Bras Lia Terceiro Marco
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Translational Medicine
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Author : Joy A. Cavagnaro
language : en
Publisher: CRC Press
Release Date : 2021-11-26
Translational Medicine written by Joy A. Cavagnaro and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-11-26 with Medical categories.
Translational Medicine: Optimizing Preclinical Safety Evaluation of Biopharmaceuticals provides scientists responsible for the translation of novel biopharmaceuticals into clinical trials with a better understanding of how to navigate the obstacles that keep innovative medical research discoveries from becoming new therapies or even making it to clinical trials. The book includes sections on protein-based therapeutics, modified proteins, oligonucleotide-based therapies, monoclonal antibodies, antibody–drug conjugates, gene and cell-based therapies, gene-modified cell-based therapies, combination products, and therapeutic vaccines. Best practices are defined for efficient discovery research to facilitate a science-based, efficient, and predictive preclinical development program to ensure clinical efficacy and safety. Key Features: Defines best practices for leveraging of discovery research to facilitate a development program Includes general principles, animal models, biomarkers, preclinical toxicology testing paradigms, and practical applications Discusses rare diseases Discusses "What-Why-When-How" highlighting different considerations based upon product attributes. Includes special considerations for rare diseases About the Editors Joy A. Cavagnaro is an internationally recognized expert in preclinical development and regulatory strategy with an emphasis on genetic medicines.. Her 40-year career spans academia, government (FDA), and the CRO and biotech industries. She was awarded the 2019 Arnold J Lehman Award from the Society of Toxicology for introducing the concept of science-based, case-by-case approach to preclinical safety evaluation, which became the foundation of ICH S6. She currently serves on scientific advisory boards for advocacy groups and companies and consults and lectures in the area of preclinical development of novel therapies. Mary Ellen Cosenza is a regulatory toxicology consultant with over 30 years of senior leadership experience in the biopharmaceutical industry in the U.S., Europe, and emerging markets. She has held leadership position in both the American College of Toxicology (ACT) and the International Union of Toxicology (IUTOX) and is also an adjunct assistant professor at the University of Southern California where she teaches graduate-level courses in toxicology and regulation of biologics.
Brasilia Terceiro Marco
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Author : Manoel França Campos
language : pt-BR
Publisher:
Release Date : 1960
Brasilia Terceiro Marco written by Manoel França Campos and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1960 with Brasília (Distrito Federal, Brazil) categories.
Landforms And Landscapes Of Portugal
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Author : Gonçalo Vieira
language : en
Publisher: Springer
Release Date : 2016-01-08
Landforms And Landscapes Of Portugal written by Gonçalo Vieira and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-01-08 with Science categories.
The book brings together contributions from over 35 Portuguese geomorphologists, presenting a thorough overview of the main highlights of the landscape of Portugal's mainland, Azores and Madeira. The book, which is a tribute to Professor António de Brum Ferreira, first President of the Portuguese Association of Geomorphologists and former Professor at the University of Lisbon, who passed away in January 2013, is organized in 3 parts: a) Introduction, which presents a general framework of the physical geography of Portugal, b) Geomorphological landscapes, presenting ca. 30 short papers with regional focus on key geomorphological areas, c) Applied geomorphology, providing an updated vision on the protection of geomorphological heritage with a focus on geoparks, as well as on Geomorphological hazards in Portugal. This first book ever to concentrate on the geomorphology of Portugal will surely become a benchmark for Portuguese geomorphology.
World Literature Cosmopolitanism Globality
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Author : Gesine Müller
language : en
Publisher: Walter de Gruyter GmbH & Co KG
Release Date : 2019-10-21
World Literature Cosmopolitanism Globality written by Gesine Müller and has been published by Walter de Gruyter GmbH & Co KG this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-10-21 with Foreign Language Study categories.
From today’s vantage point it can be denied that the confidence in the abilities of globalism, mobility, and cosmopolitanism to illuminate cultural signification processes of our time has been severely shaken. In the face of this crisis, a key concept of this globalizing optimism as World Literature has been for the past twenty years necessarily is in the need of a comprehensive revision. World Literature, Cosmopolitanism, Globality: Beyond, Against, Post, Otherwise offers a wide range of contributions approaching the blind spots of the globally oriented Humanities for phenomena that in one way or another have gone beyond the discourses, aesthetics, and political positions of liberal cosmopolitanism and neoliberal globalization. Departing basically (but not exclusively) from different examples of Latin American literatures and cultures in globalized contexts, this volume provides innovative insights into critical readings of World Literature and its related conceptualizations. A timely book that embraces highly innovative perspectives, it will be a mustread for all scholars involved in the field of the global dimensions of literature.
Pandemic Exposures
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Author : Fassin Didier
language : en
Publisher: Hau
Release Date : 2021-11
Pandemic Exposures written by Fassin Didier and has been published by Hau this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-11 with categories.
