Animal Models And The Unity Of Neuroscience
DOWNLOAD
Download Animal Models And The Unity Of Neuroscience PDF/ePub or read online books in Mobi eBooks. Click Download or Read Online button to get Animal Models And The Unity Of Neuroscience book now. This website allows unlimited access to, at the time of writing, more than 1.5 million titles, including hundreds of thousands of titles in various foreign languages. If the content not found or just blank you must refresh this page
Animal Models And The Unity Of Neuroscience
DOWNLOAD
Author : Nina A. Atanasova
language : en
Publisher:
Release Date : 2014
Animal Models And The Unity Of Neuroscience written by Nina A. Atanasova and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014 with categories.
Contemporary neurobiology abounds with multiple experimental protocols and procedures aiming to study identical phenomena. This state of affairs seems to put in jeopardy the integration of experimental results and the extrapolation of laboratory knowledge to natural world phenomena. The problem is further complicated when knowledge produced through animal experimentation is extended to humans. My thesis is that the multiplicity of protocols fosters rather than precludes progress in neurobiology. It is especially valued when the results of different experiments converge. In these cases, the validity of knowledge claims increases. Converging experimental results get integrated. To date, no comprehensive philosophical analysis of animal experimentation in neurobiology exists. For this reason I analyze the functions of animal models in experimental neurobiology. I argue that even though animal models are related to model and experimental organisms, in the case of neurobiology, they are better conceptualized as experimental systems rather than as a subclass of the other two classes of biological models. In a case study, I trace the developments of and the variations on the basic design of Morris water maze experiments to exemplify the motivation for producing variations on basic experimental protocols. Ultimately, I defend a view of the structure of experimental neurobiology which I call optimistic pluralism. It is an extension of the so called perspectival pluralism according to which the integration of multiple partial perspectives employed in the study of any given phenomenon maximizes the knowledge about this phenomenon. It is optimistic because it justifies the possibility for multiple partial perspectives to converge and be integrated in order to provide knowledge about complex phenomena. This view justifies the desirability of multiple experimental protocols in contemporary neurobiology because it values the multiplicity of perspectives they provide.
Improving The Utility And Translation Of Animal Models For Nervous System Disorders
DOWNLOAD
Author : Forum on Neuroscience and Nervous System Disorders
language : en
Publisher: National Academies Press
Release Date : 2013-04-08
Improving The Utility And Translation Of Animal Models For Nervous System Disorders written by Forum on Neuroscience and Nervous System Disorders and has been published by National Academies Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-04-08 with Medical categories.
Nervous system diseases and disorders are highly prevalent and substantially contribute to the overall disease burden. Despite significant information provided by the use of animal models in the understanding of the biology of nervous system disorders and the development of therapeutics; limitations have also been identified. Treatment options that are high in efficacy and low in side effects are still lacking for many diseases and, in some cases are nonexistent. A particular problem in drug development is the high rate of attrition in Phase II and III clinical trials. Why do many therapeutics show promise in preclinical animal models but then fail to elicit predicted effects when tested in humans? On March 28 and 29, 2012, the Institute of Medicine Forum on Neuroscience and Nervous System Disorders convened the workshop "Improving Translation of Animal Models for Nervous System Disorders" to discuss potential opportunities for maximizing the translation of new therapies from animal models to clinical practice. The primary focus of the workshop was to examine mechanisms for increasing the efficiency of translational neuroscience research through discussions about how and when to use animal models most effectively and then best approaches for the interpretation of the data collected. Specifically, the workshop objectives were to: discuss key issues that contribute to poor translation of animal models in nervous system disorders, examine case studies that highlight successes and failures in the development and application of animal models, consider strategies to increase the scientific rigor of preclinical efficacy testing, explore the benefits and challenges to developing standardized animal and behavioral models. Improving the Utility and Translation of Animal Models for Nervous System Disorders: Workshop Summary also identifies methods to facilitate development of corresponding animal and clinical endpoints, indentifies methods that would maximize bidirectional translation between basic and clinical research and determines the next steps that will be critical for improvement of the development and testing of animal models of disorders of the nervous system.
Experimental Animal Models In Neurobehavioral Research
DOWNLOAD
Author : Allan V. Kalueff
language : en
Publisher:
Release Date : 2009
Experimental Animal Models In Neurobehavioral Research written by Allan V. Kalueff and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009 with Medical categories.
