Animal Models In Radiotracer Design
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Animal Models In Radiotracer Design
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Author : Richard M. Lambrecht
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Animal Models In Radiotracer Design written by Richard M. Lambrecht and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Psychology categories.
The editors have asked me to write this foreword probably for two reasons: First, I have spent 35 years trying to develop radiolabeled compounds that would help diagnose and treat disease. I, and the people from my laboratory, have been much involved with developing Nan'I for the diagnosis and treatment of hyperthyroidism and well-differentiated thyroid cancer. Second, I was a participant throughout the entire symposium upon which this book is based. Our latest '311-labeled compound, [l3lll metaiodobenzylguanidine, took us 13 years to develop. It has succeeded in diagnosing and treating adrenergic tumors '31 under circumstances where Na 1 would have failed for the diagnosis and treatment of thyroid cancer. I therefore hope that more scientists will be attracted to this field. This book is written by intelligent, experienced investigators who are knowl edgeable. It is a must for anyone new in the field. For the experienced, I would like to remind you that I attended the entire symposium; the breadth and timeliness of the update has helped us to redirect some of our current efforts into more scientifically productive channels. William H. Beierwaltes, M.D.
Animal Models In Radiotracer Design
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Author : Lambrecht RM Ed
language : en
Publisher:
Release Date : 1983
Animal Models In Radiotracer Design written by Lambrecht RM Ed and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1983 with categories.
Biological Models In Radiopharmaceutical Development
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Author : R.M. Lambrecht
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Biological Models In Radiopharmaceutical Development written by R.M. Lambrecht and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.
Radiophannaceuticals labeled with short-lived radionuclides are utilized to unravel biochemical processes, and to diagnosis and treat diseases of the living body are-developed through extensive evaluation in ~iological models. 'fhC first attempt to compile information was a volume entitled ANIMAL MODELS IN RADIOTRACER DESIGN that was edited by William C. Eckelman and myself in 1983. The volume had a focus on the animal models that investigators were using in order to design radiotracers that displayed in vivo selectivity as measured by biodistribution and pharmacokinetic studies. A concern in the early days of nuclear medicine was species differences. Often a series of labeled compounds were evaluated in a several different animal models in order to gain confidence that the selected radiotracer would behave appropriately in humans. During the past 12 years there have been remarkable advances in molecular genetics, molecular biology, synthetic radiopharmaceutical chemistry, molecular modeling and visualization, and emission tomography. Biological models can now be selected that are better defined in terms of molecular aspects of the disease process. The development of high resolution PET and SPET for clinical applications facilitates the development of new radiopharmaceuticals by the use of models to quantitatively evaluate drug effects, and progression of disease, and hence to arrive at better diagnosis and treatments for animals and humans. With these advances there is an effective use of biological models, and the refinement of alternatives for the development of new radiophannaceuticals.
Safety And Efficacy Of Radiopharmaceuticals 1987
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Author : Knud Kristensen
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Safety And Efficacy Of Radiopharmaceuticals 1987 written by Knud Kristensen and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.
Safety and Efficacy of Radiopharmaceuticals was established as a very important and comprehensive subject at the First Europe an Symposium on Radiopharmacy and Radiopharmaceuticals in Denmark in 1983. The interest in this subject has grown considerably since then due to the growing interest among national authorities to deal with radiopharmaceuticals. The introduction in recent years of nuclear medicine techniques based on radioactive labelled cells and on monoclonal antibodies has stressed the importance of a well functioning approval system for the clinical trial and use of new radiopharmaceuticals. The process of transferring the experience from the non radioactive drug field into the area of radiopharmaceuticals is still ongoing. International organisations such as the World Health Organisa tion is also including this into their quality assurance programme from both the radiopharmaceutical and the radiation hygiene point of view. In order to give an up-to date survey of these areas, experts were invited to prepare review papers under the following headings: Safety and Efficacy of Radiophar maceuticals with Emphasis on Biological Products, Radiophar macy/Radiation Hygiene, Legal Aspects of the Introduction of New Radiopharmaceuticals and some selected aspects of Good Radiopharmacy Practice.
Tracer Kinetics And Physiologic Modeling
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Author : R.M. Lambrecht
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-03-09
Tracer Kinetics And Physiologic Modeling written by R.M. Lambrecht and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-03-09 with Mathematics categories.
Small Animal Imaging
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Author : Fabian Kiessling
language : en
Publisher: Springer
Release Date : 2017-05-22
Small Animal Imaging written by Fabian Kiessling and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-05-22 with Medical categories.
This textbook is a practical guide to the use of small animal imaging in preclinical research that will assist in the choice of imaging modality and contrast agent and in study design, experimental setup, and data evaluation. All established imaging modalities are discussed in detail, with the assistance of numerous informative illustrations. While the focus of the new edition remains on practical basics, it has been updated to encompass a variety of emerging imaging modalities, methods, and applications. Additional useful hints are also supplied on the installation of a small animal unit, study planning, animal handling, and cost-effective performance of small animal imaging. Cross-calibration methods and data postprocessing are considered in depth. This new edition of Small Animal Imaging will be an invaluable aid for researchers, students, and technicians involved in research into and applications of small animal imaging.
