Advances Of Targeted Therapy In Gynecologic Malignancies
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Advances Of Targeted Therapy In Gynecologic Malignancies
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Author : Haifeng Qiu
language : en
Publisher: Frontiers Media SA
Release Date : 2022-04-28
Advances Of Targeted Therapy In Gynecologic Malignancies written by Haifeng Qiu and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-04-28 with Medical categories.
Ovarian Cancers
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Author : Eric Pujade-Lauraine
language : en
Publisher: Springer
Release Date : 2016-10-17
Ovarian Cancers written by Eric Pujade-Lauraine and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-10-17 with Medical categories.
This book provides an overview of the latest developments in the concepts and management of ovarian cancer. The new data presented throughout opens the way to radically different therapeutic approaches. Surgery remains the core of ovarian cancer treatment, but its ultimate goal and the standard surgical procedure have evolved, giving rise to the question of how to label expert centers for debulking surgery. Neo-adjuvant chemotherapy is becoming more popular and is also a new field for testing novel drug combinations. Over recent years, ovarian cancer management has embraced molecular biology. It is now more correct to talk about cancers of the ovary rather than ovarian cancer, since it is not a unique disease but several entities with different molecular drivers. The significant advances in drugs targeting the microenvironment or the tumor cell DNA repair mechanisms are presented in detail together with exciting future perspectives. All these advances would not have been possible without collaborative groups such as the GINECO group in France and their integration in wider clinical research networks at the European (ENGOT) and international (GCIG) level.
Molecular Diagnosis And Targeting For Gynecologic Malignancy
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Author : Seiji Isonishi
language : en
Publisher: Springer Nature
Release Date : 2021-03-05
Molecular Diagnosis And Targeting For Gynecologic Malignancy written by Seiji Isonishi and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-03-05 with Medical categories.
This book summarizes the important developments in the field of cancer research, specifically uterine cervical/endometrial cancer and ovarian cancer. It highlights the recent advances in gynecologic cancer, such as next generation models of genetically engineered animal models or cancer cell lines, focusing on their significance for advancing our understanding of gynecologic cancer biology, prevention and treatment, and drug response and resistance. Cancer research in the area of gynecologic tumors has undergone an enormous transformation over the past decade, with a greater understanding of tumor biology, elucidation of novel targets for therapeutic intervention, and better recognition of genetic predisposition syndromes. At the same time, the recent advances in basic cancer research have provided key insights into all aspects of gynecologic cancer biology, including developmental pathways and the impact of lineage plasticity, understanding metastatic progression, uncovering the roles of the tumor microenvironment , exploring tumor evolution, and discovering new therapeutic approaches and mechanisms of drug sensitivity and adaptive response. Molecular Diagnosis and Targeting for Gynecologic Malignancy appeals to investigators, clinicians, residents and postdocs who are curious about new research on gynecologic malignancies. It not only presents basic and translational research, but also explores the generalizability of the evidence covering the interface between basic and clinical science. Furthermore, a number of the topics offer the basis for new ideas that have the potential to advance into the gynecologic malignancies. This book provides readers with state-of-the-art information that will help improve the lives of patients with these challenging diseases.
Recent Advances In Endometrial Cancer
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Author : Sumita Mehta
language : en
Publisher: Springer Nature
Release Date : 2020-07-23
Recent Advances In Endometrial Cancer written by Sumita Mehta and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-07-23 with Medical categories.
This book discusses in detail the recent advances in the management of endometrial cancer, including the latest therapies and diagnostic methods. The book focuses on treatment-oriented topics such as the role of lymphadenectomy and sentinel node dissection, surgical complications, radiation techniques, and chemotherapy in endometrial cancer, and also explores treatment options in advanced disease stages, including hormonal therapy and targeted therapy. Providing insights into the evidence-based management guidelines for endometrial cancer, this book is a valuable resource for students, trainees and practitioners in the field of gynecology and gyne-oncology.
Gynecologic Oncology
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Author : Robert F. Ozols
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-03-14
Gynecologic Oncology written by Robert F. Ozols and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-03-14 with Medical categories.
