Angiotensin 1 7
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Angiotensin 1 7
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Author : Robson Augusto Souza Santos
language : en
Publisher: Springer Nature
Release Date : 2019-08-21
Angiotensin 1 7 written by Robson Augusto Souza Santos and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-08-21 with Medical categories.
This is the first book addressing in full the most important aspects of the angiotensin-(1-7), the key peptide of the protective axis and the main component in the new modulatory concept of the renin-angiotensin system. It features a detailed review of angiotensin-(1-7) and its receptor Mas, comprising the historical background, enzymatic pathways for generation, functions, integrative aspects of its protective profile, and its therapeutic potential. It also encompasses a comprehensive presentation of current knowledge about its widespread biological actions on several tissues, as well as the most recent scientific achievements, emerging from preclinical and clinical trials. Dr. Santos is a renowned researcher on the Renin-Angiontensin system, with remarkable achievements regarding the role of peptides such as alamandine and angiontensin-(1-7). He has also worked on the potential clinical applicability of angiotensin-(1-7)-related drugs for cardiovascular diseases. He has an extensive publication record in the field, including the publication of the book The Protective Arm of the Renin Angiotensin System (Academic Press, 2015). Angiotensin-(1-7) will make a unique contribution to the literature and will be an important resource for biomedical students and researchers, medical practitioners and any other professional interested in this peptide and its role in the renin-angiotensin system.
The Renin Angiotensin System In Cancer Lung Liver And Infectious Diseases
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Author : Sukhwinder K. Bhullar
language : en
Publisher: Springer Nature
Release Date : 2023-03-14
The Renin Angiotensin System In Cancer Lung Liver And Infectious Diseases written by Sukhwinder K. Bhullar and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-03-14 with Medical categories.
This book of the series on “Advances in Biochemistry in Health and Disease” includes state-of-the-art information on the status of renin-angiotensin system (RAS) in the form of 24 chapters. This book has been organized into three sections: (i) General Implications of RAS in human health and Infectious Diseases, (ii) Lung, Liver and Kidney Diseases, and (iii) Development of Cancer. Each chapter has discussed comprehensive knowledge regarding the molecular and cellular aspects of the role of RAS in the pathophysiology and pharmacotherapy of different disease processes. Biochemical mechanisms associated with angiotensin II type 1 and type II receptors, and angiotensin (1-7) MAS receptors for the occurrence of both harmful and beneficial effects of prolonged activation of RAS in different diseases have been outlined. It is noteworthy to point out that different chapter in this book were prepared by recognized global expertise in the area of inflammation, oxidative stress and signal transduction pathways to highlight the role of RAS in different diseases. It is our sincere hope that this book will be of great interest to both biomedical investigators and health professionals as well as graduate students and postdoctoral fellows all over the world.
The Protective Arm Of The Renin Angiotensin System Ras
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Author : Thomas Unger
language : en
Publisher: Academic Press
Release Date : 2015-04-18
The Protective Arm Of The Renin Angiotensin System Ras written by Thomas Unger and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-04-18 with Medical categories.
The Protective Arm of the Renin Angiotensin System: Functional Aspects and Therapeutic Implications is the first comprehensive publication to signal the protective role of a distinct part of the renin–angiotensin system (RAS), providing readers with early insight into a complex system which will become of major medical importance in the near future. Focusing on recent research, The Protective Arm of the Renin Angiotensin System presents a host of new experimental studies on specific components of the RAS, namely angiotensin AT2 receptors (AT2R), the angiotensin (1–7) peptide with its receptor Mas, and the enzyme ACE 2, which exert significant beneficial, health-promoting actions by counterbalancing the well-known harmful arm of the RAS with its classical angiotensin AT1 receptor. This innovative concept of the protective arm of the RAS, examined in this reference, represents an indispensable background and will be a strong support for biomedical students, researchers, cardiologists, surgeons, nephrologists, diabetologists, and endocrinologists, as well as any other physician or researcher concerned with RAS physiology, pathophysiology and clinical implications. Provides a complete understanding of the protective side of the Renin Angiotensin System (RAS) involving angiotensin AT2 receptor, ACE2, and Ang(1-7)/Mas receptor Combines the knowledge of editors who pioneered research on the protective renin angiotensin system including; Dr. Thomas Unger, one of the founders of AT2 receptor research; Dr. Ulrike M. Steckelings, who contributed significantly to first preclinical studies with a novel specific AT2-agonist, and Dr. Robson Santos who pioneered research on angiotensin-(1-7) and its receptor Mas. Shows that the protective RAS axes are able to ameliorate the course of several cardiovascular, renal, metabolic and neurological diseases Provides the basis for the understanding of a novel therapeutic approach to stimulate components of the protective arm of the RAS.
The Renin Angiotensin System And The Kidney
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Author : Xiao C. Li
language : en
Publisher: Biota Publishing
Release Date : 2015-03-01
The Renin Angiotensin System And The Kidney written by Xiao C. Li and has been published by Biota Publishing this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-03-01 with Medical categories.
