Biogenesis And Function Of Primary Cilia In Mammalian Cells
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Biogenesis And Function Of Primary Cilia In Mammalian Cells
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Author : Charles Thomas Anderson
language : en
Publisher:
Release Date : 2007
Biogenesis And Function Of Primary Cilia In Mammalian Cells written by Charles Thomas Anderson and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007 with categories.
Primary Cilia
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Author :
language : en
Publisher: Academic Press
Release Date : 2009-11-30
Primary Cilia written by and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009-11-30 with Science categories.
In recent years, the role of cilia in the study of health, development and disease has been increasingly clear, and new discoveries have made this an exciting and important field of research. This comprehensive volume, a complement to the new three-volume treatment of cilia and flagella by King and Pazour, presents easy-to-follow protocols and detailed background information for researchers working with cilia and flagella. Covers protocols for primary cilia across several systems and species Both classic and state-of-the-art methods readily adaptable across model systems, and designed to last the test of time Relevant to clinicians and scientists working in a wide range of fields
Ciliary Function In Mammalian Development
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Author : Bradley Yoder
language : en
Publisher: Academic Press
Release Date : 2011-09-06
Ciliary Function In Mammalian Development written by Bradley Yoder and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-09-06 with Science categories.
Cilia--the tiny hairlike structures on the surface of cells—-have recently been identified as playing a role in a variety of disease and developmental disorders. Absent or defective cilia in certain cells can cause infertility, blindness, kidney disease, and lung disease. This volume presents recent findings in cilia research and current thought on the role of cilia in disease and developmental abnormalities.
Balancing The Distal Tip Length Of Primary Cilia Is Essential For Keeping Their Signaling Function In Mammalian Cells
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Author : Taishi Kanamaru
language : en
Publisher:
Release Date : 2021*
Balancing The Distal Tip Length Of Primary Cilia Is Essential For Keeping Their Signaling Function In Mammalian Cells written by Taishi Kanamaru and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021* with categories.
The Roles Of C2cd3 In Centriole Maturation And Primary Cilium Formation In Mammalian Cells
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Author : Xuan Ye
language : en
Publisher:
Release Date : 2014
The Roles Of C2cd3 In Centriole Maturation And Primary Cilium Formation In Mammalian Cells written by Xuan Ye and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014 with categories.
The cilium/flagellum is a microtubule-based cell surface organelle that exists broadly in many living organisms, from protozoa to metazoan. It is critical for mobility, sensory functions and signal transduction. The primary cilium plays critical roles in vertebrate development and physiology. Over the last decade, benefited from active biological and medical studies on this organelle, an increasing number of human genetic diseases have been found related to cilia defects, collectively known as "ciliopathy".Previously, our lab identified C2 calcium-dependent domain containing 3 (C2cd3) as an essential regulator for ciliogenesis. C2cd3 homozygous mutants exhibit defects in neural tube development, left-right asymmetry and limb patterning, consistent with the phenotypes of other cilia mutants. A great reduction in cilia number observed in C2cd3 mutants suggests it is essential for cilia formation. However, the molecular mechanism underlying C2cd3 function in ciliogenesis is still elusive. To understand the function of C2cd3, I examined its subcellular localization. A dynamic subcellular localization of C2cd3 is observed during the cell cycle. C2cd3 forms punctae around centrosome during interphase, which are dispersed during mitosis but leaving two fine dots at each spindle pole. This implies that C2cd3 may be localized to both centriolar satellites and centrosomes.To confirm its centriolar satellite localization, I found that C2cd3 punctae were dependent on dynein-mediated microtubule-dependent retrograde transport. Furthermore, C2cd3 colocalizes and physically interacts with known centriolar satellites components, Pcm1 and Bbs4. I also discovered that C2cd3 was targeted to centriolar satellites through the interaction between its C-terminus and Pcm1. However, C2cd3 is dispensable for centriolar satellite integrity and many known centriolar satellite functions, including Rab8 ciliary localization, microtubule arrangement and cell cycle progression. Surprisingly, I found that C2cd3 is essential for centriolar satellite recruitment of Centrin, suggesting its role in centriolar satellite-mediated transport.To study the second localization of C2cd3, I pinpointed C2cd3 to the distal ends of centrioles. Interestingly, C2cd3 is essential for the recruitment of both distal and subdistal appendages to the mother centriole. Furthermore, loss of C2cd3 results in failure in the recruitment of Ttbk2 to the mother centriole as well as the removal of Ccp110 from the mother centriole, two