Aerosol Deposition In The Human Lung Periphery Is Increased By Reduced Density Gas Breathing
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Aerosol Deposition In The Human Lung Periphery Is Increased By Reduced Density Gas Breathing
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Author : Jonathan B. Peterson
language : en
Publisher:
Release Date : 2008
Aerosol Deposition In The Human Lung Periphery Is Increased By Reduced Density Gas Breathing written by Jonathan B. Peterson and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008 with categories.
Aerosols And The Human Lung An Introduction
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Author : Chantal J Darquenne
language : en
Publisher: World Scientific
Release Date : 2020-03-10
Aerosols And The Human Lung An Introduction written by Chantal J Darquenne and has been published by World Scientific this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-03-10 with Medical categories.
This book provides a comprehensive overview of the field of aerosol science related to particle inhalation and its effect on the lung, predominately in humans. It covers the basics of aerosol behavior, transport, deposition, clearance, and effects of aerosols, both environmental and therapeutic. Aimed at the researcher entering the field of aerosol inhalation it provides a valuable introductory resource in an accessible format.
Effect Of Posture On Aerosol Deposition In The Lung Periphery Of Healthy Subjects Breathing Air And 80 20 Heliox
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Author : Matthew Levin
language : en
Publisher:
Release Date : 2017
Effect Of Posture On Aerosol Deposition In The Lung Periphery Of Healthy Subjects Breathing Air And 80 20 Heliox written by Matthew Levin and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017 with categories.
Application of aerosolized drug therapies, such as bronchodilators or gene therapies, rely on optimizing drug distribution to the diseased site of the lungs. Previous studies have shown a significant decrease in aerosol deposition and dispersion in the upper respiratory tract (URT) when subjects breathe an 80:20 helium-oxygen mixture (heliox) as opposed to breathing standard medical air (1,2,3). The current theory assumes that turbulent airflow is considered to be a significant factor in aerosol mixing and deposition in the URT. Turbulence is determined by the Reynold’s number, which is a function of airway radius, gas density and gas velocity, as well as the inverse of gas viscosity. Heliox has only one-third the density of standard air, resulting in decreased turbulence and a more laminar flow as inhaled gas moves through the upper airways. The decrease in turbulence and aerosol mixing in the URT when breathing heliox allows for increased delivery of aerosol beyond the URT and potentially increased deposition in smaller conducting airways and alveoli. Despite numerous studies on the use of heliox, none have utilized differing subject positioning, and many do not mention the position of subjects at all. Our study aims to discern if subject posture significantly affects aerosol deposition and distribution while using heliox, as it could have definitive impact on current therapeutic use of heliox in hospitalized patients.
Dust In The Atmosphere Of Mars And Its Impact On Human Exploration
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Author : Joel S. Levine
language : en
Publisher: Cambridge Scholars Publishing
Release Date : 2018-10-12
Dust In The Atmosphere Of Mars And Its Impact On Human Exploration written by Joel S. Levine and has been published by Cambridge Scholars Publishing this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-10-12 with Science categories.
A major surprise of the Apollo Moon missions was the deleterious impact of lunar dust on the astronauts, their spacesuits and other equipment, and even inside the Command/Service Module during their return to Earth. Lunar dust permeated everything and impacted mechanical systems. The dust on the Moon’s surface was disturbed and became airborne by the routine actions of the astronauts as they walked and performed their exploration of the lunar surface. Over the last decade, as NASA’s plans for the human exploration of Mars have developed and matured, a major concern has been the possible negative impacts of Mars surface and atmospheric dust on human health and on the human surface systems and surface operations on the Red Planet. In this book, 41 Mars scientists, mission engineers and planners and medical researchers have reviewed our current understanding and identified the knowledge gaps in a wide range of areas, including the chemical, physical and electrical properties of Mars atmospheric dust; the evolution and occurrence of localized, regional and planetary-scale dust storms; the human health effects of Mars atmospheric dust, including inhalation of and potential toxicity of dust particles; and the impact of Mars atmospheric dust on surface systems and on surface operations, among others.
Inhaled Delivery Systems For The Treatment Of Asthma And Copd
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Author : Donald A. Mahler
language : en
Publisher: CRC Press
Release Date : 2023-07-19
Inhaled Delivery Systems For The Treatment Of Asthma And Copd written by Donald A. Mahler and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-07-19 with Medical categories.
