Assembly Of Enveloped Rna Viruses
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Assembly Of Enveloped Rna Viruses
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Author : Monique Dubois-Dalcq
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Assembly Of Enveloped Rna Viruses written by Monique Dubois-Dalcq and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.
This book is a collection of critical reviews about a diverse group of virus families with two features in common: the stable repository of genetic information in each virus is RNA, and each virus modifies and appropriates a particular patch of the eukaryotic cell membrane system to complete its structure. The reviews take the reader from the level of virus genome structure and expression through the quaternary interactions between virus-specified elements and cellular components that cooperate to produce virus particles. There are spectacular illustrations in this volume, but it is much more than a picture gallery. Reading widely in this book can be an effective antidote to overspecialization: in these pages, you are likely to learn much about viruses and about cells that you didn't know before; you'll discover illuminating parallels between diverse virus families; you'll come away with a sharpened awareness of important things that are still to be learned. Memphis, Tenn. , Summer 1984 David W. Kingsbury Preface This book was written at the suggestion of Dr. David W. Kingsbury made at a work shop on viruses organized by the Multiple Sclerosis Society in Aspen, Colorado, U. S. A. , three years ago. Originally, we had thought to focus on the morphological aspects of viral assembly. Later, during our discussions on the process of budding of enveloped RNA viruses, it became evident that we should include biochemical data in our review and correlate them with the structural aspects of virus maturation.
Virus Assembly And Exit Pathways
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Author : Margaret Kielian
language : en
Publisher: Academic Press
Release Date : 2020-10-24
Virus Assembly And Exit Pathways written by Margaret Kielian and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-10-24 with Science categories.
Advances in Virus Research, Volume 108, in this ongoing series, highlights new advances in the field, with this new volume presenting interesting chapters on topics including Virus infections of the developing brain, Geminivirus assembly, Flavivirus assembly, Cell-cell transmission, Archael virus assembly, Potyvirus assembly, Poxvirus assembly and exit, Mycovirus assembly, Reo/orbivirus assembly and exit, Giant virus assembly, Quasi-enveloped virus assembly/exit, and Betaherpesvirus assembly and exit. Provides the authority and expertise of leading contributors from an international board of authors Presents the latest release in the Advances in Virus Research series Includes the latest information on virus assembly and exit pathways
Structure Based Studies Of Rna Virus Entry And Assembly In The Native Context
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Author : David Chmielewski
language : en
Publisher:
Release Date : 2022
Structure Based Studies Of Rna Virus Entry And Assembly In The Native Context written by David Chmielewski and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022 with categories.
Electron cryomicroscopy (cryo-EM) has rapidly become the method of choice for structural studies of macromolecular complexes in vitro, but often comes at the cost of losing valuable biological context related to structure/function in the native environment of the cell. Alphaviruses, a genus of positive-strand RNA enveloped viruses with significant human health burden, are generally variable in size and shape, and thus pose a challenge to traditional cryo-EM analysis. Further, structures important to alphavirus assembly/budding and replication processes are intricately linked to the context of infected cell membranes. While the released alphavirus virion architecture has been well characterized, the structural assembly mechanism of its two icosahedral protein layers remains undefined. In chapter 2 of this thesis, we analyze the structures of purified alphavirus particles using cryo-EM imaging and single particle analysis. We discovered a subpopulation of T=3 icosahedral particles, differing from the T=4 structure of all previous alphavirus structures. We then determined near-atomic resolution structures of Mayaro and Chikungunya virus, two circulating alphaviruses in the Americas, by addressing deviations from icosahedral symmetry within each particle. In chapter 3, we studied the assembly mechanism of alphavirus particles in situ using electron cryotomography (cryo-ET) of virus-infected cells. From snapshots of virus assembly/budding events, we determined 3D structures of assembly intermediates that revealed the mechanistic roles of glycoprotein spikes and nucleocapsids in forming two-layered icosahedral particles. Further, data of CHIKV-infected cells treated with budding-inhibiting antibodies shows that spacing spikes apart to prevent their lateral interactions prevents the plasma membrane bending around NC cores, thus blocking virus budding. These findings provide the molecular mechanisms of icosahedral enveloped virus assembly/budding and budding-blocking antibodies. Finally, we present an initial in situ structure of the functional CHIKV replication complex in virus-infected cells, with a preliminary model of viral non-structural protein organization in the cell. We suggest further analysis of this replication system will reveal the functional stages of positive-strand RNA processing in the cell. Lastly, in chapter 4, we switched focus to study the near-native structures of coronavirus spike (S) trimers directly on the surface of human coronavirus (HuCoV) virions in light of the Covid-19 pandemic. S trimers protruding from the viral envelope mediate coronavirus entry and are the main target for vaccine development. We first determined the 3.4Å resolution structure of the alphacoronavirus HuCoV-NL63 prefusion S crown directly on virions without the need for recombinant, soluble protein with stabilizing mutations. Using further cryo-ET and subvolume analysis, we determined structural conformations of full-length S trimers, revealing incredible orientational flexibility mediated by a novel glycan hinge in the membrane-anchored stalk domain. Our results suggest a straightforward path for future studies of coronaviruses with external reagents such as receptors, drugs and antibodies, all in the context of pathogenicity relevant to human health.
