Bacterial Chromatin
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Bacterial Chromatin
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Author : Remus T. Dame
language : en
Publisher: Springer Science & Business Media
Release Date : 2009-12-24
Bacterial Chromatin written by Remus T. Dame and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009-12-24 with Science categories.
The birth and the development of molecular biology and, subsequently, of genetic engineering and biotechnology cannot be separated from the advancements in our knowledge of the genetics, biochemistry and physiology of bacteria and bacter- phages. Also most of the tools employed nowadays by biotechnologists are of bacterial (or bacteriophage) origin and the playground for most of the DNA manipulations still remains within bacteria. The relative simplicity of the bacterial cell, the short gene- tion times, the well defined and inexpensive culturing conditions which characterize bacteria and the auto-catalytic process whereby a wealth of in-depth information has been accumulated throughout the years have significantly contributed to generate a large number of knowledge-based, reliable and exploitable biological systems. The subtle relationships between phages and their hosts have produced a large amount of information and allowed the identification and characterization of a number of components which play essential roles in fundamental biological p- cesses such as DNA duplication, recombination, transcription and translation. For instance, to remain within the topic of this book, two important players in the or- nization of the nucleoid, FIS and IHF, have been discovered in this way. Indeed, it is difficult to find a single fundamental biological process whose structural and functional aspects are better known than in bacteria.
Bacterial Chromatin
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Author : Remus T. Dame
language : en
Publisher: Springer Nature
Release Date :
Bacterial Chromatin written by Remus T. Dame and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on with categories.
Dynamic Organization Of Bacterial Chromatin By Dna Bridging Proteins
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Author :
language : en
Publisher:
Release Date : 2020
Dynamic Organization Of Bacterial Chromatin By Dna Bridging Proteins written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020 with categories.
A Structural Role For The H Ns Protein In Bacterial Chromatin
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Author : Anne E. Fielder
language : en
Publisher:
Release Date : 1995
A Structural Role For The H Ns Protein In Bacterial Chromatin written by Anne E. Fielder and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1995 with DNA-binding proteins categories.
Bacterial Chromatin
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Author : Claudio O. Gualerzi
language : en
Publisher:
Release Date : 1986
Bacterial Chromatin written by Claudio O. Gualerzi and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1986 with categories.
Bacterial Chromatin
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Author : Remus T. Dame
language : en
Publisher: Humana
Release Date : 2024-08-23
Bacterial Chromatin written by Remus T. Dame and has been published by Humana this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-08-23 with Science categories.
This second edition brings together new and updated methods to explore the structure and function of bacterial chromatin from molecular to the cellular scale. Chapters detail experimental protocols of in vivo and in vitro approaches, approaches to genome structure modeling, and data analysis. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and key tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Bacterial Chromatin: Methods and Protocols, Second Edition aims to be a useful up-to-date reference work for researchers currently in the field and to those entering the field.
Models For Protein Localization In Bacteria And Chromatin Structure In Eukaryotes
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Author : Saeed Saberi Modaber
language : en
Publisher:
Release Date : 2014
Models For Protein Localization In Bacteria And Chromatin Structure In Eukaryotes written by Saeed Saberi Modaber and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014 with categories.
In the first part of this thesis, we focus on the problem of how proteins localize within the cytoplasm of bacteria. Experimentally, it is found that proteins that have attractive interactions are able to localize to one or both of the poles in cylindrical bacteria. We put forward a model that only relies on the aggregating tendency of proteins and the occlusion by the bacterial nucleoid. Monte-Carlo simulations enabled us to find the stable and metastable localization patterns, allowing us to explore the phase space of parameters in our model. Our findings explains the different patterns observed for PopZ localization in Escherichia coli and Caulobacter crescentus as well as misfolded proteins. We find the kinetics of expressing proteins has a crucial role: unipolar patterning is an energetically favorable state while other polar patterns can be achieved at higher rates of protein expression. Using sets of different GFP tagged aggregating proteins we are able to experimentally test this prediction and alter the localization from unipolar to bipolar simply by increasing the rate of expression. In the second part, we consider the structuring of the DNA within the eukaryotic nucleous and its associated proteins. A new high-throughput experimental technique, Hi-C, is able to measure the looping frequencies between all parts of the genome. We transform the measured data and are able to extract a distance independent free energy by subtracting out the background free energy of interactions due to the polymer nature of DNA. Our mean-field model quantities the interaction strengths between chromatin factors and loops along the chromosomes in a protein pairwise interaction matrix J. Since the Hi-C data carries dierent biases, using our approach we are able to assess the best sets of corrections that lead to the free energy having the most mutual information with the underlying chromatin profiles. Further to this, we use Principal Component Analysis (PCA) to identify the frequent modes of genome wide looping. Hence, we are able to correlate these with known domain structures such as boundaries between active and silent regions of the genome.
From Polymers To Gene Regulation
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Author :
language : en
Publisher:
Release Date : 2015
From Polymers To Gene Regulation written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015 with categories.
Mots-clés de l'auteur: DNA ; AFM ; Bacterial chromatin ; NAPs ; H-NS ; DNA structure ; Polymer physics ; DNA in confinement ; Hyperplectonemes ; DNA dyes.
Bacterial Chromosomal Segregation
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Author : P. Graumann
language : en
Publisher:
Release Date : 2015
Bacterial Chromosomal Segregation written by P. Graumann and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015 with categories.
Bacterial Chromatin
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Author : Claudio O. Gualerzi
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Bacterial Chromatin written by Claudio O. Gualerzi and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Science categories.
This book brings together various contributions aimed at the elucida tion of the structural and functional organization of the bacterial nucleoid. Most of these papers, spanning the fields of physical chemistry through biochemistry to genetics, were presented at the session on bac terial chromatin during the Symposium "Selected topics on chromatin structure and function" held at the University of Camerino, Italy, at the end of May 1985. Times when the bacterial DNA was regarded as "naked" or, at most, complexed with polyamines, and when the absence of histones and organized chromatin was considered to be a distinct feature of the pro karyotic cell, now appear remote. Our concepts of how DNA is packaged in bacteria are changing rapidly. Studies on the structure of the bacterial nucleoid are not new. Recently, however, investigations in this field have flourished again, leading to some important contributions such as the elucidation of the three-dimensional structure of what appears to be the major protein constituent of the bacterial nucleoid or the development of methods to titrate the extent of DNA supercoiling within the bacterial cell.