Autism Spectrum Disorders Developmental Trajectories Neurobiological Basis Treatment Update

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Autism Spectrum Disorders Developmental Trajectories Neurobiological Basis Treatment Update Volume 2

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Author : Roberto Canitano
language : en
Publisher: Frontiers Media SA
Release Date : 2020-07-03

Autism Spectrum Disorders Developmental Trajectories Neurobiological Basis Treatment Update Volume 2 written by Roberto Canitano and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-07-03 with categories.

Autism Spectrum Disorders Developmental Trajectories Neurobiological Basis Treatment Update

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Author : Roberto Canitano
language : en
Publisher: Frontiers Media SA
Release Date : 2017-08-30

Autism Spectrum Disorders Developmental Trajectories Neurobiological Basis Treatment Update written by Roberto Canitano and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-08-30 with categories.

This Research Topic has the aim to fill the gap of the many unresolved scientific issues on Autism Spectrum Disorders (ASD) that are still in need of investigation, Targeted treatments based on the understanding of the underlying pathogenic mechanisms of disease are still lacking. Further research is awaited and should be obtained through a significant effort on experimental treatment trials and neuroscience research. This Topic is divided in two main sections, one covering clinical issues and another on basic neurosciences of Autism Spectrum Disorders. A more detailed description of the contents of the articles is provided in the editorial at the beginning of the issue.

Neurobiology Diagnosis And Treatment In Autism

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Author :
language : en
Publisher: John Libbey Eurotext
Release Date :

Neurobiology Diagnosis And Treatment In Autism written by and has been published by John Libbey Eurotext this book supported file pdf, txt, epub, kindle and other format this book has been release on with categories.

Autism is an extremely complex neurodevelopmental disorder that is expressed in a spectrum of phenotypes and is characterized by impaired reciprocal social communication and stereotyped patterns of interests and activities. Its aetiopathogenesis remains poorly understood. This book is an exhaustive synthesis discussing various aspects: - A focus on the neurobiology of autism: the candidate genes implicate an involvement of numerous brain regions and a concomitant malfunctioning of neurotransmitter, immunologic, and other mechanisms. - The most incisive rehabilitation models in their original formulation and the results achieved with the same or similar protocols in Italian centres (understanding, educating, language therapy, social skill training…) - The psychopharmacologic options for the condition of autism per se and for its associated, very frequent, comorbidities. It suggests a potential influence on professional practice and enables an up-to-date approach to effective diagnosis and treatment.

Autism

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Author : Gregory R. Bock
language : en
Publisher: John Wiley & Sons
Release Date : 2005-01-21

Autism written by Gregory R. Bock and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2005-01-21 with Science categories.

This book draws together contributions from some of the leading investigators in the field of autism to consider specific problem areas in current research. Each contributor brings expertise from a different field, providing a balanced view of the whole spectrum of study of this disorder. It covers four main areas: Twin and family studies indicate that the heritability of the underlying liability to autism exceeds 90% and point to a multifactorial causation, involving a relatively small number of susceptibility genes. The book discusses this issue in detail, along with the problem of why some additional symptoms are associated with autism while others are not. New techniques are available for examining the neurobiology of autism. The book contains results from imaging studies showing the contributions of different brain regions to autism. It includes neuropathological data and examines the neuropharmacology of autism. There is considerable discussion concerning the fundamental psychological deficit in children with autism. There is good evidence that "Theory of Mind" deficits are associated with autism and this issue is discussed in the book, as are other competing possibilities. The most important practical question facing medical and psychological practitioners is how to help children with autism. The evidence relating to possible psychological or psychiatric interventions for rehabilitation of children with autism is examined in detail. Drug treatments have generally been disappointing in this field and there is one chapter devoted specifically to this problem. The book focusses ultimately on intervention studies and so is of practical relevance to people interested in helping autistic children. In addition, it provides a very convenient summary of the principal controversies which currently exist in research on autism.

Autism Spectrum Disorder Within Neurodevelopmental Disorders Catching Heterogeneity Specificity And Comorbidity In Clinical Phenotypes And Neurobiological Bases

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Author : Eugenia Conti
language : en
Publisher: Frontiers Media SA
Release Date : 2022-09-14

Autism Spectrum Disorder Within Neurodevelopmental Disorders Catching Heterogeneity Specificity And Comorbidity In Clinical Phenotypes And Neurobiological Bases written by Eugenia Conti and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-09-14 with Science categories.

