Advances In Medicinal Chemistry Research
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Advances In Medicinal Chemistry Research
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Author : Edeildo Ferreira Da Silva, Jr.
language : en
Publisher:
Release Date : 2019-10-15
Advances In Medicinal Chemistry Research written by Edeildo Ferreira Da Silva, Jr. and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-10-15 with categories.
Advances in Medicinal Chemistry Research is a book addressed to undergraduate and postgraduate students, where recent advances in the discovery and development of effective agents against the most remarkable wide-reaching diseases are presented, divided into seven chapters. This first edition of Advances in Medicinal Chemistry Research offers insights into medicinal chemistry that arguably have the most significant impact on our lives than any other. It draws together research on therapeutic agents from natural, synthetic, and virtual screening sources as starting points for the design of drugs against obesity, multidrug-resistant bacteria, neglected tropical diseases, Alzheimer, and cancer. From the prediction of promising hits and identification of active compounds to the extraction of more complex molecules, this book explores a range of essential topics to support the development of novel, economical, and efficacious therapeutics for these diseases, which currently affect a billion people worldwide. Beginning with an overview of obesity, showing the current research landscape, the books shows the importance of natural and synthetic products as promising anti-obesity agents. Subsequently, the medicinal chemistry of modulation of bacterial resistance is presented, focusing on the MFS, RND, ABC, and MATE superfamilies. The book goes on to discuss such topics as antituberculosis, antileishmanial, and anti-hepatitis thiophene-containing compounds, under the medicinal chemistry point of view. Also, potent human glutaminyl cyclase inhibitors are deeply discussed and displayed as hopeful anti-Alzheimer's agents. The last three chapters are focused on the development of researches involving new anticancer agents, initializing with LBDD, SBDD, QSAR, and QM/MM methods applied to the identification of novel promising anticancer compounds. Moreover, IDO1 inhibitors are exhaustively explored and analyzed as a new promise for the immunotherapy of cancer. Finally, a great update on Eg5 kinesin inhibitors is provided, exploring different chemical classes of synthetic and natural compounds, including miscellanea as a new approach for Eg5 inhibition. Combining the expertise of researchers from around the world, this volume aims to support and encourage researches for the development of novel, safe, and active agents against lipase enzyme, bacteria, neglected tropical diseases, Alzheimer, and cancer. The clear narrative truly engages the reader, holding their attention right from the opening of a chapter, and maintaining interest and understanding as a chapter leads into more complex material. Advances in Medicinal Chemistry Research is a book that reviews ongoing developments and recent cutting-edge advances in medicinal chemistry of the most relevant diseases found nowadays, underlining how medicinal chemistry research continues to make significant contributions to the discovery and development of new therapeutic entities. Key Features â¢Chapters written by active specialists and leading experts deeply engaged in the research field of most deadly and limiting diseases for drug discovery. â¢Draws together cutting-edge research advances in medicinal chemistry focused at the obesity, multidrug-resistant microorganisms, Alzheimer, and cancer in a single volume. â¢Highlights the future potential of researches for the medicinal chemistry of most impactful diseases today. â¢Contents addressed to medicinal chemistry, biochemistry, biology, and pharmacy students, professors, and researchers.
Advances In Medicinal Chemistry
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Author : Bruce E. Maryanoff
language : en
Publisher:
Release Date : 1992
Advances In Medicinal Chemistry written by Bruce E. Maryanoff and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1992 with categories.
Recent Advances In Medicinal Chemistry Volume 1
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Author : Atta-ur Rahman
language : en
Publisher: Elsevier
Release Date : 2015-06-16
Recent Advances In Medicinal Chemistry Volume 1 written by Atta-ur Rahman and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-06-16 with Science categories.
