Biomarkers For Huntington S Disease
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Biomarkers For Huntington S Disease
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Author : Elizabeth A. Thomas
language : en
Publisher: Springer Nature
Release Date : 2023-11-13
Biomarkers For Huntington S Disease written by Elizabeth A. Thomas and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-11-13 with Medical categories.
Huntington’s disease (HD) is a fatal, inherited, neurodegenerative disorder, characterized by chorea, motor instabilities, psychiatric manifestations and cognitive decline. Early genetic testing provides an opportunity for clinical interventions aimed at delaying onset and/or slowing progression of disease; however, current treatments for HD are limited, with only two FDA-approved drugs available to manage chorea. Encouragingly, however, several disease-modifying treatment approaches are in the therapeutic pipeline, with more than 200 clinical studies, and many more preclinical studies, in the works. Robust and reliable biomarkers are needed to predict disease onset, monitor disease progression and assess treatment responses. More specifically, biomarkers to stratify patients for clinical trials and biomarkers to track drug efficacy will certainly lead to improved clinical trial design and success. This book represents the first book focused solely on biomarkers for HD and represents a distinct resource that will be informative, not only for clinicians and those involved in clinical trial design, but also for a wide range of neurodegenerative disease researchers. This edited volume is written by top leaders in the field, and takes a cross-disciplinary approach to cover a broad spectrum of biomarker types, in order to provide the latest advances in the development of biochemical, molecular, imaging and digital biomarkers that have been investigated for HD. With the ultimate goal of treating patients, the development of disease-associated biomarkers has never been more important.
Biomarkers For Huntington S Disease
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Author : Jan Kobal
language : en
Publisher:
Release Date : 2012
Biomarkers For Huntington S Disease written by Jan Kobal and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012 with Science categories.
Biomarkers for Huntington's Disease.
Blood And Biomarkers In Huntington S Disease
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Author :
language : en
Publisher:
Release Date : 2017
Blood And Biomarkers In Huntington S Disease written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017 with categories.
Identification And Evaluation Of Biomarkers For Huntington S Disease
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Author : E. J. Wild
language : en
Publisher:
Release Date : 2009
Identification And Evaluation Of Biomarkers For Huntington S Disease written by E. J. Wild and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009 with categories.
Huntington's disease (HD) is a devastating, incurable inherited neurodegenerative disorder that commonly affects adults in mid-life. Despite encouraging results from in vitro and animal trials, disease-modifying therapeutic trials in HD are limited by a lack of tools to track disease progression. HD is clinically heterogeneous, and current clinical rating scales lack sensitivity and specificity, particularly over relatively short time periods. Improvements in the precision of objective measurement of disease progression in HD could lead to state markers (biomarkers) better able to predict onset, detect progression and measure the effects of therapeutic intervention. Biomarkers capable of detecting disease-related changes in premanifest gene carriers will be essential for clinical trials of treatments to delay onset. Imaging, clinical and cognitive assessment as well as laboratory markers have all been proposed as biomarkers, but few measures have been quantified over short time intervals or shown to be predictive of clinical change over longer periods. A robust panel of biomarkers from a number of modalities will be necessary to progress to interventional clinical trials of disease-modifying therapies in HD, using biomarkers to measure the success or failure of an intervention. Such cross-validation requires simultaneous multimodal biomarker evaluation within a suitable cohort of subjects studied longitudinally. This thesis describes a multi-modal approach to the discovery and evaluation of potential biomarkers for Huntington's disease in a large cohort of human volunteers. After reviewing the relevant features of Huntington's disease and current state of biomarker research in Huntington's disease, several approaches to, and outcomes from, biomarker discovery and evaluation are described, including proteomic profiling, targeted ELISA, multiplex inflammatory profiling and measurement of whole-brain atrophy by longitudinal magnetic resonance imaging. The thesis draws together these different approaches and summarises the contributions to both biomarker research and our understanding of the neurobiology of HD that the work has generated.
Development And Evaluation Of Biomarkers In Huntington S Disease
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Author : Elin M. Rees
language : en
Publisher:
Release Date : 2014
Development And Evaluation Of Biomarkers In Huntington S Disease written by Elin M. Rees and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014 with categories.
Development And Evaluation Of Biomarkers In Huntington S Disease
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Author :
language : en
Publisher:
Release Date : 2014
Development And Evaluation Of Biomarkers In Huntington S Disease written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014 with categories.
Development Of Biofluid Biomarkers For Huntington S Disease
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Author : Lauren Mary Byrne
language : en
Publisher:
Release Date : 2020
Development Of Biofluid Biomarkers For Huntington S Disease written by Lauren Mary Byrne and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020 with categories.
Evaluating The Sensitivity Of Biomarkers In Huntington S Disease
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Author : Phyllis May-Ling Chua
language : en
Publisher:
Release Date : 2013
Evaluating The Sensitivity Of Biomarkers In Huntington S Disease written by Phyllis May-Ling Chua and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013 with Biochemical markers categories.
Mri Derived Cerebral Biomarkers For Huntington S Disease
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Author : N. Z. Hobbs
language : en
Publisher:
Release Date : 2010
Mri Derived Cerebral Biomarkers For Huntington S Disease written by N. Z. Hobbs and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010 with categories.
Neurodegenerative Diseases Biomarkers
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Author : Philip V. Peplow
language : en
Publisher: Humana
Release Date : 2022-10-16
Neurodegenerative Diseases Biomarkers written by Philip V. Peplow and has been published by Humana this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-10-16 with Medical categories.
This volume presents recent data on the latest achievements in new and emerging technologies for biomarkers and for innovations in their assessment. The chapters cover topics such as activation of microglia and macrophages in neurodegenerative diseases; oxidative stress and cellular dysfunction in neurodegenerative diseases; TSPO PET imaging as a biomarker of neuroinflammation in neurodegenerative disorders; and imaging biomarkers in Huntington's disease and amyotrophic lateral sclerosis. In the Neuromethods series style, chapters include the kind of detail and key advice from the specialists needed to get successful results in your laboratory. Cutting-edge and comprehensive, Neurodegenerative Diseases Biomarkers: Towards Translating Research to Clinical Practice is a valuable resource for both experimental and clinical experts in the field of neurodegenerative diseases who are looking to expand their knowledge of novel biomarkers in different types of neurodegenerative diseases.