Bioactive Microbial Products 2
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Bioactive Microbial Products 2
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Author : L. J. Nisbet
language : en
Publisher: Academic Press
Release Date : 1983
Bioactive Microbial Products 2 written by L. J. Nisbet and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1983 with Medical categories.
Bioactive Microbial Products Vol 2 Development And Production Ed By L J Nisbet D J Winstanley
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Author :
language : en
Publisher:
Release Date : 1983
Bioactive Microbial Products Vol 2 Development And Production Ed By L J Nisbet D J Winstanley written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1983 with categories.
Bioactive Metabolites From Microorganisms
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Author : M. E. Bushell
language : en
Publisher: Elsevier Publishing Company
Release Date : 1989
Bioactive Metabolites From Microorganisms written by M. E. Bushell and has been published by Elsevier Publishing Company this book supported file pdf, txt, epub, kindle and other format this book has been release on 1989 with Science categories.
This volume summarizes major approaches and recent developments in the research on new bioactive metabolites of microbial origin including target-directed screening strategies, evaluation of new drugs, biosynthesis, genetic manipulation, and semisynthesis. Particular attentonis given to new microbial sources of drugs, new approaches towards directed screening, advances and future perspectives in antimicrobial, antineoplastic and phytoeffectory agents, and enzyme inhibitors as pharmacological agents. The contributions represent comprehensive surveys written by recognized scientists active in their fields of research. Together, they give an interdisciplinary view which focusses on exploitation of available microbial sources for drug development, problems of evaluation, mode of action, biosynthesis and application. The book will be of interest to scientists working in microbiology, pharmacology, pharmaceutical chemistry and pharmaceutical biotechnology.
Microbial Transformations Of Bioactive Compounds
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Author : John P. Rosazza
language : en
Publisher: CRC Press
Release Date : 1982-07
Microbial Transformations Of Bioactive Compounds written by John P. Rosazza and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1982-07 with Medical categories.
Volume 1: Notes on the historical development of microbial transformations; The methodology of microbial transformations of organic compounds; Microbial transformations of antibiotics; Microbial transformation of important industrial hydrocarbons; Microbial transformations of prostaglandins. Volume 2: Microbial transformations as a means of preparing mammalian drug metabolites; Transformations of xenobiotics by the intestinal microflora; Microbial transformations of alkaloids; Microbial transformations of cannabinoids; Microbial transformations of pesticides.
Bioactive Microbial Natural Products From Unique Indonesian Black Water Ecosystems
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Author : Yan Sheng
language : en
Publisher:
Release Date : 2015
Bioactive Microbial Natural Products From Unique Indonesian Black Water Ecosystems written by Yan Sheng and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015 with Macrolide antibiotics categories.
The discovery of new antibiotics reached its peak during the golden era of antibiotics in the mid 20th century and continued to thrive until the 1980s. However, after more than 50 years of fruitful exploration and exploitation of microbial natural products the discovery rate of new antibiotics has dropped drastically in recent decades. On the other hand, known compounds were re-discovered again and again, possibly from related producing organisms, making natural products discovery an expensive and time-consuming endeavor. Therefore, in recent years, efforts for discovering new natural products have been redirected towards organisms from unique and untapped areas of the globe with remarkable biodiversity potential and/or extreme environment, such as deep-sea vents, caves, and other unusual ecosystems. This dissertation describes our efforts to discover new bioactive natural products from microorganisms isolated from a unique black water ecosystem in Indonesia. Indonesia is recognized as a major center in the world for biodiversity and is one of the countries with the highest level of endemic species and microorganisms that live in its various ecosystems. Among them are the "black-water" rivers, which flow in the steamy jungles of islands along the Indonesian archipelago, providing unique environments for its flora and fauna. In collaboration with scientists at the Indonesian Center for Biodiversity and Biotechnology (ICBB), we investigated bioactive secondary metabolites of microorganisms from the soil samples of a black water ecosystem on Borneo Island, Indonesia. 