Boas Vibra Es Vida Boa
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Translational Medicine
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Author : Joy A. Cavagnaro
language : en
Publisher: CRC Press
Release Date : 2021-11-26
Translational Medicine written by Joy A. Cavagnaro and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-11-26 with Medical categories.
Translational Medicine: Optimizing Preclinical Safety Evaluation of Biopharmaceuticals provides scientists responsible for the translation of novel biopharmaceuticals into clinical trials with a better understanding of how to navigate the obstacles that keep innovative medical research discoveries from becoming new therapies or even making it to clinical trials. The book includes sections on protein-based therapeutics, modified proteins, oligonucleotide-based therapies, monoclonal antibodies, antibody–drug conjugates, gene and cell-based therapies, gene-modified cell-based therapies, combination products, and therapeutic vaccines. Best practices are defined for efficient discovery research to facilitate a science-based, efficient, and predictive preclinical development program to ensure clinical efficacy and safety. Key Features: Defines best practices for leveraging of discovery research to facilitate a development program Includes general principles, animal models, biomarkers, preclinical toxicology testing paradigms, and practical applications Discusses rare diseases Discusses "What-Why-When-How" highlighting different considerations based upon product attributes. Includes special considerations for rare diseases About the Editors Joy A. Cavagnaro is an internationally recognized expert in preclinical development and regulatory strategy with an emphasis on genetic medicines.. Her 40-year career spans academia, government (FDA), and the CRO and biotech industries. She was awarded the 2019 Arnold J Lehman Award from the Society of Toxicology for introducing the concept of science-based, case-by-case approach to preclinical safety evaluation, which became the foundation of ICH S6. She currently serves on scientific advisory boards for advocacy groups and companies and consults and lectures in the area of preclinical development of novel therapies. Mary Ellen Cosenza is a regulatory toxicology consultant with over 30 years of senior leadership experience in the biopharmaceutical industry in the U.S., Europe, and emerging markets. She has held leadership position in both the American College of Toxicology (ACT) and the International Union of Toxicology (IUTOX) and is also an adjunct assistant professor at the University of Southern California where she teaches graduate-level courses in toxicology and regulation of biologics.
The Book Of Disquiet
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Author : Fernando Pessoa
language : en
Publisher: Serpent's Tail
Release Date : 2017-08-17
The Book Of Disquiet written by Fernando Pessoa and has been published by Serpent's Tail this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-08-17 with Fiction categories.
The Book of Disquiet is one of the great literary works of the twentieth century. Written over the course of Fernando Pessoa's life, it was first published in 1982, pieced together from the thousands of individual manuscript pages left behind by Pessoa after his death in 1935. Now this fragmentary modernist masterpiece appears in a major new edition that unites Margaret Jull Costa's celebrated translation with the most complete version of the text ever produced. It is presented here, for the first time in English, by order of original composition, and accompanied by facsimiles of the original manuscript. Narrated principally by an assistant bookkeeper named Bernardo Soares - an alias of sorts for Pessoa himself - The Book of Disquiet is 'the autobiobraphy of someone who never existed', a mosaic of dreams, of hope and despair; a hymn to the streets and cafs of 1930s Lisbon, and an extraordinary record of the inner life of one of the century's most important writers. This new edition represents the most complete vision of Pessoa's genius.
A Vida Al M Da Vida
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Author : Roni Lima
language : pt-BR
Publisher: Mauad Editora Ltda
Release Date : 2005
A Vida Al M Da Vida written by Roni Lima and has been published by Mauad Editora Ltda this book supported file pdf, txt, epub, kindle and other format this book has been release on 2005 with Religion categories.
Existe vida após a morte? Pode um espírito se materializar, voltando a ter um corpo semelhante ao que possuía em vida? Pode um espírito materializado operar doentes com técnicas e instrumentos curativos jamais vistos na face da Terra? Essas e outras questões sobre as realidades espirituais são respondidas em A Vida Além da Vida, livro da autoria do jornalista Ronie Lima que aprofunda temas já abordados em sua obra Médicos do Espaço, sobre o Lar de Frei Luiz, no Rio de Janeiro, um centro espírita brasileiro. Ronie Lima relata suas pesquisas e contatos com espíritos materializados e outros fenômenos de efeitos físicos, como levitações e luzes astrais emitidas de aparelhos de cura de médicos do espaço. Tendo como base uma argumentação filosófica e científica, Ronie Lima faz uma viagem pela trajetória do espiritualismo moderno, reunindo experiências testemunhadas por pessoas idôneas, algumas delas personagens da História - como o ex-presidente dos EUA Abraham Lincoln, o escritor francês Victor Hugo, o escritor escocês Arthur Conan Doyle, o fisiologista francês Charles Richet, o médico Ronaldo Gazolla e o professor Hermógenes.
Let That Sh T Go
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Author : Nina Purewal
language : en
Publisher: Rowman & Littlefield
Release Date : 2021-01-05
Let That Sh T Go written by Nina Purewal and has been published by Rowman & Littlefield this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-01-05 with Self-Help categories.
Life is stressful. But it doesn’t have to be. It’s no wonder you can’t calm down: your to-do list is as long as your arm, your bank balance keeps dropping, you feel guilty for not calling your parents more often and there always seems to be a big deadline to meet at work. You need a serious breather—but you can barely find time to shower, let alone to exercise or meditate. In Let That Sh*t Go, Kate Petriw and Nina Purewal share the wisdom they’ve gained though decades of practising and teaching others to find peace of mind no matter how busy they are. Learn to put your life in perspective, take each day one step at a time and steal moments of calm amid the chaos. And remember: it’s not worth holding onto that sh*t.
