Alteration Of Cytochrome P450 Gene Expression And Microbial Profiles In Patients With Endometriosis
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Alteration Of Cytochrome P450 Gene Expression And Microbial Profiles In Patients With Endometriosis
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Author : Han G. Do
language : en
Publisher:
Release Date : 2023
Alteration Of Cytochrome P450 Gene Expression And Microbial Profiles In Patients With Endometriosis written by Han G. Do and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023 with Cytochrome P-450 categories.
Endometriosis is characterized by aberrant estrogen signaling and chronic inflammation that results in prolonged pelvic pain and infertility. Research from our lab along with others have found that the chronic inflammatory state is maintained by a high ratio of inflammatory/ tolerant (Th17/ Tregs) cells systemically as well as increased Treg localization (tolerance) within endometriotic lesions, allowing endometriotic lesions to escape effector immune clearance. Moreover, this phenotype creates an intolerant environment for successful implantation which poses a risk of infertility and pre-term delivery in this group of women. Our previous research has also found that women with endometriosis have microbial dysbiosis within both gastrointestinal and urogenital (GI/UG) environments that may contribute to abnormal metabolism of parent estrogens. We hypothesized that microbial disruption alters enterohepatic recirculation of endogenous hormones by changing expression of cytochrome P450 (CYPs) enzymes that metabolize parent estrogens. Along with presence of disease, many external factors might also contribute to microbial disruption within the urogenital environment such as sexual partner encounters. Surgical intervention and use of hormonal therapies for treatment of endometriosis, may also contribute to microbial composition within the GI and UG environments in diseased patients. Our goal for this study was to 1) measure several CYP enzyme gene expressions in both eutopic endometrium and ectopic endometriotic lesions of diseased subjects; and 2) investigate the association of sexual partner number on microbial profiles in vaginal, urine and fecal samples of diseased patients, and whether hormonal therapy and surgical intervention affect microbial dynamics within the GI and UG environments. Our data showed that CYP1B1 gene expression was altered in eutopic endometrium of diseased patients. Hormonal therapy (HT) increased CYP1B1 gene expression in both eutopic and ectopic endometrial tissue. Patients who had more than 7 sexual partners had increased microbial dysbiosis indicated by increased composition of anaerobic bacteria in fecal and vaginal samples, indicating that increased number of sexual partners further altered microbial dysbiosis in patients with endometriosis. In conclusion, our long-term goal is to identify a unique microbiome that may serve as a potential marker to detect the early onset of endometriosis. Our study contributes to current knowledge on the expression of CYP enzyme metabolites on endometriosis. Since our patient cohorts are divided based on hormonal and surgical treatment, we hope to contribute additional knowledge on the impact of pharmacological and surgical therapy on the expression of CYP enzymes in endometriosis. Moreover, we hope to gain more understanding about mechanisms that cause alteration of CYPs gene expression in patients with endometriosis. Understanding the pathophysiology of endometriosis is critical for advancement of novel therapeutic targets and treatment of disease. Through investigation of a patient's immune system, endocrine regulation and microbial profiling, we hope to advance our understanding of the disease and identify potential areas for improving diagnostics and therapeutic interventions.
Toxicological Profile For Toluene
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Author :
language : en
Publisher:
Release Date : 2000
Toxicological Profile For Toluene written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2000 with Toluene categories.
A Textbook Of Clinical Embryology
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Author : Eliezer Girsh
language : en
Publisher: Cambridge University Press
Release Date : 2021-05-06
A Textbook Of Clinical Embryology written by Eliezer Girsh and has been published by Cambridge University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-05-06 with Medical categories.
A comprehensive guide for trainee embryologists and medical students in the specialized techniques and technology of assisted reproduction.
Toxicological Profile For Carbon Tetrachloride
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Author :
language : en
Publisher:
Release Date : 1994
Toxicological Profile For Carbon Tetrachloride written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1994 with Carbon tetrachloride categories.
Hyperandrogenism In Women
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Author : R. Pasquali
language : en
Publisher: Karger Medical and Scientific Publishers
Release Date : 2019-09-09
Hyperandrogenism In Women written by R. Pasquali and has been published by Karger Medical and Scientific Publishers this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-09-09 with Medical categories.
