Alzheimer S Disease Pathogenesis
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Alzheimer S Disease Pathogenesis
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Author : Suzanne De La Monte
language : en
Publisher: BoD – Books on Demand
Release Date : 2011-09-12
Alzheimer S Disease Pathogenesis written by Suzanne De La Monte and has been published by BoD – Books on Demand this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-09-12 with Medical categories.
Alzheimer's Disease Pathogenesis: Core Concepts, Shifting Paradigms, and Therapeutic Targets, delivers the concepts embodied within its title. This exciting book presents the full array of theories about the causes of Alzheimer's, including fresh concepts that have gained ground among both professionals and the lay public. Acknowledged experts provide highly informative yet critical reviews of the factors that most likely contribute to Alzheimer's, including genetics, metabolic deficiencies, oxidative stress, and possibly environmental exposures. Evidence that Alzheimer's resembles a brain form of diabetes is discussed from different perspectives, ranging from disease mechanisms to therapeutics. This book is further energized by discussions of how neurotransmitter deficits, neuro-inflammation, and oxidative stress impair neuronal plasticity and contribute to Alzheimer's neurodegeneration. The diversity of topics presented in just the right depth will interest clinicians and researchers alike. This book inspires confidence that effective treatments could be developed based upon the expanding list of potential therapeutic targets.
Alzheimer S Disease
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Author : D. C. Davies
language : en
Publisher: Demos Medical Publishing
Release Date : 1989
Alzheimer S Disease written by D. C. Davies and has been published by Demos Medical Publishing this book supported file pdf, txt, epub, kindle and other format this book has been release on 1989 with Medical categories.
Alzheimer's disease is an age-related progressive degenerative disease which constitutes the principal cause of dementia. It affects approximately 5-10% of the population over 65 years of age, rising to 20% of the population over 80 years of age. Improvements in health care in the developed world have resulted in an increasingly large elderly population and thus a growing number of Alzheimer's disease sufferers. The care of these patients presents a major and increasing human burden and drain on health care resources and thus the disease constitutes one of the major challenges to public health. Despite considerable knowledge about the clinical manifestations of Alzheimer's disease, its cause is at present unknown. This book outlines the clinical problems associated with Alzheimer's disease and seeks to provide a synthesis of knowledge of the major fields of research into the disease together with suggestions for future research. The topics covered include: neurotransmitter deficits, patterns of cerebral pathology, progression of the pathological changes, structure of neurofibrillary tangles and senile plaques, hippocampal pathology and memory impairment, animal models of amnesia and dementia, trace elements and the pathogenesis of the disease and the genetics of Alzheimer's disease. The book will be of interest to a wide variety of medical practitioners, research workers and students requiring accessible information about the current focus of research into Alzheimer's disease.
Alzheimer S Disease
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Author : Khalid Iqbal
language : en
Publisher: John Wiley & Sons
Release Date : 2003-01-24
Alzheimer S Disease written by Khalid Iqbal and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2003-01-24 with Medical categories.
Alzheimer's Disease is an ever present problem affecting millions of people around the world and, as people's average lifespan lengthens, its prevalence is set to increase. A global effort is needed to combat the disease, including research to investigate the causes, development of effective treatments and, ultimately, prevention of the disease. Published every two years, these timely books discuss the very latest research. This new volume provides a unique source of reference to the important work being done in this field, it gives academics and clinicians an opportunity to learn about cutting edge developments and covers all aspects of Alzheimer's Disease, including diagnosis, clinical course, epidemiological course and therapeutics and disease mechanisms. Alzheimer's Disease: Advances in Etiology, Pathogenesis and Therapeutics will provide essential information for basic and clinical researchers in Alzheimer's Disease and other dementias as well as for those who care for patients.
Alzheimer S Disease
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Author : Thimmaiah Govindaraju
language : en
Publisher: Royal Society of Chemistry
Release Date : 2022-01-04
Alzheimer S Disease written by Thimmaiah Govindaraju and has been published by Royal Society of Chemistry this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-01-04 with Medical categories.
Alzheimer’s disease is an increasingly common form of dementia and despite rising interest in discovery of novel treatments and investigation into aetiology, there are no currently approved treatments that directly tackle the causes of the condition. Due to its multifactorial pathogenesis, current treatments are directed against symptoms and even precise diagnosis remains difficult as the majority of cases are diagnosed symptomatically and usually confirmed only by autopsy. Alzheimer’s Disease: Recent Findings in Pathophysiology, Diagnostic and Therapeutic Modalities provides a comprehensive overview from aetiology and neurochemistry to diagnosis, evaluation and management of Alzheimer's disease, and latest therapeutic approaches. Intended to provide an introduction to all aspects of the disease and latest developments, this book is ideal for students, postgraduates and researchers in neurochemistry, neurological drug discovery and Alzheimer’s disease.
