Bile Acids
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The Bile Acids Chemistry Physiology And Metabolism
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Author : P. Nair
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
The Bile Acids Chemistry Physiology And Metabolism written by P. Nair and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Science categories.
The first two volumes of this series addressed themselves to the chemistry, physiology, and metabolism of the bile acids. The present volume is devoted to the pathophysiology of bile acids. As the role of bile acids in health and disease is being increasingly recognized, we have chosen for discussion a wide range of topics of current importance. The presence of bile acids in brain tissue and their possible role in demyelinating diseases form the subject of a provocative discussion. As an extension of this theme, the presence and quantification of bile acids in extrahepatic tissues is the subject of one chapter. The pathophysiological implications of bile acids at the macromolecular level is highlighted by a chapter on the influence of bile salts on the activity of various enzymes. The general area of hepatobiliary diseases is discussed in two chapters: one describes changes in bile salt metabolism in liver diseases and the other focuses on cholesterol gallstones and their formation and dissolution. Cerebrotendinous xanthomatosis has been shown to entail a defect in bile acid and sterol metabolism, and this metabolic error is the subject of an illuminating exposition. There is presently a concerted research effort being brought to bear on the causes of colon cancer, and one important aspect of this work centers on bile acid metabolism. Aspects of bile acid metabolism and cancer are the subject of two chapters. And finally, the role of dietary fiber in bile acid metabolism is updated.
The Bile Acids Chemistry Physiology And Metabolism
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Author : P. Nair
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
The Bile Acids Chemistry Physiology And Metabolism written by P. Nair and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Science categories.
1 Mechanisms of Bile Acid Biosynthesis.- I. Introduction.- II. Formation of Cholic Acid.- A. Changes in Steroid Nucleus.- B. Oxidation of Side Chain.- III. Formation of Chenodeoxycholic Acid.- IV. Formation of Other Primary Bile Acids.- V. Conjugation of Bile Acids.- VI. Regulation of Bile Acid Formation.- VII. Formation of Bile Salts in "Primitive" Animals.- A. Changes in Steroid Nucleus.- B. Oxidation of Side Chain.- References.- 2 Bile Salt Transport Systems.- I. Introduction.- II. Active Transport in the Intestine.- III. Passive Proximal Intestinal Absorption of Bile Salts.- IV. Passive Ab.
The Bile Acids Chemistry Physiology And Metabolism
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Author : P. Nair
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-12-11
The Bile Acids Chemistry Physiology And Metabolism written by P. Nair and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-12-11 with Science categories.
The bile acids as principal end products of cholesterol metabolism occupy a focal position in our understanding of the role of steroids in bio logical systems. The biogenesis of bile acids from cholesterol in higher ani mals, and their functions in regulating sterol metabolism and in gastrointestinal physiology have been elucidated by the development of elegant methodo logical approaches during the last two decades. The molecular pleomorphism exhibited by the bile acids and bile alcohols in the animal kingdom is a classic example of their role in biochemical evolution. The total story of the bile acids, their chemistry, their role in normal and abnormal physiological processes, and their significance in biochemical evolution has never been available in the form of a comprehensive treatise written in the words of those who have contributed to the development of our knowledge in this area. The Bile Acids, in two volumes, will serve to fill this void, and will also bring together information which will prove in valuable to both the biochemist and the medical scientist. We wish to thank Mrs. Sally Wiseman and Mrs. Lillian Haas for their invaluable assistance with the editing of the manuscripts. This work was supported in part by grants AM-02131, General Research Support SS0-1- FR-05479 (P.P.N.), HE-03299, HE-05209, and a National Heart Institute Research Career Award (D.K. ), K6-HE-734, from the National Institutes of Health, United States Public Health Service. P.P.N. Baltimore, Maryland D.K.
Biology Of Bile Acids In Health And Disease
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Author : G.P. van Berge Henegouwen
language : en
Publisher: Springer Science & Business Media
Release Date : 2001-05-31
Biology Of Bile Acids In Health And Disease written by G.P. van Berge Henegouwen and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2001-05-31 with Medical categories.
Beginning in 1970, the International Bile Acid Meeting has taken place every two years and each time new progress in our understanding of the complex role of bile acids in many metabolic processes of the liver and the intestine has been revealed by a selected group of leading scientists from all over the world. Although originally mainly physiological data on bile acid synthesis and transport were emphasized, and later on also the therapeutic benefit of bile acids in gallstone disease and cholestasis was discovered, we have come now to the molecular biology and genetic era with major discoveries in transport defects and related diseases. This book is the proceedings of Falk Symposium No. 120, held in The Hague, The Netherlands, on October 12-13, 2000 - the 16th International Bile Acid Meeting. One of the main discoveries recently has been the identification of nuclear receptors for bile acids, which gives them a much broader perspective than previously anticipated. It even suggests that bile acids can regulate their biosynthesis and enterohepatic circulation transcriptionally. It will therefore not be surprising that this topic, together with the molecular regulation of cholesterol 7alpha-hydroxylase and cholesterol homeostasis, has a dominant place in these proceedings. Another important topic is the progress in our molecular understanding of hepatic (both at the basolateral and canalicular sites), cholangiocytic and intestinal bile acid transport processes. Further insights into genetic defects causing cholestasis or intestinal malabsorption in animal models and in human diseases are also discussed by a number of well-known authors. Finally the last section deals with new findings on the role of bile acid therapy in cholestatic syndromes or chemoprevention and with the potential benefit of bile acid inhibitors. All contributors provide an update on the most recent developments in their field.
