Cachexia And Wasting
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Cachexia And Wasting
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Author : Stefan D. Anker
language : en
Publisher: Springer Science & Business Media
Release Date : 2007-10-06
Cachexia And Wasting written by Stefan D. Anker and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007-10-06 with Medical categories.
Cachexia may well represent the flip side of the tremendous achievements of modern medicine. The aim of this volume, written by world-renowned scientists, is to provide the best available evidence on the pathogenesis, clinical features and therapeutic approach of cachexia, and to facilitate the understanding of the complex yet unequivocal clinical role of this syndrome, that truly represents a disease, or, more likely, a disease within other different diseases.
Holland Frei Cancer Medicine
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Author : Robert C. Bast, Jr.
language : en
Publisher: John Wiley & Sons
Release Date : 2017-03-10
Holland Frei Cancer Medicine written by Robert C. Bast, Jr. and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-03-10 with Medical categories.
Holland-Frei Cancer Medicine, Ninth Edition, offers a balanced view of the most current knowledge of cancer science and clinical oncology practice. This all-new edition is the consummate reference source for medical oncologists, radiation oncologists, internists, surgical oncologists, and others who treat cancer patients. A translational perspective throughout, integrating cancer biology with cancer management providing an in depth understanding of the disease An emphasis on multidisciplinary, research-driven patient care to improve outcomes and optimal use of all appropriate therapies Cutting-edge coverage of personalized cancer care, including molecular diagnostics and therapeutics Concise, readable, clinically relevant text with algorithms, guidelines and insight into the use of both conventional and novel drugs Includes free access to the Wiley Digital Edition providing search across the book, the full reference list with web links, illustrations and photographs, and post-publication updates
Cachexia And Wasting
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Author : Thomas R. Ziegler
language : en
Publisher:
Release Date : 2010
Cachexia And Wasting written by Thomas R. Ziegler and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010 with categories.
Nutrition And Cancer
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Author : Clare Shaw
language : en
Publisher: John Wiley & Sons
Release Date : 2010-11-29
Nutrition And Cancer written by Clare Shaw and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010-11-29 with Medical categories.
Nutrition plays a crucial role in supporting patients receiving treatment for cancer. Carefully considered nutritional options can help to manage patients with weight loss and cachexia, support the patient’s ability to recover from surgery and cope with treatments such as chemotherapy and radiotherapy. Patients living with and beyond cancer can also benefit from advice on optimal nutrition and lifestyle changes. Edited by Dr Clare Shaw, Consultant Dietitian at The Royal Marsden NHS Foundation Trust, Nutrition and Cancer takes an unrivalled look at this prevalent disease, offering the reader: An insight into the nutritional challenges faced for patients with cancer A practical guide to nutrition and dietetic practice in cancer care A detailed look at nutritional options for different diagnostic groups Contributions from a wide range of cancer specialists An excellent resource for dietitians, clinical nutritionists, doctors, nurses and other health professionals working with cancer patients, this book is also a fascinating reference for students and researchers with an interest in the area.
Mechanisms Of Muscle Wasting In Cachexia Models
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Author : Anna Salazar Degracia
language : en
Publisher:
Release Date : 2019
Mechanisms Of Muscle Wasting In Cachexia Models written by Anna Salazar Degracia and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019 with categories.
Sarcopenia Age Related Muscle Wasting And Weakness
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Author : Gordon S. Lynch
language : en
Publisher: Springer Science & Business Media
Release Date : 2010-11-30
Sarcopenia Age Related Muscle Wasting And Weakness written by Gordon S. Lynch and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010-11-30 with Medical categories.
Some of the most serious consequences of aging are its effects on skeletal muscle. ‘Sarcopenia’, the progressive age-related loss of muscle mass and associated muscle weakness, renders frail elders susceptible to serious injury from sudden falls and fractures and at risk for losing their functional independence. Not surprisingly, sarcopenia is a significant public health problem throughout the developed world. There is an urgent need to better understand the neuromuscular mechanisms underlying age-related muscle wasting and to develop therapeutic strategies that can attenuate, prevent, or ultimately reverse sarcopenia. Significant research and development in academic and research institutions and in pharmaceutical companies is being directed to sarcopenia and to related health issues in order to develop and evaluate novel therapeutics. This book provides the latest information on sarcopenia from leading international researchers studying the cellular and molecular mechanisms underlying age-related changes in skeletal muscle and identifies strategies to combat sarcopenia and related muscle wasting conditions and neuromuscular disorders. The book provides a vital resource for researchers and practitioners alike, with information relevant to gerontologists, geriatricians, sports medicine physicians, physiologists, neuroscientists, cell biologists, endocrinologists, physical therapists, allied health and musculoskeletal practitioners, strength and conditioning specialists, athletic trainers, and students of the medical and biomedical sciences.