The Power Of Habit
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Author : Charles Duhigg
language : en
Publisher: Random House
Release Date : 2012-02-28
The Power Of Habit written by Charles Duhigg and has been published by Random House this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-02-28 with Business & Economics categories.
NEW YORK TIMES BESTSELLER • This instant classic explores how we can change our lives by changing our habits. NAMED ONE OF THE BEST BOOKS OF THE YEAR BY The Wall Street Journal • Financial Times In The Power of Habit, award-winning business reporter Charles Duhigg takes us to the thrilling edge of scientific discoveries that explain why habits exist and how they can be changed. Distilling vast amounts of information into engrossing narratives that take us from the boardrooms of Procter & Gamble to the sidelines of the NFL to the front lines of the civil rights movement, Duhigg presents a whole new understanding of human nature and its potential. At its core, The Power of Habit contains an exhilarating argument: The key to exercising regularly, losing weight, being more productive, and achieving success is understanding how habits work. As Duhigg shows, by harnessing this new science, we can transform our businesses, our communities, and our lives. With a new Afterword by the author “Sharp, provocative, and useful.”—Jim Collins “Few [books] become essential manuals for business and living. The Power of Habit is an exception. Charles Duhigg not only explains how habits are formed but how to kick bad ones and hang on to the good.”—Financial Times “A flat-out great read.”—David Allen, bestselling author of Getting Things Done: The Art of Stress-Free Productivity “You’ll never look at yourself, your organization, or your world quite the same way.”—Daniel H. Pink, bestselling author of Drive and A Whole New Mind “Entertaining . . . enjoyable . . . fascinating . . . a serious look at the science of habit formation and change.”—The New York Times Book Review
The End Of The Christian Life
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Author : J. Todd Billings
language : en
Publisher: Brazos Press
Release Date : 2020-09-15
The End Of The Christian Life written by J. Todd Billings and has been published by Brazos Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-09-15 with Religion categories.
We're all going to die. Yet in our medically advanced, technological age, many of us see death as a distant reality--something that happens only at the end of a long life or to other people. In The End of the Christian Life, Todd Billings urges Christians to resist that view. Instead, he calls us to embrace our mortality in our daily life and faith. This is the journey of genuine discipleship, Billings says: following the crucified and resurrected Lord in a world of distraction and false hopes. Drawing on his experience as a professor and father living with incurable cancer, Billings offers a personal yet deeply theological account of the gospel's expansive hope for small, mortal creatures. Artfully weaving rich theology with powerful narrative, Billings writes for church leaders and laypeople alike. Whether we are young or old, reeling from loss or clinging to our own prosperity, this book challenges us to walk a strange but wondrous path: in the midst of joy and lament, to receive mortal limits as a gift, an opportunity to give ourselves over to the Lord of life.
Ncoras E Triunfos
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Author : Ana Martins
language : pt-BR
Publisher: Edições Vieira da Silva
Release Date : 2018-07-30
Ncoras E Triunfos written by Ana Martins and has been published by Edições Vieira da Silva this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-07-30 with Self-Help categories.
Qual é o propósito da nossa existência terrena? Amor. Comunicação. Potencial. Saúde. Sucesso. Ana Martins
A Vida Interna
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Author : C. W. Leadbeater
language : pt-BR
Publisher: Teosofica
Release Date : 2019-05-14
A Vida Interna written by C. W. Leadbeater and has been published by Teosofica this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-05-14 with Religion categories.
Baseado na transcrição de palestras e diálogos com estudantes de Teosofia durante encontros informais na Índia no começo do século 20, este livro aborda temas variados como a vida após a morte, a consciência búdica, o nosso dever ético para com os animais e a relação interna dos Mestres de Sabedoria com os discípulos e aspirantes ao discipulado.
To Love Intransitive Verb
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Author : Mário de Andrade
language : en
Publisher:
Release Date : 2018-09-30
To Love Intransitive Verb written by Mário de Andrade and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-09-30 with categories.
A bilingual translation of Mário de Andrade's novel Amar, verbo intransitivo, a classic Brazilian Modernist novel of prohibited love, changing morals, and the nouveau-riche of São Paulo in the early 20th century.
Preclinical Safety Evaluation Of Biopharmaceuticals
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Author : Joy A. Cavagnaro
language : en
Publisher: John Wiley & Sons
Release Date : 2013-03-07
Preclinical Safety Evaluation Of Biopharmaceuticals written by Joy A. Cavagnaro and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-03-07 with Medical categories.
"The goal is to provide a comprehensive reference book for the preclinicaldiscovery and development scientist whose responsibilities span target identification, lead candidate selection, pharmacokinetics, pharmacology, and toxicology, and for regulatory scientists whose responsibilities include the evaluation of novel therapies." —From the Afterword by Anthony D. Dayan Proper preclinical safety evaluation can improve the predictive value, lessen the time and cost of launching new biopharmaceuticals, and speed potentially lifesaving drugs to market. This guide covers topics ranging from lead candidate selection to establishing proof of concept and toxicity testing to the selection of the first human doses. With chapters contributed by experts in their specific areas, Preclinical Safety Evaluation of Biopharmaceuticals: A Science-Based Approach to Facilitating Clinical Trials: Includes an overview of biopharmaceuticals with information on regulation and methods of production Discusses the principles of ICH S6 and their implementation in the U.S., Europe, and Japan Covers current practices in preclinical development and includes a comparison of safety assessments for small molecules with those for biopharmaceuticals Addresses all aspects of the preclinical evaluation process, including: the selection of relevant species; safety/toxicity endpoints; specific considerations based upon class; and practical considerations in the design, implementation, and analysis of biopharmaceuticals Covers transitioning from preclinical development to clinical trials This is a hands-on, straightforward reference for professionals involved in preclinical drug development, including scientists, toxicologists, project managers, consultants, and regulatory personnel.
