Cancer Stem Cells And Circulating Tumor Cells Targeting By Polymeric Nanoparticles For Metastatic Melanoma Treatment
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Cancer Stem Cells And Circulating Tumor Cells Targeting By Polymeric Nanoparticles For Metastatic Melanoma Treatment
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Author : Sarah Brandão Palácio
language : en
Publisher: RFB Editora
Release Date :
Cancer Stem Cells And Circulating Tumor Cells Targeting By Polymeric Nanoparticles For Metastatic Melanoma Treatment written by Sarah Brandão Palácio and has been published by RFB Editora this book supported file pdf, txt, epub, kindle and other format this book has been release on with Antiques & Collectibles categories.
Polymeric Nanoparticles For The Treatment Of Solid Tumors
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Author : Santwana Padhi
language : en
Publisher: Springer Nature
Release Date : 2022-11-14
Polymeric Nanoparticles For The Treatment Of Solid Tumors written by Santwana Padhi and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-11-14 with Medical categories.
This book focuses on the emerging research in the field of treatment of solid tumors or cancer with new drug delivery systems using nanotechnology. Nanotechnology has given us a good scope for development of new innovative drug delivery strategies to increase the therapeutic efficacy of anticancer drugs with reduced off-target side effects. Cancer is one of the main causes of death worldwide due to the limitations of classical therapies such as low solubility of active drugs, toxic side effects on healthy cells and resistance of tumor cells. These issues are partly solved by the recent development of polymeric nanoparticles, which improve drug absorption and the therapeutic index, while reducing side effects. Drug carriers must be biocompatible, biodegradable and non-immunogenic. Coupled to a ligand that has affinity for that particular cell, polymeric nanoparticles are used to target specifically malignant cells or tissues and, in turn, improve drug stability. This book presents the latest advances in the application of polymeric particles for cancer treatment, with focus on the tumor microenvironment, synthesis, active and passive targeting, patents, targeting over-expressed receptors, tumor-targeting ligands, theranostics, glioblastoma tumors, lung cancer, breast cancer, prostate cancer and pH-responsive nanoparticles
Polymeric Nanocarriers For Treatment Of Melanoma And Genetically Modified Mesenchymal Stem Cells To Improve Outcome Of Islet Transplantation
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Author : Vaibhav Mundra
language : en
Publisher:
Release Date : 2015
Polymeric Nanocarriers For Treatment Of Melanoma And Genetically Modified Mesenchymal Stem Cells To Improve Outcome Of Islet Transplantation written by Vaibhav Mundra and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015 with categories.
Melanoma is a lethal malignancy with limited treatment options for advanced metastatic stages. New targeted therapeutic options with discovery of BRAF and MEK inhibitors have shown significant survival benefit. Despite the recent progress, inefficient tumor accumulation and dose limiting systemic toxicity remains pressing challenges for treating metastatic melanoma and there is a need for drug delivery approach to improve therapeutic index of chemotherapeutics. Nanoparticle based drug delivery represents promising approach to enhance efficacy and reduce the dose limiting systemic toxicity. Nanoparticles can be formulated either by physical encapsulation of drugs or by covalent conjugation of drugs to the polymeric backbone. Nanoparticles based strategies for encapsulation and conjugation of drugs to the polymer was reviewed in Chapter 2 where we summarized non-covalent interactions between polymer backbone and drug for physical encapsulation, various polymeric backbones for drug conjugation and application of photodynamic therapy in melanoma. Phototherapy, a light activated treatment modality is a potential therapeutic option for treatment of melanoma. Excitation of photosensitizer by light of specific wavelength can be clinically utilized for fluorescence assisted tumor surgery, photoacoustic imaging, photochemical internalization and phototherapy. Indocyanine green, water soluble FDA approved anionic tricarbocyanine with excellent safety profile and absorption in the near infrared (NIR) range is an excellent photosensitizer. However, short half-life (2-4 minutes) and limited extravascular distribution restricts PT application of ICG. In chapter 3, we have described ICG based phototherapy wherein plasma circulation and tumor accumulation of ICG was improved by designing its micelles formulation. ICG micelles were formulated by covalently conjugating ICG-NH2 to the pendant carboxyl groups of poly (ethylene glycol)-block-poly(2- methyl-2-carboxyl-propylene carbonate) (PEG-PCC) copolymer using carbodiimide coupling. ICG conjugated amphiphillic polymer self-assembled into micelles with particle size of 30-50 nm and high drug loading. These ICG conjugated micelles exhibited significant in vitro photodynamic cytotoxicity. Use of sodium azide and NIR radiation at 4° C revealed photodynamic and photothermal as primary mechanism of cytotoxicity of ICG solution and ICG conjugated micelles respectively. In vivo NIR imaging demonstrated ICG conjugated micelles prolonged ICG circulation and increased its tumor accumulation through enhanced permeability and retention effect Increase in tumor accumulation improved therapeutic efficacy with complete tumor regression in NIR irradiated ICG conjugated micelles compared to free ICG and control in A375 human