16S rRNA sequence analysis was used for the identification of the bacteria, and from 141 bacterial strains investigated, 77% were Streptomyces, 6% were non-Streptomyces actinomycetes, and 17% were non-actinomycete strains. About one third of the strains were screened for their bioactive secondary metabolites production. The EtOAc and n-BuOH extracts of the culture broths of the bacteria were subjected to antibacterial and antifungal assays, as well as mass spectrometry analysis. More than half of the screened Streptomyces (18 out of 24) showed activities against one or more pathogenic microorganisms, whereas only 2 out of 14 of the non-actinomycete strains showed antibacterial activities. Furthermore, chemical screening of 9 non-Streptomyces actinomycetes revealed that 3 strains, all of which are Amycolatopsis spp., produce the anticancer agents the apoptolidins. Chemical investigation of the strain Streptomyces albiflaviniger ICBB 9297 delivered four new elaiophylin-like macrolides and five known elaiophylins. The new compounds have macrocyclic skeletons distinct from those of the known elaiophylins, in which one or both of the dimeric polyketide chains contain(s) an additional pendant methyl group. However, they showed comparable antibacterial activity to elaiophylin against Staphylococcus aureus. Interestingly, those with the additional pendant methyl group on only one of the polyketide chains showed significantly increased activity against Mycobacterium smegmatis, whereas the one with two additional methyl groups and the known elaiophylin analogues showed no activity. The production of the new analogues suggests that the last acyltrasferase (AT) domain of the elaiophylin polyketide synthases has relaxed substrate specificity. Bioinfomatic analysis of the conserved active site residues within the AT domains revealed an unusual amino acid sequence of the active site motif in the AT7 domain. Investigations of the apoptolidin producer Amycolatopsis sp. ICBB 8242 led to the discovery of two succinylated apoptolidin analogues and linear apoptolidin A. The two succinylated compounds can inhibit the proliferation and viability of human H292 and HeLa cells. However, in contrast to apoptolidin A, they do not inhibit cellular respiration in H292 cells. This seemingly contradictory results may be due to an alternative biological mechanism of action or due to degradation of succinyl-apoptolidin A to apoptolidin A in the cell viability assay. This hydrolysis may not occur during the real time analysis of cellular respiration, which was performed in a relatively short experimental time. The production of succinylated apoptolidins by Amycolatopsis sp. ICBB 8242 suggests that succinylation may play a role in self-resistance and/or as an export mechanism.
Recent Progress In The Chemical Synthesis Of Antibiotics And Related Microbial Products Vol 2
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Author : Gabor Lukacs
language : en
Publisher: Springer
Release Date : 2011-12-05
Recent Progress In The Chemical Synthesis Of Antibiotics And Related Microbial Products Vol 2 written by Gabor Lukacs and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-12-05 with Science categories.
The 1st Euchem Symposium on the Chemical Synthesis of Antibiotics was held in Aussois in Savoie, France on May 2-6, 1988 thanks to the efforts of Prof. G. Lukacs, chairperson, and Prof. F. Arcamone and Prof. P. Welzel, vice-chairpersons of the International Organizing Committee. Following the great success of the Ist Symposium, the 2nd Symposium, which was chaired by Prof. Ohno, was held in Oiso, Japan in 1990. The 3rd Symposium, chaired by Prof. K. Krohn, was held in Kloster Banz, Germany in 1992. It has been decided that the 4th Symposium will take place in the United States in 1994 and be chaired by Dr. H. A. Kirst of Lilly Research Laboratories. The Euchem Symposium has come to serve as an important symposium where one can understand the development and the future directions of the chemical synthesis of antibiotics and other bioactive metabolites from microorganisms. Prof. G. Lukacs, in cooperation with Prof. M. Ohno, edited the book "Recent Progress in the Chemical Synthesis of Antibiotics" three years ago. Most of its contributors were the participants of the Aussois Symposium. This book attracted the attention of researchers specializing in organic synthesis and stimulated considerable progress in this field.
Recent Advancement In White Biotechnology Through Fungi
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Author : Ajar Nath Yadav
language : en
Publisher: Springer
Release Date : 2019-05-08
Recent Advancement In White Biotechnology Through Fungi written by Ajar Nath Yadav and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-05-08 with Science categories.
