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Financial Statistics Of Major Investor Owned Electric Utilities
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Author :
language : en
Publisher:
Release Date : 1993
Financial Statistics Of Major Investor Owned Electric Utilities written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1993 with Electric utilities categories.
Nbs Special Publication
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Author :
language : en
Publisher:
Release Date : 1978
Nbs Special Publication written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1978 with Weights and measures categories.
Soil Survey Of Camp Franklin Morris And Titus Counties Texas
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Author : Kirthell Roberts
language : en
Publisher:
Release Date : 1990
Soil Survey Of Camp Franklin Morris And Titus Counties Texas written by Kirthell Roberts and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1990 with Soil surveys categories.
Central America Panama And The Dominican Republic
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Author : Mr.Marco Pinon
language : en
Publisher: International Monetary Fund
Release Date : 2012-07-16
Central America Panama And The Dominican Republic written by Mr.Marco Pinon and has been published by International Monetary Fund this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-07-16 with Business & Economics categories.
Central America, Panama, and the Dominican Republic coped well with the global financial crisis of 2008-09. The impact was generally less severe and shorter lived than in previous episodes, the balance of payments adjustment was orderly, and the stability of the financial system was not compromised. This resilience can be attributed to a large extent to the strengthening of the fiscal frameworks, monetary management, and financial reforms conducted in the years preceding the global crisis. Nevertheless, the region faces considerable challenges for the period ahead, including the need to raise medium term growth above historical levels and protect macroeconomic and financial stability. This book argues that meeting these challenges will have to come from within, in light of the anticipated modest demand growth from trade partners. Raising growth in the region will depend on the adoption of structural reforms that generate substantial productivity gains. Rebuilding fiscal space and securing debt sustainability will hinge on efforts to increase tax revenue and reorienting spending to social and investment priorities. In the non-officially dollarized economies, it will also be essential to strengthen the monetary policy frameworks to keep inflation low and increase exchange rate flexibility, and improve financial regulation and supervision.
Maintenance Of Nas Enroute Stage A Air Traffic Control System
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Author : United States. Federal Aviation Administration
language : en
Publisher:
Release Date : 1968
Maintenance Of Nas Enroute Stage A Air Traffic Control System written by United States. Federal Aviation Administration and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1968 with Air traffic control categories.
Biobetters
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Author : Amy Rosenberg
language : en
Publisher: Springer
Release Date : 2015-08-21
Biobetters written by Amy Rosenberg and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-08-21 with Medical categories.
“Biobetters: Protein Engineering to Approach the Curative” discusses the optimization of protein therapeutic products for treatment of human diseases. It is based on the fact that though numerous important therapeutic protein products have been developed for life threatening and chronic diseases that possess acceptable safety and efficacy profiles, these products have generally not been reexamined and modified for an improved clinical performance, with enhancements both to safety and efficacy profiles. Advances in protein engineering, coupled with greatly enhanced understanding of critical product quality attributes for efficacy and safety, make it possible to optimize predecessor products for clinical performance, thereby enhancing patient quality of life and with the potential for great savings in health care costs. Yet despite such knowledge, there is little movement towards such modifications. This book examines engineering protein therapeutic products such that they exhibit an optimal, not just an adequate, clinical performance profile. Two product classes, therapeutic enzymes for lysosomal storage diseases (enzyme replacement therapies, ERT) and monoclonal antibodies (mAbs), are used as examples of what modifications to such proteins could be made to enhance clinical performance, “closer to a cure” as it were. For ERT, the key to optimizing clinical performance is to ensure the ERT is endowed with moieties that target the protein to the relevant target tissue. Thus, for Gaucher Disease, our best example of how to optimize an ERT to address a disease that manifests in specific target tissues (macrophages and monocytes), the enzyme has been extensively modified to target macrophages. For diseases such as Pompe Disease, largely a disorder of muscle, optimal performance of ERT will depend on endowing the enzyme with the ability to be taken up via the Mannose 6 Phosphate Receptor, and so one of the chapters in the book will discuss such approaches. Moreover, a major failure of biotechnology based products is to gain access to the CNS, a key target tissue in numerous diseases. Thus, a chapter has been devoted to strategies to access the CNS. Additionally, immune responses to therapeutic proteins can be highly problematic, eliminating the efficacy of life saving or highly effective protein therapeutics. This is especially poignant in the case of Pompe Disease wherein great improvement in muscle strength and functionality is lost following development of an immune response to the ERT with consequent patient deterioration and death. Thus, a chapter regarding protein engineering, as well as other non-clinical approaches to diminishing immunogenicity is a valuable part of the book. Monoclonal antibodies (mAbs) can be engineered to bind targets relevant to a wide variety of diseases; binding affinity, however, is only part of the equation and one of the chapters will present a molecular assessment approach that balances affinity with pharmacokinetics and manufacturability. As with other proteins immunogenicity can be problematic, being responsible for loss of efficacy of anti-TNF mAbs, often after prolonged successful treatment. The authors will also share their perspective on the consequences of physico-chemical modifications occurring to mAbs once they reach the circulation or their target, a research area open to further development from a protein engineering as well as analytical perspective. This book will also discuss novel platforms for protein therapeutics, technologies that exceed mAbs with respect to potency, and hence, potentially efficacy. These platforms consist largely of repeat domain proteins with very high affinity for their target ligands, but while potentially more efficacious, immunogenicity may be a major problem limiting use. The economics surrounding the issue of biobetters is another high-profile issue - this final chapter will explore the incentives and disincentives for developing biobetters and consider incentives that might make their pursuit more rewarding.
British Museum Catalogue Of Printed Books
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Author :
language : en
Publisher:
Release Date : 1884
British Museum Catalogue Of Printed Books written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1884 with categories.
Index Of Federal Specifications Standards And Commercial Item Descriptions
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language : en
Publisher:
Release Date :
Index Of Federal Specifications Standards And Commercial Item Descriptions written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on with Commercial products categories.
Daily River Stages
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Author :
language : en
Publisher:
Release Date : 1966
Daily River Stages written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1966 with Stream measurements categories.
The Blood Brain Barrier Bbb
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Author : Gert Fricker
language : en
Publisher: Springer
Release Date : 2014-10-24
The Blood Brain Barrier Bbb written by Gert Fricker and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-10-24 with Science categories.
Medicinal chemistry is both science and art. The science of medicinal chemistry offers mankind one of its best hopes for improving the quality of life. The art of medicinal chemistry continues to challenge its practitioners with the need for both intuition and experience to discover new drugs. Hence sharing the experience of drug research is uniquely beneficial to the field of medicinal chemistry. Drug research requires interdisciplinary team-work at the interface between chemistry, biology and medicine. Therefore, the topic-related series Topics in Medicinal Chemistry covers all relevant aspects of drug research, e.g. pathobiochemistry of diseases, identification and validation of (emerging) drug targets, structural biology, drugability of targets, drug design approaches, chemogenomics, synthetic chemistry including combinatorial methods, bioorganic chemistry, natural compounds, high-throughput screening, pharmacological in vitro and in vivo investigations, drug-receptor interactions on the molecular level, structure-activity relationships, drug absorption, distribution, metabolism, elimination, toxicology and pharmacogenomics. In general, special volumes are edited by well known guest editors.