melanoma tumor model in athymic nude mice. These results suggest that ICG conjugated micelles can be potentially utilized for phototherapy. Clinical translation of tubulin inhibitors for treating melanoma is limited by multidrug efflux transporters, poor aqueous solubility, and dose-limiting peripheral toxicities. Tubulin inhibitors with efficacy in taxane-resistant cancers are promising drug candidates and can be used as single agent or in conjunction with other chemotherapy. In chapter 4, we describe synthesis of tubulin inhibitors with activity in taxane resistant cell lines with IC50 in nanomolar range for the treatment of metastatic melanoma. LY293, a 5 indole derivative analog, binds to colchicine binding site and does not exhibit clinically prevalent drug resistance mechanism such as multidrug resistance (MDR) protein, breast cancer resistance protein (BCRP) and P-glycoprotein (P-gp). Since LY293 is poorly soluble in water, LY293 was formulated as polymeric nanoparticles for systemic therapy of melanoma. Methoxy polyethylene glycol-b-poly (carbonate-co-lactide) (mPEG-b-P (CB-co-LA)) random copolymer was synthesized and characterized by 1H NMR and gel permeation chromatography (GPC). Polymeric nanoparticles were formulated using o/w emulsification method with a mean particle size of 150 nm and loading efficiency of 7.40%. Treatment with LY293 loaded nanoparticles effectively inhibited the proliferation of melanoma cells in vitro and exhibited concentration dependent cell cycle arrest in G2/M phase. In vivo, LY293 loaded nanoparticles significantly inhibited the proliferation of highly aggressive metastasized melanoma in a syngeneic lung metastasis melanoma mouse model without toxicity to vital organs. Islet transplantation has been performed in many patients especially undergoing kidney transplantation to treat Type I diabetes. Proportion of recipients who achieved insulin independence is low and is limited by long-term graft rejection and by primary non-function of islets. Primary non-function is characterized as the loss of islet viability and function caused by non-immune reasons, such as the disruption of islet microvasculature and apoptosis of islets due to production of inflammatory cytokines at the transplantation sites. In chapter 5, we studied the potential of human bone marrow derived mesenchymal stem cells (hBMSCs) as gene carriers for improving the outcome of human islet transplantation. hBMSCs were transduced with Adv-hVEGF-hIL-1Ra to overexpress human vascular endothelial growth factor (hVEGF) and human interleukin-1 receptor antagonist (hIL-1Ra). Viability of human islets co-cultured with hBMSCs was determined by membrane fluorescent method and glucose stimulation test. Transduced hBMSCs and human islets were co-transplanted under the kidney capsule of NOD. Cg-Prkdcscid Il2rgtm1Wjl/SzJ diabetic mice and blood glucose levels were measured over time to evaluate the efficacy of genetically modified hBMSCs. Our in vitro and in vivo results showed hBMSCs can be used as gene delivery vehicles to improve the outcome of islet transplantation without affecting their stemness and differentiation potential.
Cutaneous Melanoma
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Author :
language : en
Publisher:
Release Date :
Cutaneous Melanoma written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on with categories.
Nanopharmaceuticals Principles And Applications Vol 3
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Author : Vinod Kumar Yata
language : en
Publisher: Springer Nature
Release Date : 2020-08-19
Nanopharmaceuticals Principles And Applications Vol 3 written by Vinod Kumar Yata and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-08-19 with Technology & Engineering categories.
This book is the third volume on this subject and focuses on the recent advances of nanopharmaceuticals in cancer, dental, dermal and drug delivery applications and presents their safety, toxicity and therapeutic efficacy. The book also includes the transport phenomenon of nanomaterials and important pathways for drug delivery applications. It goes on to explain the toxicity of nanoparticles to different physiological systems and methods used to assess this for different organ systems using examples of in vivo systems.
Nanotechnology In Medicine
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Author : Vishnu Kirthi Arivarasan
language : en
Publisher: Springer Nature
Release Date : 2021-01-21
Nanotechnology In Medicine written by Vishnu Kirthi Arivarasan and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-01-21 with Science categories.
Nanomedicine is the field of science that deals with organic applications of medicine at the nano-scale level. It primarily addresses finding, anticipating, and treating sickness, as well as using nanotechnology to assist in controlling human frameworks at the cellular level. The nature of nanotechnology allows it to address numerous medical issues in humans. This book offers comprehensive information to better comprehend and apply multifunctional nanoparticles in nanomedicine, and thus open avenues in the field. Medicating at the nanolevel is an exceptional therapeutic avenue, as it avoids symptoms associated with conventional medicines. This book investigates recent insights into structuring novel drug delivery frameworks. It concentrates on the physical characteristics of drug delivery transporters, and the preliminary procedures involved in their use. The book offers in-depth detail that benefits academics and researchers alike, containing broad research from experts in the field, and serves as a guide for students and researchers in the field of nanomedicine, drug delivery, and nanotechnology.
