Angiogenesis Based Dermatology
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Angiogenesis Based Dermatology
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Author : Jack L. Arbiser
language : en
Publisher: Springer
Release Date : 2017-02-27
Angiogenesis Based Dermatology written by Jack L. Arbiser and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-02-27 with Medical categories.
This book provides a complete overview of all aspects of angiogenesis in dermatology. This is a guide to the principles of angiogenesis that will allow all involved in dermatology from the medical student and nurse practitioner to the experienced dermatologist to apply these principles for the treatment of patients. Angiogenesis is a principle that can be used to guide treatment of diseases of any organ system. Dermatology may be the first specialty to be guided by the principle of angiogenesis because the lesions are visible and response can be easily monitored. Dermatologists already inhibit angiogenesis as part of their treatment of multiple common dermatologic disorders, including acne, warts, and nonmelanoma skin cancer.
Angiogenesis
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Author : Michael E. Maragoudakis
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Angiogenesis written by Michael E. Maragoudakis and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.
Proceedings of the 5th Biannual International Meeting on Angiogenesis: From the Molecular to Integrative Pharmacology, held July 1-7, 1999, in Crete, Greece. Angiogenesis, as a vastly complex biological process, has challenged researchers from all basic scientific disciplines, including pharmacology, biochemistry, physiology, embryology and anatomy. The significance of this phenomenon for the study of disease states has also interested clinicians from a number of specialist fields. This multidisciplinary work reflects the growth of awareness of concepts such as angiogenesis based therapy, the enormous therapeutic and commercial potential of which has attracted major research and investment in recent years. This volume, which aims to bridge the gap between basic and clinical methodology and understanding, presents the most up-to-date developments in this field.
Tumor Angiogenesis And Microcirculation
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Author : Emile E. Voest
language : en
Publisher: CRC Press
Release Date : 2001-03-30
Tumor Angiogenesis And Microcirculation written by Emile E. Voest and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2001-03-30 with Medical categories.
Compiling the latest developments in anticancer therapies based on the connection between tumor and capillary growth, Tumor Angiogenesis and Microcirculation presents a comprehensive overview of diverse aspects of angiogenesis-related cancer research. Highlights the role angiogenesis and its inhibitors play in the growth, metastasis, and dormancy of tumors! Facilitating the progress of clinical practice with insights from methodological and scientific results, Tumor Angiogenesis and Microcirculation summarizes biological principles of angiogenesis and microcirculation, from endothelial cells and pericytes, and extracellular matrix regulation to matrix metalloproteinases (MMPs) and plasmin and plasmin inhibitors examines proangiogenic factors such as vascular endothelial (VEGF) and basic fibroblast (bFGF) growth factors, tie receptors, and cytokines outlines methods for discovering angiogenesis stimulators and inhibitor peptides, particularly the clinical development of thrombospondin, angiostatin, endostatin, and MMP inhibitors reveals the link between oncogenes and neoplastic angiogenesis and its regulation by the organ microenvironment investigates tumor vascularity in relation to tumor growth and the spread of cancer details promising future applications, including perspectives in vascular cancer therapy and more! Combining the resources of 60 recognized experts and nearly 3000 pertinent literature references, drawings, photographs, and x-rays, Tumor Angiogenesis and Microcirculation profits oncologists, pathologists, hematologists, and radiation and hemato-oncologists; surgeons and internists; cardiologists; immunologists; cell, molecular, and developmental biologists; rheumatologists; ophthalmologists; dermatologists; and medical school students in these disciplines.
Regulation Of Inflammation And Angiogenesis In The Cornea
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Author : Anthony Mukwaya
language : en
Publisher: Linköping University Electronic Press
Release Date : 2018-05-21
Regulation Of Inflammation And Angiogenesis In The Cornea written by Anthony Mukwaya and has been published by Linköping University Electronic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-05-21 with categories.