Originally published by Bentham and now distributed by Elsevier, Recent Advances in Medicinal Chemistry, Volume 1 covers leading-edge research and recent developments in rational drug design, synthetic chemistry, bioorganic chemistry, high-throughput screening, combinatorial chemistry, drug targets, and natural product research and structure-activity relationship studies. The fourteen updated reviews include unique experimental data and references, and each article highlights an important topic in current medicinal chemistry research. Topics covered include: aureolic acid group of anti-cancer antibiotics and non-steroidal anti-inflammatory drugs; aromatase inhibitors in adjuvant endocrine treatment of early-stage breast cancer in postmenopausal women; Rho GTPases and statins in targeting and developing therapies for tumors; and more. Edited and written by leading experts in medicinal chemistry research Reviews recent advances in the field, including the characterization of inorganic nanomaterials as therapeutic vehicles Covers a variety of topical areas, such as HPLC and in the analysis of tricyclic antidepressants in biological samples, and tannins and their influence on health
Recent Advances In Medicinal Chemistry
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Author : Atta-ur-Rahman
language : en
Publisher: Bentham Science Publishers
Release Date : 2015-12-01
Recent Advances In Medicinal Chemistry written by Atta-ur-Rahman and has been published by Bentham Science Publishers this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-12-01 with Science categories.
Recent Advances in Medicinal Chemistry is a book series focused on leading-edge research on developments in rational drug design, synthetic chemistry, bioorganic chemistry, high-throughput screening, combinatorial chemistry, drug targets, and natural product research and structure-activity relationship studies. The series presents highly cited contributions first published in the impact factor journal Mini-Reviews in Medicinal Chemistry. Contributors to this volume have updated their work with new experimental data and references following their initial research. Each volume highlights a number of important topics in current research in medicinal chemistry. Selected chapters in this volume include: - A brief review of polyphenols as phytotherapeutic agents - Flavonoids in foods and biological samples - Cannabinoid use in treating Parkinson’s Disease symptoms … And much more.
Advances In Medicinal Chemistry
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Author : B.E. Maryanoff
language : en
Publisher: Elsevier
Release Date : 1999-04-01
Advances In Medicinal Chemistry written by B.E. Maryanoff and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 1999-04-01 with Science categories.
Volume 4 of Advances in Medicinal Chemistry is comprised of six chapters on a wide range of topics in medicinal chemistry, including molecular modeling, structure-based drug design, organic synthesis, peptide conformational analysis, biological assessment, structure-activity correlation, and lead optimization. Chapter 1 presents an account about amino acid-based peptide mimetics corresponding to b-turn, loop, helical motifs in proteins as a probe of ligand-receptor and ligand-enzyme molecular interactions. Chapter 2 addresses new facets of the medicinal chemistry of the important anticancer drug Taxol® (paclitaxel). Chapter 3 relates an account of the search for new drugs for the treatment of malaria based on the natural product artemisinin. Chapter 4 applies computational chemistry to the evaluation of compound libraries for biological testing. Chapter 5 describes the construction of a 3-dimensional molecular model of the human thrombin receptor, the first protease-activated G-protein coupled receptor (PAR-1), as a means to explore the intermolecular contacts involved in agonist peptide recognition. Finally, Chapter 6 describes the research conducted at Merck on inhibitors of farnesyl transferase as a potential treatment for human cancers.
Handbook Of Research On Medicinal Chemistry
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Author : Debarshi Kar Mahapatra
language : en
Publisher: Taylor & Francis
Release Date : 2017-11-20
Handbook Of Research On Medicinal Chemistry written by Debarshi Kar Mahapatra and has been published by Taylor & Francis this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-11-20 with Medical categories.
This valuable new book, Handbook of Research on Medicinal Chemistry: Innovations and Methodologies, presents some of the latest advancements in the various fields of combinatorial chemistry, drug discovery, biochemical aspects, pharmacology of medicinal agents, current practical problems, and nutraceuticals. The editors keep the drug molecule as the central component of the volume and aim to explain the associated features essential to exhibiting pharmacological activity. With a unique combination of chapters in biology, clinical aspects, biochemistry, synthetic chemistry, medicine and technology, the volume provides broad exposure to the essential aspect of pharmaceuticals. The volume many important aspects of medicinal chemistry, including techniques in drug discovery pharmacological aspects of natural products chemical mediators: druggable targets advances in medicinal chemistry The field of medicinal chemistry is growing at an unprecedented pace, and this volume takes an interdisciplinary approach, covering a range of new research and new practices in the field. The volume takes into account the latest therapeutic guidelines put forward by the World Health Organization and the U.S Food and Drug Administration.. Topics include: drug design drug discovery natural products and supplements and nutraceuticals pharmaceutical approaches to sexual dysfunction drug resistance parasites new natural compounds and identification of new targets stereochemistry aspects in medicinal chemistry common drug interactions in daily practices Handbook of Research on Medicinal Chemistry: Innovations and Methodologies will be a valuable addition to the bookshelves of pharmaceutical scientists and faculty as well as for industry professionals.
