Application Of Remote Ischaemic Preconditioning To Human Coronary Artery Bypass Surgery
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Application Of Remote Ischaemic Preconditioning To Human Coronary Artery Bypass Surgery
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Author : Ishtiaq Ali Rahman
language : en
Publisher:
Release Date : 2010
Application Of Remote Ischaemic Preconditioning To Human Coronary Artery Bypass Surgery written by Ishtiaq Ali Rahman and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010 with categories.
Application Of Remote Ischaemic Preconditioning To Human Coronary Artery Bypass Surgery
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Author :
language : en
Publisher:
Release Date :
Application Of Remote Ischaemic Preconditioning To Human Coronary Artery Bypass Surgery written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on with categories.
This thesis reports a clinical study designed to assess myocardial, renal and lung outcomes following cardiac surgery. In a single centre, prospective randomized, placebo intervention-controlled trial the effects of intermittent upper limb ischaemia (remote ischaemic preconditioning (RIPC)) were compared in non-diabetic adult patients undergoing on-pump multi-vessel coronary artery surgery. Patients, investigators, anaesthetists, surgeons and critical care teams were all blind to group allocation. Subjects were randomized(1:1) to RIPC(or placebo) stimuli (3x upper limb (or dummy arm) 5 minute cycles of 200mmHg cuff inflation/deflation) during sternotomy and conduit procurement. Anaesthesia, perfusion, cardioplegia and surgical techniques were standardized. Groups were well matched on demographic and operative variables. In contrast to prior smaller studies, RIPC did not reduce troponin T (48 hour area under the curve (AUC); 6hour and peak) release, improve post-operative haemodynamics (cardiac indices; low cardiac output episodes incidence; IABP usage; inotrope and vasoconstrictor use; M mode, 2D contrastenhanced echocardiography and tissue Doppler imaging) or offer antiarrhythmic benefit (de novo left bundle branch block or Q waves; ventricular tachyarrhythmia incidence). RIPC did not afford renal (peak creatinine, AUC urinary albumin-creatinine ratios, dialysis requirement) or lung protection (intubation times, 6hour and 12 hour pO2/FiO2 ratios). Case urgency did not influence RIPC effect.
Effect Of Remote Ischemic Preconditioning Of Human Heart During Coronary Artery Bypass Grafting
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Author : Erika Anna Hernekamp
language : en
Publisher:
Release Date : 2017
Effect Of Remote Ischemic Preconditioning Of Human Heart During Coronary Artery Bypass Grafting written by Erika Anna Hernekamp and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017 with categories.
Remote Ischaemic Preconditioning In Coronary Artery Bypass Graft Surgery
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Author :
language : en
Publisher:
Release Date : 2010
Remote Ischaemic Preconditioning In Coronary Artery Bypass Graft Surgery written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010 with categories.
Remote Ischaemic Preconditioning In The Settings Of Cardiac Bypass Surgery And Coronary Angioplasty
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Author : G. G. Babu
language : en
Publisher:
Release Date : 2012
Remote Ischaemic Preconditioning In The Settings Of Cardiac Bypass Surgery And Coronary Angioplasty written by G. G. Babu and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012 with categories.
Myocardial revascularisation in the form of coronary artery bypass surgery (CABG) and percutaneous coronary interventions (PCI) are the two important treatment strategies in combating ischaemic heart disease. There have been tremendous improvements in many aspects of these revascularisation methods over the years. However both these forms of revascularisation can have a deleterious effect on the myocardium while its vascularity is re-established. This revascularisation induced myocardial injury is one of the prognostically important deleterious effects. Consequently, many therapeutic strategies are being studied which can cardioprotect and reduce peri-operative myocardial injury during CABG and peri-procedural myocardial injury during PCI. We evaluate Remote ischaemic preconditioning, a cardioprotective strategy, for its effect on myocardial revascularisation methods of PCI and CABG. In the PCI settings, the beneficial effect of remote ischaemic preconditioning in patients undergoing elective PCI has now been established. However its role in patients admitted with Non ST elevation acute coronary syndrome (NSEACS) and undergoing urgent PCI is still unknown. This group of patients particularly has increased peri-procedural myocardial injury due to their soft coronary plaque and thrombi. In the CABG settings, remote preconditioning has been shown reduce perioperative myocardial injury in non diabetic patients. There are no clinical studies looking at the beneficial effect of remote preconditioning in diabetic cohort of patients undergoing CABG. In animal models, diabetic myocardium is known to possess higher threshold for preconditioning, albeit still possible to precondition. As diabetic patients, are more vulnerable for myocardial injury during CABG and also tolerate the injury relatively poorly compared to their non diabetic counterparts, it is important to explore for cardioprotective strategies to be applied to this high risk diabetic population. The two clinical studies in this thesis evaluate the effect of remote ischemic preconditioning in a) reducing peri-procedural myocardial injury in patients with NSTEACS undergoing urgent percutaneous intervention and b) reducing peri-operative myocardial injury in type 2 diabetic patients undergoing coronary artery bypass surgery.
Remote Ischaemic Preconditioning In The Settings Of Cardiac Bypass Surgery And Coronary Angioplasty
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Author : Girish Gamesha Babu
language : en
Publisher:
Release Date : 2012
Remote Ischaemic Preconditioning In The Settings Of Cardiac Bypass Surgery And Coronary Angioplasty written by Girish Gamesha Babu and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012 with categories.
Effect Of Remote Ischaemic Preconditioning On Clinical Outcomes In Patients Undergoing Coronary Artery Bypass Graft Surgery Ericca Study
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Author :
language : en
Publisher:
Release Date : 2016
Effect Of Remote Ischaemic Preconditioning On Clinical Outcomes In Patients Undergoing Coronary Artery Bypass Graft Surgery Ericca Study written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016 with categories.
Effect Of Remote Ischaemic Preconditioning On Clinical Outcomes In Patients Undergoing Coronary Artery Bypass Graft Surgery Ericca Study A Multicentre Double Blind Randomised Controlled Clinical Tr
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Author :
language : en
Publisher:
Release Date : 2016
Effect Of Remote Ischaemic Preconditioning On Clinical Outcomes In Patients Undergoing Coronary Artery Bypass Graft Surgery Ericca Study A Multicentre Double Blind Randomised Controlled Clinical Tr written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016 with categories.
Myocardial Protection
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Author : Tomas A. Salerno
language : en
Publisher: John Wiley & Sons
Release Date : 2008-04-15
Myocardial Protection written by Tomas A. Salerno and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-04-15 with Medical categories.
Myocardial protection is regarded as one of the most important, yet also most controversial aspects of cardiac surgery. There has been considerable improvement in myocardial protection strategies over recent years, utilising a variety of new approaches to treat cardiac diseases, and this text is intended to embrace the state of the art in this field. The book summarises the state of knowledge on all aspects of myocardial protection, including the latest in the treatment of cardiac diseases, robotics, pediatric surgery and the treatment of cardiac failure. Robotic surgery, valvular surgery, pediatric surgery and coronary surgery are all covered by renowned experts, producing a comprehensive, forward-looking view of the field of myocardial protection. This book should function to update physicians and surgeons interested in the field of cardiac surgery on the current state of knowledge on myocardial protection.
Cardioprotection
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Author : Derek Hausenloy
language : en
Publisher: Oxford University Press
Release Date : 2009-08-20
Cardioprotection written by Derek Hausenloy and has been published by Oxford University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009-08-20 with Medical categories.
Coronary heart disease (CHD) is the leading cause of death worldwide. Cardioprotection refers to the prevention of CHD and the clinical improvement in patients suffering from cardiovascular problems.