The Bile Acids Chemistry Physiology And Metabolism
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Author : K.D.R. Setchell
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
The Bile Acids Chemistry Physiology And Metabolism written by K.D.R. Setchell and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.
Over a decade has elapsed since the last volume in this series was published. At that time we considered that we had comprehensively covered all aspects relating to bile acid chemistry and physiology. However, major strides have been made in our understanding of the physiology and pathophysiology of bile acids, due largely to the great advances which have taken place in analytical technology. As a result, the need to document these advances was felt acutely, and therefore this volume is devoted to methodologies in bile acid analysis and their applications. This volume includes twelve chapters written by prominent scientists in the field of bile acid research. The initial chapter discusses techniques of extraction and isolation of bile acids from biological fluids. It is followed by descriptions of physical methods of analysis and discussions of the way these techniques have been applied in the field of bile acid research. Of practical value is the inclusion of a comprehensive list of spectra obtained for refer ences by nuclear magnetic resonance spectroscopy and mass spectrometry . These chapters are followed by reviews of biological methods of immuno assay and bioluminescence. Specific applications of these techniques are then addressed in contributions relating to bile acid analysis of tissue, serum, urine, and feces. With this integrated approach we have attempted to provide a volume which represents a comprehensive review of the analytical field of bile acids, while also serving as a useful reference book for those workers involved in bile acid analysis.
Bile Acids
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Author : Gareth J. Jenkins
language : en
Publisher: Royal Society of Chemistry
Release Date : 2008
Bile Acids written by Gareth J. Jenkins and has been published by Royal Society of Chemistry this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008 with Medical categories.
Bile acids are increasingly being seen as extremely important carcinogenic agents in cancers of the bile duct, liver, colon, rectum, and oesophagus. They are essential agents involved in lipid digestion and absorption in mammals, however, they also play wide-ranging roles in a variety of disease states ranging from diabetes to cancer. They have evolved exquisite mechanisms for controlling their own synthesis and to ensure that they are produced at correct concentrations and also kept in the correct anatomical environment. It is only when these fine levels of controls are breached that Bile aci.
Workshops In Bile Acid Research
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Author : L. Barbara
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Workshops In Bile Acid Research written by L. Barbara and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.
During the 7th International Bile Acid meeting held in Cortina d'Ampezzo. , Italy, during March 1982, there were two important Workshops dealing with recent advances in two areas of bile acid metabolism - Serum Bile Acids i,n Health and Disease and The Pathophysiology of the Enterohepatic Circulation. These Workshops complemented the broad range of topics in bile acid metabolism which were presented formally as part of a Postgraduate Course. The proceedings of these formal presentations have already been pub lished by MTP Press under the title Bile Acids in Gastroenterology but in view of the exciting, important, new information which emerged during both Workshops, the organisers of the meeting felt that it would be valuable to record and edit the proceedings of the Work shops, which form the basis of this volume. The advent of new techniques for measurement of total and indi vidual bile acids in serum now means that accurate and reliable 7 PREFACE measurements of bile acids in peripheral circulation are available to all. This has resulted in a veritable explosion of information in the serum bile acid field and, therefore, the appearance of a critical evalu ation of the technical and basic scientific and clinical aspects of measuring serum bile acids is indeed timely.
Liver Nutrition And Bile Acids
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Author : G. Galli
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-03-09
Liver Nutrition And Bile Acids written by G. Galli and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-03-09 with Science categories.
Sterols And Bile Acids
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Author :
language : en
Publisher: Elsevier
Release Date : 1985-01-01
Sterols And Bile Acids written by and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 1985-01-01 with Science categories.
Sterols and Bile Acids
Bile Acids In Gastroenterology
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Author : Susumu Tazuma
language : en
Publisher: Springer
Release Date : 2017-04-03
Bile Acids In Gastroenterology written by Susumu Tazuma and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-04-03 with Medical categories.
This book examines the biological aspects of bile acid analysis and their clinical applications, providing readers with an overview of cutting-edge discussions on Bile Acid research and diseases. It begins with detailed discussions on the biological aspects of bile acid, with chapters examining bile acid from various perspectives, from its metabolism to its use in therapeutic agents. Subsequent chapters focus on diseases involving bile acid abnormalities, and specific applications are addressed concerning gallstones, cholestatic liver disease, NAFLD/NASH, hepatitis, pancreatitis, esophageal cancer and colon cancer. In keeping with the book’s integrated approach, the Editor has gathered a broad range of eminent scholars and practitioners to provide a comprehensive review of modern bile acid research. The book offers clinical physicians, basic researchers and postgraduate students essential insights into cutting-edge research and paves the way for further research.