In recent years, there have been major advances in the treatment of patients with gynecologic malignancies. Perhaps the biggest advances have been in the area of ovarian cancer. Gynecologic Oncology focuses primarily upon this malignancy. This volume discusses cytoreductive surgery; screening for ovarian cancer; chemotherapy; new chemotherapeutic drugs; the controversy regarding the role of high-dose chemotherapy in gynecologic cancers; the hereditary basis for gynecologic malignancies; molecular genetics; molecular biology and new biologic therapies. Other topics covered are the treatment of all stages of cervical cancer, including radiotherapy. In addition, a chapter on advances in the pathology of gynecologic cancers is included. The advances made in the treatment of gynecologic malignancies are due, in part, to the clinical studies performed by many of the contributors to this volume. Clinical advances have been the result of multidisciplinary approaches which involve molecular biologists, pathologists, radiation therapists, surgeons and chemotherapists. Future advances will continue to rely upon collaborative interaction among these different disciplines.
Management Of Endometrial Cancer
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Author : Mansoor R. Mirza
language : en
Publisher: Springer
Release Date : 2019-08-26
Management Of Endometrial Cancer written by Mansoor R. Mirza and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-08-26 with Medical categories.
This practical reference book provides up-to-date, evidence-based multidisciplinary guidelines on the epidemiology, biology, diagnosis, and treatment of endometrial cancer. Individual chapters focus on topics such as hormonal interactions, cancer prevention, genetic classification and its clinical applications. Recent advances in diagnostic methods are described. The treatment-oriented chapters include coverage of the roles of lymphadenectomy and sentinel node dissection, surgical complications, radiation techniques, and chemotherapy in early-stage disease. Treatment options in advanced disease, including hormonal therapy and targeted therapy, are considered separately, as is the management of rare tumor types. The authors are international key opinion leaders. Summaries of the ESMO/ESGO/ESTRO guidelines on management are included. Each clinical chapter ends with a summary of recommendations with the level of evidence.
Overcoming Drug Resistance In Gynecologic Cancers
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Author :
language : en
Publisher: Academic Press
Release Date : 2021-08-11
Overcoming Drug Resistance In Gynecologic Cancers written by and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-08-11 with Science categories.
Overcoming Drug Resistance in Gynecologic Cancers provides up-to-date information related to important gynecologic cancers and focuses on mechanisms of drug resistance, genetics, signaling, immunology, health disparities, nanotechnology, economic considerations and financial impacts. The book covers not only drug resistance but also important means to reverse resistance both in the laboratory and clinic. The book discusses topics such as lifestyle, nutrition and risk of gynecologic cancers, the financial impact of drug resistance, chemosensitizing agents and targeted therapies in cervical, endometrial and ovarian cancer, immunotherapy to overcome drug resistance, and genetic polymorphisms in gynecologic cancers. Additionally, it discusses ethnic and racial health disparity perspectives and future developments in chemosensitizing activities to reverse drug resistance in gynecologic cancers. It is a valuable resource for cancer researchers, oncologists, clinicians and other biomedical field members who are interested in new approaches to improve chemotherapy outcome in patients with gynecologic cancers. Provides a comprehensive resource with all the details needed for readers to understand and follow information Encompasses schematics, diagrams and flow charts in all chapters to help readers easily follow critical information Presents tables and figures especially developed to summarize the information with appropriate statistical rigor and to show details of clinical specimens such as pathological, radiological characteristics, and/or laboratory biomarkers
Gynecologic Cancer Care Innovative Progress
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Author : Carolyn Y. Muller
language : en
Publisher: Elsevier Health Sciences
Release Date : 2019-01-23
Gynecologic Cancer Care Innovative Progress written by Carolyn Y. Muller and has been published by Elsevier Health Sciences this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-01-23 with Medical categories.
