHC ligands to allow for the hydrohydrazination of alkynes with parent hydrazine. Chapter 4 examines the development and application of a series of (PR3)AuCl complexes for use in such transformations, leading to the identification of the first effective phosphine-bound gold complex for use in the hydrohydrazination of alkynes at room temperature.
Metals And Non Metals
DOWNLOAD
Author : Navjeet Kaur
language : en
Publisher: CRC Press
Release Date : 2020-01-28
Metals And Non Metals written by Navjeet Kaur and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-01-28 with Science categories.
Design of new processes that avoid the use of toxic reagents has been the focus of intense research of late. Catalysis by metals and non-metals offers diverse opportunities for the development of new organic reactions with promising range of selectivities—chemoselectivity, regioselectivity, diastereoselectivity, and enantioselectivity. Furthermore, these transformations frequently occur under mild conditions, tolerate a broad array of functional groups, and proceed with high stereoselectivity. The area of catalysis is sometimes referred to as a ‘foundational pillar’ of green chemistry. Catalytic reactions often reduce energy requirements and decrease separations because of increased selectivity; they are also capable of permitting the use of renewable feedstocks of less toxic reagents or minimizing the quantities of reagents needed. New catalytic organic synthesis methodologies have, thus, offered several possibilities for considerable improvement in the eco-compatibility of fine chemical production. Hence, these catalytic methodologies have emerged as powerful tools for the efficient and chemoselective synthesis of heterocyclic molecules. Key Features: Presents the synthesis of different five-membered heterocycles. Contains the most up-to-date information in this fast-moving field. Covers novel catalytic approaches used in the study and application of catalysts in synthetic organic reactions. Presents new methodologies for the synthesis of heterocycles.
Heterocycles Via Cross Dehydrogenative Coupling
DOWNLOAD
Author : Ananya Srivastava
language : en
Publisher: Springer Nature
Release Date : 2019-08-23
Heterocycles Via Cross Dehydrogenative Coupling written by Ananya Srivastava and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-08-23 with Science categories.
This book discusses the developments in the synthesis and functionalization of different heterocycles based on the formation of carbon-carbon (C-C) and carbon-heteroatom (C-X) bonds using cross-dehydrogenative coupling (CDC). Consisting of 13 chapters, the book systematically describes the advances in the synthesis and functionalization of nitrogen, oxygen, and sulfur-containing heterocycles. It also discusses the various mechanistic pathways to help readers gain an in-depth understanding of the CDC reactions of heterocycles. Lastly, in order to promote green chemistry, it addresses a range of metal-free CDC reactions of heterocycles – an area that has attracted significant attention in both academic and industrial research.
Catalyzed Carbon Heteroatom Bond Formation
DOWNLOAD
Author : Andrei K. Yudin
language : en
Publisher: John Wiley & Sons
Release Date : 2010-12-01
Catalyzed Carbon Heteroatom Bond Formation written by Andrei K. Yudin and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010-12-01 with Science categories.
Written by an experienced editor widely acclaimed within the scientific community, this book covers everything fromo9xygen to nitrogen functionalities. From the contents: Palladium-Catalyzed Syntheses of Five-Member Saturated Heterocyclic and of Aromatic Heterodynes Palladium-Catalysis for Oxidative 1, 2-Difunctionalization of Alkenes Rhodium-Catalyzed Amination of C-H-Bonds Carbon-Heteroatom Bond Formation by RH(I)-Catalyzed Ring-Opening Reactions Transition Metal-Catalyzed Synthesis of Lactones and of Monocyclic and Fused Five-Membered Aromatic heterocycles the Formation of Carbon-Sulfur and Carbon-Selenium bonds by Substitution and Addition reactions catalyzed by Transition Metal Complexes New Reactions of Copper Acetylides Gold Catalyzed Addition of Nitrogen, Sulfur and Oxygen Nucleophiles to C-C Multiple Bonds. The result is an indispensable source of information for the Strategic Planning of the Synthetic routes for organic, catalytic and medicinal chemists, as well as chemists in industry.
Heterocycles From Transition Metal Catalysis
DOWNLOAD
Author : András Kotschy
language : en
Publisher: Springer Science & Business Media
Release Date : 2005-09-30
Heterocycles From Transition Metal Catalysis written by András Kotschy and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2005-09-30 with Science categories.
"Heterocycles from Transition Metal Catalysis: Formation and Functionalization" provides a concise summary of the prominent role of late transition metal (palladium, nickel, copper) catalysed processes in the synthesis and functionalization of heterocyclic systems. It gives an introduction to catalytic transformations, an overview of the most important reaction types, and presents synthetically useful catalytic processes classified by the target system and the type of transformation. The book provides a representative selection of transition metal catalysed reactions transformations that are relevant in heterocyclic chemistry. In this way, the authors present a useful resource for members of the academic community looking for a textbook as well as industrial chemists in search of a reference book. This book will be an invaluable resource for synthetic chemists, medicinal chemists, and those more generally interested in applied catalysis.
Synthesis Of Nitrogenous Heterocycles Via Group 3 Metal Catalyzed Hydroamination And Zinc Ii Mediated Metalloamination
DOWNLOAD
Author : Adrian Robert Smith
language : en
Publisher:
Release Date : 2015
Synthesis Of Nitrogenous Heterocycles Via Group 3 Metal Catalyzed Hydroamination And Zinc Ii Mediated Metalloamination written by Adrian Robert Smith and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015 with Amination categories.