Cancer Imaging With Radiolabeled Antibodies
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Author : David M. Goldenberg
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Cancer Imaging With Radiolabeled Antibodies written by David M. Goldenberg and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.
Where do you begin to look for a recent, authoritative article on the diagnosis or management of a particular malignancy? The few general oncology text books are generally out of date. Single papers in specialized journals are informative but seldom comprehensive; these are more often preliminary reports on a very limited number of patients. Certain general journals frequently publish good in-depth reviews of cancer topics, and published symposium lectures are often the best overviews available. Unfortunately, these reviews and supplements appear sporadically, and the reader can never be sure when a topic of special interest will be covered. Cancer Treatment and Research is a series of authoritative volumes that aim to meet this need. It is an attempt to establish a critical mass of oncology literature covering virtually all oncology topics, revised frequently to keep the coverage up to date, and easily available on a single library shelf or by a single personal subscription. We have approached the problem in the following fashion: first, by dividing the oncology literature into specific subdivisions such as lung cancer, genitourinary cancer, pediatric oncology, etc.; and second, by asking eminent authorities in each of these areas to edit a volume on the specific topic on an annual or biannual basis. Each topic and tumor type is covered in a volume appearing frequently and predictably, discussing current diagnosis, staging, markers, all forms of treatment modalities, basic biology, and more.
Current Catalog
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Author : National Library of Medicine (U.S.)
language : en
Publisher:
Release Date :
Current Catalog written by National Library of Medicine (U.S.) and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on with Medicine categories.
First multi-year cumulation covers six years: 1965-70.
Clinical Nuclear Cardiology State Of The Art And Future Directions E Book
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Author : Barry L. Zaret
language : en
Publisher: Elsevier Health Sciences
Release Date : 2010-05-24
Clinical Nuclear Cardiology State Of The Art And Future Directions E Book written by Barry L. Zaret and has been published by Elsevier Health Sciences this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010-05-24 with Medical categories.
Clinical Nuclear Cardiology—now in its fourth edition—covers the tremendous clinical growth in this field, focusing on new instrumentation and techniques. Drs. Barry L. Zaret and George A Beller address the latest developments in technology, radiopharmaceuticals, molecular imaging, and perfusion imaging. Thoroughly revised to include 20 new chapters—Digital/Fast SPECT, Imaging in Revascularized Patients, and more—this new edition provides state-of-the-art guidance on key areas and hot topics with stunning visuals. Online access to the fully searchable text at expertconsult.com includes highly illustrated case studies that let you see the problem using a variety of imaging modalities. In other words, this is an invaluable resource no clinician or researcher in nuclear cardiology should be without. Features an editorial and contributing team of worldwide leaders in nuclear cardiology to provide you with current and authoritative guidance. Includes a section focusing on acute coronary syndromes to provide you with practical management tools for these conditions. Presents a full-color design that allows color images to be integrated throughout the text. Includes access to the fully searchable contents of the book online at expertconsult.com, along with highly illustrated case studies that let you see the problem using a variety of imaging modalities. Features 20 new chapters including Cellular Mechanisms of Tracer Uptake and Clearance; Attenuation/Scatter Corrections: Clinical Aspects; Hybrid Imaging; Digital/Fast SPECT; Imaging in Revascularized Patients; and more. Focuses on perfusion imaging in a section dedicated to this hot topic so you get all the information you need to stay current.
Safety And Efficacy Of Radiopharmaceuticals
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Author : Knud Kristensen
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Safety And Efficacy Of Radiopharmaceuticals written by Knud Kristensen and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.
Safety and efficacy of radiopharmaceuticals are elements of great importance in nuclear medicine. Since the first meeting in 1965 in Oak Ridge with the title Radiopharmaceuticals tremendous developments have taken place. In 1965 the whole technetium-99m area was just in its very beginning. Safety and efficacy of the non-radioactive pharmaceuticals have attracted great attention during the last 10 years and so have similar aspects of radiopharmaceuticals during the later years. Regulatory agencies are extending their work also to the preparation of radiopharmaceuticals at hospitals and to requirements for registration of radiopharmaceuticals. In a fast developing field there might be tendencies to confrontation between interests and there have certainly been some tendencies to put undue restrictions on the use of radio pharmaceuticals due to the lack of understanding between the industry and the regulatory authorities and between regulatory authorities and hospitals. Much of this may have been due to lack of information and certainly is due to the lack of fundamental scientific knowledge in many radiopharmaceutical aspects. A fast and safe introduction of new radio pharmaceuticals and the proper handling of these requires a lot of development work, but also an understanding of how general principles from the non-radioactive drug field may be sensibly transformed into the radiopharmaceutical area. It may even require compromises between requirements for safety in different areas such as radiation protection and pharmaceutical aspects.