Bacterial Transcription Factors And The Cell Cycle 2nd Edition
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Bacterial Transcription Factors And The Cell Cycle 2nd Edition
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Author : Morigen Morigen
language : en
Publisher: Frontiers Media SA
Release Date : 2022-10-10
Bacterial Transcription Factors And The Cell Cycle 2nd Edition written by Morigen Morigen and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-10-10 with Science categories.
Analogous to the eukaryotic G1, S and M phase of the cell cycle, the bacterial cell cycle can be classified into independent stages. Slowly growing bacterial cells undergo three different stages, B-, C- and D-phase, respectively, while the cell cycle of fast-growing bacteria involves at least two independent cycles: the chromosome replication and the cell division. The oscillation in gene expression regulated by transcription factors, and proteolysis mediated by ClpXP, are closely correlated with progression of the cell cycle. Indeed, it has been shown that DnaA couples DNA replication initiation with the expression of the two oscillating regulators GcrA and CtrA, and the DnaA/GcrA/CtrA regulatory cascade drives the forward progression of the Caulobacter cell cycle. Furthermore, it has been found that: the DnaA oscillation in Eschericha coli and Caulobacter crescentus plays an important role in the cell cycle coordination; RpoS in Coxiella regulates the gene expression involved in the developmental cycle; the SigB and SinR transcription factors control whether cells remain in or leave a biofilm responding to metabolic conditions in Bacillus subtilis; similarly, BolA in most Gram-negative bacteria turns off motility and turns on biofilm development as a transcription factor; CtrA regulates cell division and outer membrane composition of the pathogen Brucella abortus; an essential transcription factor SciP enhances robustness of Caulobacter cell cycle regulation. Interestingly, transcription factors mediated metabolism fluctuations are also related to progression of the cell cycle. It has been shown that: CggR and Cra factors are involved in the flux-signaling metabolite fructose-1,6-bisphosphate; IclR mediates para-hydroxybenzoate catabolism in Streptomyces coelicolor; CceR and AkgR regulate central carbon and energy metabolism in alphaproteobacteria; and these metabolism changes affect cell growth. In line with the argument, AspC-mediated aspartate metabolism coordinates the E. coli cell cycle. However, the molecular mechanisms of maintaining the proper cell cycle progression through coordination of transcription factors mediated gene transcription oscillation, cellular metabolism with the cell cycle are not yet well-established. This Research Topic is intended to cover the spectrum of cell cycle regulatory mechanisms, in particular the coordination of transcription factor mediated gene transcription oscillations, and the cellular metabolisms associated with the cell cycle. We welcome all types of articles including Original Research, Review, and Mini Review. The subject areas of interest include but are not limited to: 1. Cell cycle coordination through gene expression and expression oscillation mediated by transcription factors. 2. Regulation of the cell cycle by proteolysis oscillation. 3. Coordination of the cell cycle with metabolism fluctuation. 4. DNA methylation fluctuation and the cell cycle. 5. Novel transcription factors and gene expression patterns associated with the cell cycle.
Bacterial Transcription Factors And The Cell Cycle
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Author : Morigen Morigen
language : en
Publisher: Frontiers Media SA
Release Date : 2022-02-10
Bacterial Transcription Factors And The Cell Cycle written by Morigen Morigen and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-02-10 with Science categories.
New Mechanisms In Transcription Regulation And Chromosome Organization In Caulobacter Crescentus
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Author : Diane Laure Haakonsen
language : en
Publisher:
Release Date : 2016
New Mechanisms In Transcription Regulation And Chromosome Organization In Caulobacter Crescentus written by Diane Laure Haakonsen and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016 with categories.
Bacteria use a variety of mechanisms to control transcription in response to environmental cues or growth conditions. Activation or repression of transcription is often carried out by proteins, called transcription factors, that interact with DNA or RNA polymerase (RNAP) or both, and can change the preference of RNAP for target promoters. Additionally, DNA is tightly compacted and organized inside cells. In bacteria, nucleoid-associated proteins (NAPs) play critical roles in shaping and compacting the chromosome by bending, wrapping and bridging the DNA. The binding of these proteins can also profoundly affect gene expression regulation. In this work, I have characterized two DNA-binding proteins from the bacterium Caulobacter crescentus; one transcription factor, GcrA, and one NAP, CnpA. First, I found that GcrA, an essential cell-cycle regulator in Caulobacter, activates transcription by a new mechanism. Unlike most transcription factors that bind to promoters independently of RNAP, GcrA constitutively associates with RNAP via an interaction with Domain 2 of Y70, the primary sigma factor. I showed that GcrA recognizes a subset of methylation sites and can promote binding of RNAP and increase the rate of open complex formation at promoters harboring such sites. Understanding the mechanism by which GcrA activates transcription enabled the identification of its direct regulon and provided important insights into its essential cell-cycle function. For my second project, I identified a new nucleoid-associated protein (NAP), CnpA, in Caulobacter, via mass-spectrometry analysis of its nucleoid content. I showed that CnpA associates with AT-rich DNA but unlike other NAPs, likely does not repress transcription at these loci. We propose a model in which CnpA impacts global supercoiling levels. In sum, these two projects have contributed to expanding our views of how gene expression and chromosome organization are regulated in bacteria.
Molecular Biology Of The Cell
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Author : Bruce Alberts
language : en
Publisher:
Release Date : 2002
Molecular Biology Of The Cell written by Bruce Alberts and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2002 with Cytology categories.
Two Component Signal Transduction
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Author : James A. Hoch
language : en
Publisher: Amer Society for Microbiology
Release Date : 1995
Two Component Signal Transduction written by James A. Hoch and has been published by Amer Society for Microbiology this book supported file pdf, txt, epub, kindle and other format this book has been release on 1995 with Medical categories.
