Blog Do Mois S Duarte
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Translational Medicine
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Author : Joy A. Cavagnaro
language : en
Publisher: CRC Press
Release Date : 2021-11-26
Translational Medicine written by Joy A. Cavagnaro and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-11-26 with Medical categories.
Translational Medicine: Optimizing Preclinical Safety Evaluation of Biopharmaceuticals provides scientists responsible for the translation of novel biopharmaceuticals into clinical trials with a better understanding of how to navigate the obstacles that keep innovative medical research discoveries from becoming new therapies or even making it to clinical trials. The book includes sections on protein-based therapeutics, modified proteins, oligonucleotide-based therapies, monoclonal antibodies, antibody–drug conjugates, gene and cell-based therapies, gene-modified cell-based therapies, combination products, and therapeutic vaccines. Best practices are defined for efficient discovery research to facilitate a science-based, efficient, and predictive preclinical development program to ensure clinical efficacy and safety. Key Features: Defines best practices for leveraging of discovery research to facilitate a development program Includes general principles, animal models, biomarkers, preclinical toxicology testing paradigms, and practical applications Discusses rare diseases Discusses "What-Why-When-How" highlighting different considerations based upon product attributes. Includes special considerations for rare diseases About the Editors Joy A. Cavagnaro is an internationally recognized expert in preclinical development and regulatory strategy with an emphasis on genetic medicines.. Her 40-year career spans academia, government (FDA), and the CRO and biotech industries. She was awarded the 2019 Arnold J Lehman Award from the Society of Toxicology for introducing the concept of science-based, case-by-case approach to preclinical safety evaluation, which became the foundation of ICH S6. She currently serves on scientific advisory boards for advocacy groups and companies and consults and lectures in the area of preclinical development of novel therapies. Mary Ellen Cosenza is a regulatory toxicology consultant with over 30 years of senior leadership experience in the biopharmaceutical industry in the U.S., Europe, and emerging markets. She has held leadership position in both the American College of Toxicology (ACT) and the International Union of Toxicology (IUTOX) and is also an adjunct assistant professor at the University of Southern California where she teaches graduate-level courses in toxicology and regulation of biologics.
The Raven King The Raven Cycle Book 4
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Author : Maggie Stiefvater
language : en
Publisher: Scholastic Inc.
Release Date : 2016-04-26
The Raven King The Raven Cycle Book 4 written by Maggie Stiefvater and has been published by Scholastic Inc. this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-04-26 with Young Adult Fiction categories.
The fourth and final installment in the spellbinding series from the irrepressible, #1 New York Times bestselling author Maggie Stiefvater. All her life, Blue has been warned that she will cause her true love's death. She doesn't believe in true love and never thought this would be a problem, but as her life becomes caught up in the strange and sinister world of the Raven Boys, she's not so sure anymore. In a starred review for Blue Lily, Lily Blue, Kirkus Reviews declared: "Expect this truly one-of-a-kind series to come to a thundering close."
Can Bis Maldita E Maravilhosa
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Author : Margarita Cardoso de Menezes
language : pt-BR
Publisher: Leya
Release Date : 2024-04-01
Can Bis Maldita E Maravilhosa written by Margarita Cardoso de Menezes and has been published by Leya this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-04-01 with Health & Fitness categories.
A canábis foi proibida pelos seus efeitos psicotrópicos, graças a uma campanha destinada a servir interesses pouco claros. E, assim, a mesma planta que, três milénios antes de Cristo, já era utilizada na China para produzir chás medicinais – e que viria a fornecer velas e cabos quase indestrutíveis aos navegadores portugueses – tornava-se ilegal, passando a ser encarada como uma droga infame, capaz de levar os jovens à loucura e morte... Mais recentemente, porém, a legalização da canábis começou a ser reclamada por uma parte considerável da sociedade graças às suas múltiplas virtudes e usos, sendo a dimensão psicotrópica apenas um deles. Ao longo destas páginas, viajamos pela incrível diversidade que, sob todos os pontos de vista, a canábis encerra. Identificamos as principais características de cada uma das suas três variedades, percebemos a diferença fundamental entre plantas macho e plantas fêmea, percorremos a já longa história da relação do ser humano com a «erva» e descobrimos os verdadeiros motivos que conduziram à sua proibição. Ficamos também a saber o que diz a ciência sobre este fármaco ímpar e a conhecer o enorme impacto do chamado «ouro verde» em diversas atividades económicas que geram lucros cada vez mais expressivos. Com uma visão de 360 graus, este é um livro fundamental para compreender a planta maldita e maravilhosa que, no fim de contas, será sempre aquilo que o Homem quiser fazer dela.
