Carcinogenic And Mutagenic Metal Compounds 2
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Carcinogenic And Mutagenic Metal Compounds 2
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Author : Ernest Merian
language : en
Publisher: CRC Press
Release Date : 1988
Carcinogenic And Mutagenic Metal Compounds 2 written by Ernest Merian and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1988 with Medical categories.
Cytotoxic Mutagenic And Carcinogenic Potential Of Heavy Metals Related To Human Environment
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Author : N. Hadjiliadis
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Cytotoxic Mutagenic And Carcinogenic Potential Of Heavy Metals Related To Human Environment written by N. Hadjiliadis and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Science categories.
Environmental pollution is one of the main problems to confront humanity, with the heavy metals occupying a leading role among the most pernicious pollutants. The metals cause cancer and other sicknesses. Their cytotoxic, mutagenic and carcinogenic potentials are not fully understood, and any thorough investigation demands the combined efforts of scientists drawn from many different disciplines. But the effects of heavy metals are not all negative: some, like cis-DDP, and some ruthenium and tin complexes, have antitumour activity. The idea underlying the present work is therefore to present a multidisciplinary perspective on heavy metals in the environment, affording a better understanding of their action on human organisms and health, aiming to make them less polluting and more environmentally friendly.
Carcinogenic And Mutagenic Metal Compounds
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Author : Ernest Merian
language : en
Publisher: Routledge
Release Date : 1991
Carcinogenic And Mutagenic Metal Compounds written by Ernest Merian and has been published by Routledge this book supported file pdf, txt, epub, kindle and other format this book has been release on 1991 with Metals categories.
Selected papers from the Third Hans Wolfgang Nurnberg Memorial Workshop on Toxic Metal Compounds, Follinica, Italy, April 1988. The workshop discussed the gaps between chemistry and biology, and the topics covered include: the analytical chemistry and speciation of air particulates, water, sediments, soils, and of food and tissue; uptake by plants, mosses, and lichens, including biomonitoring techniques; and the uptake and biological effects of chromium, nickel, cadmium, and aluminum compounds. the papers were first published in issues of Toxicological and environmental chemistry and International journal of environmental analytical chemistry. Annotation copyrighted by Book News, Inc., Portland, OR
Carcinogenic And Mutagenic Metal Compounds
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Author : E. Merian
language : en
Publisher: CRC Press
Release Date : 1985
Carcinogenic And Mutagenic Metal Compounds written by E. Merian and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1985 with Medical categories.
This book contains selected papers presented at the Third Hans Wolfgang Nurnberg Memorial Workshop on Toxic Metal compounds held in Follinica, Italy in April 1988. This workship discussed the areas of research which link chemistry and biology, difining real problems for further research, and was attended by experts from different fields including analytical chemistry, speciation, environmental chemistry, biochemistry, short-term testing and risk assessment.
Biological Effects Of Heavy Metals
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Author : E. C. Foulkes
language : en
Publisher: CRC Press
Release Date : 1990-09-06
Biological Effects Of Heavy Metals written by E. C. Foulkes and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1990-09-06 with Medical categories.
V.1. [without special title] -- v.2. Metal carcinogenesis.
Carcinogenic And Mutagenic Metal Compounds 3
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Author : Ernest Merian
language : en
Publisher: CRC Press
Release Date : 1991
Carcinogenic And Mutagenic Metal Compounds 3 written by Ernest Merian and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1991 with Medical categories.
Selected papers from the Third Hans Wolfgang Nurnberg Memorial Workshop on Toxic Metal Compounds, Follinica, Italy, April 1988. The workshop discussed the gaps between chemistry and biology, and the topics covered include: the analytical chemistry and speciation of air particulates, water, sediments, soils, and of food and tissue; uptake by plants, mosses, and lichens, including biomonitoring techniques; and the uptake and biological effects of chromium, nickel, cadmium, and aluminum compounds. the papers were first published in issues of Toxicological and environmental chemistry and International journal of environmental analytical chemistry. Annotation copyrighted by Book News, Inc., Portland, OR
The Carcinogenicity Of Metals
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Author : Alan B. G. Lansdown
language : en
Publisher: Royal Society of Chemistry
Release Date : 2013-10-31
The Carcinogenicity Of Metals written by Alan B. G. Lansdown and has been published by Royal Society of Chemistry this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-10-31 with Science categories.
This book re-evaluates epidemiological and occupational health studies, experimental studies in animals and in vitro experiments relating to the toxicity of 27 metal and metalloid elements for which evidence of carcinogenicity has been presented. Human carcinogenic risk is substantiated in relation to arsenic, beryllium, thorium, chromium, radioactive elements, probably lead, and some nickel and cobalt compounds, and respirable silica particles, but the carcinogenicity of iron, aluminium, titanium, tungsten, antimony, bismuth, mercury, precious metals, and certain related compounds in humans is unresolved. The toxicity and carcinogenicity of each element is specific but correlates poorly with its position in the Periodic Table. Carcinogenicity differs according to the valency of the ion and its ability to interact with and penetrate membranes in target cells and to bind, denature or induce mutations by genotoxic or epigenetic mechanisms. This important text comprehensively examines each of the elements providing detailed information on the carcinogenicity and toxicity and detailing the most up-to-date research in this area. The book is an essential tool for toxicologists, medicinal and biochemists, and environmental scientists working in both industry and academia.