The renin-angiotensin system (RAS) is one of the most important endocrine (tissue-to-tissue), paracrine (cell-to-cell) and intracrine (intracellular/nuclear) humoral systems in the regulation of blood pressure, cardiovascular, and kidney function in health and disease. The RAS has remarkably evolved from the initial discovery of the rate-limiting enzyme renin to a complex biochemical and physiological cascade involving more than a dozen members. Currently, there are up to five axes or pathways identified in the RAS; each has its substrate, enzyme, effector peptide, receptor, and downstream signaling pathways. These include the renin/ACE/ANG II/AT1 receptor, the APA/ANG III/AT2 receptor, the ACE2/ANG (1-7)/Mas receptor, the prorenin/prorenin receptor (PRR), and the ANG IV/AT4 receptor (IRAP) pathways. Accordingly, the roles of the RAS have expanded well beyond the classic endocrine paradigm as a powerful vasoconstrictor, a potent aldosterone stimulator, or a sodium-retaining hormonal system. The goals of this article are to review and discuss the current insights into and new perspectives on the expression, localization, and novel actions of the RAS with a focus in the kidney. Special emphasis will be placed on recently discovered new members of the RAS derived from studies using innovative mutant rats or mice that either overexpress (knockin) or are deficient (knockout) of a particular substrate, enzyme, ANG peptide, or receptor. This new knowledge will help improve our understanding how each of these pathways act directly or indirectly to regulate blood pressure, cardiovascular and kidney function in physiology, and can be targeted to treat hypertension, cardiovascular and renal diseases.
Interplay Of Angiotensin Ii And Angiotensin 1 7 In The Modulation Of Cardiac Angiotensin Converting Enzyme Ii Of Human Cardiofibroblasts
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Author :
language : en
Publisher:
Release Date : 2009
Interplay Of Angiotensin Ii And Angiotensin 1 7 In The Modulation Of Cardiac Angiotensin Converting Enzyme Ii Of Human Cardiofibroblasts written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009 with categories.
Beyond The Conventional Renin Angiotensin System
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Author : Walmor De Mello
language : en
Publisher: Frontiers E-books
Release Date : 2014-11-19
Beyond The Conventional Renin Angiotensin System written by Walmor De Mello and has been published by Frontiers E-books this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-11-19 with Biology (General) categories.
The Role Of Angiotensin Ii And Angiotensin 1 7 On The Overflow Of Neuropeptide Y And Norepinephrine In Spontaneously Hypertensive Rats
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Author : Mirnela Byku
language : en
Publisher:
Release Date : 2008
The Role Of Angiotensin Ii And Angiotensin 1 7 On The Overflow Of Neuropeptide Y And Norepinephrine In Spontaneously Hypertensive Rats written by Mirnela Byku and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008 with Adenosine triphosphatase categories.
Angiotensin 1 7 Is A Negative Modulator Of Aldosterone Secretion In Vitro And In Vivo
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Author :
language : en
Publisher:
Release Date : 2016
Angiotensin 1 7 Is A Negative Modulator Of Aldosterone Secretion In Vitro And In Vivo written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016 with categories.
Renin Angiotensin System And Cardiovascular Disease
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Author : Walmor C. DeMello
language : en
Publisher: Springer Science & Business Media
Release Date : 2009-09-01
Renin Angiotensin System And Cardiovascular Disease written by Walmor C. DeMello and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009-09-01 with Medical categories.
This book offers the latest research into the role of the renin angiotensin system on cardiac and vascular functions and in cardiovascular diseases. It covers vital aspects such as intracellular signaling and regulation of cell volume in the failing heart.
The Mechanism Of Action For Angiotensin 1 7 In The Rostral Ventrolateral Medulla In The Modulation Of Cardiovascular Sympathetic Nerve Activity
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Author : Mark S. Bilodeau
language : en
Publisher:
Release Date : 2016
The Mechanism Of Action For Angiotensin 1 7 In The Rostral Ventrolateral Medulla In The Modulation Of Cardiovascular Sympathetic Nerve Activity written by Mark S. Bilodeau and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016 with categories.
Elevated sympathetic discharge from the CNS is an underlying pathogenic mechanism in neurogenic hypertension and an exacerbating factor in chronic heart failure (CHF). Current treatment of these diseases focuses on attenuation of the downstream effects of this sympathetic discharge, and often involves a complex pharmaceutical regimen. The central renin angiotensin system (RAS) plays a key role in both acute and long-term regulation of cardiovascular sympathetic tone, and the rostral ventrolateral medulla (RVLM) is the site from which most of this sympathetic discharge is propagated, making it an attractive target for therapies to treat diseases involving enhanced sympathetic discharge to the cardiovascular system. Angiotensin 1-7 (ANG-(1-7)), a derivative of angiotensin I or II, is found throughout the central nervous system, and in the RVLM the receptor for ANG-(1-7), the Mas receptor, is expressed on astrocytes. To this end, we investigated the actions of ANG-(1-7) in the RVLM. We recorded mean arterial pressure (MAP) and splanchnic sympathetic nerve activity (SSNA) after focal injections of ANG-(1-7) or glutamate with and without the glutamate antagonists CNQX and D-AP5 in a quest to understand the role of, and mechanism of action for ANG-(1-7) in the RVLM. We repeated these experiments with the purinergic receptor antagonist PPADS to investigate the role of ATP as a cotransmitter with glutamate. We also injected ANG-(1-7) or glutamate in the presence of the Mas receptor antagonist A-779. Last, we examined the effect of ANG-(1-7) in the setting of CHF. Unilateral injection of ANG-(1-7) into the RVLM, acting through the Mas receptor, increased SSNA and MAP, and glutamate receptor antagonists partially reduced this effect; however, ATP seems to be a co-transmitter in the ANG-(1-7) effect on BP and SSNA. To our surprise, we found that the Mas receptor antagonist A-779 injected alone elicited a significant pressor effect. We investigated this finding and showed that A-779 activates the same neurotransmitters as ANG-(1-7). We did not show an effect for ANG-(1-7) in CHF. We conclude that astrocytes in the RVLM participate in central, angiotensin-dependent regulation of blood pressure and sympathetic nerve activity by activating glutamatergic and purinergic pathways.