Biologics For Early Rheumatoid Arhritis

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Biologics For Early Rheumatoid Arthritis

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Author :
language : en
Publisher:
Release Date : 2011

Biologics For Early Rheumatoid Arthritis written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011 with categories.

Biologics For Early Rheumatoid Arhritis

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Author :
language : en
Publisher:
Release Date : 2010

Biologics For Early Rheumatoid Arhritis written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010 with categories.

Biologics For The Treatment Of Rheumatoid Arthritis

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Author : Ronald van Vollenhoven
language : en
Publisher: Springer
Release Date : 2015-12-22

Biologics For The Treatment Of Rheumatoid Arthritis written by Ronald van Vollenhoven and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-12-22 with Medical categories.

This book provides a comprehensive overview of the available biologic therapies whilst comparing them to standard disease modifying anti-rheumatic drugs, and discusses how best to determine which therapy is most appropriate for an individual patient in the framework of current guidelines. Biologics for the Treatment of Rheumatoid Arthritis is an up-to-date and concise practical guide to the latest therapeutic developments in this field. This book is an invaluable source of topical information for all rheumatologists and health care professionals treating patients with rheumatoid arthritis.

Rheumatoid Arthritis

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Author : John J. Cush
language : en
Publisher: Professional Communications
Release Date : 2010

Rheumatoid Arthritis written by John J. Cush and has been published by Professional Communications this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010 with Health & Fitness categories.

Emphasizes the importance of early intervention in RA with focus on pharmacologic treatments of RA. Detailed information on the various medications employed in treatment, including corticosteroids, NSAIDs, DMARDs, biologic agents, and combination therapy, is reviewed, including evidence-based data on efficacy, safety, side effects, and monitoring requirements. Clinical evaluation is presented, including lab findings, joint scoring, diagnostic criteria, and radiographic outcomes. Surgical options and the management of advanced RA are discussed.

Drug Therapy For Early Rheumatoid Arthritis

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Author : Katrina E. Donahue
language : en
Publisher:
Release Date : 2018

Drug Therapy For Early Rheumatoid Arthritis written by Katrina E. Donahue and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018 with categories.

OBJECTIVES: Compare the benefits and harms of drug therapies for adults with early rheumatoid arthritis (RA) within 1 year of diagnosis, updating the findings on early RA from the 2012 review. DATA SOURCES: English-language articles identified through MEDLINE®, Cochrane Library, Embase®, International Pharmaceutical Abstracts, gray literature, the previous 2012 review, expert recommendations, reference lists of published literature, and supplemental evidence data requests from January 2011 to October 5, 2017. REVIEW METHODS: Literature was synthesized qualitatively in narrative form and summary tables within and between corticosteroids and classes of disease-modifying antirheumatic drugs (DMARDs). Additionally, combination treatment strategies were examined. We conducted network meta-analysis for five outcomes: American College of Rheumatology 50-percent improvement (ACR50), remission based on Disease Activity Score (DAS), radiographic joint damage, all discontinuations, and discontinuations due to adverse events. Eligibility for network meta-analyses required the following: (1) patients with early RA had not attempted prior treatment with methotrexate (MTX), (2) doses of treatments were within ranges approved by the Food and Drug Administration (FDA), (3) length of followup was similar, and (4) studies were double-blinded randomized controlled trials of low or medium risk of bias. RESULTS: We analyzed 49 studies: 41 RCTs and 8 observational studies reported in 124 published articles. All included studies enrolled patients with moderate to high disease activity at baseline as measured with mean or median DAS 28 scores. A combination of corticosteroids plus MTX achieved higher remission rates than with MTX monotherapy (low strength of evidence [SOE]). Combination therapy with TNF (tumor necrosis factor) or non-TNF biologics plus MTX improved disease control, remission, and functional capacity compared with monotherapy with either MTX or a biologic (low to moderate SOE). Network meta-analyses found higher ACR50 response for combination therapy of biologics plus MTX than for MTX monotherapy (range of relative risk, 1.20 [95% confidence interval (CI), 1.04 to 1.38] to 1.57 [95% CI, 1.30 to 1.88]). In available data, consisting mostly of clinical trials, no significant differences emerged between any DMARDs for rates of discontinuation attributable to adverse events or serious adverse events (low SOE for adalimumab, certolizumab pegol, etanercept, infliximab, or abatacept with MTX, and moderate SOE for rituximab or tocilizumab with MTX). Data about subgroups (based on disease activity, prior therapy, demographics, and the presence of other serious conditions) were insufficient. No difference in findings were noted in MTX naïve and resistant populations. We found no studies of biosimilars for patients with early RA. CONCLUSIONS: Qualitative synthesis and network meta-analyses suggest that the combination of MTX with TNF or non-TNF biologics improves disease activity and remission when compared with biologic monotherapy or a conventional synthetic DMARD (csDMARD) monotherapy in patients with moderate to high disease activity at baseline as measured with mean or median DAS 28 scores. Overall rates of adverse events and discontinuation were similar among patients given csDMARDs, TNF biologics, and non-TNF biologics. We did not find eligible studies of biosimilars.