Inflammation and angiogenesis, the growth of new blood vessels from pre-existing ones, are involved in tumor growth, ocular diseases and wound healing. In ocular angiogenesis, new pathological vessels grow into a specific eye tissue, leak fluid, and disrupt vision. The development of safe and effective therapies for ocular angiogenesis is of great importance for preventing blindness, given that current treatments have limited efficacy or are associated with undesirable side effects. The search for alternative treatment targets requires a deeper understanding of inflammation and how it can lead to angiogenesis in the eye in pathologic situations. This thesis provides new insights into the regulation of inflammation and angiogenesis, particularly at the gene expression and phenotypic levels, in different situations characterized by angiogenesis of the cornea, often called corneal neovascularization. For instance, specific genes and pathways are either endogenously activated or suppressed during active inflammation, wound healing, and during resolution of inflammation and angiogenesis, serving as potential targets to modulate the inflammatory and angiogenic response. In addition, as part of the healing response to restore corneal transparency, inflammation and angiogenesis subside with time in the cornea. In this context, LXR/RXR signaling was found to be activated in a time-dependent manner, to potentially regulate resolution of inflammation and angiogenesis. During regression of new angiogenic capillaries, ghost vessels and empty basement membrane sleeves are formed, which can persist in the cornea for a long time. Here, ghost vessels were found to facilitate subsequent revascularization of the cornea, while empty basement membrane sleeves did not revascularize. The revascularization response observed here was characterised by vasodilation, increased inflammatory cell infiltration and by sprouting at the front of the reperfused vessels. Importantly, reactive oxygen species and nitrous oxide signaling among other pro-inflammatory pathways were activated, and at the same time anti-inflammatory LXR/RXR signaling was inhibited. The interplay between activation and inhibition of these pathways highlights potential mechanisms that regulate corneal revascularization. When treating corneal neovascularization clinically, corticosteroids are in widespread use due to their effectiveness. To minimize the many undesirable side effects associated with corticosteroid use, however, identifying new and more selective agents is of great importance. Here, it was observed that corticosteroids not only suppressed pro-inflammatory chemokines and cytokines, but also activated the classical complement pathway. Classical complement may represent a candidate for further selective therapeutic manipulation to investigate its effect on treatment of corneal neovascularization. In summary, this thesis identifies genes, pathways, and phenotypic responses involved in sprouting and remodeling of corneal capillaries, highlights novel pathways and factors that may regulate inflammation and angiogenesis in the cornea, and provides insights into regulation of capillary regression and reactivation. Further investigation of these regulatory mechanisms may offer alternative and effective treatment targets for the treatment of corneal inflammation and angiogenesis.
Evidence Based Dermatology
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Author : Howard I. Maibach
language : en
Publisher: PMPH-USA
Release Date : 2001-12-31
Evidence Based Dermatology written by Howard I. Maibach and has been published by PMPH-USA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2001-12-31 with Dermatology categories.
This book introduces and encourages the concept of evidence-based pati ent care in dermatology. This is a growing area in dermatology, and th is work presents the ideology and methodology of critical thinking and also the available evidence across the field. Evidence-Based Dermatol ogy is aimed at both primary care physicians and dermatologists, encou raging disease management decisions to be based on the highest level o f evidence.
Molecular Mechanisms Of Angiogenesis
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Author : Jean-Jacques Feige
language : en
Publisher: Springer
Release Date : 2014-05-27
Molecular Mechanisms Of Angiogenesis written by Jean-Jacques Feige and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-05-27 with Science categories.
Angiogenesis is a multi-stage process that drives the generation of new blood and lymphatic vessels from pre-existing ones. It is highly active during embryogenesis, largely inactive during adulthood but reactivated during wound healing and under a number of pathological conditions including cancer and ocular diseases. In addition to endothelial cells, which line the walls of the vessels, several other cell types (pericytes, macrophages, progenitor cells...) also contribute to angiogenesis. A number of signaling pathways are activated and very finely tune the delicate morphogenetic events that ultimately lead to the formation of stable blood proof neovessels. This book reviews recent advances in our understanding of the molecular and cellular mechanisms of angiogenesis, with a focus on how to integrate these observations into the context of developmental, post-natal and pathological neovascularization. The book was published under the auspices of the French Angiogenesis Society. Most contributors are prominent members of this Society or international researchers who have actively contributed to the Annual Meetings of the Society.
Nanoscience In Dermatology
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Author : Michael R. Hamblin
language : en
Publisher: Academic Press
Release Date : 2016-08-13
Nanoscience In Dermatology written by Michael R. Hamblin and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-08-13 with Science categories.
