Bacterial Evasion Of The Host Immune System
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Bacterial Evasion Of The Host Immune System
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Author : Pedro Escoll
language : en
Publisher: Caister Academic Press Limited
Release Date : 2017
Bacterial Evasion Of The Host Immune System written by Pedro Escoll and has been published by Caister Academic Press Limited this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017 with Medical categories.
Expert international authors critically review the most important current research in bacterial evasion of the host immune response. Topics range from an overview of the seven most important bacterial secretion systems to a thorough review of evsaion by mycobacteria. Essential reading for everyone involved in bacterial pathogenesis research.
Bacterial Evasion Of Host Immune Responses
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Author : Brian Henderson
language : en
Publisher: Cambridge University Press
Release Date : 2003-04-28
Bacterial Evasion Of Host Immune Responses written by Brian Henderson and has been published by Cambridge University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2003-04-28 with Medical categories.
Table of contents
Bacterial Evasion Of Host Immune Responses
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Author :
language : en
Publisher:
Release Date : 2003
Bacterial Evasion Of Host Immune Responses written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2003 with Bacteria categories.
Janeway S Immunobiology
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Author : Kenneth Murphy
language : en
Publisher: Garland Science
Release Date : 2010-06-22
Janeway S Immunobiology written by Kenneth Murphy and has been published by Garland Science this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010-06-22 with Medical categories.
The Janeway's Immunobiology CD-ROM, Immunobiology Interactive, is included with each book, and can be purchased separately. It contains animations and videos with voiceover narration, as well as the figures from the text for presentation purposes.
Bacterial Exotoxins How Bacteria Fight The Immune System
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Author : Inka Sastalla
language : en
Publisher: Frontiers Media SA
Release Date : 2016-10-07
Bacterial Exotoxins How Bacteria Fight The Immune System written by Inka Sastalla and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-10-07 with Immunologic diseases. Allergy categories.
Bacterial pathogenicity factors are functionally diverse. They may facilitate the adhesion and colonization of bacteria, influence the host immune response, assist spreading of the bacterium by e.g. evading recognition by immune cells, or allow bacteria to dwell within protected niches inside the eukaryotic cell. Exotoxins can be single polypeptides or heteromeric protein complexes that act on different parts of the cells. At the cell surface, they may insert into the membrane to cause damage; bind to receptors to initiate their uptake; or facilitate the interaction with other cell types. For example, bacterial superantigens specifically bind to major histocompatibility complex (MHC) II molecules on the surface of antigen presenting cells and the T cell receptor, while cytolysins cause pore formation. For intracellular activity, exotoxins need to be translocated across the eukaryotic membrane. Gram-negative bacteria can directly inject effector proteins in a receptor-independent manner by use of specialized needle apparatus such as bacterial type II, III, or type IV secretion systems. Other methods of translocation include the phagocytic uptake of bacteria followed by toxin secretion, or receptor-mediated endocytosis which allows the targeting of distinct cell types. Receptor-based uptake is initiated by the binding of heteromeric toxin complexes to the cell surface and completed by the translocation of the effector protein(s) across the endosomal membrane. In the cytosol, toxins interact with specific eukaryotic target proteins to cause post-translational modifications that often result in the manipulation of cellular signalling cascades and inflammatory responses. It has become evident that the actions of some bacterial toxins may exceed their originally assumed cytotoxic function. For example, pore-forming toxins do not only cause cytolysis, but may also induce autophagy, pyroptosis, or activation of the MAPK pathways, resulting in adjustment of the host immune response to infection and modification of inflammatory responses both locally and systemically. Other recently elucidated examples of the immunomodulatory function of cell death-inducing exotoxins include TcdB of Clostridium difficile which activates the inflammasome through modification of cellular Rho GTPases, or the Staphyloccocus d-toxin which activates mast cells. The goal of this research topic was to gather current knowledge on the interaction of bacterial exotoxins and effector proteins with the host immune system. The following 16 research and review articles in this special issue describe mechanisms of immune modification and evasion and provide an overview over the complexity of bacterial toxin interaction with different cells of the immune system.
The Pathogenic Spirochetes Strategies For Evasion Of Host Immunity And Persistence
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Author : Monica E. Embers
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-09
The Pathogenic Spirochetes Strategies For Evasion Of Host Immunity And Persistence written by Monica E. Embers and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-09 with Medical categories.
This book explores the many mechanisms by which the most prevalent Spirochetal pathogens persist in a healthy immune-competent host. Among them are the direct and indirect suppression of host immune signals, phase and antigenic variation, escaping recognition by host complement proteins, and seclusion into immune privileged sites. We also explore antibiotic therapy for control of infection, a baffling topic that lends itself to exalted interpretation.
Modulation Of The Immune System By Bacteria From Evasion To Therapy
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Author : Marina De Bernard
language : en
Publisher: Frontiers Media SA
Release Date : 2023-04-10
Modulation Of The Immune System By Bacteria From Evasion To Therapy written by Marina De Bernard and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-04-10 with Medical categories.
Bacterial Exotoxins How Bacteria Fight The Immune System
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Author :
language : en
Publisher:
Release Date : 2016
Bacterial Exotoxins How Bacteria Fight The Immune System written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016 with categories.
The goal of this research topic was to gather current knowledge on the interaction of bacterial exotoxins and effector proteins with the host immune system. The following 16 research and review articles in this special issue describe mechanisms of immune modification and evasion and provide an overview over the complexity of bacterial toxin interaction with different cells of the immune system.
Microbial Subversion Of Immunity
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Author : Peter Julius Lachmann
language : en
Publisher: Caister Academic Press Limited
Release Date : 2006
Microbial Subversion Of Immunity written by Peter Julius Lachmann and has been published by Caister Academic Press Limited this book supported file pdf, txt, epub, kindle and other format this book has been release on 2006 with Science categories.
Microbes have evolved in an impressive and diverse range of strategies to subvert the host immune system. Two major types of strategies exist. The first is the evasion of recognition by the host, for example by using antigenic variation, masking of epitopes, the use of decoys, molecular mimicry, etc. The second is the modulation and/or suppression of the innate (e.g. complement, NK cells) and adaptive (e.g. antibodies) immune responses. A better understanding of the underlying mechanisms involved is critical for the rational design of novel therapeutic agents and vaccines to treat and/or prevent infectious diseases. Another area of active research is the application of microbial immunomodulatory factors in the treatment of human immunological disorders (e.g. inflammatory bowel disease and asthma) and as sources of pharmacologically active agents. In this book, internationally renown scientists critically review the current cutting-edge research in this area. Topics covered include the subversion of complement, NK cell function, mucosal innate immune response, evasion/subversion mechanisms used by bacteria, helminths, viruses, and the measles model system. Containing over 1,700 references, this book is an essential resource book for researchers in the fields of microbiology, immunology, pharmacology, and molecular medicine.
Molecular Biology Of The Cell
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Author : Bruce Alberts
language : en
Publisher:
Release Date : 2002
Molecular Biology Of The Cell written by Bruce Alberts and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2002 with Cytology categories.
