Bacteriocins And Other Ribosomally Synthesised And Post Translationally Modified Peptides Ripps As Alternatives To Antibiotics
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Bacteriocins And Other Ribosomally Synthesised And Post Translationally Modified Peptides Ripps As Alternatives To Antibiotics
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Author : Harsh Mathur
language : en
Publisher: Frontiers Media SA
Release Date : 2021-08-17
Bacteriocins And Other Ribosomally Synthesised And Post Translationally Modified Peptides Ripps As Alternatives To Antibiotics written by Harsh Mathur and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-08-17 with Science categories.
Prof Upton is the director of Amprologix, a company developing new bacteriocins; the other editors declare no competing interest in regard to editing this Research Topic.
Lasso Peptides
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Author : Yanyan Li
language : en
Publisher: Springer
Release Date : 2014-10-21
Lasso Peptides written by Yanyan Li and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-10-21 with Medical categories.
Lasso peptides form a growing family of fascinating ribosomally-synthesized and post-translationally modified peptides produced by bacteria. They contain 15 to 24 residues and share a unique interlocked topology that involves an N-terminal 7 to 9-residue macrolactam ring where the C-terminal tail is threaded and irreversibly trapped. The ring results from the condensation of the N-terminal amino group with a side-chain carboxylate of a glutamate at position 8 or 9, or an aspartate at position 7, 8 or 9. The trapping of the tail involves bulky amino acids located in the tail below and above the ring and/or disulfide bridges connecting the ring and the tail. Lasso peptides are subdivided into three subtypes depending on the absence (class II) or presence of one (class III) or two (class I) disulfide bridges. The lasso topology results in highly compact structures that give to lasso peptides an extraordinary stability towards both protease degradation and denaturing conditions. Lasso peptides are generally receptor antagonists, enzyme inhibitors and/or antibacterial or antiviral (anti-HIV) agents. The lasso scaffold and the associated biological activities shown by lasso peptides on different key targets make them promising molecules with high therapeutic potential. Their application in drug design has been exemplified by the development of an integrin antagonist based on a lasso peptide scaffold. The biosynthesis machinery of lasso peptides is therefore of high biotechnological interest, especially since such highly compact and stable structures have to date revealed inaccessible by peptide synthesis. Lasso peptides are produced from a linear precursor LasA, which undergoes a maturation process involving several steps, in particular cleavage of the leader peptide and cyclization. The post-translational modifications are ensured by a dedicated enzymatic machinery, which is composed of an ATP-dependent cysteine protease (LasB) and a lactam synthetase (LasC) that form an enzymatic complex called lasso synthetase. Microcin J25, produced by Escherichia coli AY25, is the archetype of lasso peptides and the most extensively studied. To date only around forty lasso peptides have been isolated, but genome mining approaches have revealed that they are widely distributed among Proteobacteria and Actinobacteria, particularly in Streptomyces, making available a rich resource of novel lasso peptides and enzyme machineries towards lasso topologies.
Nanocomposite And Nanohybrid Materials
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Author : Rajesh Kumar Verma
language : en
Publisher: Walter de Gruyter GmbH & Co KG
Release Date : 2023-11-06
Nanocomposite And Nanohybrid Materials written by Rajesh Kumar Verma and has been published by Walter de Gruyter GmbH & Co KG this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-11-06 with Science categories.
The volume "Nanocomposite and Nanohybrid Materials: Processing and Applications" is an outstanding resource for exploring the findings and recent trends of nanocomposites and nanohybrid materials. Herein, a full grasp of cutting-edge research, new technologies, and exciting opportunities linked with nanocomposites and nanohybrids. Nanomaterials, including their synthesis, development, and advanced properties, are thoroughly investigated. Several processes for preparing nanomaterials are presented to the reader, along with their characteristics and development phase. It offers the latest applications of nanoparticles for diagnosing and treating neurological disorders and their use in biological imaging and targeted cancer treatments. This provides a strong basis for future study and innovation in this intriguing issue that is very important to methodology, qualitative approaches, and applications.
