Breves Dan As Margem
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Translational Medicine
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Author : Joy A. Cavagnaro
language : en
Publisher: CRC Press
Release Date : 2021-11-26
Translational Medicine written by Joy A. Cavagnaro and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-11-26 with Medical categories.
Translational Medicine: Optimizing Preclinical Safety Evaluation of Biopharmaceuticals provides scientists responsible for the translation of novel biopharmaceuticals into clinical trials with a better understanding of how to navigate the obstacles that keep innovative medical research discoveries from becoming new therapies or even making it to clinical trials. The book includes sections on protein-based therapeutics, modified proteins, oligonucleotide-based therapies, monoclonal antibodies, antibody–drug conjugates, gene and cell-based therapies, gene-modified cell-based therapies, combination products, and therapeutic vaccines. Best practices are defined for efficient discovery research to facilitate a science-based, efficient, and predictive preclinical development program to ensure clinical efficacy and safety. Key Features: Defines best practices for leveraging of discovery research to facilitate a development program Includes general principles, animal models, biomarkers, preclinical toxicology testing paradigms, and practical applications Discusses rare diseases Discusses "What-Why-When-How" highlighting different considerations based upon product attributes. Includes special considerations for rare diseases About the Editors Joy A. Cavagnaro is an internationally recognized expert in preclinical development and regulatory strategy with an emphasis on genetic medicines.. Her 40-year career spans academia, government (FDA), and the CRO and biotech industries. She was awarded the 2019 Arnold J Lehman Award from the Society of Toxicology for introducing the concept of science-based, case-by-case approach to preclinical safety evaluation, which became the foundation of ICH S6. She currently serves on scientific advisory boards for advocacy groups and companies and consults and lectures in the area of preclinical development of novel therapies. Mary Ellen Cosenza is a regulatory toxicology consultant with over 30 years of senior leadership experience in the biopharmaceutical industry in the U.S., Europe, and emerging markets. She has held leadership position in both the American College of Toxicology (ACT) and the International Union of Toxicology (IUTOX) and is also an adjunct assistant professor at the University of Southern California where she teaches graduate-level courses in toxicology and regulation of biologics.
Swamp Thing
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Author : Len Wein
language : en
Publisher: Vertigo
Release Date : 1991
Swamp Thing written by Len Wein and has been published by Vertigo this book supported file pdf, txt, epub, kindle and other format this book has been release on 1991 with Comic books, strips, etc categories.
"He has become a modern legend, this mysterious creature of the Louisiana bayou. Feared as a monster, hailed as a god, by turns wonderfully benevolent and pitiless in his wrath, the Swamp Thing has carved his unique niche in the American Landscape. Writer Len Wein and legendary horror artist Bernie Wrightson, the original creators of the most complex creature in comics, brought the 'Swamp Thing' to life in an 8-page story from House of secrets #92. Now that classic story, plus the first ten issues of SWAMP THING Volume One, are reprinted in a new edition of Swamp thing - Dark genesis. In 'Dark genesis', learn the astonishing secret of Swamp Thing's "birth"; share the forbidden passions of Anton Arcane and the measureless sorrow of the Patchwork Man; shiver to the timeless horror of the witch named Rebecca Ravenwind and of a tortured Scottish werewolf. These eleven stories are not merely acknowledged classics of the comics field; they are an incredible reading experience, and the ideal introduction to the many-faceted creature known as Swamp Thing"--googlebooks.com.
Annaes Da Bibliotheca E Archivo Publico Do Par
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Author : Belém (Brazil). Bibliotheca e Archivo Publico
language : pt-BR
Publisher:
Release Date : 1910
Annaes Da Bibliotheca E Archivo Publico Do Par written by Belém (Brazil). Bibliotheca e Archivo Publico and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1910 with Belém (Brazil) categories.
Annaes Da Bibliotheca E Archivo P Blicos Do Par
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Author : Biblioteca e Arquivo Públicos do Pará
language : pt-BR
Publisher:
Release Date : 1913
Annaes Da Bibliotheca E Archivo P Blicos Do Par written by Biblioteca e Arquivo Públicos do Pará and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1913 with Belém (Brazil : State) categories.
Geografia Econ Mica
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Author : Elian Alabi Lucci
language : en
Publisher:
Release Date : 1975
Geografia Econ Mica written by Elian Alabi Lucci and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1975 with Brazil categories.
Arteduca O Ou Na Margem
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Author : Gilbert Daniel Da Silva
language : pt-BR
Publisher: Clube de Autores
Release Date : 2019-12-10
Arteduca O Ou Na Margem written by Gilbert Daniel Da Silva and has been published by Clube de Autores this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-12-10 with Art categories.
