Analysis Of Golgi Apparatus During Germ Cell Differentiation And Formation And Function Of The Hermes Body Of Epididymal Sperm
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Analysis Of Golgi Apparatus During Germ Cell Differentiation And Formation And Function Of The Hermes Body Of Epididymal Sperm
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Author : Elliot Byrne
language : en
Publisher:
Release Date : 2015
Analysis Of Golgi Apparatus During Germ Cell Differentiation And Formation And Function Of The Hermes Body Of Epididymal Sperm written by Elliot Byrne and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015 with categories.
"Introduction: At the last step of spermiogenesis, Oko et al. (1993) proposed that unstacked cisternae of the Golgi ribbon organized into a structure previously known as the cytoplasmic droplet, here referred to as the Hermes body. Conserved among all mammalian species, the migration of the Hermes body along the midpiece of sperm in the epididymis is observed to coincide with the initiation of sperm motility. The objective of this study was to compare the most abundant protein constituents of isolated Hermes bodies of epididymal sperm as well as Golgi apparatuses of germ cells in order to provide insight into the formation and function of the Hermes body as well as to ascertain the patterns of expression and differentiation of several Golgi markers during spermatogenesis. Methods: 58 antibodies were selected for immunohistochemical localization (IHC) done on sections of adult male rat testes and epididymides (n=4). Reaction patterns were visualized in all germ cell types across the 14 stages of spermatogenesis, in epididymal sperm throughout the epididymal duct, as well as in all somatic cell types in order to establish each protein's pattern of expression.Results: Each of the 58 antibodies analyzed in this study was investigated as a molecular map of protein expression through the 14 stages of spermatogenesis and for their presence in the Hermes body. Quantitatively, the most abundant Hermes body proteins were those for glucose transport (Glut3) and metabolism (Hexokinase 1), each was localized to the Hermes body by IHC. Actin and myosin were identified to propel the Hermes along the flagellum. In addition, the Hermes body contained proteins characteristic of ER, endosomes, and Golgi apparatus both by proteomics as well as by IHC. In the testis Golgi fraction, the transmembrane 9 family of proteins were prominent and of unknown function along with 200 other proteins. The most abundant protein of this fraction was a novel putative glycosyl transferase (GL54D), an unkown protein but verified by IHC in situ. Golgi proteins conserved between the Hermes and the testis germ cell Golgi apparatus and verified by IHC included the TMED family of transmembrane proteins and COPI/II coatomer proteins. Golgi proteins were also revealed during mitosis, meiosis, acrosome and postacrosomal formation, and Hermes body formation, establishing a protein signature for each during germ cell differentiation. Of the 43 proteins localized to the Hermes body of epididymal sperm, only 31 were maintained down the entire duct, which is explained by the presence of members of the ubiquitin-proteasome system. Discussion: The results of this study reveal that although noted in the Hermes body, Golgi apparatus proteins were not abundant in forming and epididymal Hermes bodies. Hence, the flattened cisternae of the Hermes body may represent a hybrid structure that has evolved to suit the specific needs of the sperm during its maturation.Conclusions: The Hermes body is deduced to compartmentalize glycolysis, cytoskeletal, membrane trafficking, stress response, and protein degradation for the initiation of sperm motility and sperm maturation in the epididymis with its complete protein compendium realized in the step 19 spermatid during Hermes body formation. The Golgi apparatus of germ cells also demonstrates a specific complement of proteins that would serve for the differentiation of germ cells during spermatogenesis." --
Spermatogenesis
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Author : C. Yan Cheng
language : en
Publisher: CRC Press
Release Date : 2018-09-03
Spermatogenesis written by C. Yan Cheng and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-09-03 with Medical categories.
Senior investigators internationally have here collaborated to produce an international reference work. Each contributor provides critical and thought provoking concepts and ideas based on the latest developments in their field. The result is a must read and timely reference work for investigators who are interested in how spermatogenesis is currently understood and which are the most promising avenues for future research; an Introduction sets the context for the chapter and points out the relevance of the research for basic research scientists and clinicians.
Encyclopedia Of Reproduction
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Author :
language : en
Publisher: Academic Press
Release Date : 2018-06-29
Encyclopedia Of Reproduction written by and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-06-29 with Medical categories.