critical steps in initiating ciliogenesis. C2cd3 is also required for recruiting the intraflagellar transport proteins Ift88 and Ift52 to the mother centriole during ciliogenesis. Consistent with its role in distal appendage assembly, C2cd3 is essential for ciliary vesicle docking to the mother centriole. These results suggest that C2cd3 regulates cilium biogenesis by promoting the assembly of centriolar distal appendages, which are critical for docking ciliary vesicles and recruiting other essential ciliogenic proteins.Finally, to elucidate the role of C2cd3 in distal appendage assembly, I found that C2cd3 contributes to the centriolar recruitment of Centrin, a centriolar distal end protein. Ofd1 and Dzip1, two regulators of distal and subdistal appendages, fail to be recruited to centrioles in C2cd3 mutant cells. I propose that C2cd3 may mediate distal appendage recruitment by regulating centriole elongation.In summary, my results indicate that C2cd3 regulates cilia formation by facilitating the recruitment of centriolar distal appendages. In the absence of C2cd3, distal appendages fail to be installed onto the mother centriole and all the downstream events for initiating the ciliogenesis are affected. The distal appendage defect might be a secondary effect of disrupted centriole diatal structure when C2cd3 is absent. I have also described the road map for studying how C2cd3 regulates centriole biogenesis and interplays with other distal appendage regulators in the future.
Cilia And Flagella
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Author :
language : en
Publisher: Academic Press
Release Date : 1995-08-31
Cilia And Flagella written by and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1995-08-31 with Science categories.
Cilia and Flagella presents protocols accessible to all individuals working with eukaryotic cilia and flagella. These recipes delineate laboratory methods and reagents, as well as critical steps and pitfalls of the procedures. The volume covers the roles of cilia and flagella in cell assembly and motility, the cell cycle, cell-cell recognition and other sensory functions, as well as human diseases and disorders. Students, researchers, professors, and clinicians should find the book's combination of "classic" and innovative techniques essential to the study of cilia and flagella. Key Features* A complete guide containing more than 80 concise technical chapters friendly to both the novice and experienced researcher* Covers protocols for cilia and flagella across systems and species from Chlamydomonas and Euglena to mammals* Both classic and state-of-the-art methods readily adaptable across model systems, and designed to last the test of time, including microscopy, electrophoresis, and PCR* Relevant to clinicians interested in respiratory disease, male infertility, and other syndromes, who need to learn biochemical, molecular, and genetic approaches to studying cilia, flagella, and related structures
Autophagy Cancer Other Pathologies Inflammation Immunity Infection And Aging
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Author : M. A. Hayat
language : en
Publisher: Academic Press
Release Date : 2016-12-28
Autophagy Cancer Other Pathologies Inflammation Immunity Infection And Aging written by M. A. Hayat and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-12-28 with Medical categories.
Autophagy: Cancer, Other Pathologies, Inflammation, Immunity, Infection, and Aging is an eleven volume series that discusses in detail all aspects of autophagy machinery in the context of health, cancer, and other pathologies. Autophagy maintains homeostasis during starvation or stress conditions by balancing the synthesis of cellular components and their deregulation by autophagy. This series discusses the characterization of autophagosome-enriched vaccines and its efficacy in cancer immunotherapy. Autophagy serves to maintain healthy cells, tissues, and organs, but also promotes cancer survival and growth of established tumors. Impaired or deregulated autophagy can also contribute to disease pathogenesis. Understanding the importance and necessity of the role of autophagy in health and disease is vital for the studies of cancer, aging, neurodegeneration, immunology, and infectious diseases. Comprehensive and forward-thinking, these books offer a valuable guide to cellular processes while also inciting researchers to explore their potentially important connections. Presents the most advanced information regarding the role of the autophagic system in life and death Examines whether autophagy acts fundamentally as a cell survivor or cell death pathway or both Introduces new, more effective therapeutic strategies in the development of targeted drugs and programmed cell death, providing information that will aid in preventing detrimental inflammation Features recent advancements in the molecular mechanisms underlying a large number of genetic and epigenetic diseases and abnormalities, including atherosclerosis and CNS tumors, and their development and treatment Includes chapters authored by leaders in the field around the globe—the broadest, most expert coverage available
Integrated Nano Biomechanics
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Author : Takami Yamaguchi
language : en
Publisher: William Andrew
Release Date : 2018-06-27
Integrated Nano Biomechanics written by Takami Yamaguchi and has been published by William Andrew this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-06-27 with Medical categories.