Nanotechnology For Cancer Therapy
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Author : Mansoor M. Amiji
language : en
Publisher: CRC Press
Release Date : 2006-12-19
Nanotechnology For Cancer Therapy written by Mansoor M. Amiji and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2006-12-19 with Medical categories.
While simultaneous breakthroughs occurring in molecular biology and nanoscience/technology will ultimately revolutionize all of medicine, it is with our efforts to prevent, diagnose, and treat cancer that many of the most dramatic advances will occur. In support of this potential, the U.S. National Cancer Institute (NCI) established the Alliance fo
Cancer Targeted Drug Delivery
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Author : You Han Bae
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-08-31
Cancer Targeted Drug Delivery written by You Han Bae and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-08-31 with Medical categories.
This book was conceived from a simple question as to why cancer is so difficult to treat. Ultimately we want to find ways to cure cancers, but that may be an elusive dream at least with the technologies we have now and expect to have in the near future. This leads the question of whether it is possible to improve current cancer treatment methods, especially from the perspective of enhancing targeted drug delivery to tumors. This volume is designed to provide information related to the difficulties in treating cancers through targeted drug delivery, our current understanding of cancer biology, and potential technologies that might be used to achieve enhanced drug delivery to tumors. An ideal drug delivery system for treating cancers would maximize the therapeutic efficacy with minimal side effects in clinical applications. The seemingly improved anticancer efficacy of the current nanoparticle-based formulations needs to be viewed from the context of very poor success rates for translation to human applications. The results of in vitro cell culture models and small animal in vivo experiments have not been extrapolated to clinical applications. Finding the reasons for the lack of successful translation is required if we are to discover approaches to substantially extend the survival time of cancer patients, and hopefully identify cures. Cancer Targeted Drug Delivery: Elusive Dream describes some answers of achieving the so far elusive dream of treating cancers like other chronic diseases with therapies that focus using improved drug delivery systems designed to better align with the unique biological and physiological properties of cancer.
Biointerface Engineering Prospects In Medical Diagnostics And Drug Delivery
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Author : Pranjal Chandra
language : en
Publisher: Springer Nature
Release Date : 2020-07-21
Biointerface Engineering Prospects In Medical Diagnostics And Drug Delivery written by Pranjal Chandra and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-07-21 with Medical categories.
This book provides detailed information on the surface and surface chemistry of various biointerfaces for the understanding and development of biosensors, biocompatible devices, and drug delivery systems. It highlights the role of interfacial phenomena towards the behaviour of biomolecules on different surfaces and their significance in recent applications. The book also addresses various surface engineering techniques for the modification of biomaterials that are implemented for improving biocompatibility. It provides an updated scientific concept of various interactions of biological systems with surfaces/modified surfaces at the molecular and cellular level. The chapters include various in-vitro, in-vivo, ex-vivo models to illustrate various aspects of Biointerface Engineering. Finally, the book elucidates troubleshooting strategies and future prospects of Biointerface Engineering in Medical Diagnostics and Drug Delivery.
Advanced Healthcare Materials
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Author : Ashutosh Tiwari
language : en
Publisher: John Wiley & Sons
Release Date : 2014-05-09
Advanced Healthcare Materials written by Ashutosh Tiwari and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-05-09 with Technology & Engineering categories.
Offers a comprehensive and interdisciplinary view of cutting-edge research on advanced materials for healthcare technology and applications Advanced healthcare materials are attracting strong interest in fundamental as well as applied medical science and technology. This book summarizes the current state of knowledge in the field of advanced materials for functional therapeutics, point-of-care diagnostics, translational materials, and up-and-coming bioengineering devices. Advanced Healthcare Materials highlights the key features that enable the design of stimuli-responsive smart nanoparticles, novel biomaterials, and nano/micro devices for either diagnosis or therapy, or both, called theranostics. It also presents the latest advancements in healthcare materials and medical technology. The senior researchers from global knowledge centers have written topics including: State-of-the-art of biomaterials for human health Micro- and nanoparticles and their application in biosensors The role of immunoassays Stimuli-responsive smart nanoparticles Diagnosis and treatment of cancer Advanced materials for biomedical application and drug delivery Nanoparticles for diagnosis and/or treatment of Alzheimers disease Hierarchical modelling of elastic behavior of human dental tissue Biodegradable porous hydrogels Hydrogels in tissue engineering, drug delivery, and wound care Modified natural zeolites Supramolecular hydrogels based on cyclodextrin poly(pseudo)rotaxane Polyhydroxyalkanoate-based biomaterials Biomimetic molecularly imprinted polymers