Iremos discorrer sobre alguns aspectos da Arteducação quando mediada em contextos periféricos. Primeiro, ocupar-nos-emos de um breve comentário sobre arte educação e suas contribuições para a formação integral dos jovens.
Onde O Sol Castiga Mais
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Author : António Gonçalves Manuel Castro
language : en
Publisher: Europa Edizioni
Release Date : 2022-12-31
Onde O Sol Castiga Mais written by António Gonçalves Manuel Castro and has been published by Europa Edizioni this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-12-31 with Fiction categories.
“Enquanto mirava aqueles corpos pálidos, franzinos e seminus, sentia no ar uma desagradável atmosfera de Dachau e Auschwitz; estavam todos condenados. Tentava perceber como é que tantos pais, por temor e respeito a um ‘Deus omnipotente’, chamado Pátria, entregavam, quase sem ripostar, os seus próprios filhos a um destino que se adivinhava sórdido e cruel. No palco da guerra, a morte não se comprazia com carne doente e estafada. Exigia, sobretudo, corpos tenros e saudáveis para as suas orgias de sangue, e o homem apressava-se a fornecer-lha, como se de um tributo se tratasse. Era um processo que Daniel assimilava com muito custo. – É uma verdadeira perda de tempo. – Insistia o Rebelo pessimista. – Vamos todos ser chamados... – ... e lixados com ‘F’ grande! – Rematou Daniel.”
Daniel
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Author : Paulo Gabriel Ferreira
language : pt-BR
Publisher: Editora Dialética
Release Date : 2024-02-27
Daniel written by Paulo Gabriel Ferreira and has been published by Editora Dialética this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-02-27 with Biography & Autobiography categories.
Daniel narra a história de sua infância e juventude na cidade de Guaxu. Depois de passar no concurso do banco, é enviado à longínqua cidade de Catus, no interior de Sergipe, cuja cultura é completamente diferente da sua e de seus antepassados libaneses. Em Catus, constitui família e decide se mudar para Belo Horizonte, em busca de melhor qualidade de vida. Em pouco tempo, sua vida irá tomar inesperados rumos. A carreira de Daniel se torna promissora, mas um acidente de carro, envolvendo ele e toda a sua família, trará à tona um lado sombrio de Bete, que Daniel desconhecia. Depois do acidente, sob a influência negativa de vários amigos de Bete, o ambiente familiar na casa de Daniel torna-se insuportável. Bete se aproveita da situação e também por estar se recuperando de ferimentos causados no acidente, para se vitimizar perante sua família de Catus e vizinhança, colocando seu diabólico plano em prática, destruir Daniel. Bete pede a separação. Daniel, a princípio, fez de tudo para que Bete voltasse atrás com sua decisão. Diante da recusa, se separam e Daniel sai de casa e vai morar sozinho. Bete abandona os filhos e Daniel os assume, voltando então para o seu lar. Quando tudo parecia entrar em equilíbrio, surge a inesperada doença de Pedrinho e sua enfermidade mudará para sempre a trajetória de Daniel e sua família.
Breve Noticia Da Crea O E Exercicio Da Aula De Principios De Phisica Chimica E Historia Natural Do Estado Da India Portugueza
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Author : Miguel Vicente de Abreu
language : pt-BR
Publisher:
Release Date : 1873
Breve Noticia Da Crea O E Exercicio Da Aula De Principios De Phisica Chimica E Historia Natural Do Estado Da India Portugueza written by Miguel Vicente de Abreu and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1873 with Education categories.
Hist Ria Da Medicina Uma Introdu O Escandalosamente Breve
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Author : Jacalyn Duffin
language : pt-BR
Publisher: Leya
Release Date : 2023-09-06
Hist Ria Da Medicina Uma Introdu O Escandalosamente Breve written by Jacalyn Duffin and has been published by Leya this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-09-06 with History categories.
«História da Medicina», de Jacalyn Duffin, é um dos textos de referência no ensino da história da profissão médica. A ênfase em conceitos abrangentes, em vez de em nomes e em datas, e a escrita vibrante da autora, fizeram com que esta obra tivesse tido amplo acolhimento por parte do público em geral. O livro está organizado em torno de temas de interesse clínico e científico, tais como a origem e a evolução da anatomia, da fisiologia, da farmacologia, da cirurgia, da obstetrícia, da educação médica, da prestação de cuidados de saúde e da saúde pública.