Cancer Metabolomics
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Cancer Metabolomics
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Author : Shen Hu
language : en
Publisher: Springer Nature
Release Date : 2021-04-01
Cancer Metabolomics written by Shen Hu and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-04-01 with Medical categories.
Cancer metabolomics is a rapidly evolving field that aims for a comprehensive dissection of the metabolic phenotypes and functional network of metabolites in human cancers. State of the art metabolomics tools have been developed and applied to studying cancer metabolism and developing metabolic targets for improved diagnosis, prognosis and therapeutic treatment of human cancers. Chapters are written by subject experts in the field of cancer metabolomics with cross-disciplinary contributions. Coverage includes advanced metabolomics technologies and methodologies, including chemical isotope labelling liquid chromatography - mass spectrometry, capillary ion chromatography - mass spectrometry, 2-D gas chromatography – mass spectrometry, capillary electrophoresis – mass spectrometry, nuclear magnetic resonance spectroscopy, shotgun lipidomics, tracer-based metabolomics, microbial metabolomics, mass spectrometry imaging for single cell metabolomics and functional metabolomics. In addition, the book highlights new discoveries in cancer metabolism such as hypoxia inducible factor pathway, isocitrate dehydrogenase 1 mutation and oncometabolites. Finally, contributors focus on the translational applications of metabolomics in human cancers such as glioma, head and neck cancer, and gastric cancer. This new volume will be a unique reference source for cancer researchers and promote applications of metabolomics in understanding cancer metabolism.
Cancer Metabolomics 2018
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Author : Paula Guedes De Pinho
language : en
Publisher: MDPI
Release Date : 2019-09-03
Cancer Metabolomics 2018 written by Paula Guedes De Pinho and has been published by MDPI this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-09-03 with Medical categories.
The metabolomics approach, defined as the study of all endogenously-produced low-molecular-weight compounds, appeared as a promising strategy to define new cancer biomarkers. Information obtained from metabolomic data can help to highlight disrupted cellular pathways and, consequently, contribute to the development of new-targeted therapies and the optimization of therapeutics. Therefore, metabolomic research may be more clinically translatable than other omics approaches, since metabolites are closely related to the phenotype and the metabolome is sensitive to many factors. Metabolomics seems promising to identify key metabolic pathways characterizing features of pathological and physiological states. Thus, knowing that tumor metabolism markedly differs from the metabolism of normal cells, the use of metabolomics is ideally suited for biomarker research. Some works have already focused on the application of metabolomic approaches to different cancers, namely lung, breast and liver, using urine, exhaled breath and blood. In this Special Issue we contribute to a more complete understanding of cancer disease using metabolomics approaches.
Correlation Based Network Analysis Of Cancer Metabolism
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Author : Emily G. Armitage
language : en
Publisher: Springer
Release Date : 2014-05-12
Correlation Based Network Analysis Of Cancer Metabolism written by Emily G. Armitage and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-05-12 with Science categories.
With the rise of systems biology as an approach in biochemistry research, using high throughput techniques such as mass spectrometry to generate metabolic profiles of cancer metabolism is becoming increasingly popular. There are examples of cancer metabolic profiling studies in the academic literature; however they are often only in journals specific to the metabolomics community. This book will be particularly useful for post-graduate students and post-doctoral researchers using this pioneering technique of network-based correlation analysis. The approach can be adapted to the analysis of any large scale metabolic profiling experiment to answer a range of biological questions in a range of species or for a range of diseases.
Cancer Metabolomics 2018
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Author : Paula Guedes De Pinho
language : en
Publisher:
Release Date : 2019
Cancer Metabolomics 2018 written by Paula Guedes De Pinho and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019 with Electronic books categories.
The metabolomics approach, defined as the study of all endogenously-produced low-molecular-weight compounds, appeared as a promising strategy to define new cancer biomarkers. Information obtained from metabolomic data can help to highlight disrupted cellular pathways and, consequently, contribute to the development of new-targeted therapies and the optimization of therapeutics. Therefore, metabolomic research may be more clinically translatable than other omics approaches, since metabolites are closely related to the phenotype and the metabolome is sensitive to many factors. Metabolomics seems promising to identify key metabolic pathways characterizing features of pathological and physiological states. Thus, knowing that tumor metabolism markedly differs from the metabolism of normal cells, the use of metabolomics is ideally suited for biomarker research. Some works have already focused on the application of metabolomic approaches to different cancers, namely lung, breast and liver, using urine, exhaled breath and blood. In this Special Issue we contribute to a more complete understanding of cancer disease using metabolomics approaches.
Nmr Metabolomics In Cancer Research
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Author : Miroslava Čuperlović-Culf
language : en
Publisher: Elsevier
Release Date : 2012-12-17
Nmr Metabolomics In Cancer Research written by Miroslava Čuperlović-Culf and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-17 with Medical categories.
The application of nuclear magnetic resonance (NMR) metabolomics in cancer research requires an understanding of the many possibilities that NMR metabolomics can offer, as well as of the specific characteristics of the cancer metabolic phenotype and the open questions in cancer research. NMR metabolomics in cancer research presents a detailed account of the NMR spectroscopy methods applied to metabolomics mixture analysis along with a discussion of their advantages and disadvantages. Following an overview of the potential use of NMR metabolomics in cancer research, the book begins with an examination of the cancer metabolic phenotype and experimental methodology, before moving on to cover data pre-processing and data analysis. Chapters in the latter part of the book look at dynamic metabolic profiling, biomarker discovery, and the application of NMR metabolomics for different types of cancer, before a concluding chapter discusses future perspectives in the field. Focused description of NMR spectroscopy needed by cancer biologists who are starting to use metabolomics Current overview of knowledge related to the cancer metabolic phenotype from the perspective of metabolomics applications Information about the best practices in NMR metabolomics experimentation and data preprocessing as applied to different sample types
Metabolomics
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Author : Vijay Soni
language : en
Publisher: Springer Nature
Release Date : 2023-10-24
Metabolomics written by Vijay Soni and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-10-24 with Science categories.