Encyclopedia of Reproduction, Second Edition, Six Volume Set comprehensively reviews biology and abnormalities, also covering the most common diseases in humans, such as prostate and breast cancer, as well as normal developmental biology, including embryogenesis, gestation, birth and puberty. Each article provides a comprehensive overview of the selected topic to inform a broad spectrum of readers, from advanced undergraduate students, to research professionals. Chapters also explore the latest advances in cloning, stem cells, endocrinology, clinical reproductive medicine and genomics. As reproductive health is a fundamental component of an individual’s overall health status and a central determinant of quality of life, this book provides the most extensive and authoritative reference within the field. Provides a one-stop shop for information on reproduction that is not available elsewhere Includes extensive coverage of the full range of topics, from basic, to clinical considerations, including evolutionary advances in molecular, cellular, developmental and clinical sciences Includes multimedia and interactive teaching tools, such as downloadable PowerPoint slides, video content and interactive elements, such as the Virtual Microscope
Clues In The Diagnosis Of Non Tumoral Testicular Pathology
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Author : Manuel Nistal
language : en
Publisher: Springer
Release Date : 2017-03-07
Clues In The Diagnosis Of Non Tumoral Testicular Pathology written by Manuel Nistal and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-03-07 with Medical categories.
This book presents the morphology of different non-tumoral lesions of the testis. By showing the differential diagnosis of each lesion, it offers clinicians vital support with diagnosis and treatment. The book is divided into seven main parts: genetic and developmental pathology of the testis; infertility; vascular pathology of the testis; inflammatory pathology; pathology of the rete testis and epididymis; pathology of the vaginal tunic and paratesticular structures; and a final part dealing with miscellanea. Each chapter includes carefully selected figures and a variety of diagrams highlighting the main characteristics of a specific lesion to facilitate its diagnosis.Based on the authors’ experience with hundreds of biopsies, surgical specimens and autopsies, the book presents material that has been gathered over the past 40 years, providing an essential tool for pathologists, urologists, andrologists and pediatricians who face diagnostic problems.
Cellular Migration And Formation Of Neuronal Connections
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Author :
language : en
Publisher: Academic Press
Release Date : 2013-05-06
Cellular Migration And Formation Of Neuronal Connections written by and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-05-06 with Science categories.
The genetic, molecular, and cellular mechanisms of neural development are essential for understanding evolution and disorders of neural systems. Recent advances in genetic, molecular, and cell biological methods have generated a massive increase in new information, but there is a paucity of comprehensive and up-to-date syntheses, references, and historical perspectives on this important subject. The Comprehensive Developmental Neuroscience series is designed to fill this gap, offering the most thorough coverage of this field on the market today and addressing all aspects of how the nervous system and its components develop. Particular attention is paid to the effects of abnormal development and on new psychiatric/neurological treatments being developed based on our increased understanding of developmental mechanisms. Each volume in the series consists of review style articles that average 15-20pp and feature numerous illustrations and full references. Volume 2 offers 56 high level articles devoted mainly to Formation of Axons and Dendrites, Migration, Synaptogenesis, Developmental Sequences in the Maturation of Intrinsic and Synapse Driven Patterns. Series offers 144 articles for 2904 full color pages addressing ways in which the nervous system and its components develop Features leading experts in various subfields as Section Editors and article Authors All articles peer reviewed by Section Editors to ensure accuracy, thoroughness, and scholarship Volume 2 sections include coverage of mechanisms which regulate: the formation of axons and dendrites, cell migration, synapse formation and maintenance during development, and neural activity, from cell-intrinsic maturation to early correlated patterns of activity
Leong S Manual Of Diagnostic Antibodies For Immunohistology
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Author : Runjan Chetty
language : en
Publisher: Cambridge University Press
Release Date : 2016-11-28
Leong S Manual Of Diagnostic Antibodies For Immunohistology written by Runjan Chetty and has been published by Cambridge University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-11-28 with Medical categories.
A detailed, A-Z guide and an indispensable source for pathologists ensuring correct application of immunohistochemistry in daily practice.
The Sperm Cell
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Author : Christopher J. De Jonge
language : en
Publisher: Cambridge University Press
Release Date : 2006-04-06
The Sperm Cell written by Christopher J. De Jonge and has been published by Cambridge University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2006-04-06 with Medical categories.
