Affinity Capillary Electrophoresis In Pharmaceutics And Biopharmaceutics
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Affinity Capillary Electrophoresis In Pharmaceutics And Biopharmaceutics
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Author : Reinhard H. H. Neubert
language : en
Publisher: CRC Press
Release Date : 2003-01-14
Affinity Capillary Electrophoresis In Pharmaceutics And Biopharmaceutics written by Reinhard H. H. Neubert and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2003-01-14 with Medical categories.
This reference presents the most recent breakthroughs and techniques in affinity capillary electrophoresis (ACE) to measure and determine the physicochemical and thermodynamic parameters of drug compounds. The authors offer strategies to explore and characterize interactions between drugs, drug vehicles, and biological membranes to facilitate devel
Affinity Capillary Electrophoresis In Pharmaceutics And Biopharmaceutics
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Author : Reinhard H. H. Neubert
language : en
Publisher: CRC Press
Release Date : 2003-01-14
Affinity Capillary Electrophoresis In Pharmaceutics And Biopharmaceutics written by Reinhard H. H. Neubert and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2003-01-14 with Medical categories.
This reference presents the most recent breakthroughs and techniques in affinity capillary electrophoresis (ACE) to measure and determine the physicochemical and thermodynamic parameters of drug compounds. The authors offer strategies to explore and characterize interactions between drugs, drug vehicles, and biological membranes to facilitate developments in controlled drug delivery and targeting. The book contains current applications and procedures to identify binding constants between drugs, biological structures, proteins, nucleic acids, and plasmids, increase drug bioavailability, enhance the permeability, solubility, strength, and function of drug formulations, examine protein-protein exchanges and reactions, and calculate pKa values.
Capillary Electrophoresis Of Proteins And Peptides
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Author : Mark A. Strege
language : en
Publisher: Springer Science & Business Media
Release Date : 2008-02-04
Capillary Electrophoresis Of Proteins And Peptides written by Mark A. Strege and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-02-04 with Science categories.
Throughout the more than 20 years that have followed the beginnings of capillary electrophoresis (CE), its application to the analysis of proteins and peptides has continued to be reliable, versatile, and productive. Over time, CE has matured to become a superb complement to HLPC, and in many cases has also evolved as an automated and quantitative replacement for conventional slab gel electrophoresis methods such as SDS-PAGE and isoelectric focusing. Within Capillary Electrophoresis of Proteins and Peptides, we have assembled contributions from researchers who are applying state-of-the-art CE for protein and peptide analysis, including topics that we believe are of great potential both in the present and for the future. In comparison to traditional separation methods, CE represents a miniaturized analysis technique (especially in its microchip-based format) that is highly dependent upon the basic fundamentals of effective sample recovery and high sensitivity detection. With these issues in mind, Chapters 1–4 describe recently developed approaches for both capillary coatings and analyte detection via laser-induced fluorescence. Since the discipline of biotechnology has established itself as a primary platform for the application of CE to the analysis of proteins and peptides, Chapters 5–7 demonstrate a variety of examples of the specific techniques that have been applied for the development of biopharmaceuticals and their commercialization. The methods covered here include also the analysis of oligosaccharides from glycoproteins.
Capillary Electrophoresis
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Author : Suvardhan Kanchi
language : en
Publisher: CRC Press
Release Date : 2017-08-21
Capillary Electrophoresis written by Suvardhan Kanchi and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-08-21 with Medical categories.
Capillary electrophoresis (CE) has become an established method with widespread recognition as an analytical technique of choice in numerous analytical laboratories, including industrial and academic sectors. Pharmaceutical and biochemical research and quality control are the most important CE applications. This book provides a comparative assessment of related techniques on mode selection, method development, detection, and quantitative analysis and estimation of pharmacokinetic parameters and broadens the understanding of modern CE applications, developments, and prospects. It introduces the fundamentals of CE and clearly outlines the procedures used to mitigate several barriers, such as detection limits, signal detection, changing capillary environment, resolution separation of analytes, and hyphenation of mass spectrometry with CE, for a range of analytical problems. Each chapter outlines a specific electrophoretic variant with detailed instructions and some standard operating procedures. In this respect, the book meets its desired goal of rendering assistance to lovers of electrophoresis.