Mechanisms Of Carcinogenesis
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Author : Elizabeth K. Weisburger
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Mechanisms Of Carcinogenesis written by Elizabeth K. Weisburger and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.
but also the possibility of intervention in specific stages. In Human behavior, including stress and other factors, plays an important role in neoplasia, although too little is known addition, variables which affect cancer development as well on the reasons for such development. Carcinogens, which as some endogenous factors can be better delineated help initiate the neoplastic process, may be either synthetic through such investigations. The topics of this volume encompass premalignant non or naturally-occurring. Cancer causation may be ascribed to invasive lesions, species-specific aspects of carcinogenicity, certain chemicals, physical agents, radioactive materials, viruses, parasites, the genetic make-up of the organism, and radiation, viruses, a quantum theory of carinogenesis, onco bacteria. Humans, eumetazoan animals and vascular plants genes, and selected environmental carcinogens. are susceptible to the first six groups of cancer causes, whe reas the last group, bacteria, seems to affect only vascular plants. Neoplastic development may begin with impairment ofJmdy defenses by a toxic material (carcinogen) which acts as an initiator, followed by promotion and progression to an overt neoplastic state. Investigation of these processes Series Editor Volume Editor allows not only a better insight into the mechanism of action Hans E. Kaiser Elizabeth K. Weisburger vii ACKNOWLEDGEMENT Inspiration and encouragement for this wide ranging project on cancer distribution and dissemination from a comparative biological and clinical point of view, was given by my late friend E. H. Krokowski.
How Tobacco Smoke Causes Disease
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Author : United States. Public Health Service. Office of the Surgeon General
language : en
Publisher:
Release Date : 2010
How Tobacco Smoke Causes Disease written by United States. Public Health Service. Office of the Surgeon General and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010 with Government publications categories.
This report considers the biological and behavioral mechanisms that may underlie the pathogenicity of tobacco smoke. Many Surgeon General's reports have considered research findings on mechanisms in assessing the biological plausibility of associations observed in epidemiologic studies. Mechanisms of disease are important because they may provide plausibility, which is one of the guideline criteria for assessing evidence on causation. This report specifically reviews the evidence on the potential mechanisms by which smoking causes diseases and considers whether a mechanism is likely to be operative in the production of human disease by tobacco smoke. This evidence is relevant to understanding how smoking causes disease, to identifying those who may be particularly susceptible, and to assessing the potential risks of tobacco products.
Quantitative Mammalian Cell Mutagenesis And A Preliminary Study Of The Mutagenic Potential Of Metallic Compounds
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Author :
language : en
Publisher:
Release Date : 1978
Quantitative Mammalian Cell Mutagenesis And A Preliminary Study Of The Mutagenic Potential Of Metallic Compounds written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1978 with Mutagenesis categories.
We have defined a set of stringent conditions required to quantify specific gene mutation in a mammalian cell system, CHO/HGPRT. Greater than 98% of the 6-thioguanine (TG)-resistant variants were shown to be deficient in the hypoxanthine-guanine phosphoribosyl transferase (HGPRT) activity in Chinese hamster ovary (CHO) cells. The sensitive and quantitative nature of this assay was utilized to study the structure-activity (mutagenicity) relationship of various classes of chemicals. Mutagenicity as determined in the CHO/HGPRT assay, appears to correlate well (76/83 (92%)) with the reported animal carcinogenicity of 108 chemicals studied. The system also appears to be suitable for studying the mutagenicity and cytotoxicity of metallic compounds. We found that cis-dichlorodiammine Pt(II) (cis-Pt(NH/sub 3/)/sub 2/Cl/sub 2/) (cis-DDP), one of the widely used inorganic antitumor agents, is cytotoxic and mutagenic. Mutagenicity of cis-DDP correlates with its binding to DNA. However, trans-DDP, (Pt(NH/sub 3/)/sub 4/)Cl/sub 2/, and K/sub 2/(PtCl/sub 4/) exhibit greatly reduced biological activities. Among 14 other metals studied, we found that carcinogenic metallic compounds, such as MnCl/sub 2/, NiCl/sub 2/, and BeSO/sub 4/ are mutagenic, while non-carcinogenic compounds such as MgCl/sub 2/ and H/sub 2/SeO/sub 3/ are not. Determination of metal mutagenicity is apparently complicated by the ionic composition of the medium. This may account in part for varying results in studies of the mutagenicity of other metallic compounds. Further refinement of the assay conditions, especially with respect to the ionic environment necessary for quantifying mutagenesis of each metallic agent, is in progress.