This book Introduces the extensive applications of metabolomics from all possible areas of research and development so that not only an undergraduate can understand the advancement of metabolomics, but an entrepreneur can harness the knowledge to address possible problems to make a perfect tool to address their research question. Topics covered include the role of metabolomics in the development of agriculture, plant pathology, and their applications; the generalized application of the metabolomics and use of related technologies in various sectors of industries; and the future of metabolomics and upcoming related technologies that can fill the gap between different -omics and their applications for the betterment of humankind. This is an ideal book for university professors, researchers, and advanced-level scientists who are exploring different avenues in metabolomics. Availability of this concise information in one place will aid scientists by expanding their arsenal of techniques and can be helpful to bring more collaborations and to identify the expert at the global level.
Metabolomics In Health And Disease Biology
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Author :
language : en
Publisher: Elsevier
Release Date : 2024-02-26
Metabolomics In Health And Disease Biology written by and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-02-26 with Science categories.
Metabolomics in Health and Disease Biology, Volume 104 covers this rapidly emerging field that aims for metabolic phenotyping and understanding the blueprint of metabolic pathways under various health and disease conditions by comprehensive analysis of metabolites. Chapters in this new release include Metabolomics approaches: Biomarkers to Disease mechanisms, Metabolomics in sleep disorders, Metabolomics in predicting the hallmark of Cancer Metabolism, Spectroscopic based rapid metabolic fingerprinting approaches for Cancer diagnosis, Lipidomics in assessing the health of osteoarthritis, Metabolomics Applications in Type 2 Diabetes mellitus, Metabolomics of Diabetic retinopathy, Metabolomics in Neurodegenerative disorders- Parkinson's disease, and Metabolomic of Neurodegenerative disorder: Alzheimer's Disease. Presents crucial reviews from selected experts in the field of metabolomics, with cross-disciplinary contributions Provides the latest insights into our understanding of diseases using metabolomics-based approaches Includes graphical material for metabolomics application that provide useful information for ease of reading of audience
Metabolomics Of Bladder Cancer
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Author : Vishwajeet Singh
language : en
Publisher: Elsevier
Release Date : 2024-09-01
Metabolomics Of Bladder Cancer written by Vishwajeet Singh and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-09-01 with Science categories.
Metabolomics of Bladder Cancer: An Emerging Application provides a unique perspective on the role of metabolomics in identifying new cancer biomarkers and offers insights into the latest research methodologies and potential therapeutic applications. With a strong focus on foundational research of bladder cancer, the book examines how applied research on the discovery of metabolomic biomarkers with prognostic and predictive value is needed to stratify patients into different risk groups, minimizing overtreatment and the risk of drug resistance development. In 8 chapters Metabolomics of Bladder Cancer: An Emerging Application gives an in-depth analysis of recent findings in both fundamental and applied research, with a focus on the metabolomics approach and its potential for identifying major metabolic pathways that characterize various diseases and physiological states. It intuitively leads from the discovery of biomarkers for bladder cancer, to the metabolisms of glutamine and fatty acids and finalizes with a chapter on the metabolic effect of cancer therapy. Overall, this book is a comprehensive and insightful resource for researchers, clinicians, and academic professionals interested in the latest developments in bladder cancer research. Gives an in-depth analysis of the most recent findings in both fundamental and applied research on bladder cancer Focuses on metabolomics and how this type of research strategy identifies biomarkers to understand the disease and identify targetable therapeutic molecules Provides insight into the technological advancements in metabolomic analysis for bladder cancer
Tumor Metabolome Targeting And Drug Development
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Author : Steven Kanner
language : en
Publisher: Springer Science & Business Media
Release Date : 2014-01-07
Tumor Metabolome Targeting And Drug Development written by Steven Kanner and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-01-07 with Medical categories.
In this volume, the major metabolic alterations identified in cancer and tumor-associated cells are explored, including discussions of former and emerging approaches to drug development in targeting cancer cell metabolism. The metabolic network in cells promotes the generation of both energy and biomass needed for them to grow, divide and differentiate. However, the metabolism of malignant cells generally varies from that of normal cells. These differences provide a platform for the discovery of new approaches to targeting potential vulnerabilities in cancer cells for therapeutic options Some of the significant changes that occur involve ATP production and consumption that modulates the ATP to ADP ratio, hypoxia and the effects of reactive oxygen species on glycolysis, regulation of mitochondrial respiration, induction and suppression of autophagy, and the Warburg effect and “reverse” Warburg effect--these topics and more are discussed in this volume.
Metabolomics
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Author :
language : en
Publisher: BoD – Books on Demand
Release Date : 2020-07-01
Metabolomics written by and has been published by BoD – Books on Demand this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-07-01 with Science categories.
This book is mainly for researchers interested in the new developments and applications of metabolomics. It is also important for physicians using metabolomic approaches in the diagnosis of diseases or treatment, and for postgraduate students starting their research projects on metabolomics. The book is divided into two sections as indicated from its title, namely: new insights into biology and new insights into medicine. It gives examples of the different applications of metabolomics from the production of biosurfactants by marine microorganisms to the applications of data from fecal metabolomics, serum metabolomics, and metabolomics of microbiota, as well as the use of Chinese medicines for cancer treatment. Overall, this is a well-written book, containing some very interesting research avenues and cutting-edge approaches. Finally, the editing of this book was of special interest to me and I hope that readers will also find it stimulating.