Originally published in 2006, this is a comprehensive and definitive account of the human male gamete. The volume summarizes many unique and revealing characteristics of the sperm cell. It provides a detailed overview of human sperm production, maturation and function, and looks at how these processes affect and influence fertility, infertility and ART. The volume thus provides a detailed review of the most important research and developments, augmented with pertinent references. This book will appeal to all practitioners and scientists in reproductive medicine and in particular to clinical scientists, graduate and post-graduate scientists, and laboratory personnel.
Male Infertility
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Author : Sijo J. Parekattil
language : en
Publisher: Springer Nature
Release Date : 2020-01-24
Male Infertility written by Sijo J. Parekattil and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-01-24 with Health & Fitness categories.
A groundbreaking contribution to the literature now in its revised and expanded second edition, this textbook offers a comprehensive review of diagnostic and treatment techniques for male infertility. This state-of-the-art, evidence-based textbook incorporates new multidisciplinary and complementary medicine approaches to create a first-of-its-kind guide to treatment strategies for male infertility and beyond. While this new edition is primarily designed as a reference for students and residents in reproductive medicine and andrology, it will be equally useful as well for professionals in urology, reproductive endocrinology, embryology, and research fields who are interested in the role that antioxidants play in male infertility. World-renowned experts in these areas have been selected to participate in this work. Careful selection of the highest quality content will span the whole range of topics in the area of male infertility, providing a complete review of well-established and current diagnostic and treatment techniques for male infertility. The incorporation of 20 new chapters will enhance the book’s appeal by including the most recent advances brought to the male infertility arena. Additionally, this edition incorporates new features, including bulleted key points, review criteria and select video clips demonstrating some of the most fascinating male infertility treatment modalities. A dedicated new section on current guidelines on male infertility will enlighten readers on how to most optimally manage male infertility clinical scenarios. Covering all aspects of diagnosis and management, ART, lifestyle factors and associated conditions for male infertility, Male Infertility: Contemporary Clinical Approaches, Andrology, ART and Antioxidants will be a readily accessible, high quality reference for medical students and residents, and will be of significant value to professionals working in the various fields treating this condition as well.
Animal Models And Human Reproduction
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Author : Heide Schatten
language : en
Publisher: John Wiley & Sons
Release Date : 2017-01-13
Animal Models And Human Reproduction written by Heide Schatten and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-01-13 with Science categories.
Our knowledge of reproductive biology has increased enormously in recent years on cellular, molecular, and genetic levels, leading to significant breakthroughs that have directly benefitted in vitro fertilization (IVF) and other assisted reproductive technologies (ART) in humans and animal systems. Animal Models and Human Reproduction presents a comprehensive reference that reflects the latest scientific research being done in human reproductive biology utilizing domestic animal models. Chapters on canine, equine, cow, pig, frog, and mouse models of reproduction reflect frontier research in placental biology, ovarian function and fertility, non-coding RNAs in gametogenesis, oocyte and embryo metabolism, fertilization, cryopreservation, signal transduction pathways, chromatin dynamics, epigenetics, reproductive aging, and inflammation. Chapters on non-human primate models also highlight recent advancements into such issues as human in vitro fertilization (IVF) and assisted reproductive technologies (ART). This book offers animal scientists, reproductive biology scientists, clinicians and practitioners, invaluable insights into a wide range of issues at the forefront of human reproductive health.
Development And Reproduction In Humans And Animal Model Species
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Author : Werner A. Mueller
language : en
Publisher: Springer
Release Date : 2015-01-03
Development And Reproduction In Humans And Animal Model Species written by Werner A. Mueller and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-01-03 with Science categories.
This book describes human development including sexual reproduction and stem cell research with the development of model organisms that are accessible to genetic and experimental analysis in readily understandable texts and 315 multi-colored graphics. The introductory account of model organisms selected from the entire animal kingdom presents general principles, which are then outlined in subsequent chapters devoted to, for example, sexual development; genes controlling development and their contemporary molecular-analysis methods; production of clones and transgenic animals; development of the nervous and circulatory systems; regenerative medicine and ageing. Finally the evolution of developmental toolkits and novelties is discussed including the genetic basis of the enlargement of the human forebrain. Separate boxes are devoted to controversial questions such as the benefits and problems of prenatal diagnostics or the construction of ancient body plans.