In consultation with Dr. William Rayburn, Dr. Muller has put together an issue designed to educate the reader on the rapid progress in Gynecologic Cancer Care. More than any other field in obstetrics and gynecology, gynecologic oncology has seen an explosion in integrated drug development and technology, including personalized medicine, germline and somatic testing, targeted therapeutics, biologic and immunotherapies, improved robotic technology, and a paradigm shift towards “less is more. Evolving data in quality measures including enhanced surgical recovery, integrative palliative care, and survivorship management has strengthened the need for a seemless team approach to the care of our patients. Despite the complexity and rapid discoveries leading to significant change in practice, the dedication to patients is the driver to stay up to date and participate in the research and clinical trials that lead to the cancer care advances that are substantial in this update. Expert authors have contributed articles on the following topics: Trends in Gynecologic Cancer Care in North America: Safety, Value and Quality; Cancer Screening and Prevention Highlights in Gynecologic Cancer; Germline and Somatic Tumor Testing in Gynecologic Cancer Care; Less is More: Minimally Invasive and Quality Surgical Management of Gynecologic Cancer; Ovarian Cancer: Clinical Trial Breakthroughs and Impact on Management; Endometrial Cancer: Obesity, Genetics and Targeted Trials; Cervical Cancer: A Global and Access to Care Crisis; Vulvar and Vaginal Cancer; Gestational Trophoblastic Neoplasia; Chemotherapy, Biologic and Immunotherapy Breakthroughs in Cancer Care; Palliative Care in Gynecologic Oncology; Personalized Medicine in Gynecologic Cancer: Fact or Fiction; and Survivorship Care in Gynecologic Cancer.
Gynecologic Oncology Handbook
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Author : Michelle F. Benoit, MD
language : en
Publisher: Springer Publishing Company
Release Date : 2023-01-20
Gynecologic Oncology Handbook written by Michelle F. Benoit, MD and has been published by Springer Publishing Company this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-01-20 with Medical categories.
Known as the “blue book”, the Gynecologic Oncology Handbook: An Evidence-Based Clinical Guide is an invaluable resource for fellows, residents, and clinicians in the diagnosis and management of gynecologic cancers. Retaining the format and features that have made it a leading practical reference, this new edition has been thoroughly updated and reflects the latest advances in surgical techniques, chemotherapy protocols, breakthroughs in immunotherapies and targeted therapies, and much more. The handbook covers the full scope of disease management in a concise and accessible format. Its compact size allows it to be easily taken with the busy practitioner on the ward or in the clinic. Clear illustrations that reinforce key concepts and essential algorithms for diagnostic techniques help clinicians to a quick and accurate diagnosis. Evidence-based practices for managing gynecologic cancers are emphasized throughout the handbook including for surgical care, and for all adjuvant therapies including chemotherapy, biologics, targeted therapies, immunotherapies, and combination radiation therapy. Detailed sections on survivorship care, palliative care, and management of reproductive function and other comorbid medical conditions round out the book’s comprehensive scope. Its extensive coverage of current breakthroughs in treatment, references to critical clinical studies, and breakdown of directed gynecologic cancer workups and treatments make the Gynecologic Oncology Handbook, 3rd Edition a go-to resource within the field—including in preparation for the gynecologic oncology subspecialty certification oral board exam. Key Features: Covers all fundamentals of gynecologic oncology including workup, AJCC and FIGO staging, surgical management, chemotherapy, targeted therapy, immunotherapy, and radiation therapy treatment, comorbidity diagnosis and management, and background study data Contains insight into recently approved immunotherapies for recurrent advanced and metastatic cervical and uterine disease Provides Gynecologic Oncology Referral Parameters, Performance Status Scales, Adverse Event Grading, RECIST evaluation criteria, chemotherapy protocols, statistics, and other useful formulas Includes clinical study references, medical comorbidity algorithms, directed workups, and treatment guidelines
Gynecologic Cancers
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Author : Samir Farghaly
language : en
Publisher: BoD – Books on Demand
Release Date : 2016-03-02
Gynecologic Cancers written by Samir Farghaly and has been published by BoD – Books on Demand this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-03-02 with Medical categories.
Gynecologic cancers include malignancies of the female genital tract involving the vulva, vagina, cervix, uterus, fallopian tubes or ovaries. In the USA, 98,280 women had gynecological cancers in 2015, and 30,440 died of these cancers. World wide, the number of women who had cancers of the female genital tract was 1,085,900, in 2012 and the number of deaths was 417,600. Cancers of the uterus, cervix and ovary are most common. Widespread screening with the Pap test has allowed physicians to find per-cancerous changes in the cervix and vagina. This has assisted in identifying some invasive cancers early. Multidisciplinary team of experts includes specialists in medical oncology, gynecologic oncology, radiology, urology, radiotherapy, and surgery who work together to determine the best treatment approach for the patient. Recent progress in the development of new surgical techniques has transformed the treatment of gynecologic cancers, resulting in greater surgical precision and fewer complications. In addition targeted adjuvant therapy has become useful in improving the oncologic outcome of patients with these cancers.