Bioinformatics Approaches To Understanding The Breast Cancer Microenvironment
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Bioinformatics Approaches To Understanding The Breast Cancer Microenvironment
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Author : François Pepin
language : en
Publisher:
Release Date : 2010
Bioinformatics Approaches To Understanding The Breast Cancer Microenvironment written by François Pepin and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010 with categories.
Combined Biology And Bioinformatics Approaches To Breast Cancer
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Author :
language : en
Publisher:
Release Date : 2007
Combined Biology And Bioinformatics Approaches To Breast Cancer written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007 with categories.
LMO4 is highly expressed in breast epithelial cells and is related to cell proliferation and/or invasion in vivo. Because these cellular features are associated with breast carcinogenesis and since LMO4 is overexpressed in more than 50% of breast cancer cases, we hypothesize that LMO4 may play roles in oncogenesis of breast epithelial cells by regulating proliferation, invasion and/or other cellular features. Using LMO4 over-expression or shRNA expression system in vitro, I found that LMO4 play crucial roles in the regulation of cell proliferation and apoptosis of normal mammary gland epithelial cells or breast cancer cells. Furthermore, I have also observed that deletion of LMO4 impaired the function and development of mammary gland in LMO4 conditional knockout mice, indicating that LMO4 protein is necessary for maintaining the normal development of mice mammary gland. In addition, I demonstrated that the LMO4 can modulate TGF signaling and regulated the proliferative response of epithelial cells to TGF signaling, and thereby linked LMO4 to a conserved signaling pathway that plays important roles in epithelial homeostasis. Under the support of grant, I received excellent training in bioinformatics. By combining previously described functional methods with bioinformatics approaches, we used DNA microarrays to discover LMO4-responsive genes, and identified BMP7 as a key down-stream gene of LMO4. In addition, we also found a significant correlation between LMO4 and BMP7 transcript levels in a large dataset of human breast cancers, providing additional support that BMP7 is a bona fide target gene of LMO4. Finally, we demonstrated that LMO4 binds to HDAC2 and that they are recruited together to the BMP7 promoter. We also suggested a novel mechanism for LMOs; LMO4, Clim2 and HDAC2 are part of a transcriptional complex, and alterations in LMO4 levels can disrupt the complex, leading to decreased HDAC2 recruitment and increased promoter activity.
Application Of Bioinformatics In Cancers
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Author : Chad Brenner
language : en
Publisher: MDPI
Release Date : 2019-11-20
Application Of Bioinformatics In Cancers written by Chad Brenner and has been published by MDPI this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-11-20 with Medical categories.
This collection of 25 research papers comprised of 22 original articles and 3 reviews is brought together from international leaders in bioinformatics and biostatistics. The collection highlights recent computational advances that improve the ability to analyze highly complex data sets to identify factors critical to cancer biology. Novel deep learning algorithms represent an emerging and highly valuable approach for collecting, characterizing and predicting clinical outcomes data. The collection highlights several of these approaches that are likely to become the foundation of research and clinical practice in the future. In fact, many of these technologies reveal new insights about basic cancer mechanisms by integrating data sets and structures that were previously immiscible. Accordingly, the series presented here bring forward a wide range of artificial intelligence approaches and statistical methods that can be applied to imaging and genomics data sets to identify previously unrecognized features that are critical for cancer. Our hope is that these articles will serve as a foundation for future research as the field of cancer biology transitions to integrating electronic health record, imaging, genomics and other complex datasets in order to develop new strategies that improve the overall health of individual patients.
A Concise Review Of Molecular Pathology Of Breast Cancer
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Author : Mehmet Gunduz
language : en
Publisher: BoD – Books on Demand
Release Date : 2015-03-25
A Concise Review Of Molecular Pathology Of Breast Cancer written by Mehmet Gunduz and has been published by BoD – Books on Demand this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-03-25 with Medical categories.
Cancer is one of the leading causes of death in most countries and its consequences result in huge economic, social and psychological burden. Breast cancer is the most frequently diagnosed cancer type and the leading cause of cancer death among females. In this book, we discussed gene expression and DNA abnormalities including methylation in breast cancer. A recent important topic, roles of miRNAs and their potential use in cancer therapy have been discussed in this cancer type as well. Bioinformatics is very important part of recent human genome developments and data mining and thus this topic has also been added for the readers. It is hoped that this book will contribute to development of novel diagnostic as well as therapeutic approaches, which lead to cure of breast cancer.
Systems Biology Of Cancer
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Author : Sam Thiagalingam
language : en
Publisher: Cambridge University Press
Release Date : 2015-04-09
Systems Biology Of Cancer written by Sam Thiagalingam and has been published by Cambridge University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-04-09 with Mathematics categories.
An overview of the current systems biology-based knowledge and the experimental approaches for deciphering the biological basis of cancer.
Breast Cancer Current Trends In Molecular Research
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Author : Shankar Suman
language : en
Publisher: Bentham Science Publishers
Release Date : 2022-07-18
Breast Cancer Current Trends In Molecular Research written by Shankar Suman and has been published by Bentham Science Publishers this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-07-18 with Medical categories.
