Alzheimer S Disease From Basic Research To Clinical Applications
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Alzheimer S Disease From Basic Research To Clinical Applications
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Author : Hermann J. Gertz
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-06-29
Alzheimer S Disease From Basic Research To Clinical Applications written by Hermann J. Gertz and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-06-29 with Medical categories.
As human longevity continues to be extended, so will the impact of age-associated dementia on individual lives and society. Alzheimer’s disease as the most common cause of dementia in the elderly remains a sentinal problem and its underlying pathology is still poorly understood. Available therapeutic strategies require considerable refinement and the development of new therapeutic strategies need input from basic research. Thus continued efforts are necessary both to understand basic mechanisms of the condition and to achieve more powerfull therapies. This volume brings together the reports of basic scientists and clinical investigators. The chapters provide a spectrum of information valuable for clinicians and scientists. This issue bridges the gap between laboratory work in basic science and the development of urgently needed therapeutic strategies. Areas presented are the molecular and cellular biology of the disease, pathogenetic mechanisms and potential therapeutic targets, genetics, risk factors, strategies of prevention and treatment as well as practical aspects of medical and social care for patients with Alzheimer’s disease.
Studies On Alzheimer S Disease
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Author : Domenico Praticὸ
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-09-21
Studies On Alzheimer S Disease written by Domenico Praticὸ and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-09-21 with Science categories.
This volume systematically reviews the basic science and clinical knowledge of the role of free radicals and antioxidants, collectively known as “oxidative stress,” in the pathology of Alzheimer’s disease. It describes the most current diagnostic tools, laboratory methods and technology, and suggests ways of prevention and treatment to emphasize the concept of the bench-to-bedside approach. Studies on Alzheimer’s Disease provides thorough coverage of emerging technology and medical applications including discussions of biomarkers and antioxidants as therapeutic agents, and several more relevant aspects. In addition, this book promotes the concept of using biomarkers representative of oxidative stress reactions and free-radical damageand describes the effects of antioxidants in treating disease in clinical trials. This content is invaluable to both researchers and clinicians studying the development of and treating patients with Alzheimer’s Disease.
Alzheimer S Disease
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Author : Benedetto Corain
language : en
Publisher:
Release Date : 1993-05-24
Alzheimer S Disease written by Benedetto Corain and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1993-05-24 with Medical categories.
Charts the considerable progress made toward understanding the basic molecular mechanisms of this disorder and toward developing diagnostic and therapeutic strategies. Articles by leading scientists in the field cover such areas as neuroimaging, brain energy metabolism, biomarkers, brain amyloidosis, environmental and metabolic factors, similarities and differences between transmissible dementias and Alzheimer's disease.
Neuroinflammatory Mechanisms In Alzheimer S Disease
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Author : Joseph Rogers
language : en
Publisher: Springer Science & Business Media
Release Date : 2001
Neuroinflammatory Mechanisms In Alzheimer S Disease written by Joseph Rogers and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2001 with Alzheimer's disease categories.
There has been an increasing appreciation of the economic and human toll that age-related disorders take throughout the world. Unprecedented research efforts have followed, aiming at the understanding and treatment of Alzheimer's Disease (AD) in particular, and this effort has finally begun to bear fruit - sometimes in surprising ways: Twenty years ago, the idea that AD involved any sort of inflammatory or immune component seemed implausible, if considered at all. Now, there are hundreds of laboratories world-wide that are pursuing basic research in this area, and multi-site clinical trials are underway to test the therapeutic potential of common anti-inflammatory drugs in AD. How this dramatic sea-change came about is made clear in this book, both through overviews of the field and through focused papers on specific topics of recent interest. Complement, cytokines and the complex host of other acute phase reactants are covered, as are summaries of many epidemiologic and clinical-pathological findings...
Assessing The Impact Of Applications Of Digital Health Records On Alzheimer S Disease Research
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Author : National Academies of Sciences, Engineering, and Medicine
language : en
Publisher: National Academies Press
Release Date : 2016-03-26
Assessing The Impact Of Applications Of Digital Health Records On Alzheimer S Disease Research written by National Academies of Sciences, Engineering, and Medicine and has been published by National Academies Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-03-26 with Medical categories.
Health information technology is providing patients, clinicians, and researchers with access to data that will enable novel approaches to science and medicine. Digital health records (DHRs) are capable of being shared across different health care settings for the examination of possible trends and long-term changes in a patient's disease progression or status as well as the effectiveness of the health care delivery system. While prevalence of paper records remains high, there has been a rapid trend toward the digitalization of medical and health records in many countries. DHRs are widely viewed as essential for improving health, reducing medical errors, and lowering costs. However, given that these databases have the potential to house the complete medical and health information of individuals, the potential misuse, de-identification or breaching of this data may have serious implications. On July 20, 2015, the Institute of Medicine's Forum on Neuroscience and Nervous System Disorders held a public session at the 2015 Alzheimer's Association International Conference to assess the impact of DHRs on Alzheimer's disease (AD) research. An estimated 46.8 million people worldwide are currently living with dementia, and the prevalence is expected to double every year for the next 20 years. Given the few therapies currently available to treat the symptoms of AD, compared to other central nervous system disorders, participants explored how DHRs may be used to help improve clinical trial design and methodology for AD research. This report summarizes the presentations and discussions from this workshop.
Clinical Use Of Biomarkers For Neurodegenerative Disorders
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Author : Manuel Menéndez-González
language : en
Publisher: Frontiers Media SA
Release Date : 2014-12-03
Clinical Use Of Biomarkers For Neurodegenerative Disorders written by Manuel Menéndez-González and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-12-03 with Biochemical markers categories.