As Luzes Apagam
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Author : Magna Ferreira
language : pt-BR
Publisher: Viseu
Release Date : 2024-06-28
As Luzes Apagam written by Magna Ferreira and has been published by Viseu this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-06-28 with Poetry categories.
Falando de gentilezas, sonhos, fantasias, de forma poética e enfática sobre a brevidade da vida. Sabemos que nascemos, crescemos e morremos, isto é nomeado como o ciclo da vida, ou seja, todos os que vieram são exatamente os que foram chamados por um ser supremo denominado Deus. Essa é a Teoria Criacionista, a Bíblia sagrada: no livro de Gênesis, no capítulo dois, versículo sete, que diz: "Do pó viemos, ao pó voltaremos." Nascemos desde a antiguidade até os dias atuais da mesma maneira. Existem alguns cientistas, como Charles Darwin, em sua "Teoria da Evolução", que diz: somos seres que viemos do macaco; existem outras mais recentes que derrubaram essa teoria, dizendo que a humanidade está sempre em transformação. Há outras onde relatam que somos de poeira das estrelas, segundo Giovana Girardi. O astrônomo americano Carl Sagan, provavelmente o maior divulgador científico de todos os tempos, costumava dizer que nós humanos, seres vivos da Terra, o próprio planeta e todo o sistema solar somos poeiras das estrelas. Bom, isto é uma outra história, como disse anteriormente, quero falar sobre "vida e morte" poeticamente. Enfatizando a ideia que, quando morrermos, o que deixaremos pouco importa. Diante desse cenário caótico, em que nos encontramos no mundo, desde o ano de dois mil e vinte. Onde o que vemos todos os dias nos noticiários é falar sobre "morte" em municípios, em estados, em países, por todos os continentes! Aos homens, Deus deu sabedoria, para criarem armas de fogo, nucleares, químicas etc. Mas sua inteligência não os deixa invulneráveis quando, de repente, são surpreendidos pela morte. Na Bíblia, no livro de Eclesiastes, capítulo nove, versículo dez diz: "Tudo quanto te vier à mão para fazer, faça segundo as tuas forças, porque na sepultura, para onde vais, lá não há obra, nem indústria, nem ciência, nem sabedoria alguma." Não a cito só na condição religiosa, mas a tomo como um alerta, como uma reflexão sobre se importar com o outro; de se dispor a fazer o bem sem olhar a quem. Lembra quando falei em gentilezas? Bom é saber que não somos eternos, que se faz necessário deixar o egoísmo, a tristeza, a usura, entre outros sentimentos ruins, e, se apoderar de bons sentimentos, tornando-se altruísta, empático, amável... Porque chegamos ao mundo e saímos dele sozinhos! Pois o que se deixa, às vezes não fará ninguém feliz, nem o tornará saudoso por isso! Em algumas situações agradecem por sua partida. Logo, as luzes apagam portanto, cuidemos uns dos outros agora.
A Arte De Educar Gingando
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Author : Francisco Orismidio Duarte da Silva
language : pt-BR
Publisher: Pimenta Cultural
Release Date : 2021-12-17
A Arte De Educar Gingando written by Francisco Orismidio Duarte da Silva and has been published by Pimenta Cultural this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-12-17 with Education categories.
Este livro é fruto de uma pesquisa sobre a capoeira e suas possibilidades para a educação que foi realizada no Mestrado Profissional em Educação da Universidade Regional do Cariri – URCA, orientada pelo professor Dr. Josier Ferreira da Silva.