Study Of Assembly And Budding Motifs In The Structural Proteins Of Enveloped Rna Viruses
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Author : Yosef Sabo
language : en
Publisher:
Release Date : 2010
Study Of Assembly And Budding Motifs In The Structural Proteins Of Enveloped Rna Viruses written by Yosef Sabo and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010 with categories.
Virus Structure And Assembly
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Author : Polly Roy
language : en
Publisher: Elsevier
Release Date : 2005-07-15
Virus Structure And Assembly written by Polly Roy and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2005-07-15 with Science categories.
Written by experts in their field, Virus Structure and Assembly summarizes our current state of knowledge in the field of virus structure and assembly, comparing and contrasting the mechanisms adopted by viruses with a wide diversity of genome and host. It will serve as an invaluable reference for researchers in virology, microbiology, epidemiology, molecular biology, and public health. * Witness to the remarkable advancement in the field of virus structure and assembly * A unique opportunity to compare and contrast mechanisms adopted by a diverse range of viruses from bacteriophages and RNA viruses to Bluetongue, Influenza and Hepatitis B * Numerous illustrations including color * Discussion on the VIPER database, a repository for all high-resolution structures of simple icosahedral viruses, and on application of mass spectrometry to the analysis of structures present in biological specimens, such as HIV-1
Structure Of Small Rna Phages
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Author : Kaspars Tars
language : en
Publisher:
Release Date : 1999
Structure Of Small Rna Phages written by Kaspars Tars and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1999 with Bacteriophages categories.
Role Of Lipids In Virus Assembly
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Author : Jamil S. Saad
language : en
Publisher: Frontiers Media SA
Release Date : 2015-07-28
Role Of Lipids In Virus Assembly written by Jamil S. Saad and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-07-28 with Science (General) categories.
RNA enveloped viruses comprise several families belonging to plus and minus strand RNA viruses, such as retroviruses, flavoviruses and orthomyxoviruses. Viruses utilize cellular lipids during critical steps of replication like entry, assembly and egress. Growing evidence indicate important roles for lipids and lipid nanodomains in virus assembly. This special topic covers key aspects of virus-membrane interactions during assembly and egress, especially those of retroviruses and Ebola virus (EBOV). Virus assembly and release involve specific and nonspecific interactions between viral proteins and membrane compartments. Retroviral Gag proteins assemble predominantly on the PM. Despite the great progress in identifying the factors that modulate retroviral Gag assembly on the PM, there are still gaps in our understanding of precise mechanisms of Gag-membrane interactions. Studies over the last two decades have focused on the mechanisms by which other retroviral Gag proteins interact with membranes during assembly. These include human immunodeficiency virus (HIV), Rous sarcoma virus (RSV), equine infectious anemia virus (EIAV), Mason-Pfizer monkey virus (M-PMV), murine leukemia virus (MLV), and human T-lymphotropic virus type (HTLV-1). Additionally, assembly of filoviruses such as EBOV also occurs on the inner leaflet of the PM. The articles published under this special topic highlight the latest understanding of the role of membrane lipids during virus assembly, egress and release.
Structure And Assembly
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Author : Heinz Fraenkel-Conrat
language : en
Publisher:
Release Date : 1976
Structure And Assembly written by Heinz Fraenkel-Conrat and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1976 with RNA viruses categories.
Virus Structure
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Author :
language : en
Publisher: Elsevier
Release Date : 2003-10-02
Virus Structure written by and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2003-10-02 with Science categories.
Virus Structure covers the full spectrum of modern structural virology. Its goal is to describe the means for defining moderate to high resolution structures and the basic principles that have emerged from these studies. Among the topics covered are Hybrid Vigor, Structural Folds of Viral Proteins, Virus Particle Dynamics, Viral Gemone Organization, Enveloped Viruses and Large Viruses. Covers viral assembly using heterologous expression systems and cell extracts Discusses molecular mechanisms in bacteriophage T7 procapsid assembly, maturation and DNA containment Includes information on structural studies on antibody/virus complexes
Structure And Assembly
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Author : Heinz Fraenkel-Conrat
language : en
Publisher:
Release Date : 1976
Structure And Assembly written by Heinz Fraenkel-Conrat and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1976 with RNA viruses categories.