Behavioural research has been an exciting staple of the neuroscientific community's efforts in combating the rising challenges of mental healthcare. New innovations are bringing a greater understanding of the pathogenic mechanisms behind the disorders and allowing for progress towards their remedies. this translational approach, using newly developed animal modes, is of critical importance for the study of neuropsychiatric disorders. While the differences between the subjects of clinical research and basic research are obvious, there are many neurobiological similarities that allow for the possibility of creating an accurate animal analogue of a human disorder. These tools contribute to translational research and are the best hope for countering the challenges facing the field of mental health. This book provides chapters on a range of issues in biopsychology and behavioural neuroscience. It offers innovative methodological and conceptual advances regarding topics such as sleep, depression, and anxiety, as well as how these domains interact. All authors of the book are recognised experts in the field, and have written their chapters for an international audience of basic and clinical neuroscientists who are interested in behavioural neurophenotyping. The writing will also be accessible to students at the undergraduate level, while still providing an important update to graduate students and professional researchers in the disciplines of psychology, biology, and neuroscience on this rapidly developing field.
Animal Models Of Behavioral Analysis
DOWNLOAD
Author : Jacob Raber
language : en
Publisher: Humana Press
Release Date : 2010-10-11
Animal Models Of Behavioral Analysis written by Jacob Raber and has been published by Humana Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010-10-11 with Medical categories.
Despite the difficulty in comparing clinic-based human tests with animal model testing, there is still great value in pursuing translational approaches, as tests and treatment strategies might be developed to improve brain function in humans suffering from neurological conditions and knowledge obtained from human behavioral studies can be used to further improve the animal models of behavioral analysis. In Animal Models of Behavioral Analysis, expert neuroscientists focus on approaches to translate and compare behavioral tests used in animals with those used in humans not only to increase our understanding of brain function across species but also to provide objective performance measures and bridge the gap between behavioral alterations in humans with cognitive disorders and the correlating animal models of these conditions. Written in the Neuromethods series format, the chapters provide authoritative reviews of many commonly used approaches in the field today. Provocative and cutting-edge, Animal Models of Behavioral Analysis seeks to aid researchers in further developing these vital techniques in an effort to advance studies in both the clinic and the laboratory.
Animal Models Of Behavior Genetics
DOWNLOAD
Author : Jonathan C. Gewirtz
language : en
Publisher: Springer
Release Date : 2016-08-10
Animal Models Of Behavior Genetics written by Jonathan C. Gewirtz and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-08-10 with Medical categories.
This stimulating analysis reviews the broad potential of animal models to foster a deeper understanding of human pathology, strengthen connections between genetic and behavioral studies, and develop more effective treatments for mental disorders. Widely-studied and lesser-used species are examined in models that capture features along the continuum of normative and pathological behavior. The models highlight genetic causes of core features, or endophenotypes, of developmental, internalizing, and externalizing disorders, as well as dementia. Expert contributors address questions ranging from how suitable species are chosen for study to the costs and benefits of using inbred versus outbred strains, and the effects of housing environment on subject animals. Larger issues addressed include how to evaluate the applicability of animal behavioral models to the human condition and how these models can harness emerging molecular technologies to further our understanding of the genetic basis of mental illness. Included in the coverage: Mating and fighting in Drosophila. Attachment and social bonding. Impulsivity in rodents and humans. Animal models of cognitive decline. Animal models of social cognition. Future directions for animal models in behavioral genetics. A detailed map of where this evolving field is headed, Animal Models of Behavior Genetics shows geneticists, molecular biologists, and cognitive neuroscientists paths beyond established concepts toward a more knowledgeable and collaborative future.
Animal Models In Psychiatry I
DOWNLOAD
Author : Alan A. Boulton
language : en
Publisher: Springer Science & Business Media
Release Date : 1991-08-20
Animal Models In Psychiatry I written by Alan A. Boulton and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 1991-08-20 with Medical categories.
The two Animal Models in Psychiatry volumes are loosely organized by subject. The first volume contains a number of chapters concerned with schizophrenia, psyc- ses, neuroleptic-induced tardive dyskinesias, and other d- orders that may involve dopamine, such as attention deficit disorder and mania. The second volume deals with affective and anxiety disorders, but also includes chapters on subjects not easily classified as either psychotic, or affective, or an- ety-related, such as aggression, mental retardation, and memory disorders. Four chapters on animal models of schizophrenia or psychoses are included in the present v- ume because of the importance of these disorders in p- chiatry. Likewise, three chapters in the subsequent volume deal with depression. The first of the two volumes begins with an introd- tion by Paul Willner reviewing the criteria for assessing the validity of animal models in psychiatry. He has written - tensively on this subject, and his thorough description of the issues of various forms of validity provides a framework in which to evaluate the subsequent chapters. As will be seen, the remaining chapters in both volumes will refer frequently to these issues. The second chapter, by Melvin Lyon, describes a large number of different procedures that have been p- posed as potential animal models of schizophrenia. This is a departure from the usual format, consisting of detailed - scriptions of specific models.
Animal Models In Psychiatry I
DOWNLOAD
Author : Alan A. Boulton
language : en
Publisher: Humana Press
Release Date : 1991-08-20
Animal Models In Psychiatry I written by Alan A. Boulton and has been published by Humana Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1991-08-20 with Medical categories.