Breast cancer is one of the most common cancer types worldwide, and is a leading cause of cancer related deaths in women. In this book, medical experts review our current understanding of the molecular biology and characteristics of breast cancer. The topics covered in this book provide comprehensive knowledge of mechanisms underlying breast carcinogenesis, and are intended for a wide audience including scientists, teachers, and students. 11 chapters present information about several topics on breast cancer, including the role of cell growth and proliferation pathways, androgen and cytokine signaling, germline mutations in breast cancer susceptibility genes, and molecular factors causing invasive and metastatic breast cancer. In addition, the editors discuss the recent advancements in multi-omics data analysis based on inter-and intra-tumor molecular profiles. The reference highlights how the knowledge and understanding of the biological behavior of breast neoplasms have facilitated ongoing investigations into dietary polyphenolic compounds with antioxidant properties, making them function as cancer chemopreventive agents. Along with this, the current development of treatment strategies such as targeted molecular therapy, and radiation therapy is brought to the fore to update readers.
Molecular And Multi Omic Approaches In Understanding Cancer Biology And Anticancer Therapies Current Perspectives And New Challenges
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Author : Basel A. Abdel-Wahab
language : en
Publisher: Frontiers Media SA
Release Date : 2023-07-03
Molecular And Multi Omic Approaches In Understanding Cancer Biology And Anticancer Therapies Current Perspectives And New Challenges written by Basel A. Abdel-Wahab and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-07-03 with Science categories.
Chemokine Receptors In Cancer
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Author : Amy M. Fulton
language : en
Publisher: Springer Science & Business Media
Release Date : 2009-06-12
Chemokine Receptors In Cancer written by Amy M. Fulton and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009-06-12 with Medical categories.
Chemokines are a superfamily of low molecular weight cytokines that were initially described based on their ability to induce the directed migration of leukocytes to sites of inflammation or injury. In humans, there are approximately 45 chemokines that bind to 19 G-protein-coupled receptors. In addition to mediating cellular migration, chemokines have now been shown to affect many cellular functions including survival, adhesion, invasion, proliferation, and to regulate circulating chemokine levels. Although chemokine receptors were first described on leukocytes, it is now appreciated that chemokine receptors are also expressed by many other cells including endothelial and epithelial cells. Since the first description of chemokine receptors on malignant cells in 2001, an extensive literature has developed describing the expression and function of chemokine receptors in many malignancies. These studies support the initial hypothesis that malignant cells use chemokine receptors to migrate to distant sites of ligand expression and that expression of certain receptors is associated with a poor prognosis. It has also become apparent that malignancies of different tissues may use a diverse profile of chemokine receptors and that the same receptor may mediate metastasis to different sites in tumors of different histological origins. Receptor function may also maintain survival and expansion of the primary tumor.
Breast Cancer
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Author : Phuc Van Pham
language : en
Publisher: BoD – Books on Demand
Release Date : 2017-04-05
Breast Cancer written by Phuc Van Pham and has been published by BoD – Books on Demand this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-04-05 with Medical categories.
Breast Cancer - From Biology to Medicine thoroughly examines breast cancer from basic definitions, to cellular and molecular biology, to diagnosis and treatment. This book also has some additional focus on preclinical and clinical results in diagnosis and treatment of breast cancer. The book begins with introduction on epidemiology and pathophysiology of breast cancer in Section 1. In Section 2, the subsequent chapters introduce molecular and cellular biology of breast cancer with some particular signaling pathways, the gene expression, as well as the gene methylation and genomic imprinting, especially the existence of breast cancer stem cells. In Section 3, some new diagnostic methods and updated therapies from surgery, chemotherapy, hormone therapy, immunotherapy, radiotherapy, and some complementary therapies are discussed. This book provides a succinct yet comprehensive overview of breast cancer for advanced students, graduate students, and researchers as well as those working with breast cancer in a clinical setting.
Personalized Medicine In Oncology
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Author : Ari VanderWalde
language : en
Publisher: Mdpi AG
Release Date : 2022-01-25
Personalized Medicine In Oncology written by Ari VanderWalde and has been published by Mdpi AG this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-01-25 with categories.
Nowhere is the explosion in comprehensive genomic testing more evident than in oncology. Multiple consensus guidelines now recommend molecular testing as the standard of care for most metastatic tumors. To aid in the advancement of this rapidly changing field, we intend this Special Issue of JPM to focus on technical developments in the genomic profiling of cancer, detail promising somatic alterations that either are, or have a high likelihood of being, relevant in the near future, and to address issues related to the pricing and value of these tests. The last few years have seen the cost of molecular testing decrease by orders of magnitude. In 2018, we saw the first "site-agnostic" drug approvals in cancer (for microsatellite unstable cancer (PD-1 inhibitors) and NTRK-fusions (TRK inhibitors)). Research on targetable mutations, determination of genetic "signatures" that can use multiple individual genes/pathways, development of targeted therapy, and insight into the value of new technology remains at the cutting edge of research in this field. We are soliciting papers that present new technologies to assess predictive biomarkers in cancer, original research (pre-clinical or clinical) that demonstrates promise for particular targeted therapies in cancer, and articles that explore the clinical and financial impacts of this paradigmatic shift in cancer diagnostics and treatment.