Progress In Medicinal Chemistry
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Author : F.D. King
language : en
Publisher: Elsevier
Release Date : 2006-04-25
Progress In Medicinal Chemistry written by F.D. King and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2006-04-25 with Science categories.
The perceived lack of drug discovery productivity in recent times has led to much debate in the pharmaceutical/biotechnology industry as escalating R&D costs are not being matched by increased output. Few observers doubt that selecting the right targets, ie those which are critical to disease pathology and are ‘druggable’, is the best starting point for improved productivity.The seven chapters of this volume describe recent progress towards drugs acting at a range of ‘druggable’ targets. One chapter addresses kinases, one covers an ion channel, two proteases are featured and three of the chapters cover G-protein coupled receptors, which has historically perhaps been the most fruitful area for medicinal chemists. *Presents the latest research in the field of drug discovery *Publishes on an annual basis to bring you the most innovative updates in medicinal chemistry *Available as an online resource via ScienceDirect
Advances In Medicinal Chemistry
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Author : Bruce E. Maryanoff
language : en
Publisher: Elsevier Science Limited
Release Date : 1999
Advances In Medicinal Chemistry written by Bruce E. Maryanoff and has been published by Elsevier Science Limited this book supported file pdf, txt, epub, kindle and other format this book has been release on 1999 with Medical categories.
Volume 4 of Advances in Medicinal Chemistry is comprised of six chapters on a wide range of topics in medicinal chemistry, including molecular modeling, structure-based drug design, organic synthesis, peptide conformational analysis, biological assessment, structure-activity correlation, and lead optimization. Chapter 1 presents an account about amino acid-based peptide mimetics corresponding to b-turn, loop, helical motifs in proteins as a probe of ligand-receptor and ligand-enzyme molecular interactions. Chapter 2 addresses new facets of the medicinal chemistry of the important anticancer drug Taxol® (paclitaxel). Chapter 3 relates an account of the search for new drugs for the treatment of malaria based on the natural product artemisinin. Chapter 4 applies computational chemistry to the evaluation of compound libraries for biological testing. Chapter 5 describes the construction of a 3-dimensional molecular model of the human thrombin receptor, the first protease-activated G-protein coupled receptor (PAR-1), as a means to explore the intermolecular contacts involved in agonist peptide recognition. Finally, Chapter 6 describes the research conducted at Merck on inhibitors of farnesyl transferase as a potential treatment for human cancers.
New Developments In Medicinal Chemistry
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Author : Carlton Anthony Taft
language : en
Publisher: Bentham Science Publishers
Release Date : 2014-10-10
New Developments In Medicinal Chemistry written by Carlton Anthony Taft and has been published by Bentham Science Publishers this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-10-10 with Medical categories.
This e-book series is recommended for readers who are interested in or work with current theoretical and experimental research in medicinal chemistry, with an emphasis on computer aided-drug design and organic synthesis for therapeutic purposes. The e-book series encompasses the multidisciplinary field of medicinal chemistry which overlaps the knowledge of chemistry, physics, biochemistry, biology and pharmacology. The second volume of the series contains the following topics: -Current State-of-the-Art for Virtual Screening and Docking Methods -Estimating Protein-Ligand Binding Affinity by NMR -ADME/Tox Predictions in Drug Design -Bioisosteric Replacements in Drug Design
Medicinal Chemistry Research Progress
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Author : Giulia P. Colombo
language : en
Publisher: Nova Biomedical Books
Release Date : 2014-05-14
Medicinal Chemistry Research Progress written by Giulia P. Colombo and has been published by Nova Biomedical Books this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-05-14 with Chemistry categories.