Attention Genes And Adhd

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Attention Genes And Adhd

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Author : Florence Levy
language : en
Publisher: Psychology Press
Release Date : 2021-04-14

Attention Genes And Adhd written by Florence Levy and has been published by Psychology Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-04-14 with Medical categories.

This book focuses on the application of behaviour genetic approaches to twin studies, and reviews diagnostic to Attention Deficit Hyperactivity Disorder (ADHD), the relationships between reading, spelling and ADHD, and family and genetic influences on speech and speech and language.

Attention Deficit Hyperactivity Disorder

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Author : David Gozal
language : en
Publisher: Springer Science & Business Media
Release Date : 2007-10-28

Attention Deficit Hyperactivity Disorder written by David Gozal and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007-10-28 with Medical categories.

Attention deficit hyperactivity disorder (ADHD) is a common neurobehavioral disorder affecting 5–10% of children and adolescents and 3% of adults. Attention Deficit Hyperactivity Disorder: From Genes to Patients aims to provide a comp- hensive, state-of-the-art overview of the critical aspects of ADHD, and hopefully will serve as a quick and up-to-date reference source for professionals with an int- est in ADHD. The book is divided into three major areas that follow an historical survey. The first group of chapters deals with current theories on the pathophysiology of ADHD, and focuses on neurotransmitters and the contributions and validity of animal m- els. The second section emphasizes the evaluation and treatment of patients with ADHD, from the day-to-day approach by the clinical psychologist to the more sophisticated anatomical and functional imaging strategies that have emerged in the last decade. In addition, chapters dealing with specific impairments, such as those pertaining to reading, social interaction, and working memory, are also included for more detailed analysis of these important aspects and their respective contributions to global functioning. The third and final section provides an expanded review on the pharmacotherapy of ADHD and the appropriate methods for selection of specific drugs for individual patients based on drug kinetics and gene expression. David Gozal, MD Dennis L. Molfese, PhD vii CONTENTS Dedication . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . v Preface. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . vii Contributors. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . xi 1 Historical Aspects of Attention Deficit Hyperactivity Disorder . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1 Roscoe A. Dykman 2 Scanning the Genome for Attention Deficit Hyperactivity Disorder . . . . . . . . . . . . . . . . . . . . . . . . .

Attention Genes And Developmental Disorders

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Author : Kim Cornish
language : en
Publisher: Oxford University Press
Release Date : 2010-08-12

Attention Genes And Developmental Disorders written by Kim Cornish and has been published by Oxford University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010-08-12 with Psychology categories.

What is attention? How does it go wrong? Do attention deficits arise from genes or from the environment? Can we cure it with drugs or training? Are there disorders of attention other than deficit disorders? The past decade has seen a burgeoning of research on the subject of attention. This research has been facilitated by advances on several fronts: New methods are now available for viewing brain activity in real time, there is expanding information on the complexities of the biochemistry of neural activity, individual genes can be isolated and their functions identified, analysis of the component processes included under the broad umbrella of "attention" has become increasingly sophisticated, and ingenious methods have been devised for measuring typical and atypical development of these processes, from infancy into childhood, and then into adulthood. In this book, Kim Cornish and John Wilding are concerned with attention and its development, both typical and atypical, particularly in disorders with a known genetic etiology or assumed genetic linkage. Tremendous advances across seemingly diverse disciplines - molecular genetics, pediatric neurology, child psychiatry, developmental cognitive neuroscience, and education - have culminated in a wealth of new methods for elucidating disorders at multiple levels, possibly paving the way for new treatment options. Cornish and Wilding use three specific-yet-interlinking levels of analysis: genetic blueprint (genotype), the developing brain, and the behavioral-cognitive outcomes (phenotype), as the basis for charting the attention profiles of six well-documented neurodevelopmental disorders: ADHD, autism, fragile X syndrome, Down syndrome, Williams syndrome, and 22q11 deletion syndrome. Their overarching aim in this book is to provide the most authoritative and extensive account to date of disorder-specific attention profiles and their development from infancy through adolescence.

The Molecular Genetics Of Attention Deficit Hyperactivity Disorder Adhd

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Author : Matthew Naaim Ogdie
language : en
Publisher:
Release Date : 2005

The Molecular Genetics Of Attention Deficit Hyperactivity Disorder Adhd written by Matthew Naaim Ogdie and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2005 with categories.

Genetics Of Attention Deficity Hyperactivity Disorder Adhd

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Author : Weam Fageera
language : en
Publisher:
Release Date : 2020

Genetics Of Attention Deficity Hyperactivity Disorder Adhd written by Weam Fageera and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020 with categories.