Dictionary Catalog Of The Research Libraries Of The New York Public Library 1911 1971
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Author : New York Public Library. Research Libraries
language : en
Publisher:
Release Date : 1979
Dictionary Catalog Of The Research Libraries Of The New York Public Library 1911 1971 written by New York Public Library. Research Libraries and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1979 with Library catalogs categories.
Eu Ele E Sr G
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Author : Sue Hecker
language : pt-BR
Publisher: HarperCollins Brasil
Release Date : 2017-08-01
Eu Ele E Sr G written by Sue Hecker and has been published by HarperCollins Brasil this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-08-01 with Fiction categories.
Como seguir com um coração dividido? Dividida entre a emoção e o desejo, Patrícia resolve tirar um tempo para repensar em sua vida e nas questões que deixou em São Paulo. Contudo, a ausência de Carlos se torna torturante e as questões mal resolvidas de sua própria família fazem com que Patrícia retorne mais determinada do que nunca a resolver suas pendências não só com Carlos, mas com Dom Leon e, claro, com o Sr. G Na continuação de Sr. G, Sue Hecker retoma a história envolvente de Patrícia – que continua determinada em sua busca por prazer absoluto e felicidade emocional. Mas seria realmente Carlos o sujeito que contornará seus ímpetos? Quem será o Dom Leon que continua cobrindo sua vida com mistérios e sedução? Seria um retiro a melhor saída para ver as coisas de maneira clara e ordeira? Qual será o real desejo do Sr. G?
The Cruel Prince
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Author : Holly Black
language : en
Publisher: Hachette UK
Release Date : 2018-01-02
The Cruel Prince written by Holly Black and has been published by Hachette UK this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-01-02 with Young Adult Fiction categories.
From #1 New York Times bestselling author Holly Black, comes the first book in a stunning new series about a mortal girl who finds herself caught in a web of royal faerie intrigue. Of course I want to be like them. They're beautiful as blades forged in some divine fire. They will live forever. And Cardan is even more beautiful than the rest. I hate him more than all the others. I hate him so much that sometimes when I look at him, I can hardly breathe. Jude was seven years old when her parents were murdered and she and her two sisters were stolen away to live in the treacherous High Court of Faerie. Ten years later, Jude wants nothing more than to belong there, despite her mortality. But many of the fey despise humans. Especially Prince Cardan, the youngest and wickedest son of the High King. To win a place at the Court, she must defy him--and face the consequences. In doing so, she becomes embroiled in palace intrigues and deceptions, discovering her own capacity for bloodshed. But as civil war threatens to drown the Courts of Faerie in violence, Jude will need to risk her life in a dangerous alliance to save her sisters, and Faerie itself.
A General Theory Of Oblivion
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Author : Jose Eduardo Agualusa
language : en
Publisher: Archipelago
Release Date : 2015-12-15
A General Theory Of Oblivion written by Jose Eduardo Agualusa and has been published by Archipelago this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-12-15 with Fiction categories.
Shortlisted for the Man Booker International Prize A Portuguese woman shuts herself away after the Angolan War of Independence in this stunning novel from a master storyteller whose writing evokes Gabriel García Márquez and J.M. Coetzee. On the eve of Angolan independence, an agoraphobic woman named Ludo bricks herself into her Luandan apartment for 30 years, living off vegetables and the pigeons she lures in with diamonds, burning her furniture and books to stay alive, and writing her story on the apartment's walls. As the country goes through various political upheavals—from colony to socialist republic to civil war to peace and capitalism—the world outside seeps into Ludo’s life through snippets on the radio, voices from next door, glimpses of someone peeing on a balcony, or a man fleeing his pursuers. Almost as if we're eavesdropping, the history of Angola unfolds through the stories of those she sees from her window . . . A General Theory of Oblivion is a perfectly crafted, wild patchwork of a novel, playing on a love of storytelling and fable.
Festival Panorama 2010 05 21 Nov
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Author :
language : en
Publisher:
Release Date : 2010
Festival Panorama 2010 05 21 Nov written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010 with Dance festivals categories.