An illuminating, indispensable analysis of a watershed moment and its possible aftermath. For people and governments around the world, the onset of the COVID-19 pandemic seemed to place the preservation of human life at odds with the pursuit of economic and social life. Yet this naive alternative belies the complexity of the entanglements the crisis has created and revealed not just between health and wealth but also around morality, knowledge, governance, culture, and everyday subsistence. Didier Fassin and Marion Fourcade have assembled an eminent team of scholars from across the social sciences to reflect on the myriad ways SARS-CoV-2 has entered, reshaped, or exacerbated existing trends and structures in every part of the globe. The contributors show how the disruptions caused by the pandemic have both hastened the rise of new social divisions and hardened old inequalities and dilemmas. An indispensable volume, Pandemic Exposures provides an illuminating analysis of this watershed moment and its possible aftermath.
Submarine Mass Movements And Their Consequences
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Author : Geoffroy Lamarche
language : en
Publisher: Springer
Release Date : 2015-10-02
Submarine Mass Movements And Their Consequences written by Geoffroy Lamarche and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-10-02 with Science categories.
This book is a comprehensive collection of state-of-the-art studies of seafloor slope instability and their societal implications. The volume captures the most recent and exciting scientific progress made in this research field. As the world’s climate and energy needs change, the conditions under which slope instability occurs and needs to be considered, are also changing. The science and engineering of submarine – or more widely subaqueous – mass movements is greatly benefiting from advances in seafloor and sub-seafloor surveying technologies. Ultra-high-resolution seafloor mapping and 3D seismic reflection cubes are becoming commonly available datasets that are dramatically increasing our knowledge of the mechanisms and controls of subaqueous slope failure. Monitoring of slope deformation, repeat surveying and deep drilling, on the other hand, are emerging as important new techniques for understanding the temporal scales of slope instability. In essence, rapid advances in technology are being readily incorporated into scientific research and as a result, our understanding of submarine mass movements is increasing at a very fast rate. The volume also marks the beginning of the third IGCP project for the submarine mass movement research community, IGCP-640 S4SLIDE (Significance of Modern and Ancient Submarine Slope LandSLIDEs). The Submarine Mass Movements and Their Consequences symposium is the biannual meeting under the IGCP umbrella.
Ecology And Conservation Of Mountaintop Grasslands In Brazil
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Author : Geraldo Wilson Fernandes
language : en
Publisher: Springer
Release Date : 2016-04-20
Ecology And Conservation Of Mountaintop Grasslands In Brazil written by Geraldo Wilson Fernandes and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-04-20 with Nature categories.
This book is a pioneer attempt to bring forward the first synthesis on the most diverse and threatened mountain top vegetation of South America, the rupestrian grasslands. It brings to light the state of the art information on this ecosystem geology, soil formation and distribution, environmental filters that lead to biodiversity, species interactions and their fine tuned adaptations to survive the harsh mountain environment. The human dimensions of the rupestrian grassland are also addressed, including the anthropogenic threats that may irreversibly impact biodiversity and ecosystem services. The book also highlights the ongoing studies on ecological restoration and first attempt to model the impacts of climate change on its speciose biota.
Manual De Ongs Guia Pr Tico De Orienta O Jur Dica
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Author : Maria Nazaré Lins Barbosa
language : pt-BR
Publisher: FGV Editora
Release Date : 2001
Manual De Ongs Guia Pr Tico De Orienta O Jur Dica written by Maria Nazaré Lins Barbosa and has been published by FGV Editora this book supported file pdf, txt, epub, kindle and other format this book has been release on 2001 with Nonprofit organizations categories.
On legal aspects of domestic nonprofit organizations in Brazil.
Placar Magazine
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Author :
language : pt
Publisher:
Release Date : 1978-05-12
Placar Magazine written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1978-05-12 with categories.
PLACAR: a maior revista brasileira de futebol. Notícias, perfis, entrevistas, fotos exclusivas.
Innovation And Transition In Law Experiences And Theoretical Settings
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Author :
language : en
Publisher: Dykinson
Release Date :
Innovation And Transition In Law Experiences And Theoretical Settings written by and has been published by Dykinson this book supported file pdf, txt, epub, kindle and other format this book has been release on with categories.
This book features a discussion on the modernisation of law and legal change, focusing on the key concepts of innovation" and "transition". These concepts both appear to be relevant and poorly defined in contemporary legal science. A critical reflection on the heuristic value of these categories seems appropriate, particularly considering their dyadic value. While innovation is increasingly appearing in the present day as being the category in which one looks at the modernisation of law, the concept of transition also seems to be the privileged place of occurrence for such dynamics. This group of Italian and Brazilian scholars contributing to this volume intends to investigate such problems through an interdisciplinary prism. It includes points of view both internal to legal studies - such as the history of law, theory of law, constitutional law, private law and commercial law - and external, such as political philosophy and history of justice and political institutions.