Frailty And Sarcopenia
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Author : Yannis Dionyssiotis
language : en
Publisher: BoD – Books on Demand
Release Date : 2017-08-30
Frailty And Sarcopenia written by Yannis Dionyssiotis and has been published by BoD – Books on Demand this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-08-30 with Medical categories.
Frailty is considered a multisystem impairment that makes an individual vulnerable to external or internal stressors. Sarcopenia, the age-dependent loss of muscle mass and function, is proposed as the biological substrate and the pathway whereby the consequences of physical frailty develop. These syndromes are associated with a negative impact in quality of life and can lead to the occurrence of disability, institutionalization, and even mortality. The book focuses upon all the related aspects of frailty and sarcopenia and the new advancements in the related treatments including complex issues and research. It includes high-quality chapters in all related aspects for the syndromes of sarcopenia and frailty, which adversely affect the function and overall effectiveness of the musculoskeletal system and interventions to promote rehabilitation.
16th International Conference On Sarcopenia Cachexia And Wasting Disorders
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Author :
language : en
Publisher:
Release Date : 2023
16th International Conference On Sarcopenia Cachexia And Wasting Disorders written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023 with categories.
What Moves Wasting Muscle
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Author :
language : en
Publisher:
Release Date : 2019
What Moves Wasting Muscle written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019 with categories.
Within the field of cancer cachexia research, large amounts of data are increasingly being generated. Potential for future research is to focus more on sharing and integrating data. By doing so, more thorough insight can be gained in the complex mechanisms driving cachexia allowing the design of more specific and personalized treatment strategies.
Cancer Induced Muscle Wasting
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Author : Jacob Levi Brown
language : en
Publisher:
Release Date : 2018
Cancer Induced Muscle Wasting written by Jacob Levi Brown and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018 with Cancer categories.
Cancer-induced muscle wasting, otherwise known as cancer-cachexia, is a wasting syndrome that occurs in approximately 80% of cancer patients that is the primary cause of death for 22%-30% of cancer cases. Cancer-cachexia may be metabolically induced; therefore, the central hypothesis of this dissertation is mitochondrial degeneration occurs before cancer-cachexia, and increased oxidative stress because of mitochondrial degeneration in muscle may instigate cancer-cachexia. Lewis Lung Carcinoma cells (LLC) or PBS (control) were injected into the hind-flank of C57Bl6/J mice at 8 wks age, and tumor allowed to develop for 1, 2, 3 or 4 wks. Mitochondrial quality, function, ROS emission, protein synthesis and protein breakdown were assessed. LLC Conditioned Media (LCM) treatment of C2C12 myotubes was used to analyze cancer-cachexia in-vitro. Data were analyzed by one-way (animal experiments) or two-way (cell culture experiments) ANOVA with Student-Newman Kuels post hoc test. Cachectic muscle loss and decreased oxidative capacity was evident only at 4 wks post-tumor implantation. Mitochondrial function decreased by ~25% by 3wks after tumor implantation. Mitochondrial degeneration (MitoTimer) was evident by 2 weeks LLC compared to PBS control. Mitochondrial ROS production was elevated by ~50% to ~100% when compared to PBS at 1-3 wks post-tumor implantation. Mixed FSR Protein synthesis was ~40% lower in 4 wk tumor-bearing mice when compared to PBS controls. Mitochondrial quality control and protein turnover signaling were dysregulated throughout the progression of cancer-cachexia. Ubiquitin content was elevated by ~50% 4wks after tumor implantation. ERK and p38 MAPK phosphorylation was 4 and 3 fold greater than control muscle 4 wks following tumor implantation, respectively. MitoT treatment and inhibition of p38 MAPK ameliorated LCM-induced loss of myotube diameter. These data provide novel insight into mechanisms which may induce cancer-cachexia.