"Like other complex disorders, different factors are believed to play a critical role in the pathophysiology of ADHD and its related phenotypes. This dissertation focused on dissecting the complexity of ADHD etiology and response to treatment by combining different approaches to investigate the role of several candidate genes. Sex discrepancy in ADHD and its related phenotypes (including response to treatment) is well documented in the literature; therefore, we sought to study the role of DRD3, TPH2, and COMT genes in ADHD while stratifying our analyses by sex. These genes were selected because they play a major role in the regulation of synaptic catecholamines, which are believed to play a major role in the regulation of attention and motor behaviours. While DRD3 genetic variations were significantly associated with various phenotypes pertinent to ADHD in boys, TPH2 genetic variants were associated with ADHD (and its various behavioural dimensions) in girls. These results suggest that the observed gender disparity in ADHD might be related, at least in part, to different molecular and etiological mechanisms between boys and girls. While the COMT is an important enzyme in the metabolism of catecholamines, no significant associations were observed with the COMT gene and ADHD. We hypothesized that the effect of COMT might not be detected unless other genetic variations in the same molecular network are simultaneously investigated (epistasis). Because COMT and DRD3 are part of the same network of synaptic molecules regulating Dopamine transmission, we tested the interaction between COMT and DRD3 in modulating ADHD relevant phenotypes. The results showed a significant interaction between the two genes on modulating ADHD behaviors and response to treatment, indicating that the effect of COMT gene might not be observed without considering the potential synergistic effect with other genes. We further explored the role of the COMT gene by studying the effect of genetic variants on modulating the level of methylation for several CpG sites in this gene and correlated the level of methylation with response to treatments. Single nucleotide polymorphisms (SNPs) have shown to modulate the level of methylation of two CpG sites located in the promotor region of the gene. Interestingly, one of the two CpG sites was significantly correlated with response to placebo and methylphenidate. Taken together, this work highlights the importance of using different approaches to study the role of candidate genes in ADHD rather than examining the disorder as a monolithic construct. This strategy could help to better understand the pathophysiology of the disorder. More specifically, candidate genes might have different effects based on sex, on genetic interaction with other genes (epistasis), and on other biological mechanisms that could affect the gene expression and eventually have an effect on the studied phenotypes"--

Genetic Risk And Phenotypic Variation In Attention Deficit Hyperactivity Disorder Microform

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Author : Jennifer Crosbie
language : en
Publisher: Library and Archives Canada = Bibliothèque et Archives Canada
Release Date : 2004

Genetic Risk And Phenotypic Variation In Attention Deficit Hyperactivity Disorder Microform written by Jennifer Crosbie and has been published by Library and Archives Canada = Bibliothèque et Archives Canada this book supported file pdf, txt, epub, kindle and other format this book has been release on 2004 with Attention-deficit hyperactivity disorder categories.

Genetic factors play a major role in the etiology of Attention Deficit Hyperactivity Disorder (ADHD), as is evident from family, twin and adoption studies. Molecular genetic research has implicated a number of genes as risk factors for ADHD. Despite solid evidence the mode of genetic transmission has been elusive. The difficulty in identifying genes for ADHD may be, at least in part, a reflection of the complex relationship between the causative genes underlying the disorder and their phenotypic expression at the behavioural level. Objective: The immediate goal of this thesis was to investigate specific behavioural traits and potential cognitive endophenotypes in relation to three candidate genes of ADHD; the dopamine transporter (DAT1), dopamine receptor D4 (DRD4), and synaptosomal-associated protein of 25 kDa (SNAP-25). Rather than relying on ADHD as categorical diagnosis of affected or unaffected, inattention and hyperactivity-impulsivity are investigated independently as continuous traits to determine the relationship with the specific genetic risks for ADHD. Different informants were investigated independently by evaluating symptoms reported by parents and by teachers across the two behavioural dimensions. Inhibitory control and working memory were evaluated to determine the relationship with the genetic risks and argued as potential cognitive endophenotypes. Results: The 4-repeat allele of the 48 bp repeat located in the third exon of DRD4 was linked with lower parent-reported symptom scores of inattention. No significant results were found for teacher reported behaviours. Better inhibitory control was linked with the 4-repeat allele. Inattention and hyperactivity-impulsivity as reported by parent, by not teacher, were linked with a risk haplotype of DAT1. No relationship was found between inhibitory control and DAT1. SNAP-25 was linked with higher ratings of both inattention and hyperactivity-impulsivity. No relationship with deficits in verbal working memory was found for any of the genes investigated. In contrast, better working memory was linked with DAT1. Conclusions: The relationship between behavioural and cognitive traits showed variation across the candidate genes investigated, as was broadly predicted. Differentiation of the relationship of traits across genetic risk factors was evident for behavioural dimensions and for informant. The study findings support inhibitory control as a genetically informative endophenotype for ADHD. Overall, these results highlight the potential of quantitative approaches for the elucidation of genetic traits, and underlying genes, in ADHD.

Attention Deficit Hyperactivity Disorder

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Author : Keith McBurnett
language : en
Publisher: CRC Press
Release Date : 2007-11-28

Attention Deficit Hyperactivity Disorder written by Keith McBurnett and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007-11-28 with Medical categories.

Compiling the expertise and research of many of the most widely-cited opinion leaders in the field, this reference spans the etiology, assessment, and management of ADHD and covers all the essential data required to care for patients with this disorder including clinical definitions, psychosocial management approaches, medication dosing ranges, and

Hyperactivity And Attention Disorders Of Childhood

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Author : Seija Sandberg
language : en
Publisher: Cambridge University Press
Release Date : 2002-07-11

Hyperactivity And Attention Disorders Of Childhood written by Seija Sandberg and has been published by Cambridge University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2002-07-11 with Medical categories.

In this 2002 edition, a distinguished, international team of researchers and clinicians revisit attention-deficit and hyperactivity disorders in young people.

Investigation Of The Genetic Factors Associated With Attention Deficit Hyperactivity Disorder Adhd Reading Disability Rd And Language Ability

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Author : Sabah Husain
language : en
Publisher:
Release Date : 2013

Investigation Of The Genetic Factors Associated With Attention Deficit Hyperactivity Disorder Adhd Reading Disability Rd And Language Ability written by Sabah Husain and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013 with categories.

A Genetic Study Of Attention Deficit Hyperactivity Disorder

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Author : Leeyoung Park
language : en
Publisher:
Release Date : 2005

A Genetic Study Of Attention Deficit Hyperactivity Disorder written by Leeyoung Park and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2005 with Attention-deficit hyperactivity disorder categories.