Prokaryotic Antimicrobial Peptides
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Author : Djamel Drider
language : en
Publisher: Springer Science & Business Media
Release Date : 2011-03-08
Prokaryotic Antimicrobial Peptides written by Djamel Drider and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-03-08 with Science categories.
The book will provide an overview of the advancement of fundamental knowledge and applications of antimicrobial peptides in biomedical, agricultural, veterinary, food, and cosmetic products. Antimicrobial peptides stand as potentially great alternatives to current antibiotics, and most research in this newly-created area has been published in journals and other periodicals. It is the editors’ opinion that it is timely to sum up the most important achievements in the field and provide the scientific community in a reference book. The goals of this project include illustrating the achievements made so far, debating the state of the art, and drawing new perspectives.
Application Of Protective Cultures And Bacteriocins For Food Biopreservation
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Author : Riadh Hammami
language : en
Publisher: Frontiers Media SA
Release Date : 2019-09-20
Application Of Protective Cultures And Bacteriocins For Food Biopreservation written by Riadh Hammami and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-09-20 with categories.
The use of microorganisms and their metabolites for the preservation of foods began in prehistory. Lactic acid bacteria are generally recognized as safe (GRAS) for this purpose. They produce organic acids, diacetyl, acetoin, hydrogen peroxide, reuterin, reutericyclin and bacteriocins, all of which inhibit foodborne pathogens and spoilage microorganisms. Bacteriocins and the strains that produce them are particularly effective as bio-preservatives in cheese, meat and vegetables. They hold the promise of ensuring the quality and safety of ready-to-eat, extended-shelf-life, fresh-tasting and minimally processed foods without chemical preservatives. This Research Topic provides an overview of bacterial cultures, bacteriocins and other metabolites that have shown promise for use as antimicrobial bio-preservatives in foods in general. Articles describing novel analytical technologies, strategies to reduce or eliminate pathogens in food systems or emerging technologies for the production or use of protective cultures or their bacteriocins are presented.
Comprehensive Natural Products Chemistry
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Author : Derek Barton
language : en
Publisher: Newnes
Release Date : 1999-02-18
Comprehensive Natural Products Chemistry written by Derek Barton and has been published by Newnes this book supported file pdf, txt, epub, kindle and other format this book has been release on 1999-02-18 with Science categories.
Comprehensive Natural Products Chemistry
Diet Microbe Interactions In The Gut
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Author : Kieran Tuohy
language : en
Publisher: Academic Press
Release Date : 2014-08-04
Diet Microbe Interactions In The Gut written by Kieran Tuohy and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-08-04 with Medical categories.
Drawing on expert opinions from the fields of nutrition, gut microbiology, mammalian physiology, and immunology, Diet-Microbe Interactions for Human Health investigates the evidence for a unified disease mechanism working through the gut and its resident microbiota, and linking many inflammation-related chronic diet associated diseases. State of the art post-genomic studies can highlight the important role played by our resident intestinal microbiota in determining human health and disease. Many chronic human diseases associated with modern lifestyles and diets — including those localized to the intestinal tract like inflammatory bowel disease and celiac disease, and more pervasive systemic conditions such as obesity, diabetes and cardiovascular disease — are characterized by aberrant profiles of gut bacteria or their metabolites. Many of these diseases have an inflammatory basis, often presenting with a chronic low-grade systemic inflammation, hinting at persistent and inappropriate activation of inflammatory pathways. Through the presentation and analysis of recent nutrition studies, this book discusses the possible mechanisms underpinning the disease processes associated with these pathologies, with high fat diets appearing to predispose to disease, and biologically active plant components, mainly fiber and polyphenols, appearing to reduce the risk of chronic disease development. One comprehensive, translational source for all aspects of nutrition and diet's effect on gastrointestinal health and disease Experts in nutrition, diet, microbiology and immunology take readers from the bench research (cellular and biochemical mechanisms of vitamins and nutrients) to new preventive and therapeutic approaches Clear presentations by leading researchers of the cellular mechanisms underlying diet, immune response, and gastrointestinal disease help practicing nutritionists and clinicians (gastroenterologists, endocrinologists) map out new areas for clinical research and structuring clinical recommendations
Radical Sam Enzymes
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Author :
language : en
Publisher: Academic Press
Release Date : 2018-08-09
Radical Sam Enzymes written by and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-08-09 with Science categories.