Handbook Of Life Course Health Development

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Author : Neal Halfon
language : en
Publisher: Springer
Release Date : 2017-11-20

Handbook Of Life Course Health Development written by Neal Halfon and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-11-20 with Medical categories.

This book is open access under a CC BY 4.0 license. ​This handbook synthesizes and analyzes the growing knowledge base on life course health development (LCHD) from the prenatal period through emerging adulthood, with implications for clinical practice and public health. It presents LCHD as an innovative field with a sound theoretical framework for understanding wellness and disease from a lifespan perspective, replacing previous medical, biopsychosocial, and early genomic models of health. Interdisciplinary chapters discuss major health concerns (diabetes, obesity), important less-studied conditions (hearing, kidney health), and large-scale issues (nutrition, adversity) from a lifespan viewpoint. In addition, chapters address methodological approaches and challenges by analyzing existing measures, studies, and surveys. The book concludes with the editors’ research agenda that proposes priorities for future LCHD research and its application to health care practice and health policy. Topics featured in the Handbook include: The prenatal period and its effect on child obesity and metabolic outcomes. Pregnancy complications and their effect on women’s cardiovascular health. A multi-level approach for obesity prevention in children. Application of the LCHD framework to autism spectrum disorder. Socioeconomic disadvantage and its influence on health development across the lifespan. The importance of nutrition to optimal health development across the lifespan. The Handbook of Life Course Health Development is a must-have resource for researchers, clinicians/professionals, and graduate students in developmental psychology/science; maternal and child health; social work; health economics; educational policy and politics; and medical law as well as many interrelated subdisciplines in psychology, medicine, public health, mental health, education, social welfare, economics, sociology, and law.

Regressive And Early Onset Autism Spectrum Disorders

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Author : Hilary Corinne Boorstein
language : en
Publisher:
Release Date : 2010

Regressive And Early Onset Autism Spectrum Disorders written by Hilary Corinne Boorstein and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010 with categories.

Dissecting Brain Based Variability In Autism Impact Of Sex Polygenic Risk And Age

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Author : Katherine Elizabeth Lawrence
language : en
Publisher:
Release Date : 2019

Dissecting Brain Based Variability In Autism Impact Of Sex Polygenic Risk And Age written by Katherine Elizabeth Lawrence and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019 with categories.

Autism spectrum disorder (ASD) is an extraordinarily heterogeneous neurodevelopmental condition which is characterized by challenges with social interaction and communication, the presence of restricted and repetitive behaviors, and differences in sensory processing. Other behavioral and cognitive domains are also impacted in ASD, including alterations in salience detection, social cognition, executive functioning, and social reward processing. Despite the high prevalence of ASD, its neurobiological basis remains poorly understood and there is a paucity of broadly effective treatments. Prior work has demonstrated that ASD is associated with neural atypicalities, but the exact nature of such alterations remains unclear and their association with individual differences has been insufficiently examined to date. This dissertation aims to elucidate the relationship between three sources of individual differences - participant sex, polygenic risk for ASD, and age - and variability in brain connectivity and activity among youth with ASD and typically developing (TD) youth. Chapter 1 describes a study that analyzed sex differences in functional connectivity within and between three brain networks which underlie salience perception, social cognition, and executive functions. Youth with ASD displayed altered sex differences in these networks, highlighting the importance of considering participant sex when characterizing the neural mechanisms underlying ASD. Chapter 2 describes a related study examining neural responsivity to social rewards among girls and boys with and without ASD. Girls with ASD displayed greater activity to socially rewarding stimuli than both boys with ASD and TD girls in brain regions associated with reward processing and salience detection. These findings indicate that girls with ASD may be more sensitive to social rewards, which may in turn have implications for the use and personalization of reinforcement-based interventions. Chapter 3 presents data investigating the association between polygenic risk for ASD and functional connectivity of the salience network. Polygenic load for ASD significantly influenced the functional connectivity of this network in boys with and without ASD, and such connectivity was furthermore significantly more sensitive to cumulative genetic risk among boys than girls. These results suggest a pathway through which polygenic risk may contribute to ASD and highlight a neurobiological mechanism for the reduced prevalence of ASD in females, thereby suggesting an area of investigation for future treatment studies. Chapter 4 describes a study which examined longitudinal trajectories of functional connectivity among adolescents with ASD and TD adolescents. Such developmental trajectories significantly differed between adolescents with and without ASD, underscoring the value of considering age in our understanding of brain connectivity in ASD. Taken together, the body of work presented in this dissertation demonstrates that participant sex, polygenic risk for ASD, and age all significantly impact the brain in ASD. As such, these findings improve our understanding of individual variability in ASD and may ultimately contribute to the future development and personalization of interventions.