Hyperandrogenism profoundly affects women’s lives from lowering self-esteem to changing cognition and affective motivation. The polycystic ovary syndrome (PCOS) is the most common androgen excess disorder worldwide. While it is not the focus of this book, some aspects are discussed. The aim of this book is to improve understanding of androgen excess and its impact on several conditions. Topics include development of adipose tissue in females, insulin sensitivity, congenital adrenal hyperplasia, and Cushing’s disease/syndrome. There is also a discussion of PCOS with emphasis on in utero origins and specific genetic and epigenetic factors. This book provides a wealth of relevant information for every endocrinologist and gynecologist who wants to broaden their knowledge of androgens in various conditions.
Herbal Medicine
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Author : Iris F. F. Benzie
language : en
Publisher: CRC Press
Release Date : 2011-03-28
Herbal Medicine written by Iris F. F. Benzie and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-03-28 with Health & Fitness categories.
The global popularity of herbal supplements and the promise they hold in treating various disease states has caused an unprecedented interest in understanding the molecular basis of the biological activity of traditional remedies. Herbal Medicine: Biomolecular and Clinical Aspects focuses on presenting current scientific evidence of biomolecular ef
A Critical Evaluation Of Vitamin D
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Author : Sivakumar Joghi Thatha Gowder
language : en
Publisher:
Release Date : 2017-04-12
A Critical Evaluation Of Vitamin D written by Sivakumar Joghi Thatha Gowder and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-04-12 with categories.
Network Pharmacology
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Author : Shao Li
language : en
Publisher: Springer Nature
Release Date : 2021-09-29
Network Pharmacology written by Shao Li and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-09-29 with Medical categories.
This book introduces “network pharmacology” as an emerging frontier subject of systematic drug research in the era of artificial intelligence and big data. Network Pharmacology is an original subject of fusion system biology, bioinformatics, network science and other related disciplines. It emphasizes on starting from the overall perspective of the system level and biological networks, the analysis of the laws of molecular association between drugs and their treatment objects, reveals the systematic pharmacological mechanisms of drugs, and guides the research and development of new drugs and clinical diagnosis and treatment. After it was proposed, network pharmacology has been paid attention by researchers, and it has been rapidly developed and widely used. In order to systematically reveal the biological basis of diagnosis and treatment in traditional Chinese medicine and modern medicine, we proposed a new concept of "network target" for the first time, which has become the core theory of "network pharmacology". The core principle of a network target is to construct a biological network that can be used to decipher complex diseases. The network is then used as the therapeutic target, to which multicomponent remedies are applied. This book mainly includes four parts: 1) The concept and theory of network pharmacology; 2) Common analysis methods, databases and software in network pharmacological research; 3) Typical cases of traditional Chinese medicine modernization and modern drug research based on network pharmacology; 4) Network pharmacology practice process based on drugs and diseases.
Nutrient Metabolism
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Author : Martin Kohlmeier
language : en
Publisher: Academic Press
Release Date : 2015-05-12
Nutrient Metabolism written by Martin Kohlmeier and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-05-12 with Technology & Engineering categories.
Nutrient Metabolism, Second Edition, provides a comprehensive overview of the supply and use of nutrients in the human body and how the body regulates intake. Chapters detail the principles determining digestion and absorption of food ingredients and how these compounds and their metabolites get into the brain, cross the placenta and pass through the kidneys. Each nutrient’s coverage contains a nutritional summary that describes its function, its food sources, dietary requirements, potential health risks if deficient, and impact of excessive intake. This handbook contains the latest information on the scope of structures, processes, genes and cofactors involved in maintaining a healthy balance of nutrient supplies. Of interest to a wide range of professionals because nutrient issues connect to so many audiences, the book contains a useful link to dietary supplements. Latest research findings on health and clinical effects of nutrients and of interventions affecting nutrient supply or metabolism Each nutrient covered contains a nutritional summary describing its function, food sources, dietary requirements, potential health risks if deficient, and impact of excessive intake. Nutrient information immediately accessible--from source to effect--in one volume
Taking An Exposure History
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Author : Arthur L. Frank
language : en
Publisher:
Release Date : 2001
Taking An Exposure History written by Arthur L. Frank and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2001 with Environmental monitoring categories.