Angiotensin Ii Receptors
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Angiotensin Ii Receptor Blockade Physiological And Clinical Implications
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Author : Naranjan S. Dhalla
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Angiotensin Ii Receptor Blockade Physiological And Clinical Implications written by Naranjan S. Dhalla and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.
The relationship between angiotensin II and hypertension was established in 1898 when angiotensin II was shown to modulate systemic blood pressure. Over the intervening decades, a complete characterization of the renin-angiotensin system (RAS) has been achieved, and our understanding of its biochemistry and physiology has led to the directed development of agents such ·as ACE inhibitors and receptor antagonists capable of controlling hypertension. More recently, it was shown that angiotensin II is secreted within certain tissues and that these tissue-specific systems operate independently of the systemic RAS. The novel concept that angiotensin II regulates a number of cardiovascular processes that are unrelated to blood pressure has renewed the interest of both basic and clinical scientists in angiotensin II. The association between angiotensin II and cardiac growth, in particular, has indicated that therapies currently in use for hypertension may have direct application to the treatment of heart failure. The Manitoba Cardiovascular Forum on Angiotensin Receptor Blockade in Winnipeg was convened October 18-20, 1996 to examine the clinical and basic aspects of angiotensin receptor biology as they apply to hypertension and heart failure. In addition, the potential treatment of these conditions using specific angio tensin receptor antagonists was addressed within the context of their immediate therapeutic application and future potential.
Angiotensin Ii Receptors
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Author : Robert R. Ruffolo, Jr.
language : en
Publisher: CRC Press
Release Date : 1994-07-13
Angiotensin Ii Receptors written by Robert R. Ruffolo, Jr. and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1994-07-13 with Medical categories.
This unique reference set provides a broad-based, in-depth presentation on angiotensin II receptors, from the genes that encode them to the responses they mediate in humans. The books emphasize known and potential therapeutic applications of the antagonists of angiotensin II receptors and the angiotensin-converting enzyme inhibitors. The molecular biology of angiotensin II receptors is reviewed, as are the biochemical effects mediated by angiotensin II receptors. This is the first publication to analyze in detail the structure-activity relationships for both peptide and nonpeptide angiotensin II receptor agonists and antagonists. It also presents the pharmacological effects mediated by angiotensin II receptors both in the periphery and in the brain.
Angiotensin Ii Receptor Antagonists
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Author : Murray Epstein
language : en
Publisher:
Release Date : 2001
Angiotensin Ii Receptor Antagonists written by Murray Epstein and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2001 with Medical categories.
The recent development of several new, non-peptide, orally active angiotensin II receptor antagonists is revolutionizing the treatment of patients with hypertension and various cardiovascular disorders. In this book experts review the current state of angiotensin II antagonists and survey the progress of these diverse applications. Issues relating to angiotensin II and their receptors are examined in relation to their effects on the kidney, non-diabetic renal disease, heart disease, diabetes mellitus, and various other disorders. The combination of AT1 receptor antagonists with other antihypertensive agents is reviewed in depth. The clinical attributes of these drugs are complemented by in-depth reviews of the physiology and pharmacology of angiotensin II peptides. The authors present the most recent findings in ligand recognition, activation, signal coupling, desensitization and functional alterations of vessels, especially small arteries, in patients with hypertension. This book constitutes the only available compendium on the clinical and experimental features of angiotensin II receptor antagonists. The unique features of the rapidly emerging class of drugs are surveyed throughout. Contributions have been made from international experts who have personally contributed to the discovery and development of these novel drugs. Recent cutting-edge physiology and pharmacology studies by renowned international experts provide a platform for considering the clinical applications of these agents.
Drugs Enzymes And Receptors Of The Renin Angiotensin System
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Author : Ahsan Husain
language : en
Publisher: CRC Press
Release Date : 2003-09-02
Drugs Enzymes And Receptors Of The Renin Angiotensin System written by Ahsan Husain and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2003-09-02 with Medical categories.
Since 1898, when Tigerstadt and Bergman first extracted renin from rabbit kidney, the reninrugs, Enzymes and Receptors of the Renin is designed to highlight molecular and clinical approaches to understanding the renin Chapter topics have been specifically chosen to cover selected contemporary, controversial and unresolved issues. A novel and uni
Angiotensin Vol Ii
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Author : Thomas Unger
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-02-02
Angiotensin Vol Ii written by Thomas Unger and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-02-02 with Medical categories.