Molecular Pathology Of Alzheimer S Disease
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Author : Rudy Castellani
language : en
Publisher: Biota Publishing
Release Date : 2013-10-01
Molecular Pathology Of Alzheimer S Disease written by Rudy Castellani and has been published by Biota Publishing this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-10-01 with Health & Fitness categories.
Alzheimer’s Disease is characterized pathologically by two principal hallmark lesions: the senile plaque and the neurofibrillary tangle. Since the identification of each over 100 years ago, the major protein components have been elucidated. This has led in turn to the elaboration of metabolic cascades involving amyloid-β production in the case of the senile plaque, and phosphorylated-tau protein in the case of the neurofibrillary tangle. The pathogenesis and histogenesis of each have been the source of extensive investigation and some controversy in recent years, as both cascades have been implicated in the pathogenesis of Alzheimer’s Disease, relied upon in the diagnostic criteria for Alzheimer’s Disease at autopsy, and targeted for therapeutic intervention. With the accumulation of data and expansion of knowledge of the molecular biology of Alzheimer’s Disease, it appears that the enthusiasm for successful intervention has been premature. In this book, we detail the discovery and characterization of the major pathological lesions, their associated molecular biology, their relationship to clinical disease, and potential fundamental errors in understanding that may be leading scientific investigators in unintended directions.
Mechanisms Of Alzheimer S Disease Pathogenesis
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Author : Jonathan C. Sedeyn
language : en
Publisher:
Release Date : 2010
Mechanisms Of Alzheimer S Disease Pathogenesis written by Jonathan C. Sedeyn and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010 with categories.
Proteases And Protease Inhibitors In Alzheimer S Disease Pathogenesis
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Author : Carl D. B. Banner
language : en
Publisher:
Release Date : 1992
Proteases And Protease Inhibitors In Alzheimer S Disease Pathogenesis written by Carl D. B. Banner and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1992 with Medical categories.
These 22 papers cover protein trafficking, lysosomal proteolysis, calpains, serpins, processing of cytoskeletal proteins, and complex proteolytic cascades of the circulatory system.
Neurochemical Aspects Of Alzheimer S Disease
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Author : Akhlaq A. Farooqui
language : en
Publisher: Academic Press
Release Date : 2017-05-25
Neurochemical Aspects Of Alzheimer S Disease written by Akhlaq A. Farooqui and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-05-25 with Science categories.
Neurochemical Aspects of Alzheimer's Disease provides a comprehensive overview of molecular aspects of risk factors, pathogenesis, biomarkers, and therapeutic strategies. The book focuses on molecular mechanisms and signal transduction processes associated with the pathogenesis, biomarkers, and therapeutic strategies of AD. The comprehensive and cutting edge information in this monograph may not only help in early detection of AD, but also promote discovery of new drugs to treat this chronic disease. Chapters discuss involvement of neural membrane phospholipids, sphingolipids, and cholesterol-derived lipid mediators, abnormal APP processing, and nucleic acid damage, risk factors, biomarker, and therapeutic strategies of Alzheimer's disease. This book is written for neurologists, neuroscientists, neurochemists, neuropharmacologists, and clinicianswho are interested in molecular mechanisms associated with the pathogenesis of age-related neurological disorders. Provides a comprehensive overview of molecular aspects of risk factors, pathogenesis, biomarkers, and therapeutic strategies for Alzheimer's disease Written for researchers, clinicians, and advanced graduate students in neurology, neuroscience, neurochemistry, and neuropharmacology Acts as the first book to provide a comprehensive description of the signal transduction processes associated with pathogenesis of Alzheimer's disease
Aspects Of The Pathogenesis And Pathophysiology Of Alzheimer S Disease
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Author : Ashley Ian Bush
language : en
Publisher:
Release Date : 1992
Aspects Of The Pathogenesis And Pathophysiology Of Alzheimer S Disease written by Ashley Ian Bush and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1992 with Alzheimer's disease categories.
Pathogenesis And Management Of Alzheimer S Disease
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Author : Elliot Cooper
language : en
Publisher: States Academic Press
Release Date : 2021-11-16
Pathogenesis And Management Of Alzheimer S Disease written by Elliot Cooper and has been published by States Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-11-16 with Health & Fitness categories.
Alzheimer's disease is a medical condition in which the normal functioning of the brain is hampered. Some of the common symptoms of this disease are loss of memory, unstable behavior and language problems. The patients also have difficulty in executing complex tasks and recognizing people. The major characteristics of Alzheimer's disease are tangles and plaques in the brain. The disease is broadly categorized into three stages, mild, moderate and severe. The dependency on others for everyday tasks increases as the disease gets more severe. It is diagnosed with the help of procedures such as neurologic function tests, genetic testing, cognitive and memory tests, and CT scan and MRI scan. This book unfolds the innovative aspects of research on Alzheimer's disease which will be crucial for the progress of this field in the future. Also included herein is a detailed explanation of the various ways of managing this disease. Those in search of information to further their knowledge will be greatly assisted by this book.