White biotechnology is industrial biotechnology dealing with various biotech products through applications of microbes. The main application of white biotechnology is commercial production of various useful organic substances, such as acetic acid, citric acid, acetone, glycerine, etc., and antibiotics like penicillin, streptomycin, mitomycin, etc., and value added product through the use of microorganisms especially fungi and bacteria. The value-added products included bioactive compounds, secondary metabolites, pigments and industrially important enzymes for potential applications in agriculture, pharmaceuticals, medicine and allied sectors for human welfare. In the 21st century, techniques were developed to harness fungi to protect human health (through antibiotics, antimicrobial, immunosuppressive agents, value-added products etc.), which led to industrial scale production of enzymes, alkaloids, detergents, acids, biosurfactants. The first large-scale industrial applications of modern biotechnology have been made in the areas of food and animal feed production (agricultural/green biotechnology) and pharmaceuticals (medical/red biotechnology). In contrast, the production of bio-active compounds through fermentation or enzymatic conversion is known industrial or white biotechnology. The beneficial fungal strains may play important role in agriculture, industry and the medical sectors. The beneficial fungi play a significance role in plant growth promotion, and soil fertility using both, direct (solubilization of phosphorus, potassium and zinc; production of indole acetic acid, gibberellic acid, cytokinin and siderophores) and indirect (production of hydrolytic enzymes, siderophores, ammonia, hydrogen cyanides and antibiotics) mechanisms of plant growth promotion for sustainable agriculture. The fungal strains and their products (enzymes, bio-active compounds and secondary metabolites) are very useful for industry. The discovery of antibiotics is a milestone in the development of white biotechnology. Since then, white biotechnology has steadily developed and now plays a key role in several industrial sectors, providing both high valued nutraceuticals and pharmaceutical products. The fungal strains and bio-active compounds also play important role in the environmental cleaning. This volume covers the latest research developments related to value-added products in white biotechnology through fungi.
The Search For Bioactive Compounds From Microorganisms
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Author : Satoshi Omura
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
The Search For Bioactive Compounds From Microorganisms written by Satoshi Omura and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Science categories.
Biologically active compounds isolated from microorganisms continue to be vital to the development of new drugs and agricultural chemicals. This book was prepared by current and past members of the laboratory of Dr. Satoshi Omura of the Kitasato Institute in Japan. Dr. Omura and his colleagues have discovered and studied a number of important antibiotics, and in their work they have pioneered new methods for screening microbes for interesting and important compounds. This book presents strategies and methods for identifying novel molecules with several types of biological activity. In addition, the book discusses the identification of microbial compounds of agrochemical importance, presents information on chemical screening methods, and concludes with chapters on microbial strain selection, fermentation technology, and genetic engineering of antibiotic-producing microorganisms. This book will be of great interest to scientists working in the very active and competitive fields of antibiotic and agrochemical discovery.
Bioactive Microbial Products 2
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Author : L. J. Nisbet
language : en
Publisher: Academic Press
Release Date : 1983
Bioactive Microbial Products 2 written by L. J. Nisbet and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1983 with Medical categories.
Biotechnology Of Bioactive Compounds
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Author : Vijai Kumar Gupta
language : en
Publisher: John Wiley & Sons
Release Date : 2015-04-20
Biotechnology Of Bioactive Compounds written by Vijai Kumar Gupta and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-04-20 with Technology & Engineering categories.
Bioactive compounds play a central role in high-value product development in the chemical industry. Bioactive compounds have been identified from diverse sources and their therapeutic benefits, nutritional value and protective effects in human and animal healthcare have underpinned their application as pharmaceuticals and functional food ingredients. The orderly study of biologically active products and the exploration of potential biological activities of these secondary metabolites, including their clinical applications, standardization, quality control, mode of action and potential biomolecular interactions, has emerged as one of the most exciting developments in modern natural medicine. Biotechnology of Bioactive Compounds describes the current stage of knowledge on the production of bioactive compounds from microbial, algal and vegetable sources. In addition, the molecular approach for screening bioactive compounds is also discussed, as well as examples of applications of these compounds on human health. The first half of the book comprises information on diverse sources of bioactive compounds, ranging from microorganisms and algae to plants and dietary foods. The second half of the book reviews synthetic approaches, as well as selected bioactivities and biotechnological and biomedical potential. The bioactive compounds profiled include compounds such as C-phycocyanins, glycosides, phytosterols and natural steroids. An overview of the usage of bioactive compounds as antioxidants and anti-inflammatory agents, anti-allergic compounds and in stem cell research is also presented, along with an overview of the medicinal applications of plant-derived compounds. Biotechnology of Bioactive Compounds will be an informative text for undergraduate and graduate students of bio-medicinal chemistry who are keen to explore the potential of bioactive natural products. It also provides useful information for scientists working in various research fields where natural products have a primary role.