Nearly thirty years ago, in 1974, the volume on Angiotensin edited by Irvine H.Page and F. Merlin Bumpus expanded the Handbook of Experimental Pharmacology. Even after two decades the multiplicity of its actions appears not to have been fully discovered. To call attention to its many functions is one of the purposes of this book. This new edition of the volume on Angiotensin attempts to provide an updated account of the knowledge and findings accumulated since the complexity of angiotensin was so accurately recognized.
Angiotensin Vol I
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Author : E. M. Abdel-Rahman
language : en
Publisher: Springer Science & Business Media
Release Date : 2004-03-31
Angiotensin Vol I written by E. M. Abdel-Rahman and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2004-03-31 with Medical categories.
with contributions by numerous experts
Recent Advances In Cellular And Molecular Aspects Of Angiotensin Receptors
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Author : Mohan K. Raizada
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-06-29
Recent Advances In Cellular And Molecular Aspects Of Angiotensin Receptors written by Mohan K. Raizada and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-06-29 with Science categories.
Scientific advances over the past two decades have afforded unprecedented oppor tunities to understand the structure and function of receptors, receptor-ligand interactions, and receptor signaling. The extent ofprogress in this area is underscored by the recent Nobel Prize for Medicine and Physiology to Alfred Gilman and Martin Rodbell, both of whose work in understanding receptorlG-protein interactions has redefined the way in which we think of how hormones and neurochemicals exert their activity on cellular function. This book is replete with examples of current research approaches to help us better understand the cellular roles in which the renin-angiotensin system and the angiotensin receptors participate. Clearly, defining the structure of angiotensin receptor subtypes is an important first step in cJarifying the mechanisms by which these receptors take part in cellular function. However, the chapters within this book range far beyond structural studies and encompass research on tissue specific expression of the angiotensin receptor subtypes, the genetic regulation ofthese receptors, and the unique function ofvarious angiotensin subtypes in different organ systems, such as the brain, the reproductive system, adipose tissue, the heart, and the kidneys.
Angiotensin Vol I
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Author : Thomas Unger
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Angiotensin Vol I written by Thomas Unger and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.
Nearly thirty years ago, in 1974, the volume on Angiotensin edited by Irvine H.Page and F. Merlin Bumpus expanded the Handbook of Experimental Pharmacology. Even after two decades the multiplicity of its actions appears not to have been fully discovered. To call attention to its many functions is one of the purposes of this book. This new edition of the volume on Angiotensin attempts to provide an updated account of the knowledge and findings accumulated since the complexity of angiotensin was so accurately recognized.
Angiotensin Ii Receptor Antagonists
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Author : Mancia Giuseppe
language : en
Publisher: CRC Press
Release Date : 2006-05-25
Angiotensin Ii Receptor Antagonists written by Mancia Giuseppe and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2006-05-25 with Medical categories.
Since angiotensin II is one of the most potent vasoconstrictors and an important stimulus for the secretion of aldosterone from the adrenal gland, the development of of angiotensin II inhibitors is an important step in regulating blood pressure. This class of drug is well-tolerated by pateints and these drugs have the added advantage over ACE inhibitors in that they are not associated with cough. Because most drugs can be given once daily and, like ACEIs, they have a useful additive hypotensive effect in combination with diuretics, they are a welcome therapeutic tool in the treatment of hypertension. This Second Edition builds on the success of the first and brings to the reader all the latest developments, clinical trial data, and the contributors's personal perspectives when treating patients with angiotensin II receptors antagonists. offers chapters by well-known contributors in the fields of both hypertension and heart failure, especially with regard to pharmacological interventions covers the new role of AIIR in neuroprotection builds upon the strengths of the first edition
Cellular And Molecular Biology Of The Renin Angiotensin System
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Author : Mohan K. Raizada
language : en
Publisher: CRC Press
Release Date : 2018-01-18
Cellular And Molecular Biology Of The Renin Angiotensin System written by Mohan K. Raizada and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-01-18 with Science categories.
Cellular and Molecular Biology of the Renin-Angiotensin System provides the first review and update of the state-of-the-art cellular and molecular aspects of the renin-angiotensin system. The book presents detailed analyses from world experts on each component of this system, including future directions. Topics range from angiotensin II receptor subtypes to processing of renin to the use of transgenic animal models for studying the role of this system in hypertension. Cellular and Molecular Biology of the Renin-Angiotensin System is essential reading for physiologists of the renin-angiotensin system, endocrinologists, cardiovascular specialists, renal physiologists, and neurobiologists.