The prevalence of neurodegenerative disorders is increasing dramatically and one of the major challenges today is the need of early and accurate diagnosis, the other is the need of more effective therapies -in turn the development of such therapies also requires early and accurate diagnosis-. The main hope for an earlier and more accurate diagnosis comes from the use of biomarkers. Much research is being done trying to solve the many interrogates related to the role of biomarkers in clinical practice, including the early diagnosis, differential diagnosis and follow-up of neurodegenerative disorders. This is a field where translational research is intense enough to make this topic interesting for basic researchers and clinicians. Indeed, the amount and quality of articles received in response to the call for contributions was very good. This eBook contains a good amount of high quality articles devoted to diverse techniques across several neurodegenerative disorders from different perspectives, including original reports, reviews, methods reports and opinion letters on biochemical biomarkers in biological fluids, neuroimaging techniques and multidimensional approaches linking clinical findings with biomarkers. The disorders covered are also diverse: Alzheimer’s disease, Frontotemporal Dementia, Dementia with Lewy Bodies, Huntington’s disease, Parkinson’s disease among others. As we can learn from articles in this Research Topic, biomarkers are allowing us to expand the knowledge on the biological and anatomical basis of neurodegenerative diseases and to implement diagnostic techniques in clinical practice and clinical trials.
Alzheimer S Disease
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Author : Neal R. Cutler
language : en
Publisher:
Release Date : 1995-07-11
Alzheimer S Disease written by Neal R. Cutler and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1995-07-11 with Medical categories.
Progress in the basic and clinical research of Alzheimer?s disease has been substantial in recent years and has contributed significantly to our understanding of the pathology which underlies the disease process. Although there has been no treatment breakthrough, advances in neuroscience research have provided a clearer focus for the clinical development of promising therapeutic strategies. Presented here is a comprehensive and authoritative account of the latest discoveries on Alzheimer?s disease. Crucial areas of basic research are discussed as well as viable neurotransmitter treatment approaches and a method for determining the proper dose to use in clinical drug trials. Written by an international group of authors, the book will be of value to all researchers in Alzheimer?s disease and to neuroscientists, neurologists and psychiatrists.
Alzheimer S Disease
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Author : Jean-Robert Rapin
language : en
Publisher:
Release Date : 1997
Alzheimer S Disease written by Jean-Robert Rapin and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1997 with Alzheimer's disease categories.
Alzheimer S Disease
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Author : Khalid Iqbal
language : en
Publisher:
Release Date : 1991-05-30
Alzheimer S Disease written by Khalid Iqbal and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1991-05-30 with Medical categories.
Alzheimer’s Disease: Basic Mechanisms, Diagnosis and Therapeutic Strategies Edited by Khalid Iqbal New York State Institute for Basic Research, New York, USA Donald R.C. McLachlan Centre for Research on Neurodegenerative Diseases, University of Toronto, Canada Bengt Winblad Department of Geriatric Medicine, Karolinska Institute, Stockholm, Sweden and Henry M. Wisniewski New York State Institute for Basic Research, New York, USA As human longevity continues to be extended, so will the impact of age-associated dementia on individual lives and society. Although recognized as one of the most devastating diseases of the human brain, the etiology and pathogenesis of Alzheimer’s disease are still poorly understood. Continued research is required both into the basic mechanisms of the condition and into developing diagnostic and therapeutic strategies in the clinic. Presented here is a wide-ranging, authoritative and comprehensive coverage of the most recent and significant advances in basic research and clinical investigations of Alzheimer’s disease. Areas represented include neuroimaging, brain energy metabolism, structural and molecular neuropathology, mechanisms of neuronal degeneration, role of brain amyloidosis, risk factors and epidemiology, environmental factors, genetic mechanisms, biomarkers, animal models and the clinical pharmacology of current and future therapeutic strategies. Contributions are drawn from the major research groups around the world, providing an invaluable information and reference source to both basic researchers and clinicians providing primary care for the unfortunate victims of Alzheimer’s disease. Titles of related interest from Wiley: Dahlem LS43: Etiology of Dementia of Alzheimer’s Type 0 471 92075 4 1988 Giaquinto: Aging and the Nervous System 0 471 91835 0 1988 Iqbal et al.: Alzheimer’s Disease and Related Disorders 0 471 56228 9 1989 Hindmarch, Hippius and Wilcock: Dementia: Molecules, Methods and Measures due Summer 1991
Pharmacological Treatment Of Alzheimer S Disease
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Author : Jorge D. Brioni
language : en
Publisher: Wiley-Liss
Release Date : 1997-03-10
Pharmacological Treatment Of Alzheimer S Disease written by Jorge D. Brioni and has been published by Wiley-Liss this book supported file pdf, txt, epub, kindle and other format this book has been release on 1997-03-10 with Medical categories.
Prominent Alzheimer's investigators provide a comprehensive and balanced overview of the neuropharmacological basis for therapeutics in this devastating disease. Divided into three parts, the book begins with basic research on the neurobiology of cognitive function, offering relevant information on the way the brain encodes and stores data. The second segment explores the molecular aspects of Alzheimer's Disease (AD), emphasizing investigations of possible etiological factors. In the final section, a variety of issues important in developing treatments are discussed including cholinergic-based treatments, the role of neuroinflammin in AD and the therapeutic potential of anti-inflammatory agents.