The two Animal Models in Psychiatry volumes are loosely organized by subject. The first volume contains a number of chapters concerned with schizophrenia, psyc- ses, neuroleptic-induced tardive dyskinesias, and other d- orders that may involve dopamine, such as attention deficit disorder and mania. The second volume deals with affective and anxiety disorders, but also includes chapters on subjects not easily classified as either psychotic, or affective, or an- ety-related, such as aggression, mental retardation, and memory disorders. Four chapters on animal models of schizophrenia or psychoses are included in the present v- ume because of the importance of these disorders in p- chiatry. Likewise, three chapters in the subsequent volume deal with depression. The first of the two volumes begins with an introd- tion by Paul Willner reviewing the criteria for assessing the validity of animal models in psychiatry. He has written - tensively on this subject, and his thorough description of the issues of various forms of validity provides a framework in which to evaluate the subsequent chapters. As will be seen, the remaining chapters in both volumes will refer frequently to these issues. The second chapter, by Melvin Lyon, describes a large number of different procedures that have been p- posed as potential animal models of schizophrenia. This is a departure from the usual format, consisting of detailed - scriptions of specific models.
Animal Models In Human Psychobiology
DOWNLOAD
Author : George Serban
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Animal Models In Human Psychobiology written by George Serban and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Science categories.
In March, 1974, an International Symposium was held at the Harmonie Club in New York to discuss a highly pertinent problem in today's research: the "Rele vance of the Animal Psychopathological Model to the Human." This meeting was sponsored by the Kittay Foundation, which brought together an outstanding group of scientists involved in widely different fields of research. This volume, it is hoped, will convey the tone of lively and cordial exchange between inter nationally renowned investigators, including Dr. I. Eibl-Eibesfeldt from Germany, Dr. Robert A. Hinde from England, Dr. Edward F. Domino from Michigan, and Dr. Pierre Pichot from France, Chairman of the Steering Committee. In his welcoming address, Mr. Sol Kittay reminded us that man has achieved remarkable control over his environment but not over himself, and he suggested that we should reexamine our ancestral origins, and search in animal behavior for clues to the understanding of normal and abnormal behavior in man.
Animal Models Of Neurological Disease Ii
DOWNLOAD
Author : Alan A. Boulton
language : en
Publisher: Humana
Release Date : 2013-08-11
Animal Models Of Neurological Disease Ii written by Alan A. Boulton and has been published by Humana this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-08-11 with Medical categories.
to the Animal Models Volumes This and several other volumes in the Neuromethods series will describe a number of animal models of neuropsychiatric disorders. Because of increasing public concern over the ethical treatment of animals in research, we felt it incumbent upon us to include this general preface to these volumes in order to indicate why we think further - search using animals is necessary and why animal models of psychiatric disorders, in particular, are so important. We recognize that animals should only be used when suitable alternatives are not available. We think it self-e- dent, however, that humans can only be experimented upon in severely proscribed circumstances and alternative pro- dures using cell or tissue culture are inadequate in any models requiring assessments of behavioral change or of complex in vivo processes. However, when the distress, discomfort, or pain to the animals outweighs the anticipated gains for human welfare, then the research is not ethical and should not be carried out. It is imperative that each individual researcher examine his/her own research from a critical moral standpoint - fore engaging in it, taking into consideration the animals’ welfare as well as the anticipated gains. Furthermore, once a decision to proceed with research is made, it is the researcher’s responsibility to ensure that the animals’ w- fare is of prime concern in terms of appropriate housing, feeding, and maximum reduction of any uncomfortable or distressing effects of the experimental conditions, and that these conditions undergo frequent formalized monitoring.
Neuroethics And Nonhuman Animals
DOWNLOAD
Author : L. Syd M Johnson
language : en
Publisher: Springer Nature
Release Date : 2020-03-06
Neuroethics And Nonhuman Animals written by L. Syd M Johnson and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-03-06 with Medical categories.
This edited volume represents a unique addition to the available literature on animal ethics, animal studies, and neuroethics. Its goal is to expand discussions on animal ethics and neuroethics by weaving together different threads: philosophy of mind and animal minds, neuroscientific study of animal minds, and animal ethics. Neuroethical questions concerning animals’ moral status, animal minds and consciousness, animal pain, and the adequacy of animal models for neuropsychiatric disease have long been topics of debate in philosophy and ethics, and more recently also in neuroscientific research. The book presents a transdisciplinary blend of voices, underscoring different perspectives on the broad questions of how neuroscience can contribute to our understanding of nonhuman minds, and on debates over the moral status of nonhuman animals. All chapters were written by outstanding scholars in philosophy, neuroscience, animal behavior, biology, neuroethics, and bioethics, and cover a range of issues and species/taxa. Given its scope, the book will appeal to scientists and students interested in the debate on animal ethics, while also offering an important resource for future researchers. Chapter 13 is available open access under a CC BY 4.0 license at link.springer.com.