Nanoscience in Dermatology covers one of the two fastest growing areas within dermatological science, nanoscience and nanotechnology in dermatology. Recently, great progress has been made in the research and development of nanotechnologies and nanomaterials related to various applications in medicine and, in general, the life sciences. There is increasing enthusiasm for nanotechnology applications in dermatology (drug delivery, diagnostics, therapeutics, imaging, sensors, etc.) for understanding skin biology, improving early detection and treatment of skin diseases, and in the design and optimization of cosmetics. Light sensitive nanoparticles have recently been explored, opening a new era for the combined applications of light with nanotechnology, also called photonanodermatology. However, concerns have been raised regarding the adverse effects of intentional and unintentional nanoparticle exposure and their toxicity. Written by experts working in these exciting fields, this book extensively covers nanotechnology applications, together with the fundamentals and toxicity aspects. It not only addresses current applications of nanotechnology, but also discusses future trends of these ever-growing and rapidly changing fields, providing scientists and dermatologists with a clear understanding of the advantages and challenges of nanotechnology in skin medicine. Provides knowledge of current and future applications of nanoscience and nanotechnology in dermatology Outlines the fundamentals, methods, toxicity aspects, and other relevant aspects for nanotechnology based applications in dermatology Coherently structured book written by experts working in the fields covered
Atopic Dermatitis Inside Out Or Outside In
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Author : Lawrence S Chan
language : en
Publisher: Elsevier Health Sciences
Release Date : 2022-01-14
Atopic Dermatitis Inside Out Or Outside In written by Lawrence S Chan and has been published by Elsevier Health Sciences this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-01-14 with Medical categories.
Atopic dermatitis (eczema) is one of the most common and most challenging skin conditions, for patients and practitioners alike. Uniquely organized by intrinsic and extrinsic etiologies, Atopic Dermatitis: Inside Out or Outside In? examines a myriad of causes that start from both the inside of the body and from the external environment, offering physicians practical ways to design treatments that specifically address these causes. Drs. Lawrence S. Chan and Vivian Y. Shi, along with a team of expert contributing authors, examine the etiology of this complex disorder and provide targeted, comprehensive solutions and the most useful therapeutic plans based on pathophysiology, including evidence-based integrative management. Analyzes the pathophysiology of atopic dermatitis from two distinct fronts: inside out and outside in—an approach that is unique in the field. Begins with an overview of the disease, then delves into both internal and external pathogenic factors, followed by the Clinician’s Corner, which offers practical recommendations for treatment. Organizes therapeutic discussions by corresponding pathophysiology rather than a one-size-fits-all approach. Covers recently FDA-approved and emerging medications, as well as atopic comorbidities.
Evidence Based Procedural Dermatology
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Author : Murad Alam
language : en
Publisher: Springer
Release Date : 2019-05-16
Evidence Based Procedural Dermatology written by Murad Alam and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-05-16 with Medical categories.
This book compiles the best evidence in procedural dermatology, including skin cancer surgery, laser techniques, minimally invasive cosmetic surgery, and emerging techniques. Building on the highly successful first edition, this volume provides much expanded coverage of a range of topics. The best information is provided to reveal the most appropriate interventions for particular indications, optimal treatment techniques, and strategies for avoiding adverse events. Evidence-Based Procedural Dermatology, 2nd edition, includes two types of chapters: procedures and indications. Each chapter is designed to be clear and concise, with tables and flowcharts to showcase main findings. Each cited study is tagged with a level of evidence, and every recommendation includes a strength of evidence score. More than double the length of the first edition, this newest edition includes added procedures and interventions like: new lasers and energy devices for skin resurfacing and pigmentation; non-invasive fat reduction and skin tightening using cryolipolysis, radiofrequency, ultrasound, and chemical adipocytolysis; specific post-skin cancer excision reconstruction techniques; and novel approaches for melanoma.
Evidence Based Dermatology
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Author : Michael Bigby
language : en
Publisher: John Wiley & Sons
Release Date : 2014-06-05
Evidence Based Dermatology written by Michael Bigby and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-06-05 with Medical categories.
Be sure your skin-care treatments have strong evidential support Evidence-based Dermatology, Third Edition takes a unique approach to clinical dermatology by emphasising use of only the highest quality available evidence when treating people with skin diseases. Beginning with a toolbox introduction to the practice of evidence-based dermatology, it then covers the application of evidence for dermatological treatments across a wide range of ailments, including: • Common inflammatory skin diseases • Skin cancer, moles and actinic keratoses • Infective skin disease, exanthems and infestations • Disorders of pigmentation In addition, many of the rarer skin disorders are also included so as to provide comprehensive coverage of the topic. World-leading experts in dermatology follow a clinical approach for each disease, and as well as providing their expert guidance on the description and diagnosis of dermatologic disorders, they also discuss common dilemmas that clinicians face when considering the best approach to patient management. ‘Key Points’ accompany each chapter to provide a quick review of the most important points. Clinically oriented and practically focused, Evidence-based Dermatology ensures that your treatments are entirely patient-focused and fully supported by the very latest medical evidence.