Bioelectronic Medicine
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Bioelectronic Medicine
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Author : Valentin A. Pavlov
language : en
Publisher:
Release Date : 2019
Bioelectronic Medicine written by Valentin A. Pavlov and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019 with categories.
"Electronic devices can now be used to analyse and modulate the electrical activity within the nervous system. This book explores how development of these devices is leading to new diagnostics and treatment options for patients. Topics covered in this essential volume include:- Restoring Movement in Paralyzed Limbs: Future Directions and Challenges- The Use of Bioelectronics in the Gastrointestinal Tract- Harnessing the Cholinergic Inflammatory Reflex with Neurostimulation- The Vagus Nerve as a Sensor-Actuator Network: A Computer Science Perspective- Alternative Methods for Noninvasive Neuromodulation of the Peripheral Nervous System Using Ultrasound- Diabetes Technology: Monitoring, Analytics, and Optimal Control"--Provided by publisher.
Wireless Bioelectronic Devices Driven By Deep Red Light
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Author : Marie Jakešová
language : en
Publisher: Linköping University Electronic Press
Release Date : 2021-01-22
Wireless Bioelectronic Devices Driven By Deep Red Light written by Marie Jakešová and has been published by Linköping University Electronic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-01-22 with Electronic books categories.
The use of electronic devices in medical care is one of the main targets of precision medicine. The field of bioelectronic medicine uses electronic devices to diagnose or treat diseases and disorders in a complementary or alternative way to chemical drugs. It has been more than sixty years since the world’s first implantable battery-driven cardiac pacemaker was implanted here in Sweden. Since then, electronic therapies have been implemented for neurological disorders such as Parkinson’s disease, epilepsy, sensory and motor function restoration, and many more. However, electronics can also be used for delivery of conventional drugs in a more controlled, localized, and specific fashion. Therapeutic utility and patient comfort are maximized when the devices are as minimally invasive as possible. The most important milestone in the development of the cardiac stimulator was making it wireless. The early versions of the device required bulky parts to be placed outside of the body with transcutaneous electrical leads to the target site which led to high infection risk and frequent failures. To date, batteries remain the most common way to power implantable electronics. However, their large size and the necessity for replacement surgeries makes the technology relatively invasive. Alternative approaches to wireless power transfer are thus sought after. The most promising technologies are based on electromagnetic, ultrasound, or light-coupling methods. The aim of this thesis is to utilize tissue-penetrating deep red light for powering implantable devices. The overarching concept is an organic photovoltaic based on small molecule donor-acceptor bilayer junctions, which allows for ultrathin, flexible, minimally-invasive devices. Within this thesis, the photovoltaic device was utilized in two ways. Firstly, the photovoltaics are fabricated to act as an integrated driver for other implantable electronic components: 1) an organic electronic ion pump for acetylcholine delivery; 2) a depth-probe microelectrode stimulation device for epilepsy applications. Secondly, an alternative device, the organic electrolytic photocapacitor, is formed by replacing one of the solid electrodes by an electrolytic contact, thus yielding a minimalistic device acting as a direct photoelectrical stimulator. Within the thesis, the photocapacitive stimulation mechanism is validated by studying voltage-gated ion channels in a frog oocyte model. Next, two lithography-based patterning techniques are developed for fabricating these devices with better resolution and on flexible substrates suitable for in vivo operation. Finally, a chronic implant is demonstrated for in vivo sciatic nerve stimulation in rodents. The end result of this thesis is a series of novel device concepts and methods for stimulation of the nervous system using deep red light.
Electric Curses
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Author :
language : en
Publisher:
Release Date : 2015
Electric Curses written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015 with categories.
Bioelectronic Medicine
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Author : Valentin A. Pavlov
language : en
Publisher: Perspectives Cshl
Release Date : 2019
Bioelectronic Medicine written by Valentin A. Pavlov and has been published by Perspectives Cshl this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019 with Medical categories.
"Cold Spring Harbor perspectives in medicine."
Detection Of Acute Biomarkers To Optimize Target Engagement In Bioelectronic Medicine
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Author : Nishant Verma
language : en
Publisher:
Release Date : 2022
Detection Of Acute Biomarkers To Optimize Target Engagement In Bioelectronic Medicine written by Nishant Verma and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022 with categories.