Pyrrolidines and piperidines respresent a motif found in a wide array of bioactive compounds. Hydroamination, or the insertion of a carbon-nitrogen bond into a site of unsaturation, represents an atom economical method for accessing substituted pyrrolidines and piperidines. Synthesis of nitrogenous heterocycles through group 3 metal hydroamination and zinc(II) metalloamination has been achieved. The hydroamination of aminoalkenes has been thoroughly screened and has shown good tolerance for ethereal solvents, and solvent choice can result in improved rate and diastereoselectivity. The hydroamination of secondary amines with electron rich heteroatoms has also been realized utilizing a new group 3 metal trisamide developed in these labs. Additionally, zinc(II) metalloamination has been performed on N, N-dimethylhydrazinoalkenes and successfully resulted in the synchronous formation of a nitrogen-carbon bond to form a ring as well as carbon-zinc bond formation at the adjacent carbon. This carbon-zinc bond has been intercepted by different carbon electrophiles to synchronously form a nitrogen-carbon bond and carbon-carbon bond in situ. Ligand studies for these transformations suggest 1,1,1-trifluoroacetylenamines as well as acetoacetamides are promising motifs for future ligand scaffolds due to their ease of synthesis, low cost, and good reactivity with a range of N, N-dimethylhydrazinoalkene substrates.
Transition Metal Catalyzed Preparation And Functionalization Of Nitrogen Containing Heterocycles
DOWNLOAD
Author : Malcolm P. Huestis
language : en
Publisher:
Release Date : 2009
Transition Metal Catalyzed Preparation And Functionalization Of Nitrogen Containing Heterocycles written by Malcolm P. Huestis and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009 with University of Ottawa theses categories.
Organic Chemistry Of Explosives
DOWNLOAD
Author : Jai Prakash Agrawal
language : en
Publisher: John Wiley & Sons
Release Date : 2007-01-11
Organic Chemistry Of Explosives written by Jai Prakash Agrawal and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007-01-11 with Science categories.
Organic Chemistry of Explosives is the first text to bring together the essential methods and routes used for the synthesis of organic explosives in a single volume. Assuming no prior knowledge, the book discusses everything from the simplest mixed acid nitration of toluene, to the complex synthesis of highly energetic caged nitro compounds. Reviews laboratory and industrial methods, which can be used to introduce aliphatic C-nitro, aromatic C-nitro, N-nitro, and nitrate ester functionality into organic compounds Discusses the advantages and disadvantages of each synthetic method or route, with scope, limitations, substrate compatibility and other important considerations Features numerous examples in the form of text, reaction diagrams, and tables.
Advances In Cross Coupling Reactions
DOWNLOAD
Author : José Pérez Sestelo
language : en
Publisher: MDPI
Release Date : 2020-12-03
Advances In Cross Coupling Reactions written by José Pérez Sestelo and has been published by MDPI this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-12-03 with Science categories.
In this Special Issue, recent advances in cross-coupling reactions are presented in the form of original research articles, reviews, and short communications. These contributions cover different topics in this area, including novel coupling reactions, reaction conditions, synthetic alternatives, metal ligands, and applications for new pharmaceutical compounds and organic materials. In particular, the reviews deal with methodologies such as the synthesis of diarylketones through palladium catalysis and the most relevant examples of Suzuki–Miyaura and Buchwald–Hartwig coupling reactions in the synthesis of bioactive compounds. The synthetic utility of cross-coupling reactions for the synthesis of medium-size rings and the utility of Stille and Suzuki coupling reactions for the synthesis of new molecular machines based on sterically hindered anthracenyl trypticenyl units are also summarized. The original research articles present the synthesis of 2-alkynylpyrrols by inverse Sonogashira coupling and the synthesis of indoles under oxidative dearomative cross-dehydrogenative conditions. The efficient combination of iridium-catalyzed C–H borylation of aryl halides with the Sonogashira coupling and a sequential iridium-catalyzed borylation of NH-free pyrroles followed by a Suzuki–Miyaura reaction are included. The synthesis of aryl propionic acids, a common structural motif in medicinal chemistry, and the synthesis of new organic dyes are also covered.
Bio Based Solvents
DOWNLOAD
Author : François Jérôme
language : en
Publisher: John Wiley & Sons
Release Date : 2017-06-29
Bio Based Solvents written by François Jérôme and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-06-29 with Science categories.
A multidisciplinary overview of bio-derived solvent applications, life cycle analysis, and strategies required for industrial commercialization This book provides the first and only comprehensive review of the state-of-the-science in bio-derived solvents. Drawing on their own pioneering work in the field, as well as an exhaustive survey of the world literature on the subject, the authors cover all the bases—from bio-derived solvent applications to life cycle analysis to strategies for industrial commercialization—for researchers and professional chemists working across a range of industries. In the increasingly critical area of sustainable chemistry, the search for new and better green solvents has become a top priority. Thanks to their renewability, biodegradability and low toxicity, as well as their potential to promote advantageous organic reactions, green solvents offer the promise of significantly reducing the pernicious effects of chemical processes on human health and the environment. Following an overview of the current solvents markets and the challenges and opportunities presented by bio-derived solvents, a series of dedicated chapters cover all significant classes of solvent arranged by origin and/or chemical structure. Throughout, real-world examples are used to help demonstrate the various advantages, drawbacks, and limitations of each class of solvent. Topics covered include: The commercial potential of various renewably sourced solvents, such as glycerol The various advantages and disadvantages of bio-derived versus petroleum-based solvents Renewably-sourced and waste-derived solvents in the design of eco-efficient processes Life cycle assessment and predictive methods for bio-based solvents Industrial and commercial viability of bio-based solvents now and in the years ahead Potential and limitations of methodologies involving bio-derived solvents New developments and emerging trends in the field and the shape of things to come Considering the vast potential for new and better products suggested by recent developments in this exciting field, Bio-Based Solvents will be a welcome resource among students and researchers in catalysis, organic synthesis, electrochemistry, and pharmaceuticals, as well as industrial chemists involved in manufacturing processes and formulation, and policy makers.