The Use Of Affinity Capillary Electrophoresis For The Study Of Drug Protein Interactions And Capillary Gell Electrophoresis For Drug Dna Interactions
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Author : Ahalya Wise
language : en
Publisher:
Release Date : 1996*
The Use Of Affinity Capillary Electrophoresis For The Study Of Drug Protein Interactions And Capillary Gell Electrophoresis For Drug Dna Interactions written by Ahalya Wise and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1996* with Capillary electrophoresis categories.
Pharmaceutical And Biomedical Applications Of Capillary Electrophoresis
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Author : S.M. Lunte
language : en
Publisher: Elsevier
Release Date : 1996-08-13
Pharmaceutical And Biomedical Applications Of Capillary Electrophoresis written by S.M. Lunte and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 1996-08-13 with Science categories.
The book describes the theory and applications of Capillary Electrophoresis (CE) in the field of pharmaceutical and biomedical analysis. It is targeted towards users who are intimately involved in analytical problems, especially those which involve small samples. This book presents the technique of capillary electrophoresis from the point of view of the serious hands-on use in the field of pharmaceutical and biomedical analysis. An overview of general theory is presented to acquaint the novice with the fundamental principles. A more theoretical approach is taken in the presentation of electrokinetic chromatography. The next chapter discusses advances in column technologies, the preceding chapters having provided a foundation as to how separations occur. In the next three chapters, recognized experts in their fields present fundamentals and state-of-the-art techniques in the areas of optical, electrochemical and mass spectrometric detection. The major focus of the remaining chapters is on applications. This includes the analysis of pharmaceuticals, amino acids and peptides, macromolecules, nucleosides, nucleotides and oligonucleotides. The use of CE for analysis of small ions and separation of biological particles is also discussed. The issue of sample preparation for analysis by CE is addressed, especially as it relates to clinical analysis.
Paper Symposium Affinity Capillary Electrophoresis
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Author : Niels H. H. Heegaard
language : en
Publisher:
Release Date : 1998
Paper Symposium Affinity Capillary Electrophoresis written by Niels H. H. Heegaard and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1998 with categories.
Analytical Techniques In The Pharmaceutical Sciences
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Author : Anette Müllertz
language : en
Publisher: Springer
Release Date : 2016-08-30
Analytical Techniques In The Pharmaceutical Sciences written by Anette Müllertz and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-08-30 with Medical categories.
The aim of this book is to present a range of analytical methods that can be used in formulation design and development and focus on how these systems can be applied to understand formulation components and the dosage form these build. To effectively design and exploit drug delivery systems, the underlying characteristic of a dosage form must be understood--from the characteristics of the individual formulation components, to how they act and interact within the formulation, and finally, to how this formulation responds in different biological environments. To achieve this, there is a wide range of analytical techniques that can be adopted to understand and elucidate the mechanics of drug delivery and drug formulation. Such methods include e.g. spectroscopic analysis, diffractometric analysis, thermal investigations, surface analytical techniques, particle size analysis, rheological techniques, methods to characterize drug stability and release, and biological analysis in appropriate cell and animal models. Whilst each of these methods can encompass a full research area in their own right, formulation scientists must be able to effectively apply these methods to the delivery system they are considering. The information in this book is designed to support researchers in their ability to fully characterize and analyze a range of delivery systems, using an appropriate selection of analytical techniques. Due to its consideration of regulatory approval, this book will also be suitable for industrial researchers both at early stage up to pre-clinical research.
Capillary Electrophoresis Based Methods For Lipophilicity Determination Of Pharmaceuticals And Quality Control Of Biopharmaceuticals
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Author : Robert Klaus Peter Minkner
language : en
Publisher:
Release Date : 2024
Capillary Electrophoresis Based Methods For Lipophilicity Determination Of Pharmaceuticals And Quality Control Of Biopharmaceuticals written by Robert Klaus Peter Minkner and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024 with categories.
Capillary Electrophoresis
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Author : Philippe Schmitt-Kopplin
language : en
Publisher: Humana Press
Release Date : 2016-05-01
Capillary Electrophoresis written by Philippe Schmitt-Kopplin and has been published by Humana Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-05-01 with categories.
This book presents a selection of current capillary electrophoresis methods used to separate representative types of molecules and particles and in combination with different detection techniques. It includes practical details which are hard to find elsewhere. The volume is intended for beginners in the field and provides an overview of the technique and a starting point for the exploration of the defined literature on different application topics.