Frontiers In Clinical Drug Research Cns And Neurological Disorders

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Author : Atta-ur-Rahman
language : en
Publisher: Bentham Science Publishers
Release Date : 2013-09-06

Frontiers In Clinical Drug Research Cns And Neurological Disorders written by Atta-ur-Rahman and has been published by Bentham Science Publishers this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-09-06 with Science categories.

Frontiers in Clinical Drug Research - CNS and Neurological Disorders is an eBook series that brings updated reviews to readers interested in advances in the development of pharmaceutical agents for the treatment of central nervous system (CNS) and other nerve disorders. The scope of the eBook series covers a range of topics including the medicinal chemistry, pharmacology, molecular biology and biochemistry of contemporary molecular targets involved in neurological and CNS disorders. Reviews presented in the series are mainly focused on clinical and therapeutic aspects of novel drugs intended for these targets. Frontiers in Clinical Drug Research - CNS and Neurological Disorders is a valuable resource for pharmaceutical scientists and postgraduate students seeking updated and critical information for developing clinical trials and devising research plans in the field of neurology. The first volume of the series features 9 chapters that cover a variety of therapeutic areas such as: -advances in the treatment of cerebral gliomas, multiple sclerosis and schizophrenia, -different uses for antidepressants in treating drug users and adolescents suffering from depression, -research on epilepsy and autism spectrum disorder therapy -advances in the treatment of cerebral gliomas, multiple sclerosis and schizophrenia, -different uses for antidepressants in treating drug users and adolescents suffering from depression, -research on epilepsy and autism spectrum disorder therapy.

Neurobiology Of Brain Disorders

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Author : Michael J. Zigmond
language : en
Publisher: Academic Press
Release Date : 2022-05-20

Neurobiology Of Brain Disorders written by Michael J. Zigmond and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-05-20 with Science categories.

Neurobiology of Brain Disorders: Biological Basis of Neurological and Psychiatric Disorders, Second Edition provides basic scientists a comprehensive overview of neurological and neuropsychiatric disease. This book links basic, translational, and clinical research, covering the genetic, developmental, molecular and cellular mechanisms underlying all major categories of brain disorders. It offers students, postdoctoral fellows, and researchers in diverse fields of neuroscience, neurobiology, neurology, and psychiatry the tools they need to obtain a basic background in the major neurological and psychiatric diseases. Topics include developmental, autoimmune, central, and peripheral neurodegeneration, infectious diseases, and diseases of higher function. Organized by individual disorder, each chapter includes coverage of the clinical condition, diagnosis, treatment, underlying mechanisms, relevant basic and translational research, and key unanswered questions. This volume reflects progress in the field since publication of the first edition, with fully updated chapters, and new chapters on isolation, aging, global diseases, vascular diseases, and toxic/metabolic disease. New disorder coverage includes fibromyalgia, chronic fatigue, Restless Legs Syndrome, myasthenia gravis, and more. Links basic, translational and clinical research on disorders of the nervous system Covers a vast array of neurological and psychiatric disorders, including Down syndrome, autism, muscular dystrophy, diabetes, TBI, Parkinson's, Huntington's, Alzheimer's, OCD, PTSD, schizophrenia, depression and pain Features new chapters on the effects of aging and isolation on brain health Expands coverage on disorders, including new chapters on fibromyalgia, chronic fatigue, and restless legs syndrome Features in-text summary points, special feature boxes and research questions