Radical SAM Enzymes, Volume 606, the latest release in the Methods in Enzymology series, highlights new advances in the field, with this new volume presenting interesting chapters on the Characterization of the glycyl radical enzyme choline trimethylamine-lyase and its radical S-adenosylmethionine activating enzyme, Diphathimide biosynthesis, Radical SAM glycyl radical activating enzymes, Radical SAM enzyme BioB in the biosynthesis of biotin, Biogenesis of the PQQ cofactor, Role of MoaAC in the biogenesis of the molybdenum cofactor, Biosynthesis of the nitrogenase cofactor, Bioinformatics of the radical SAM superfamily, The involvement of SAM radical enzymes in the biosynthesis of methanogenic coenzymes, methanopterin and coenzyme F420, and more.
Biomedical Research Medicine And Disease
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Author : RC Sobti
language : en
Publisher: CRC Press
Release Date : 2023-04-04
Biomedical Research Medicine And Disease written by RC Sobti and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-04-04 with Medical categories.
Biomedical research is the first step towards the creation of new medications and treatments that help to manage different types of health conditions and diseases. The prevention and cure of diseases would be practically impossible without such type of research. Although the drug discovery and development processes are far too costly, time-consuming, prone to failure, and have low success rate, today the term "translational research or medicine" seems to have become trendy, yet it is insufficient. The present book is a sincere attempt by dedicated researchers to convey the importance of translational biomedical research, medicine, and disease, primarily, basic and clinical difficulties in the translation of diagnostic measures, pharmaceutical advances, biomarkers, diagnostics, and therapeutics. This book is meant for researchers, scientists, healthcare professionals, industry, innovators, and students of biomedical sciences, as well as for those involved in the basic sciences, biochemistry, biotechnology, biophysics, and life sciences in general. The volume comprehensively covers: Emerging technologies for health care Various aspects of biomedical research toward understanding of pathophysiology of the diseases Advances in improvement in diagnostic procedures and therapeutic tools The fundamental role of biomedical research in the development of new medicinal products
The Microbiota In Gastrointestinal Pathophysiology
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Author : Martin H. Floch
language : en
Publisher: Academic Press
Release Date : 2016-11-16
The Microbiota In Gastrointestinal Pathophysiology written by Martin H. Floch and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-11-16 with Science categories.
The Microbiota in Gastrointestinal Pathophysiology: Implications for Human Health, Prebiotics, Probiotics and Dysbiosis is a one-stop reference on the state-of-the-art research on gut microbial ecology in relation to human disease. This important resource starts with an overview of the normal microbiota of the gastrointestinal tract, including the esophagus, stomach, Ileum, and colon. The book then identifies what a healthy vs. unhealthy microbial community looks like, including methods of identification. Also included is insight into which features and contributions the microbiota make that are essential and useful to host physiology, as is information on how to promote appropriate mutualisms and prevent undesirable dysbioses. Through the power of synthesizing what is known by experienced researchers in the field, current gaps are closed, raising understanding of the role of the microbiome and allowing for further research. Explains how to modify the gut microbiota and how the current strategies used to do this produce their effects Explores the gut microbiota as a therapeutic target Provides the synthesis of existing data from both mainstream and non-mainstream sources through experienced researchers in the field Serves as a ‘one-stop’ shop for a topic that’s currently spread across a number of various journals