Arachidonate Related Lipid Mediators
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Arachidonate Related Lipid Mediators
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Author : Robert C. Murphy
language : en
Publisher:
Release Date : 1990
Arachidonate Related Lipid Mediators written by Robert C. Murphy and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1990 with Arachidonic acid categories.
This volume includes information on arachidonic acid metabolites and platelet activating factor. Assays for the quantitative measurement of prostaglandins, leukotrienes, and platelet-activating factor, including enzyme immunoassays and mass spectrophotometric techniques, are presented. Preparation and analysis of cytochrome P-450 metabolites of arachidonic acid are discussed. The isolation, purification, and assay of enzymes important in the biosynthesis and metabolism of these lipids are included.
Lipid Mediators
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Author : Fiona M. Cunningham
language : en
Publisher: Elsevier
Release Date : 2016-10-27
Lipid Mediators written by Fiona M. Cunningham and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-10-27 with Medical categories.
The Handbook of Immunopharmacology: Lipid Mediators covers a comprehensive overview of lipid mediators, from synthesis through to inhibition. The book discusses the metabolism of arachidonic acid; the measurement of fatty acids and their metabolites; and the biological properties of cyclooxygenase products. The text also describes other essential fatty acids, their metabolites and cell-cell interactions; the inhibitors of fatty acid-derived mediators; as well as the biosynthesis and catabolism of platelet-activating factor. The cellular sources of platelet-activating factor and related lipids; the biological properties of platelet-activating factor; and the effects of platelet-activating factor receptor antagonists are also considered. Immunopharmacologists, immunologists, and pharmacologists will find the book invaluable.
Methods In Enzymology Arachidonate Related Lipid Mediators
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Author : Frank A. Fitzpatrick
language : en
Publisher:
Release Date : 1990
Methods In Enzymology Arachidonate Related Lipid Mediators written by Frank A. Fitzpatrick and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1990 with Lipids categories.
Arachidonate Remodeling And Inflammation
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Author : Alfred N. Fonteh
language : en
Publisher: Springer
Release Date : 2012-12-06
Arachidonate Remodeling And Inflammation written by Alfred N. Fonteh and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.
Arachidonic acid (AA) and other 20 or 22-carbon polyunsaturated fatty acids (PUFAs) are precursors of lipid mediators of inflammation known as eicosanoids. These mediators are critical in disease processes and in regulating normal cell function. Remodeling is important in maintaining homeostasis and in regulating cell function by dictating how PUFAs are converted to lipid mediators of inflammation. Thus, PUFA remodeling is a critical process in the biosynthesis of a multitude of mediators, and understanding this process will unravel better therapeutic targets for controlling inflammatory diseases such as asthma and Alzheimer’s disease. AA metabolism is described in an integrated context linking the remodeling processes with the biosynthesis of mediators and diseases. By following the movement of the substrate (AA), the volume describes how upstream biosynthetic pathways influence the formation of lipid mediators of inflammation, showing the metabolic interrelationship between all AA-derived mediators.
The Role Of Bioactive Lipids In Cancer Inflammation And Related Diseases
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Author : Kenneth V. Honn
language : en
Publisher: Springer Nature
Release Date : 2019-09-27
The Role Of Bioactive Lipids In Cancer Inflammation And Related Diseases written by Kenneth V. Honn and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-09-27 with Medical categories.
The Organizing Committee of the 15th International Conference on Bioactive Lipids in Cancer, Inflammation and Related Diseases compiled a group of junior investigators to provide reviews on the topics they presented at the Puerto Vallarta Bioactive Lipids conference, as part of the book series, Advances in Experimental Medicine and Biology (AEMB). The book in this series will be titled Bioactive Lipids in Cancer, Inflammation and Related Diseases. Topics range from all classes of lipids including prostaglandins, resolvins, spingolipids, P450-derived lipids, endocannabanoids and phospholipids. The focus includes physiology, cell biology, and structural studies in organisms from bacteria to humans and how these studies addressed the role of lipids in various disease i.e. cancer, inflammation, diabetes, obesity, cardiovascular disease and others.
Bioactive Lipid Mediators
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Author : Takehiko Yokomizo
language : en
Publisher: Springer
Release Date : 2015-10-27
Bioactive Lipid Mediators written by Takehiko Yokomizo and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-10-27 with Science categories.
This book summarizes the most recent progress in the studies of lipid mediators from the molecular to clinical level and introduces newly created tools for analysis including imaging mass spectrometry. Comprising 29 chapters divided into four major parts, the book describes the molecular natures of enzymes, transporters, and receptors for lipid mediators (Part I), the function of lipid mediators in Drosophila and Zebrafish (Part II), the relationships between lipid mediators and various diseases (Part III), and detailed procedures of extraction, preparation, and quantification of lipid mediators (Part IV). Research on lipid mediators initially started with analysis of the action of aspirin, and subsequent biochemical experiments identified many enzymes and receptors responsible for the biosynthesis and signal transduction of individual lipid mediators. Through the phenotypic analyses of transgenic and knockout mice, it has been shown that the dysregulation of some lipid mediators causes inflammatory, immune, or oncogenic disorders. Lipid mediators have attracted increased attention because their structures are conserved among different species, and their biosynthetic and signaling pathways have been deciphered at the molecular level. Many drugs that target lipid mediators are already being used in hospitals, and this book suggests further possibilities for development of a wide variety of such drugs. Very recently, highly sensitive mass spectrometry has begun to be used to identify novel lipid mediators that are present only in trace amounts in tissues but with robust biological activity. Written by international experts, this book provides readers a comprehensive view of lipid mediators and related topics and helps in the process of determining research targets for the near future.