Bioelectronic medicine, or neuromodulation, is a class of medical therapies that act by delivering stimulation to directly manipulate neurobiological activity and address pathophysiology. While the therapeutic response can be highly effective, it is often limited to a subset of 'responders'. We show that bioelectronic therapies are critically limited by inconsistent engagement of on- and off-target neural substrates at the site of stimulation. The work presented here consists of four studies focusing on improving local neural target engagement in bioelectronic medicine. In the first study, we develop a technique to directly measure on- and off-target neural activation that is minimally invasive and could be used clinically. A real-time measure is critical to guide stimulation electrode design and placement to optimize neural target engagement. We showed in large-animal experiments that a microneurography electrode, currently used in human research to measure spontaneous neural activity, can also be used to measure stimulation evoked neural activity relevant to bioelectronic medicine. In the second study, we use cadaver-validated computational models to investigate the Injectrode, a minimally invasive stimulation electrode. We showed the Injectrode increased the target engagement profile of noninvasive transcutaneous electrical stimulation (TENS) based bioelectronic medicine therapies by over an order of magnitude. In the third study, we apply the methods developed in the first two studies to improve the target engagement of an existing bioelectronic device: electronic bone growth stimulators (EBGSs). EBGS therapy has been used clinically for decades but shows sign of poor local target engagement. We used cadaver experiments and computational modeling to show that a miniscule fraction of the externally applied electric field (1,100 V/m) reaches the fracture site (21 V/m) during noninvasive EBGS therapy. We showed that Injectrode delivered at the fracture site could increase the electric field strength at the fracture site. In the fourth study, we combine MRI-based biomarkers, reflecting physiological effect, with considerations of local neural target engagement to develop a novel bioelectronic medicine therapy to restore glymphatic function with applications to Alzheimer's disease. We showed that electrical stimulation increased cerebral blood flow and decreased flow pulsatility, reversing the trends established with disease progression. This fourth preliminary study lays the groundwork for future directions in my career. This thesis contains a chapter, Chapter 6, written for the public audience to communicate the main findings and significance of the work.
Bioelectronics And Medical Devices
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Author : Garima Srivastava
language : en
Publisher: CRC Press
Release Date : 2021-12-16
Bioelectronics And Medical Devices written by Garima Srivastava and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-12-16 with Technology & Engineering categories.
This new volume provides an abundance of information on new biomedical applications being used today. The book covers a wide range of concepts and technologies, discussing such modern technological methods as the Internet of Things, e-pills, biomedical sensors, support vector machines, wireless devices, image and signal processing in e-health, and machine learning. It also includes a discussion on software implementation for the devices used in biomedical applications. The different types of antennas, including antennas using RF energy harvesting for biomedical applications, are covered as well.
Additive Manufacturing Of Electrochemical Systems And Their Application In Bioelectronic Medicine
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Author : Paola Sanjuan Alberte
language : en
Publisher:
Release Date : 2019
Additive Manufacturing Of Electrochemical Systems And Their Application In Bioelectronic Medicine written by Paola Sanjuan Alberte and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019 with categories.
Bioelectronics
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Author : Itamar Willner
language : en
Publisher: John Wiley & Sons
Release Date : 2006-03-06
Bioelectronics written by Itamar Willner and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2006-03-06 with Science categories.
Medicine, chemistry, physics and engineering stand poised to benefit within the next few years from the ingenuity of complex biological structures invented and perfected by nature over millions of years. This book provides both researchers and engineers as well as students of all the natural sciences a vivid insight into the world of bioelectronics and nature's own nanotechnological treasure chamber.
Bioelectronics And Medical Devices
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Author : Kunal Pal
language : en
Publisher: Woodhead Publishing
Release Date : 2019-06-18
Bioelectronics And Medical Devices written by Kunal Pal and has been published by Woodhead Publishing this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-06-18 with Technology & Engineering categories.
Bioelectronics and Medical Devices: From Materials to Devices-Fabrication, Applications and Reliability reviews the latest research on electronic devices used in the healthcare sector, from materials, to applications, including biosensors, rehabilitation devices, drug delivery devices, and devices based on wireless technology. This information is presented from the unique interdisciplinary perspective of the editors and contributors, all with materials science, biomedical engineering, physics, and chemistry backgrounds. Each applicable chapter includes a discussion of these devices, from materials and fabrication, to reliability and technology applications. Case studies, future research directions and recommendations for additional readings are also included. The book addresses hot topics, such as the latest, state-of the-art biosensing devices that have the ability for early detection of life-threatening diseases, such as tuberculosis, HIV and cancer. It covers rehabilitation devices and advancements, such as the devices that could be utilized by advanced-stage ALS patients to improve their interactions with the environment. In addition, electronic controlled delivery systems are reviewed, including those that are based on artificial intelligences.
Bioelectronic Medicines New Frontiers In Autonomic Neuromodulation
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Author : Arun Sridhar
language : en
Publisher: Frontiers Media SA
Release Date : 2022-07-05
Bioelectronic Medicines New Frontiers In Autonomic Neuromodulation written by Arun Sridhar and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-07-05 with Science categories.