Asns

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Asns

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Author :
language : un
Publisher:
Release Date : 1876

Asns written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1876 with categories.

Intramolecular Tunnel And Regulatory Mechanisms Of Asparagine Synthetase Asns

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Author : Kai Li
language : en
Publisher:
Release Date : 2007

Intramolecular Tunnel And Regulatory Mechanisms Of Asparagine Synthetase Asns written by Kai Li and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007 with categories.

Among the family of amidotransferases, the two half reactions are strictly coupled. While ASNS can catalyze the hydrolysis of glutamine without other substrates, this raises the interest in the regulatory mechanisms of this enzyme, which prevents it from consuming glutamine and releasing free ammonia. As part of my PhD research, I investigated the mechanisms of product inhibition to this enzyme. Under physiological conditions, the activity of this enzyme may be inhibited significantly by asparagine, which prevents cells from wasting glutamine and producing toxic ammonia in vivo. So far, only one crystal structure of glutamine dependent asparagine synthetase was reported. To further understand the function of ASNS, especially of human enzyme, more crystal structures are needed. Therefore, co-working with Alexandria Berry, I investigated the binding of substrate/transition state analog to hASNS and successfully prepared inhibitor bound enzyme. The prepared enzyme has been sent for crystal analysis.

Cloud Native Data Center Networking

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Author : Dinesh G. Dutt
language : en
Publisher: O'Reilly Media
Release Date : 2019-11-22

Cloud Native Data Center Networking written by Dinesh G. Dutt and has been published by O'Reilly Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-11-22 with Computers categories.

If you want to study, build, or simply validate your thinking about modern cloud native data center networks, this is your book. Whether you’re pursuing a multitenant private cloud, a network for running machine learning, or an enterprise data center, author Dinesh Dutt takes you through the steps necessary to design a data center that’s affordable, high capacity, easy to manage, agile, and reliable. Ideal for network architects, data center operators, and network and containerized application developers, this book mixes theory with practice to guide you through the architecture and protocols you need to create and operate a robust, scalable network infrastructure. The book offers a vendor-neutral way to look at network design. For those interested in open networking, this book is chock-full of examples using open source software, from FRR to Ansible. In the context of a cloud native data center, you’ll examine: Clos topology Network disaggregation Network operating system choices Routing protocol choices Container networking Network virtualization and EVPN Network automation

Asns

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Author :
language : de
Publisher:
Release Date : 1886

Asns written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1886 with categories.

Metabolism Meets Function Untangling The Cross Talk Between Signalling And Metabolism

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Author : Alessandra Castegna
language : en
Publisher: Frontiers Media SA
Release Date : 2020-12-18

Metabolism Meets Function Untangling The Cross Talk Between Signalling And Metabolism written by Alessandra Castegna and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-12-18 with Medical categories.

This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact.

Software Architecture

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Author : Ivica Crnkovic
language : en
Publisher: Springer
Release Date : 2011-09-15

Software Architecture written by Ivica Crnkovic and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-09-15 with Computers categories.

This book constitutes the refereed proceedings of the 5th European Conference on Software Architecture, ECSA 2011, held in Essen, Germany, in September 2011. The 13 revised full papers presented together with 24 emerging research papers, and 7 research challenge poster papers were carefully reviewed and selected from over 100 submissions. The papers are organized in topical sections on requirements and software architectures; software architecture, components, and compositions; quality attributes and software architectures; software product line architectures; architectural models, patterns and styles; short papers; process and management of architectural decisions; software architecture run-time aspects; ADLs and metamodels; and services and software architectures.

Emerging Technologies And Systems For Biologically Plausible Implementations Of Neural Functions

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Author : Erika Covi
language : en
Publisher: Frontiers Media SA
Release Date : 2022-04-26

Emerging Technologies And Systems For Biologically Plausible Implementations Of Neural Functions written by Erika Covi and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-04-26 with Science categories.

Amino Acids In Higher Plants

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Author : J P F D'Mello
language : en
Publisher: CABI
Release Date : 2015-04-15

Amino Acids In Higher Plants written by J P F D'Mello and has been published by CABI this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-04-15 with Science categories.

Amino acids play a role in the defence mechanisms and stress responses of plants, as well as in food quality and safety for humans and animals. Recent advances in the field make a comprehensive overview of the information a necessity; this book collates chapters on plant enzymes and metabolism, modulation, molecular aspects and secondary products. Also including information on ecology, the environment and mammalian nutrition and toxicology, it provides an authoritative resource.

Molecular Dynamics Simulations And Virtual Screening To Identify Potent Inhibitors Of Human Asparagine Synthetase

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Author : Lamees Hegazy
language : en
Publisher:
Release Date : 2013

Molecular Dynamics Simulations And Virtual Screening To Identify Potent Inhibitors Of Human Asparagine Synthetase written by Lamees Hegazy and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013 with categories.

Asparagine synthetase (ASNS), which mediates the biosynthesis of L-asparagine, has become of increasing interest as a drug target. Overexpression of ASNS was observed in ASNase-resistant leukemia cell lines and inhibitors of human asparagine synthetase were able to suppress the proliferation of ASNase resistant leukemia cells. Human asparagine synthetase is also involved in other forms of cancer, and was shown to be a predictive biomarker of L-asparaginase activity in ovarian cancer cell lines. In addition, recent work suggested that ASNS is up-regulated in the castration-resistant stage of prostate cancer (CRPC) where knockdown of ASNS in asparagine-depleted media led to growth inhibition in in both androgen-responsive lymph nodes and castration-resistant prostate cancer cell lines. Thus, depletion of asparagine using ASNS inhibitors may be a new approach for treatment of CRPC. In this study, new parameters that describe the acylphosphate and N-phosphonosulfonimidoyl functional groups were developed following the standard protocols of CHARMM general force field. In addition, molecular dynamics simulations were performed on ASNS complexed with a key reaction intermediate. The ligand-free ASNS was also simulated to detect related conformational changes as a result of intermediate binding. A model representative of the average structure was further used in virtual screening calculations to identify potent ASNS inhibitors. A total of 500,000 compounds from the NCI chemical database were docked to the ASNS active site. A new lead inhibitor of hASNS was identified by these docking studies. This lead inhibitor has a new structural motif that should permit the development of compounds with improved cell permeability than those previously reported.

Nutrition And Cancer

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Author :
language : en
Publisher: Academic Press
Release Date : 2022-10-22

Nutrition And Cancer written by and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-10-22 with Science categories.

Nutrition and Cancer, Volume 373 presents a collection of chapters that describe the effect of different metabolic situations, their contribution to metabolic modulation, and their impact on tumor growth. Specific chapters in this release include Impact of obesity on cancer progression and treatment, Impact of dietary protein on cancer progression and treatment, Fasting mimicking diet and cancer therapy, Fasting and cancer responses to chemotherapy, Dietary polyamines and cancer, Ketogenic diets and cancer therapy, and Nutritional and metabolic approaches to target OXPHOS and glycolysis in cancer cells. Presents a collection of chapters that describe the effect of different metabolic situations, their contribution to metabolic modulation, and their impact on tumor growth Covers the impact of obesity on cancer progression and treatment and the impact of dietary protein on cancer progression and treatment