Platelet Activating Factor And Related Lipid Mediators 2
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Author : Santosh Nigam
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-06-29
Platelet Activating Factor And Related Lipid Mediators 2 written by Santosh Nigam and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-06-29 with Medical categories.
In the last decade, research on platelet-activating factor (PAF) has expanded exponentially. Previous conferences on PAF in Paris, 1983, and the subsequent conferences in Gatlinburg, Ten nessee, Tokyo, Snowbird, Utah, and Berlin, at three-yearly intervals, have chronicled the devel opments in the field ofPAF. This volume records the proceedings of the Fifth International Con gress on PAF and Related Lipid Mediators, held at the Free University Medical Hospital Ben jamin Franklin in Berlin, from September 12-16, 1995. We are very much indebted to Free Uni versity Berlin for providing tremendous facilities and financial support. It was a great pleasure to have positive and generous input from the German Science Council (DFG), Bonn, Germany, and British·Biotech, Oxford, United Kingdom. Their support was crucial in making the congress a scientific success. Twenty other organizations provided additional financial support, for which we extend our deepest appreciation. The editors would like to thank all of those who participated in this congress and the authors for their contributions. The organization and planning of the Berlin Congress were carried out by an organizing committee. We gratefully acknowledge the support and assistance of the organizing commit tee members, especially Renate Nigam and Renate Roux for their untiring efforts to make the congress successful. Many colleagues also supported the congress with dedication, hard work, and expert input. We are grateful to them. We also wish to acknowledge the support of G. Sravan Kumar and Louis Kock for their efforts in producing this volume.
Platelet Activating Factor And Related Lipid Mediators
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Author : F. Snyder
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-11-11
Platelet Activating Factor And Related Lipid Mediators written by F. Snyder and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-11-11 with Science categories.
Platelet-activating factor (PAF) is the commonly used name for a group of potent biologically active, ether-linked phospholipids, the alkylacetylglycerophospho cholines. Following the identification of the chemical structure of P AF in 1979, much progress has been made in our understanding of these phospholipid medi ators. This is particularly true from the points of view of their molecular structural requirements for expression of biological activity, their biosynthesis and cata bolism, their diverse range of biological activities, evidence for their specific recep tors at the cell surface, the development of specific antagonists for use in receptor studies and for testing as potential anti-PAF drugs, and implications about their involvement in health and disease. Chapters in this book cover the current status of these general areas of PAF research. Although an enormous amount of information has been published about this interesting new type of phospholipid mediators, questions about their mechanism of action, regulatory controls, and the precise role and relative importance of P AF in specific diseases and physiological functions remain to be answered. Since the 1979 discovery, the PAF field has brought together scientists from a variety of different biomedical disciplines. The diversity of scientists now in PAF research is very apparent from the number of P AF publications appearing in a wide array of scientific journals, ranging from molecular biology to clinical medicine. Publications related to PAF continue to increase at an amazingly rapid rate, with the pace reminiscent of the period following the discovery of prostaglandins.
Obstructive Airway Diseases
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Author : Abhijit Ray
language : en
Publisher: CRC Press
Release Date : 2016-04-19
Obstructive Airway Diseases written by Abhijit Ray and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-04-19 with Medical categories.
Incidences of inflammatory airway diseases are on the rise across the world. Existing therapeutic options are ineffective, unsafe, and expensive, and severe cases are nonresponsive to conventional therapy. Therefore, it is imperative that research be undertaken to discover new treatment options. Obstructive Airway Diseases: Role of Lipid Mediators discusses clinically successful and potential lipid targets that can make a difference in treating some of the most intractable disease states. Topics discussed include: Obstructive airway diseases, etiology, pathophysiology, and existing therapeutic options What constitutes a lipid and how it is broken down to generate biologically active mediators The role of enzymes in the process of lipid mediator synthesis The biology of arachidonic acid, platelet-activating factor, and lysophosphatidic acid and the role they play in airway inflammation Products of arachidonic acid metabolism such as leukotrienes, prostaglandins, epieicosatrienoic acid, and oxoeicosatetraenoic acid Proresolution lipid mediators in inflammatory airway disease conditions The role of sphingosine and ceramide in inflammatory airway disease Protein kinases activated by lipid mediators and those that trigger the generation of lipid messengers The combined input of a panel of international authorities on lipid mediators makes this volume a valuable resource for all those involved in researching, teaching, and studying airway inflammation as well as those involved in drug discovery research. Punit Srivastava maintains a blog with additional information about the book and his work.
New Arachidonate Derived Lipid Mediators
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Author : Mustafa Adiyaman
language : en
Publisher:
Release Date : 1997
New Arachidonate Derived Lipid Mediators written by Mustafa Adiyaman and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1997 with Arachidonic acid categories.