The human enteroviruses, particularly the polio viruses, have had a significant role in the history of medicine and microbiology; and continue to cause clinical problems, as well as provide targets for molecular investigation. This book offers a link between the basic science and clinical medicine.
Cell Biology By The Numbers
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Author : Ron Milo
language : en
Publisher: Garland Science
Release Date : 2015-12-07
Cell Biology By The Numbers written by Ron Milo and has been published by Garland Science this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-12-07 with Science categories.
A Top 25 CHOICE 2016 Title, and recipient of the CHOICE Outstanding Academic Title (OAT) Award. How much energy is released in ATP hydrolysis? How many mRNAs are in a cell? How genetically similar are two random people? What is faster, transcription or translation?Cell Biology by the Numbers explores these questions and dozens of others provid
Prokaryotic Cytoskeletons
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Author : Jan Löwe
language : en
Publisher: Springer
Release Date : 2017-05-11
Prokaryotic Cytoskeletons written by Jan Löwe and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-05-11 with Science categories.
This book describes the structures and functions of active protein filaments, found in bacteria and archaea, and now known to perform crucial roles in cell division and intra-cellular motility, as well as being essential for controlling cell shape and growth. These roles are possible because the cytoskeletal and cytomotive filaments provide long range order from small subunits. Studies of these filaments are therefore of central importance to understanding prokaryotic cell biology. The wide variation in subunit and polymer structure and its relationship with the range of functions also provide important insights into cell evolution, including the emergence of eukaryotic cells. Individual chapters, written by leading researchers, review the great advances made in the past 20-25 years, and still ongoing, to discover the architectures, dynamics and roles of filaments found in relevant model organisms. Others describe one of the families of dynamic filaments found in many species. The most common types of filament are deeply related to eukaryotic cytoskeletal proteins, notably actin and tubulin that polymerise and depolymerise under the control of nucleotide hydrolysis. Related systems are found to perform a variety of roles, depending on the organisms. Surprisingly, prokaryotes all lack the molecular motors associated with eukaryotic F-actin and microtubules. Archaea, but not bacteria, also have active filaments related to the eukaryotic ESCRT system. Non-dynamic fibres, including intermediate filament-like structures, are known to occur in some bacteria.. Details of known filament structures are discussed and related to what has been established about their molecular mechanisms, including current controversies. The final chapter covers the use of some of these dynamic filaments in Systems Biology research. The level of information in all chapters is suitable both for active researchers and for advanced students in courses involving bacterial or archaeal physiology, molecular microbiology, structural cell biology, molecular motility or evolution. Chapter 3 of this book is open access under a CC BY 4.0 license.
Biology For Ap Courses
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Author : Julianne Zedalis
language : en
Publisher:
Release Date : 2017-10-16
Biology For Ap Courses written by Julianne Zedalis and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-10-16 with Biology categories.
Biology for AP® courses covers the scope and sequence requirements of a typical two-semester Advanced Placement® biology course. The text provides comprehensive coverage of foundational research and core biology concepts through an evolutionary lens. Biology for AP® Courses was designed to meet and exceed the requirements of the College Board’s AP® Biology framework while allowing significant flexibility for instructors. Each section of the book includes an introduction based on the AP® curriculum and includes rich features that engage students in scientific practice and AP® test preparation; it also highlights careers and research opportunities in biological sciences.
Ubiquitin And The Biology Of The Cell
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Author : Jan-Michael Peters
language : en
Publisher: Springer Science & Business Media
Release Date : 1998-05-31
Ubiquitin And The Biology Of The Cell written by Jan-Michael Peters and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 1998-05-31 with Science categories.
The last several years have been a landmark period in the ubiquitin field. The breadth of ubiquitin's roles in cell biology was first sketched, and the importance of ubiquitin-dependent proteolysis as a regulatory mechanism gained general acceptance. The many strands of work that led to this new perception are re counted in this book. A consequence of this progress is that the field has grown dramatically since the first book on ubiquitin was published almost a decade ago [M. Rechsteiner (ed. ), Ubiquitin, Plenum Press, 1988]. In this span, students of the cell cycle, transcription, signal transduction, protein sorting, neuropathology, cancer, virology, and immunology have attempted to chart the role of ubi quit in in their particular experimental systems, and this integration of the field into cell biology as a whole continues at a remarkable pace. We hope that for active researchers in the field as well as for newcomers and those on the fence, this book will prove helpful for its breadth, historical perspective, and practical tips. Structural data are now available on many of the components of the ubiquitin pathway. The structures have provided basic insights into the unusual biochemical mechanisms of ubiquitination and proteasome-mediated proteolysis. Because high-speed computer graphics can convey structures more effectively than print media, we have supplemented the figures of the book with a Worldwide Web site that can display the structures in a flexible, viewer-controlled format.
Bacterial Physiology
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Author : Walid El-Sharoud
language : en
Publisher: Springer Science & Business Media
Release Date : 2007-12-07
Bacterial Physiology written by Walid El-Sharoud and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007-12-07 with Science categories.
The application of new molecular methodologies in the study of bacterial behavior and cell architecture has enabled new revolutionary insights and discoveries in these areas. This new text presents recent developments in bacterial physiology that are highly relevant to a wide range of readership including those interested in basic and applied knowledge. Its chapters are written by international scientific authorities at the forefront of the subject. The value of this recent knowledge in bacterial physiology is not only restricted to fundamental biology. It also extends to biotechnology and drug-discovery disciplines.