Fast Facts Rheumatoid Arthritis

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Author : John D. Isaacs
language : en
Publisher: Karger Medical and Scientific Publishers
Release Date : 2011-05-01

Fast Facts Rheumatoid Arthritis written by John D. Isaacs and has been published by Karger Medical and Scientific Publishers this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-05-01 with Medical categories.

This thoroughly updated second edition of 'Fast Facts: Rheumatoid Arthritis' provides an easy-to-read overview of how the condition is thought to develop and how it is diagnosed, monitored and treated. Written by two leading UK and US rheumatologists, it covers the many recent developments in this field, including: • Recently published classification criteria • The emerging role of anti-CCP autoantibodies • The latest developments in ultrasound and MRI • The association between RA and cardiovascular disease and lung disease • New concepts of undifferentiated arthritis and treatment to remission • The importance of early referral and new biological therapies 'Fast Facts: Rheumatoid Arthritis' provides a well-referenced international perspective on this condition. It is a 'must read' for all healthcare professionals caring for patients with this debilitating inflammatory joint disease. Contents: • The normal joint • Etiology • Pathogenesis • Epidemiology • Clinical features • Investigation • Assessment • Management - traditional measures • Management - biological therapies • Therapeutic developments

Early Rheumatoid Arthritis

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Author : Paul Emery
language : en
Publisher:
Release Date : 2005

Early Rheumatoid Arthritis written by Paul Emery and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2005 with Rheumatoid arthritis categories.

This issue covers the latest developments in the understanding of rheumatoid arthritis at the early stage. Treatments such as with newer biologic agents and conventional disease-modifying antirheumatic drugs are reviewed. Also included are articles on imaging modalities as a means of identifying those in the early stages and monitoring response to treatment.

Early Arthritis

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Author : Karen Torralba
language : en
Publisher: Clinics: Internal Medicine
Release Date : 2012

Early Arthritis written by Karen Torralba and has been published by Clinics: Internal Medicine this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012 with Health & Fitness categories.

To ensure the best possible clinical outcomes for arthritis patients, it is essential that they be seen early and treated appropriately at the earliest opportunity. Early therapy has proven much more effective than that given late. This issue of Rheumatic Disease Clinics of North America brings the rheumatologist up to date on the latest treatments and interventions in evolving arthritis and established early arthritis. Topics covered include early rheumatoid arthritis, psoriatic arthritis, undifferentiated arthritis, oligoarthritis, osteoarthritis, and others. Imaging modalities are addressed as well as various contemporary treatments including biologics.

Drug Safety Managing Innovation In Rheumatology An Issue Of Rheumatic Disease Clinics

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Author : Jack Cush
language : en
Publisher: Elsevier Health Sciences
Release Date : 2012-11-15

Drug Safety Managing Innovation In Rheumatology An Issue Of Rheumatic Disease Clinics written by Jack Cush and has been published by Elsevier Health Sciences this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-11-15 with Medical categories.

Edited by Drs. Jack Cush and Kathryn Dao, this issue of Rheumatic Disease Clinics of North America addresses one of the most significant issues facing the rheumatologist today––drug safety in a changing world where rheumatoid arthritis (RA) severity is less, patients are being identified and treated at a very early stage, and prevention is on the horizon. Topics covered include: communicating the risk of side effects, urate-lowering therapies, biphosphonates, biologics, malignancy risks, and administering therapies to patients with co-morbidities.

Early Arthritis An Issue Of Rheumatic Disease Clinics E Book

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Author : Karen Torralba
language : en
Publisher: Elsevier Health Sciences
Release Date : 2012-08-08

Early Arthritis An Issue Of Rheumatic Disease Clinics E Book written by Karen Torralba and has been published by Elsevier Health Sciences this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-08-08 with Medical categories.

To ensure the best possible clinical outcomes for arthritis patients, it is essential that they be seen early and treated appropriately at the earliest opportunity. Early therapy has proven much more effective than that given late. This issue of Rheumatic Disease Clinics of North America brings the rheumatologist up to date on the latest treatments and interventions in evolving arthritis and established early arthritis. Topics covered include early rheumatoid arthritis, psoriatic arthritis, undifferentiated arthritis, oligoarthritis, osteoarthritis, and others. Imaging modalities are addressed as well as various contemporary treatments including biologics.