Integrated Nano-Biomechanics provides an integrated look into the rapidly evolving field of nanobiomechanics. The book demystifies the processes in living organisms at the micro- and nano-scale through mechanics, using theoretical, computational and experimental means. The book develops the concept of integrating different technologies along the hierarchical structure of biological systems and clarifies biomechanical interactions among different levels for the analysis of multi-scale pathophysiological phenomena. With a focus on nano-scale processes and biomedical applications, it is shown how knowledge obtained can be utilized in a range of areas, including diagnosis and treatment of various human diseases and alternative energy production. This book is based on collaboration of researchers from a unique combination of fields, including biomechanics, computational mechanics, GPU application, electron microscopy, biology of motile micro-organisms, entomological mechanics and clinical medicine. The book will be of great interest to scientists and researchers involved in disciplines, such as micro- and nano-engineering, bionanotechnology, biomedical engineering, micro- and nano-scale fluid-mechanics (such as in MEMS devices), nanomedicine and microbiology, as well as industries such as optical devices, computer simulation, plant based energy sources and clinical diagnosis of the gastric diseases. Provides knowledge of integrated biomechanics, focusing on nano-scale, in this rapidly growing research field Explains how the different technologies can be integrated and applied in a variety of biomedical application fields, as well as for alternative energy sources Uses a collaborative, multidisciplinary approach to provide a comprehensive coverage of nano-biomechanics
The Liver
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Author : Irwin M. Arias
language : en
Publisher: John Wiley & Sons
Release Date : 2020-03-09
The Liver written by Irwin M. Arias and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-03-09 with Medical categories.
Bridging the gap between basic scientific advances and the understanding of liver disease — the extensively revised new edition of the premier text in the field. The latest edition of The Liver: Biology and Pathobiology remains a definitive volume in the field of hepatology, relating advances in biomedical sciences and engineering to understanding of liver structure, function, and disease pathology and treatment. Contributions from leading researchers examine the cell biology of the liver, the pathobiology of liver disease, the liver’s growth, regeneration, metabolic functions, and more. Now in its sixth edition, this classic text has been exhaustively revised to reflect new discoveries in biology and their influence on diagnosing, managing, and preventing liver disease. Seventy new chapters — including substantial original sections on liver cancer and groundbreaking advances that will have significant impact on hepatology — provide comprehensive, fully up-to-date coverage of both the current state and future direction of hepatology. Topics include liver RNA structure and function, gene editing, single-cell and single-molecule genomic analyses, the molecular biology of hepatitis, drug interactions and engineered drug design, and liver disease mechanisms and therapies. Edited by globally-recognized experts in the field, this authoritative volume: Relates molecular physiology to understanding disease pathology and treatment Links the science and pathology of the liver to practical clinical applications Features 16 new “Horizons” chapters that explore new and emerging science and technology Includes plentiful full-color illustrations and figures The Liver: Biology and Pathobiology, Sixth Edition is an indispensable resource for practicing and trainee hepatologists, gastroenterologists, hepatobiliary and liver transplant surgeons, and researchers and scientists in areas including hepatology, cell and molecular biology, virology, and drug metabolism.
Genes And Evolution
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Author :
language : en
Publisher: Academic Press
Release Date : 2016-06-06
Genes And Evolution written by and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-06-06 with Science categories.
Genes and Evolution, the latest volume in the Current Topics in Developmental Biology series, covers genes and evolution, with contributions from an international board of authors. The chapters provide a comprehensive set of reviews covering such topics as genes and plant domestication, gene networks, phenotypic loss in vertebrates, reproducible evolutionary changes, and epithelial tissue. Covers the area of genes and evolution Contains invaluable contributions from an international board of authors Provides a comprehensive set of reviews covering such topics as genes and plant domestication, gene networks, phenotypic loss in vertebrates, reproducible evolutionary changes and epithelial tissue