Inhaled therapies form the cornerstone for treatment of patients with asthma and COPD. Evolving technology has resulted in availability of a wide range of devices for delivery of inhaled drugs. The four different delivery systems -- pressurized metered-dose inhalers, slow mist inhalers, dry powder inhalers, and nebulizers -- are unique in design and require distinct inhalational instructions for correct use. This book provides current information about inhalation devices, including their advantages and disadvantages, with guidance for optimal techniques of use. The book emphasizes appropriate selection of inhalation devices based on patient and health care professional factors as well as device attributes that allow selection of the right medication in the right inhalation device at the right time for the right patient. Key Features: • Addresses the objective of precision medicine – the right medication in the right inhaler device at the right time. • Inputs by international thought leaders who have published widely on inhaled medications and/or inhaled delivery systems for clinicians, trainees and respiratory therapists. • Discusses the development of audio-based systems and smart inhalers for patient monitoring.
Handbook Of Lung Targeted Drug Delivery Systems
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Author : Yashwant Pathak
language : en
Publisher: CRC Press
Release Date : 2021-10-18
Handbook Of Lung Targeted Drug Delivery Systems written by Yashwant Pathak and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-10-18 with Medical categories.
Handbook of Lung Targeted Drug Delivery Systems: Recent Trends and Clinical Evidences covers every aspect of the drug delivery to lungs, the physiology and pharmacology of the lung, modelling for lung delivery, drug devices focused on lung treatment, regulatory requirements, and recent trends in clinical applications. With the advent of nano sciences and significant development in the nano particulate drug delivery systems there has been a renewed interest in the lung as an absorption surface for various drugs. The emergence of the COVID-19 virus has brought lung and lung delivery systems into focus, this book covers new developments and research used to address the prevention and treatment of respiratory diseases. Written by well-known scientists with years of experience in the field this timely handbook is an excellent reference book for the scientists and industry professionals. Key Features: Focuses particularly on the chemistry, clinical pharmacology, and biological developments in this field of research. Presents comprehensive information on emerging nanotechnology applications in diagnosing and treating pulmonary diseases Explores drug devices focused on lung treatment, regulatory requirements, and recent trends in clinical applications Examines specific formulations targeted to pulmonary systems
Drug Delivery To The Lung
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Author : Hans Bisgaard
language : en
Publisher: CRC Press
Release Date : 2001-10-02
Drug Delivery To The Lung written by Hans Bisgaard and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2001-10-02 with Medical categories.
This book focuses on the aerosol treatment of lung diseases, recent improvements in the understanding of proper dosage, and major innovations in device technology applied to clinical practice. Examines the behavior of inspired spherical particles in the respiratory tract!Featuring over 1300 references, drawings, tables, and photographs.
How Tobacco Smoke Causes Disease
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Author : United States. Public Health Service. Office of the Surgeon General
language : en
Publisher:
Release Date : 2010
How Tobacco Smoke Causes Disease written by United States. Public Health Service. Office of the Surgeon General and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010 with Government publications categories.
This report considers the biological and behavioral mechanisms that may underlie the pathogenicity of tobacco smoke. Many Surgeon General's reports have considered research findings on mechanisms in assessing the biological plausibility of associations observed in epidemiologic studies. Mechanisms of disease are important because they may provide plausibility, which is one of the guideline criteria for assessing evidence on causation. This report specifically reviews the evidence on the potential mechanisms by which smoking causes diseases and considers whether a mechanism is likely to be operative in the production of human disease by tobacco smoke. This evidence is relevant to understanding how smoking causes disease, to identifying those who may be particularly susceptible, and to assessing the potential risks of tobacco products.
Pharmacology And Therapeutics Of Airway Disease
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Author : Kian Fan Chung
language : en
Publisher: CRC Press
Release Date : 2009-10-27
Pharmacology And Therapeutics Of Airway Disease written by Kian Fan Chung and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009-10-27 with Medical categories.
Written as a concise clinical reference guide covering the current and future airway disease treatments, this text encompasses: pathophysiology of respiratory tract diseasesthe methods of measuring airway and clinical responsesthe concepts upon which many treatments are used in COPD and asthma conditionsthe way in which these treatments work,
Air Pollution The Automobile And Public Health
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Author : Sponsored by The Health Effects Institute
language : en
Publisher: National Academies Press
Release Date : 1988-01-01
Air Pollution The Automobile And Public Health written by Sponsored by The Health Effects Institute and has been published by National Academies Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1988-01-01 with Science categories.
"The combination of scientific and institutional integrity represented by this book is unusual. It should be a model for future endeavors to help quantify environmental risk as a basis for good decisionmaking." â€"William D. Ruckelshaus, from the foreword. This volume, prepared under the auspices of the Health Effects Institute, an independent research organization created and funded jointly by the Environmental Protection Agency and the automobile industry, brings together experts on atmospheric exposure and on the biological effects of toxic substances to examine what is knownâ€"and not knownâ€"about the human health risks of automotive emissions.